The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Immunity and behavior: Antibodies alter emotion
Open accessAbstract
Systemic lupus erythematosus is an autoimmune disease in which most patients express Abs that bind double-stranded DNA. Recent work has shown that a subset of lupus Abs can crossreact with the NR2A and NR2B subunits of the NMDA receptor. This receptor is expressed in neurons throughout the brain but is at highest density within cells of the hippocampus, amygdala, and hypothalamus. The neurons in the CNS are normally protected from brain-reactive Abs by the blood–brain barrier (BBB); however, a breach in the barrier's integrity exposes neurons to potentially pathogenic Abs. Previously, we have shown that mice that are immunized with a peptide mimetope of DNA produce lupus-like Abs that crossreact with DNA and the NMDA receptor. Moreover, after abrogation of the BBB by treatment with lipopolysaccharide, the immunized mice display hippocampal neuron damage with ensuing memory impairment. Given that rises in epinephrine can increase cerebral blood flow and can cause leaks in the BBB, we decided to investigate whether epinephrine could act as a permissive agent for Ab-mediated neurotoxicity. Here, we show that peptide-immunized mice, given epinephrine to open the BBB, lose neurons in the lateral amygdala and develop a behavioral disorder characterized by a deficient response to fear-conditioning paradigms. Thus, the agent used to open the BBB determines which brain region is made vulnerable to neurotoxic Abs, and Abs that penetrate brain tissue can cause changes not only in cognitive competence, but also in emotional behavior.
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Cites
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Self-citationEvidence for bulk flow of brain interstitial fluid: significance for physiology and pathology
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Paraneoplastic anti– N ‐methyl‐ D ‐aspartate receptor encephalitis associated with ovarian teratoma
Dalmau, J., Tüzün, E., Wu, H., Masjuan, J., Rossi, J. E., Voloschin, A., Baehring, J. M., Shimazaki, H., Koide, R., King, D., et al. (2007) · Annals of Neurology · doi:10.1002/ana.21050 · Cited by 2,492
Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels
Hansen, K. B., Wollmuth, L. P., Bowie, D., Furukawa, H., Menniti, F. S., Sobolevsky, A. I., Swanson, G. T., Swanger, S. A., Greger, I. H., Nakagawa, T., et al. (2021) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000131 · Cited by 686
Neuropsychiatric lupus: new mechanistic insights and future treatment directions
Schwartz, N., Stock, A. D., & Putterman, C. (2019) · Nature Reviews Rheumatology · doi:10.1038/s41584-018-0156-8 · Cited by 429
Stress as a trigger of autoimmune disease
Stojanovich, L., & Marisavljevich, D. (2008) · Autoimmunity Reviews · doi:10.1016/j.autrev.2007.11.007 · Cited by 419
Metadata
- Authors
- Huerta, P. T., Kowal, C., DeGiorgio, L. A., Volpe, B. T., & Diamond, B.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2006-01-04
- Volume
- 103
- Issue
- 3
- Pages
- 678-683
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2164846242
- Cited by
- 293
- References
- 37
- FWCI
- 14.75
- Type
- journal article
- Language
- en
- Open access
- green
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- Huerta, P. T., Kowal, C., DeGiorgio, L. A., Volpe, B. T., & Diamond, B. (2006). Immunity and behavior: Antibodies alter emotion. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0510055103
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
