Core domain interactions in full-length p53 in solution

Surfing the p53 network

Vogelstein, B., Lane, D., & Levine, A. J. (2000) · Nature · doi:10.1038/35042675 · Cited by 6,607 · see citing works

Live or let die: the cell's response to p53

Vousden, K. H., & Lü, X. (2002) · Nature reviews. Cancer · doi:10.1038/nrc864 · Cited by 3,177 · see citing works

Crystal Structure of a p53 Tumor Suppressor-DNA Complex: Understanding Tumorigenic Mutations

Cho, Y., Gorina, S., Jeffrey, P. D., & Pavletich, N. P. (1994) · Science · doi:10.1126/science.8023157 · Cited by 2,559 · see citing works

Attenuated T 2 relaxation by mutual cancellation of dipole–dipole coupling and chemical shift anisotropy indicates an avenue to NMR structures of very large biological macromolecules in solution

Pervushin, K. V., Riek, R., Wider, G., & Kurt Wüthrich, A. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.23.12366 · Cited by 2,450 · see citing works

Structure of the MDM2 Oncoprotein Bound to the p53 Tumor Suppressor Transactivation Domain

Kussie, P. H., Gorina, S., Marechal, V., Elenbaas, B., Moreau, J., Levine, A. J., & Pavletich, N. P. (1996) · Science · doi:10.1126/science.274.5289.948 · Cited by 2,206 · see citing works

Definition of a consensus binding site for p53

El-Deiry, W. S., Kern, S. E., Pietenpol, J. A., Kinzler, K. W., & Vogelstein, B. (1992) · Nature Genetics · doi:10.1038/ng0492-45 · Cited by 1,985 · see citing works

Over-production of Proteins inEscherichia coli: Mutant Hosts that Allow Synthesis of some Membrane Proteins and Globular Proteins at High Levels

Miroux, B., & Walker, J. E. (1996) · Journal of Molecular Biology · doi:10.1006/jmbi.1996.0399 · Cited by 1,964 · see citing works

A graph‐theory algorithm for rapid protein side‐chain prediction

Canutescu, A. A., Shelenkov, A. A., & Dunbrack, R. L. (2003) · Protein Science · doi:10.1110/ps.03154503 · Cited by 1,000 · see citing works

Attenuated T2 relaxation by mutual cancellation of dipole–dipole coupling and chemical shift anisotropy indicates an avenue to NMR structures of very large biological macromolecules in solution

Pervushin, K. V., Riek, R., Wider, G., & Kurt Wüthrich, A. (2021) · WORLD SCIENTIFIC eBooks · doi:10.1142/9789811235795_0006 · Cited by 951 · see citing works

Modelling protein docking using shape complementarity, electrostatics and biochemical information 1 1Edited by J. Thornton

Gabb, H. A., Jackson, R. M., & Sternberg, M. J. E. (1997) · Journal of Molecular Biology · doi:10.1006/jmbi.1997.1203 · Cited by 820 · see citing works

Presence of a Potent Transcription Activating Sequence in the p53 Protein

Fields, S., & Jang, S. K. (1990) · Science · doi:10.1126/science.2144363 · Cited by 790 · see citing works

A Transcriptionally Active DNA-Binding Site for Human p53 Protein Complexes

Funk, W. D., Pak, D. T. S., Karas, R. H., Wright, W. E., & Shay, J. W. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.6.2866 · Cited by 732 · see citing works

Analyzing protein circular dichroism spectra for accurate secondary structures

Johnson, W. C. (1999) · Proteins Structure Function and Bioinformatics · doi:10.1002/(sici)1097-0134(19990515)35:3 · Cited by 639 · see citing works

Local Structural Elements in the Mostly Unstructured Transcriptional Activation Domain of Human p53

Lee, H., Mok, K. H., Muhandiram, R., Park, K.-H., Suk, J.-E., Kim, D., Chang, J., Sung, Y. C., Choi, K. Y., & Han, K. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m003107200 · Cited by 329 · see citing works

Latent and active p53 are identical in conformation.

Ayed, A., Mulder, F. A. A., Yi, G., Lu, Y., Kay, L. E., & Arrowsmith, C. H. (2001) · Nature Structural Biology · doi:10.1038/nsb0901-756 · Cited by 273 · see citing works

Solution structure of the tetrameric minimum transforming domain of p53

Lee, W., Harvey, T. S., Yin, Y., Yau, P., Litchfield, D. W., & Arrowsmith, C. H. (1994) · Nature Structural & Molecular Biology · doi:10.1038/nsb1294-877 · Cited by 265 · see citing works

Cooperative Binding of Tetrameric p53 to DNA

Weinberg, R. L., Veprintsev, D. B., & Fersht, A. R. (2004) · Journal of Molecular Biology · doi:10.1016/j.jmb.2004.06.071 · Cited by 251 · see citing works

