The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Self-assembly of synthetic collagen triple helices
Abstract
Collagen is the most abundant protein in animals and the major component of connective tissues. Although collagen isolated from natural sources has long served as the basis for some biomaterials, natural collagen is difficult to modify and can engender pathogenic and immunological side effects. Collagen comprises a helix of three strands. Triple helices derived from synthetic peptides are much shorter (<10 nm) than natural collagen (≈300 nm), limiting their utility. Here, we describe the synthesis of short collagen fragments in which the three strands are held in a staggered array by disulfide bonds. Data from CD spectroscopy, dynamic light scattering, analytical ultracentrifugation, atomic force microscopy, and transmission electron microscopy indicate that these “sticky-ended” fragments self-assemble via intermolecular triple-helix formation. The resulting fibrils resemble natural collagen, and some are longer (>400 nm) than any known collagen. We anticipate that our self-assembly strategy can provide synthetic collagen-mimetic materials for a variety of applications.
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Cites
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Self-Assembly and Mineralization of Peptide-Amphiphile Nanofibers
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Fabrication of novel biomaterials through molecular self-assembly
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Designing materials for biology and medicine
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Collagen Structure and Stability
Shoulders, M. D., & Raines, R. T. (2009) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.77.032207.120833 · Cited by 3,923
Self-citationWebber, M. J., Appel, E. A., Meijer, E. W., & Langer, R. (2016) · Nature Materials · doi:10.1038/nmat4474 · Cited by 1,605
Collagen-based biomaterials for wound healing
Chattopadhyay, S., & Raines, R. T. (2014) · Biopolymers · doi:10.1002/bip.22486 · Cited by 1,041
Self-citationO'Leary, L. E. R., Fallas, J. A., Bakota, E. L., Kang, M. K., & Hartgerink, J. D. (2011) · Nature Chemistry · doi:10.1038/nchem.1123 · Cited by 667
Recent trends in protein and peptide-based biomaterials for advanced drug delivery
Varanko, A., Saha, S., & Chilkoti, A. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.08.008 · Cited by 369
Metadata
- Authors
- Kotch, F. W., & Raines, R. T.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2006-02-17
- Volume
- 103
- Issue
- 9
- Pages
- 3028-3033
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1969946367
- Cited by
- 311
- References
- 42
- FWCI
- 12.74
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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