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In vivo targeting of dendritic cells for activation of cellular immunity using vaccine carriers based on pH-responsive microparticles
Open accessAbstract
Activating the immune system to trigger a specific response is a major challenge in vaccine development. In particular, activating sufficient cytotoxic T lymphocyte-mediated cellular immunity, which is crucial for the treatment of many diseases including cancer and AIDS, has proven to be especially challenging. In this study, antigens were encapsulated in acid-degradable polymeric particle carriers to cascade cytotoxic T lymphocyte activation. To target dendritic cells, the most potent antigen-presenting cells, the particle carriers, were further conjugated with monoclonal antibodies. A series of ex vivo and in vivo studies have shown increased receptor-mediated uptake of antibody-conjugated particles by dendritic cells as well as migration of particle-carrying dendritic cells to lymph nodes and stimulation of naïve T cells leading to enhanced cellular immune response as confirmed by specific cell lysis and IFN-γ secretion.
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Cited by
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Kabanov, A. V., & Vinogradov, S. V. (2009) · Angewandte Chemie International Edition · doi:10.1002/anie.200900441 · Cited by 1,313
From Sewer to Saviour—Targeting the Lymphatic System to Promote Drug Exposure and Activity
Trevaskis, N. L., Kaminskas, L. M., & Porter, C. J. H. (2015) · Nature Reviews Drug Discovery · doi:10.1038/nrd4608 · Cited by 654
Materials engineering for immunomodulation
Hubbell, J. A., Thomas, S. N., & Swartz, M. A. (2009) · Nature · doi:10.1038/nature08604 · Cited by 561
Targeting dendritic cells with biomaterials: developing the next generation of vaccines
Reddy, S. T., Swartz, M. A., & Hubbell, J. A. (2006) · Trends in Immunology · doi:10.1016/j.it.2006.10.005 · Cited by 406
Cruz, L. J., Tacken, P. J., Fokkink, R., Joosten, B., Stuart, M. C., Albericio, F., Torensma, R., & Figdor, C. G. (2010) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.02.013 · Cited by 281
Metadata
- Authors
- Kwon, Y. J., James, E., Shastri, N., & Fréchet, J. M. J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2005-12-12
- Volume
- 102
- Issue
- 51
- Pages
- 18264-18268
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1987576929
- Cited by
- 201
- References
- 0
- FWCI
- 2.25
- Type
- journal article
- Language
- en
- Open access
- green
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- Kwon, Y. J., James, E., Shastri, N., & Fréchet, J. M. J. (2005). In vivo targeting of dendritic cells for activation of cellular immunity using vaccine carriers based on pH-responsive microparticles. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0509541102
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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