Phosphorylation of Serine 392 Stabilizes the Tetramer Formation of Tumor Suppressor Protein p53

Sakaguchi, K., Sakamoto, H., Lewis, M. S., Anderson, C. W., Erickson, J. W., Appella, E., & Xie, D. (1997) · Biochemistry · doi:10.1021/bi970759w · Cited by 247 · see citing works

Semirational design of active tumor suppressor p53 DNA binding domain with enhanced stability

Nikolova, P. V., Henckel, J., Lane, D. P., & Fersht, A. R. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.25.14675 · Cited by 239 · see citing works

A Transcriptionally Active DNA-Binding Site for Human p53 Protein Complexes

Funk, W. D., Pak, D. T. S., Karas, R. H., et al. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.6.2866-2871.1992 · Cited by 239 · see citing works

The N-terminal Domain of p53 is Natively Unfolded

Dawson, R. J. P., Müller, L., Dehner, A., Klein, C., Kessler, H., & Büchner, J. (2003) · Journal of Molecular Biology · doi:10.1016/j.jmb.2003.08.008 · Cited by 228 · see citing works

Refined solution structure of the oligomerization domain of the tumour suppressor p53

Clore, G. M., Ernst, J. A., Clubb, R. T., Omichinski, J. G., Kennedy, W. P., Sakaguchi, K., Appella, E., & Gronenborn, A. M. (1995) · Nature Structural & Molecular Biology · doi:10.1038/nsb0495-321 · Cited by 224 · see citing works

Hot-spot mutants of p53 core domain evince characteristic local structural changes

Wong, K., DeDecker, B. S., Freund, S. M. V., Proctor, M. R., Bycroft, M., & Fersht, A. R. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.15.8438 · Cited by 219 · see citing works

Structures of p53 Cancer Mutants and Mechanism of Rescue by Second-site Suppressor Mutations

Joerger, A. C., Ang, H. C., Veprintsev, D. B., Blair, C. M., & Fersht, A. R. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m500179200 · Cited by 181 · see citing works

Crystal Structure of a Superstable Mutant of Human p53 Core Domain

Joerger, A. C., Allen, M. D., & Fersht, A. R. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m309732200 · Cited by 178 · see citing works

NMR-Based Discovery of Lead Inhibitors That Block DNA Binding of the Human Papillomavirus E2 Protein

Hajduk, P. J., Dinges, J., Miknis, G. F., Merlock, M., Middleton, T. R., Kempf, D. J., Egan, D. A., Walter, K. A., Robins, T. S., Shuker, S. B., et al. (1997) · Journal of Medicinal Chemistry · doi:10.1021/jm9703404 · Cited by 169 · see citing works

The C-terminus of p53: the more you learn the less you know.

Ahn, J., & Prives, C. L. (2001) · Nature Structural Biology · doi:10.1038/nsb0901-730 · Cited by 121 · see citing works

Regulation of DNA Binding of p53 by its C-terminal Domain

Weinberg, R. L., Freund, S. M. V., Veprintsev, D. B., Bycroft, M., & Fersht, A. R. (2004) · Journal of Molecular Biology · doi:10.1016/j.jmb.2004.07.042 · Cited by 100 · see citing works

Identification of an additional negative regulatory region for p53 sequence-specific DNA binding

Müller‐Tiemann, B., Halazonetis, T. D., & Elting, J. J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.11.6079 · Cited by 89 · see citing works

NMR Spectroscopy Reveals the Solution Dimerization Interface of p53 Core Domains Bound to Their Consensus DNA

Klein, C., Planker, E., Diercks, T., Kessler, H., Künkele, K., Lang, K., Hansen, S., & Schwaiger, M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m107516200 · Cited by 86 · see citing works

Recognition of DNA by p53 Core Domain and Location of Intermolecular Contacts of Cooperative Binding

Rippin, T. M., Freund, S. M. V., Veprintsev, D. B., & Fersht, A. R. (2002) · Journal of Molecular Biology · doi:10.1016/s0022-2836(02)00326-1 · Cited by 80 · see citing works

Architectural Accommodation in the Complex of Four p53 DNA Binding Domain Peptides with the p21/waf1/cip1 DNA Response Element

Nagaich, A. K., Zhurkin, V. B., Sakamoto, H., Gorin, A. A., Clore, G. M., Gronenborn, A. M., Appella, E., & Harrington, R. E. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.23.14830 · Cited by 66 · see citing works

Cooperative Binding of p53 to DNA: Regulation by Protein–Protein Interactions through a Double Salt Bridge

Dehner, A., Klein, C., Hansen, S., Müller, L., Büchner, J., Schwaiger, M., & Kessler, H. (2005) · Angewandte Chemie International Edition · doi:10.1002/anie.200501887 · Cited by 52 · see citing works

