Postsynaptic receptor trafficking underlying a form of associative learning
Abstract
To elucidate molecular, cellular, and circuit changes that occur in the brain during learning, we investigated the role of a glutamate receptor subtype in fear conditioning. In this form of learning, animals associate two stimuli, such as a tone and a shock. Here we report that fear conditioning drives AMPA-type glutamate receptors into the synapse of a large fraction of postsynaptic neurons in the lateral amygdala, a brain structure essential for this learning process. Furthermore, memory was reduced if AMPA receptor synaptic incorporation was blocked in as few as 10 to 20% of lateral amygdala neurons. Thus, the encoding of memories in the lateral amygdala is mediated by AMPA receptor trafficking, is widely distributed, and displays little redundancy.
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DA signaling within the hippocampus serves to consolidate the association of a neutral context with aversive, unconditioned stimuli by contributing to the plasticity of the CA3-CA1 circuitry that likely contributes to memory retention.
“Thus, DA signaling within the hippocampus serves to consolidate the association of a neutral context with aversive, unconditioned stimuli by contributing to the plasticity of the CA3-CA1 circuitry that likely contributes to memory retention (McHugh et al., 2007; Rumpel et al., 2005).”
From Dopamine regulates aversive contextual learning and associated in vivo synaptic plasticity in the Hippocampus (2016) · cites this paper as Rumpel et al., 2005
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- Authors
- Rumpel, S., LeDoux, J., Zador, A., & Malinow, R.
- Affiliations
- Cold Spring Harbor Laboratory (US)
- Corresponding author
- Malinow, Roberto
- Venue
- Science
- Published
- 2005-04
- Volume
- 308
- Issue
- 5718
- Pages
- 83-88
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1977313055
- Cited by
- 775
- References
- 53
- Citations by year
- 2026: 14 · 2025: 25 · 2024: 25 · 2023: 16 · 2022: 18 · 2021: 34 · 2020: 25 · 2019: 34 · 2018: 41 · 2017: 39 · 2016: 38 · 2015: 44 · 2014: 42 · 2013: 61 · 2012: 31
- FWCI
- 18.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) (acceptedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- AMPA receptor trafficking, fear conditioning, associative learning, lateral amygdala, postsynaptic receptors, memory encoding, glutamate receptors, synaptic plasticity
- MeSH terms
- Amygdala, Animals, Association Learning, Conditioning, Psychological, Electrophysiology, Fear, Female, Genetic Vectors, Male, Memory, Neural Pathways, Synaptic Transmission, Neuronal Plasticity, Neurons, Recombinant Fusion Proteins, Synapses, Thalamus, Rats, Sprague-Dawley, Long-Term Potentiation, Receptors, AMPA, Simplexvirus, Patch-Clamp Techniques, Protein Transport, Green Fluorescent Proteins, Rats
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