The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Expression pattern of the transcription factor Olig2 in response to brain injuries: Implications for neuronal repair
Open accessAbstract
Despite the presence of neural stem cells and ongoing neurogenesis in some regions of the adult mammalian brain, neurons are not replaced in most brain regions after injury. With the aim to unravel factors contributing to the failure of neurogenesis in the injured cerebral cortex, we examined the expression of cell fate determinants after acute brain injuries, such as stab wound or focal ischemia, and in a model of chronic amyloid deposition. Although none of the neurogenic factors, such as Pax6, Mash1, Ngn2, was detected in the injured parenchyma, we observed a strong up-regulation of the bHLH transcription factor Olig2, but not Olig1, upon acute and chronic injury. To examine the function of Olig2 in brain lesion, we injected retroviral vectors containing a dominant negative form of Olig2 into the lesioned cortex 2 days after a stab wound. Antagonizing Olig2 function resulted in a significant number of infected cells generating immature neurons that were not observed after injection of the control virus. These data, therefore, imply Olig2 as a repressor of neurogenesis in cells reacting to brain injury and open innovative perspectives toward evoking endogenous neuronal repair.
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Cites
Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo
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Subventricular zone astrocytes are neural stem cells in the adult mammalian brain
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Inflammatory Blockade Restores Adult Hippocampal Neurogenesis
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Inflammation is detrimental for neurogenesis in adult brain
Ekdahl, C. T., Claasen, J.-H., Bonde, S., Kokaia, Z., & Lindvall, O. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2234031100 · Cited by 1,559
Astrocytes give rise to new neurons in the adult mammalian hippocampus
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Self-citationThe bHLH Transcription Factors OLIG2 and OLIG1 Couple Neuronal and Glial Subtype Specification
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bHLH Transcription Factor Olig1 Is Required to Repair Demyelinated Lesions in the CNS
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Cited by
Astrocytes: Biology and pathology
Sofroniew, M. V., & Vinters, H. V. (2010) · Acta Neuropathologica · doi:10.1007/s00401-009-0619-8 · Cited by 5,196
Adult neurogenesis and functional plasticity in neuronal circuits
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Origin of oligodendrocytes in the subventricular zone of the adult brain
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Directing Astroglia from the Cerebral Cortex into Subtype Specific Functional Neurons
Heinrich, C., Blum, R., Gascón, S., Masserdotti, G., Tripathi, P., Sánchez, R., Tiedt, S., Schroeder, T., Götz, M., & Berninger, B. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000373 · Cited by 465
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Metadata
- Authors
- Buffo, A., Vosko, M. R., Ertürk, D., Hamann, G. F., Jucker, M., Rowitch, D., & Götz, M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2005-12-05
- Volume
- 102
- Issue
- 50
- Pages
- 18183-18188
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2124019758
- Cited by
- 394
- References
- 8
- FWCI
- 5.23
- Type
- journal article
- Language
- en
- Open access
- green
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- Buffo, A., Vosko, M. R., Ertürk, D., Hamann, G. F., Jucker, M., Rowitch, D., & Götz, M. (2005). Expression pattern of the transcription factor Olig2 in response to brain injuries: Implications for neuronal repair. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0506535102
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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