NMR Solution Structure of a Peptide from the mdm-2 Binding Domain of the p53 Protein that Is Selectively Cytotoxic to Cancer Cells,

Rosal, R. V., Pincus, M. R., Brandt‐Rauf, P. W., Fine, R. L., Michl, J., & Wang, H. (2004) · Biochemistry · doi:10.1021/bi035718g · Cited by 39 · see citing works

Assignment of 1HN, 15N, 13Cα, 13CO and 13Cβ resonances in a 67 kDa p53 dimer using 4D-TROSY NMR spectroscopy

Mulder, F. A. A., Ayed, A., Yang, D., Arrowsmith, C. H., & Kay, L. E. (2000) · Journal of Biomolecular NMR · doi:10.1023/a:1008317825976 · Cited by 32 · see citing works

Modeling multi-component protein–DNA complexes: the role of bending and dimerization in the complex of p53 dimers with DNA

Lebrun, A., Lavery, R., & Weinstein, H. (2001) · Protein Engineering Design and Selection · doi:10.1093/protein/14.4.233 · Cited by 18 · see citing works

The multiple mechanisms that regulate p53 activity and cell fate

Hafner, A., Bulyk, M. L., Jambhekar, A., & Lahav, G. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0110-x · Cited by 1,129 · see citing works

Census and evaluation of p53 target genes

Fischer, M. (2017) · Oncogene · doi:10.1038/onc.2016.502 · Cited by 971 · see citing works

Targeting p53 pathways: mechanisms, structures, and advances in therapy

Wang, H., Guo, M., Wei, H., & Chen, Y. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01347-1 · Cited by 1,016 · see citing works

Structural Biology of the Tumor Suppressor p53

Joerger, A. C., & Fersht, A. R. (2008) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.77.060806.091238 · Cited by 699 · see citing works

Functional Anthology of Intrinsic Disorder. 1. Biological Processes and Functions of Proteins with Long Disordered Regions

Xie, H. M., Vučetić, S., Iakoucheva, L. M., Oldfield, C. J., Dunker, A. K., Uversky, V. N., & Zoran Obradovic, A. (2007) · Journal of Proteome Research · doi:10.1021/pr060392u · Cited by 556 · see citing works

On the binding affinity of macromolecular interactions: daring to ask why proteins interact

Kastritis, P. L., & Bonvin, A. M. J. J. (2012) · Journal of The Royal Society Interface · doi:10.1098/rsif.2012.0835 · Cited by 519 · see citing works

Structure–function–rescue: the diverse nature of common p53 cancer mutants

Joerger, A. C., & Fersht, A. R. (2007) · Oncogene · doi:10.1038/sj.onc.1210291 · Cited by 430 · see citing works

Structural Basis of DNA Recognition by p53 Tetramers

Kitayner, M., Rozenberg, H., Kessler, N., Rabinovich, D., Shaulov, L., Haran, T. E., & Shakked, Z. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.05.015 · Cited by 408 · see citing works

Structure of tumor suppressor p53 and its intrinsically disordered N-terminal transactivation domain

Wells, M. A., Tidow, H., Rutherford, T. J., Markwick, P. R. L., Jensen, M. R., Mylonas, E., Svergun, D. I., Blackledge, M. J., & Fersht, A. R. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801353105 · Cited by 420 · see citing works

Structural basis for understanding oncogenic p53 mutations and designing rescue drugs

Joerger, A. C., Ang, H. C., & Fersht, A. R. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607286103 · Cited by 354 · see citing works

The Origins and Evolution of the p53 Family of GenesPreprint

Белый, В. А., Ak, P., Markert, E. K., Wang, H., Hu, W., Puzio‐Kuter, A. M., & Levine, A. J. (2009) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a001198 · Cited by 293 · see citing works

A single-molecule characterization of p53 search on DNA

Tafvizi, A., Huang, F. L., Fersht, A. R., Mirny, L. A., & van Oijen, A. M. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1016020107 · Cited by 231 · see citing works

Four domains of p300 each bind tightly to a sequence spanning both transactivation subdomains of p53

Teufel, D. P., Freund, S. M. V., Bycroft, M., & Fersht, A. R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0702010104 · Cited by 207 · see citing works

Human p53 Is Inhibited by Glutathionylation of Cysteines Present in the Proximal DNA-Binding Domain during Oxidative Stress,

Velu, C. S., Niture, S. K., Doneanu, C. E., Pattabiraman, N., & Srivenugopal, K. S. (2007) · Biochemistry · doi:10.1021/bi700425y · Cited by 201 · see citing works

High-resolution protein–protein docking

Gray, J. J. (2006) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2006.03.003 · Cited by 187 · see citing works

Quaternary structures of tumor suppressor p53 and a specific p53–DNA complex

Tidow, H., Melero, R., Mylonas, E., Freund, S. M. V., Großmann, J., Carazo, J. M., Svergun, D. I., Valle, M., & Fersht, A. R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705069104 · Cited by 182 · see citing works

Recent advances in p53 research: an interdisciplinary perspective

Olivier, M., Petitjean, A., Marcel, V., Pétré, A., Mounawar, M., Plymoth, A., de Fromentel, C. C., & Hainaut, P. L. (2008) · Cancer Gene Therapy · doi:10.1038/cgt.2008.69 · Cited by 161 · see citing works

Crystal structure of SV40 large T-antigen bound to p53: interplay between a viral oncoprotein and a cellular tumor suppressorPreprint

Lilyestrom, W. G., Klein, M. G., Zhang, R., Joachimiak, A., & Chen, X. S. (2006) · Genes & Development · doi:10.1101/gad.1456306 · Cited by 147 · see citing works

Effects of Common Cancer Mutations on Stability and DNA Binding of Full-length p53 Compared with Isolated Core Domains

Ang, H. C., Joerger, A. C., Mayer, S., & Fersht, A. R. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m604209200 · Cited by 146 · see citing works

Long-range regulation of p53 DNA binding by its intrinsically disordered N-terminal transactivation domain

Krois, A. S., Dyson, H. J., & Wright, P. E. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1814051115 · Cited by 127 · see citing works

The structure of p53 tumour suppressor protein reveals the basis for its functional plasticity

Okorokov, A. L., Sherman, M. B., Plisson‐Chastang, C., Grinkevich, V. V., Sigmundsson, K., Selivanova, G., Milner, J., & Orlova, E. V. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601382 · Cited by 125 · see citing works

Averaging of Electron Subtomograms and Random Conical Tilt Reconstructions through Likelihood Optimization

Scheres, S. H. W., Melero, R., Valle, M., & Carazo, J. M. (2009) · Structure · doi:10.1016/j.str.2009.10.009 · Cited by 117 · see citing works

Structural Biology of the Tumor Suppressor p53 and Cancer‐Associated Mutants

Joerger, A. C., & Fersht, A. R. (2007) · Advances in cancer research · doi:10.1016/s0065-230x(06)97001-8 · Cited by 122 · see citing works

Antioxidant activity and anti-proliferative effect of a bioactive peptide from chickpea (Cicer arietinum L.)

Xue, Z., Wen, H., Zhai, L., Yu, Y., Li, Y., Yu, W., Cheng, A., Wang, C., & Kou, X. (2015) · Food Research International · doi:10.1016/j.foodres.2015.09.027 · Cited by 116 · see citing works

p53—A Natural Cancer Killer: Structural Insights and Therapeutic Concepts

Römer, L., Klein, C., Dehner, A., Kessler, H., & Büchner, J. (2006) · Angewandte Chemie International Edition · doi:10.1002/anie.200600611 · Cited by 115 · see citing works

DNA Binding Cooperativity of p53 Modulates the Decision between Cell-Cycle Arrest and Apoptosis

Schlereth, K., Beinoraviciute-Kellner, R., Zeitlinger, M. K., Bretz, A. C., Sauer, M., Charles, J. P., Vogiatzi, F., Leich, E., Samans, B., Eilers, M., et al. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.02.037 · Cited by 113 · see citing works

Single-Molecule characterization of oligomerization kinetics and equilibria of the tumor suppressor p53

Rajagopalan, S., Huang, F. L., & Fersht, A. R. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq800 · Cited by 110 · see citing works

Algorithm for prediction of tumour suppressor p53 affinity for binding sites in DNA

Veprintsev, D. B., & Fersht, A. R. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkm1040 · Cited by 109 · see citing works

Multiple conformations of full-length p53 detected with single-molecule fluorescence resonance energy transfer

Huang, F. L., Rajagopalan, S., Settanni, G., Marsh, R. J., Armoogum, D. A., Nicolaou, N., Bain, A. J., Lerner, E., Haas, E., Ying, L., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909644106 · Cited by 104 · see citing works

Design of a molecular support for cryo-EM structure determination

Martin, T. G., Bharat, T. A. M., Joerger, A. C., Bai, X., Praetorius, F., Fersht, A. R., Dietz, H., & Scheres, S. H. W. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1612720113 · Cited by 98 · see citing works

Plant Carotene Cis-Trans Isomerase CRTISO

Yu, Q., Ghisla, S., Hirschberg, J., Mann, V., & Beyer, P. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.208017 · Cited by 95 · see citing works

Physical and functional interactions between human mitochondrial single-stranded DNA-binding protein and tumour suppressor p53

Wong, T. S., Rajagopalan, S., Townsley, F. M., Freund, S. M. V., Petrovich, M., Loakes, D., & Fersht, A. R. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkn974 · Cited by 93 · see citing works

The p53 network: p53 and its downstream genes

Shu, K., Li, B., & Wu, L. (2006) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2006.11.003 · Cited by 89 · see citing works

Effect of Zn2+ on DNA Recognition and Stability of the p53 DNA-Binding Domain

Duan, J., & Nilsson, L. (2006) · Biochemistry · doi:10.1021/bi0603165 · Cited by 77 · see citing works

Conservation of DNA-binding specificity and oligomerisation properties within the p53 family

Brandt, T., Petrovich, M., Joerger, A. C., & Veprintsev, D. B. (2009) · BMC Genomics · doi:10.1186/1471-2164-10-628 · Cited by 76 · see citing works

Targeting p53 as a therapeutic strategy in sensitizing TRAIL-induced apoptosis in cancer cells

Zhao, J., Lü, Y., & Shen, H. (2011) · Cancer Letters · doi:10.1016/j.canlet.2011.09.040 · Cited by 68 · see citing works

Structural biology of the p53 tumour suppressor

Okorokov, A. L., & Orlova, E. V. (2009) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2009.02.003 · Cited by 64 · see citing works

Structure and Function of p53-DNA Complexes with Inactivation and Rescue Mutations: A Molecular Dynamics Simulation Study

Kamaraj, B., & Bogaerts, A. (2015) · PLoS ONE · doi:10.1371/journal.pone.0134638 · Cited by 61 · see citing works

Urodele p53 tolerates amino acid changes found in p53 variants linked to human cancer

Villiard, É., Brinkmann, H., Moiseeva, O. V., Mallette, F. A., Ferbeyre, G., & Roy, S. (2007) · BMC Evolutionary Biology · doi:10.1186/1471-2148-7-180 · Cited by 61 · see citing works

Comparative Biophysical Characterization of p53 with the Pro-apoptotic BAK and the Anti-apoptotic BCL-xL

Sot, B., Freund, S. M. V., & Fersht, A. R. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m705544200 · Cited by 61 · see citing works

Docking study and free energy simulation of the complex between p53 DNA‐binding domain and azurin

Grandis, V. D., Bizzarri, A. R., & Cannistraro, S. (2007) · Journal of Molecular Recognition · doi:10.1002/jmr.840 · Cited by 60 · see citing works

Ultraslow oligomerization equilibria of p53 and its implications

Natan, E., Hirschberg, D., Morgner, N., Robinson, C. V., & Fersht, A. R. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0907840106 · Cited by 55 · see citing works

Reconstitution of the mitochondrial Hsp70 (mortalin)‐p53 interaction using purified proteins – Identification of additional interacting regions

Iosefson, O., & Azem, A. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.02.019 · Cited by 52 · see citing works

Sequence-dependent cooperative binding of p53 to DNA targets and its relationship to the structural properties of the DNA targets

Beno, I., Rosenthal, K., Levitine, M., Shaulov, L., & Haran, T. E. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq1044 · Cited by 52 · see citing works

Insight into the Structural Basis of Pro- and Antiapoptotic p53 Modulation by ASPP Proteins

Ahn, J., Byeon, I. L., Byeon, C., & Gronenborn, A. M. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m808821200 · Cited by 51 · see citing works

Folding of Tetrameric p53: Oligomerization and Tumorigenic Mutations Induce Misfolding and Loss of Function

Lubin, D. J., Butler, J. S., & Loh, S. N. (2009) · Journal of Molecular Biology · doi:10.1016/j.jmb.2009.11.013 · Cited by 49 · see citing works

Redox Control of Protein–DNA Interactions: From Molecular Mechanisms to Significance in Signal Transduction, Gene Expression, and DNA Replication

Shlomai, J. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.3029 · Cited by 47 · see citing works

Effects of Oncogenic Mutations and DNA Response Elements on the Binding of p53 to p53-binding Protein 2 (53BP2)

Tidow, H., Veprintsev, D. B., Freund, S. M. V., & Fersht, A. R. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m604725200 · Cited by 45 · see citing works

One-Dimensional Sliding of p53 Along DNA Is Accelerated in the Presence of Ca2+ or Mg2+ at Millimolar Concentrations

Murata, A., Ito, Y., Kashima, R., Kanbayashi, S., Nanatani, K., Igarashi, C., Okumura, M., Inaba, K., Tokino, T., Takahashi, S., et al. (2015) · Journal of Molecular Biology · doi:10.1016/j.jmb.2015.06.016 · Cited by 44 · see citing works

Diverse p53/DNA binding modes expand the repertoire of p53 response elements

Vyas, P., Beno, I., Xi, Z., Stein, Y., Golovenko, D., Kessler, N., Rotter, V., Shakked, Z., & Haran, T. E. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1618005114 · Cited by 44 · see citing works

Structural Effects of the L145Q, V157F, and R282W Cancer-Associated Mutations in the p53 DNA-Binding Core Domain

Calhoun, S., & Daggett, V. (2011) · Biochemistry · doi:10.1021/bi200192j · Cited by 42 · see citing works

Nuclear magnetic resonance analysis of protein–DNA interactions

Campagne, S., Gervais, V., & Milon, A. (2011) · Journal of The Royal Society Interface · doi:10.1098/rsif.2010.0543 · Cited by 43 · see citing works

Exploring subdomain cooperativity in T4 lysozyme II: Uncovering the C‐terminal subdomain as a hidden intermediate in the kinetic folding pathway

Cellitti, J. F., Bernstein, R., & Marqusee, S. (2007) · Protein Science · doi:10.1110/ps.062632807 · Cited by 40 · see citing works

Exploiting the p53 Pathway for the Diagnosis and Therapy of Human CancerPreprint

Lane, D. P. (2005) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2005.70.049 · Cited by 40 · see citing works

Domain–domain interactions in full-length p53 and a specific DNA complex probed by methyl NMR spectroscopy

Biśta, M., Freund, S. M. V., & Fersht, A. R. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1214176109 · Cited by 39 · see citing works

Restoration of DNA‐binding and growth‐suppressive activity of mutant forms of p53 via a PCAF‐mediated acetylation pathway

Perez, R. E., Knights, C. D., Sahu, G., Catania, J., Kolukula, V. K., Stoler, D. L., Graessmann, A., Ogryzko, V. V., Pishvaian, M. J., Albanese, C., et al. (2010) · Journal of Cellular Physiology · doi:10.1002/jcp.22285 · Cited by 39 · see citing works

Electrochemical sensing of tumor suppressor protein p53–deoxyribonucleic acid complex stability at an electrified interface

Paleček, E., Černocká, H., Ostatná, V., Navrátilová, L., & Brázdová, M. (2014) · Analytica Chimica Acta · doi:10.1016/j.aca.2014.03.029 · Cited by 37 · see citing works

Dying to Survive—The p53 Paradox

Lees, A., Sessler, T., & McDade, S. S. (2021) · Cancers · doi:10.3390/cancers13133257 · Cited by 37 · see citing works

Stability of p53 Homologs

Brandt, T., Kaar, J. L., Fersht, A. R., & Veprintsev, D. B. (2012) · PLoS ONE · doi:10.1371/journal.pone.0047889 · Cited by 35 · see citing works

Probing potential binding modes of the p53 tetramer to DNA based on the symmetries encoded in p53 response elements

Ma, B., & Levine, A. J. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm890 · Cited by 34 · see citing works

Inhibitors of MDM2 and MDMX: A Structural Perspective

Riedinger, C., & McDonnell, J. M. (2009) · Future Medicinal Chemistry · doi:10.4155/fmc.09.75 · Cited by 32 · see citing works

Transcription Pattern of p53-Targeted DNA Repair Genes in the Hypoxia-Tolerant Subterranean Mole Rat Spalax

Shams, I., Malik, A., Manov, I., Joel, A., Band, M., & Avivi, A. (2013) · Journal of Molecular Biology · doi:10.1016/j.jmb.2013.01.007 · Cited by 30 · see citing works

Redox regulation of tumour suppressor protein p53: identification of the sites of hydrogen peroxide oxidation and glutathionylation

Scotcher, J., Clarke, D. J., Mackay, C. L., Hupp, T. R., Sadler, P. J., & Langridge‐Smith, P. R. R. (2013) · Chemical Science · doi:10.1039/c2sc21702c · Cited by 31 · see citing works

Modelling the interaction between the p53 DNA‐binding domain and the p28 peptide fragment of Azurin

Santini, S., Bizzarri, A. R., & Cannistraro, S. (2011) · Journal of Molecular Recognition · doi:10.1002/jmr.1153 · Cited by 29 · see citing works

Specific Recognition of p53 Tetramers by Peptides Derived from p53 Interacting Proteins

Gabizon, R., Brandt, T., Sukenik, S., Lahav, N., Lebendiker, M., Shalev, D. E., Veprintsev, D. B., & Friedler, A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038060 · Cited by 29 · see citing works

One-Dimensional Search Dynamics of Tumor Suppressor p53 Regulated by a Disordered C-Terminal Domain

Murata, A., Itoh, Y., Mano, E., Kanbayashi, S., Igarashi, C., Takahashi, H., Takahashi, S., & Kamagata, K. (2017) · Biophysical Journal · doi:10.1016/j.bpj.2017.04.038 · Cited by 28 · see citing works

Computational Studies of Difference in Binding Modes of Peptide and Non-Peptide Inhibitors to MDM2/MDMX Based on Molecular Dynamics Simulations

Chen, J., Zhang, D., Zhang, Y., & Li, G. (2012) · International Journal of Molecular Sciences · doi:10.3390/ijms13022176 · Cited by 26 · see citing works

Azurin modulates the association of Mdm2 with p53: SPR evidence from interaction of the full‐length proteins

Domenici, F., Frasconi, M., Mazzei, F., D’Orazi, G., Bizzarri, A. R., & Cannistraro, S. (2011) · Journal of Molecular Recognition · doi:10.1002/jmr.1105 · Cited by 26 · see citing works

Protein Dynamics as Reported by NMR

Gáspári, Z., & Perczel, A. (2010) · Annual reports on NMR spectroscopy · doi:10.1016/b978-0-08-089054-8.00002-2 · Cited by 25 · see citing works

The p73 DNA Binding Domain Displays Enhanced Stability Relative to Its Homologue, the Tumor Suppressor p53, and Exhibits Cooperative DNA Binding

Patel, S. V., Bui, T. T. T., Drake, A. F., Fraternali, F., & Nikolova, P. V. (2008) · Biochemistry · doi:10.1021/bi7023207 · Cited by 25 · see citing works

The Regulatory Domain Stabilizes the p53 Tetramer by Intersubunit Contacts with the DNA Binding Domain

Retzlaff, M., Rohrberg, J., Küpper, N. J., Lagleder, S., Bepperling, A., Manzenrieder, F., Peschek, J., Kessler, H., & Büchner, J. (2012) · Journal of Molecular Biology · doi:10.1016/j.jmb.2012.10.015 · Cited by 25 · see citing works

Effects of CpG Methylation on Recognition of DNA by the Tumour Suppressor p53

Petrovich, M., & Veprintsev, D. B. (2008) · Journal of Molecular Biology · doi:10.1016/j.jmb.2008.11.054 · Cited by 18 · see citing works

DNA-Mediated Oxidation of p53

Schaefer, K. N., & Barton, J. K. (2014) · Biochemistry · doi:10.1021/bi5003184 · Cited by 18 · see citing works

Rely on Each Other: DNA Binding Cooperativity Shapes p53 Functions in Tumor Suppression and Cancer Therapy

Timofeev, O. N., & Stiewe, T. (2021) · Cancers · doi:10.3390/cancers13102422 · Cited by 17 · see citing works

Protein of a thousand faces: The tumor-suppressive and oncogenic responses of p53

Marques, M. A., de Andrade, G. C., Silva, J. L., & de Oliveira, G. A. P. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.944955 · Cited by 16 · see citing works

Oxidation of p53 through DNA Charge Transport Involves a Network of Disulfides within the DNA-Binding Domain

Schaefer, K. N., Geil, W. M., Sweredoski, M. J., Moradian, A., Hess, S. Y., & Barton, J. K. (2015) · Biochemistry · doi:10.1021/bi501424v · Cited by 15 · see citing works

Mapping Interactions of the Intrinsically Disordered C-Terminal Regions of Tetrameric p53 by Segmental Isotope Labeling and NMR

Krois, A. S., Park, S., Martinez‐Yamout, M. A., Dyson, H. J., & Wright, P. E. (2022) · Biochemistry · doi:10.1021/acs.biochem.2c00528 · Cited by 14 · see citing works

The novel p53 isoform “delta p53” is a misfolded protein and does not bind the p21 promoter site

García-Alai, M., Tidow, H., Natan, E., Townsley, F. M., Veprintsev, D. B., & Fersht, A. R. (2008) · Protein Science · doi:10.1110/ps.036996.108 · Cited by 14 · see citing works

Molecular Basis for Modulation of the p53 Target Selectivity by KLF4

Brandt, T., Townsley, F. M., Teufel, D. P., Freund, S. M. V., & Veprintsev, D. B. (2012) · PLoS ONE · doi:10.1371/journal.pone.0048252 · Cited by 13 · see citing works

ID4 regulates transcriptional activity of wild type and mutant p53 via K373 acetylation

Morton, D. J., Patel, D., Joshi, J., Hunt, A., Knowell, A. E., & Chaudhary, J. (2016) · Oncotarget · doi:10.18632/oncotarget.13701 · Cited by 11 · see citing works

p53 – ein natürlicher Krebskiller: Einsichten in die Struktur und Therapiekonzepte

Römer, L., Klein, C., Dehner, A., Kessler, H., & Büchner, J. (2006) · Angewandte Chemie · doi:10.1002/ange.200600611 · Cited by 11 · see citing works

Establishment and characterization of a novel immortalized human aortic valve interstitial cell line

Wang, Z., Rao, Z., Wang, Y., & Dong, N. (2025) · Scientific Reports · doi:10.1038/s41598-025-85909-z · Cited by 9 · see citing works

Role of p53 in Anticancer Drug Treatment- and Radiation-Induced Injury in Normal Small Intestine.

Jin, S. K. (2012) · Europe PMC (PubMed Central) · doi:10.3969/j.issn.2095-3941.2012.01.001 · Cited by 8 · see citing works

Deciphering the safeguarding role of cysteine residues in p53 against H2O2-induced oxidation using high-resolution native mass spectrometry

Peris-Díaz, M. D., Krężel, A., & Barran, P. (2025) · Communications Chemistry · doi:10.1038/s42004-024-01395-w · Cited by 5 · see citing works

Revealing binding selectivity of ligands toward murine double minute 2 and murine double minute X based on molecular dynamics simulations and binding free energy calculations

Shi, S., Sui, K., Liu, W., Lei, Y., Zhang, S., & Zhang, Q. (2019) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2019.1695671 · Cited by 6 · see citing works

Preferred drifting along the DNA major groove and cooperative anchoring of the p53 core domain: mechanisms and scenarios

Pan, Y., & Nussinov, R. (2009) · Journal of Molecular Recognition · doi:10.1002/jmr.990 · Cited by 6 · see citing works

Side-stepping the guardian of the genome: current cancer therapeutics targeting mutant p53

Taritsa, I. C., & Fossel, E. T. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1529483 · Cited by 5 · see citing works

Pathogenic Proteins Through the Lens of NMR Spectroscopy: Structural and Functional Insights into Disease

Aboalroub, A. A. (2025) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-025-01869-1 · Cited by 2 · see citing works

p53 Interacts with VDAC1, Modulating Its Expression Level and Oligomeric State to Activate Apoptosis

Gigi, E., Nivedita, A. K., Ben-Hail, D., Santhanam, M., Shteinfer‐Kuzmine, A., & Shoshan‐Barmatz, V. (2026) · Biomolecules · doi:10.3390/biom16010141 · Cited by 1 · see citing works

Tumour suppressor p53 and its prognostic value in mutation analyses in breast cancer patients

Shinjini, S., Mritunjai, S., Rakesh, K., & Indrajeet, S. G. (2011) · Journal of stress physiology & biochemistry

The Facilitation of Protein-DNA Search and Recognition by Multiple Modes of Binding

Leith, J. S. (2012) · Digital Access to Scholarship at Harvard (DASH) (Harvard University)

Einzelnukleotidpolymorphismen im p53-Gen als prädisponierender Faktor beim felinen Injektionsstellen-assoziierten Sarkom

Mucha, D. (2013) · Elektronische Hochschulschriften der LMU München (Ludwig-Maximilians-Universität München) · doi:10.5282/edoc.15666

References

(2009) · Chapman & Hall/CRC eBooks · doi:10.1201/9781420078930.bmatt

Les protéines de nucléocapside du VIH-1 : structures, dynamiques, propriétés de fixation et de déstabilisation des acides nucléiques

Belfetmi, A. (2017) · doi:10.70675/2fa3c5d6z2db6z41b0z8d46z342ee7b65514

Regulation of Netrin-1 by p53 isoforms

Sun, Y. (2020) · doi:10.70675/814a2023zacd3z4475z897dz6ee94580c5a3

NMR Spectroscopy Reveals the Solution Dimerization Interface of p53 Core Domains Bound to Their Consensus DNA

Klein, C., Planker, E., Diercks, T., Kessler, H., Künkele, K., Lang, K., Hansen, S., & Schwaiger, M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m107516200 · Cited by 86 · see citing works

Domain–domain interactions in full-length p53 and a specific DNA complex probed by methyl NMR spectroscopy

Biśta, M., Freund, S. M. V., & Fersht, A. R. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1214176109 · Cited by 39 · see citing works

J. Biol. Chem.

Klein, C., Planker, E., Diercks, T., Kessler, H., Künkele, K., Lang, K., Hansen, S., & Schwaiger, M. (2001) · MPG.PuRe (Max Planck Society)

Recognition of DNA by p53 Core Domain and Location of Intermolecular Contacts of Cooperative Binding

Rippin, T. M., Freund, S. M. V., Veprintsev, D. B., & Fersht, A. R. (2002) · Journal of Molecular Biology · doi:10.1016/s0022-2836(02)00326-1 · Cited by 80 · see citing works

Interaction of the p53 DNA-Binding Domain with Its N-Terminal Extension Modulates the Stability of the p53 Tetramer

Natan, E., Baloğlu, Ç., Pagel, K., Freund, S. M. V., Morgner, N., Robinson, C. V., Fersht, A. R., & Joerger, A. C. (2011) · Journal of Molecular Biology · doi:10.1016/j.jmb.2011.03.047 · Cited by 98 · see citing works