The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Prion protein (PrP c ) positively regulates neural precursor proliferation during developmental and adult mammalian neurogenesis
Abstract
The misfolding of the prion protein (PrP c ) is a central event in prion diseases, yet the normal function of PrP c remains unknown. PrP c has putative roles in many cellular processes including signaling, survival, adhesion, and differentiation. Given the abundance of PrP c in the developing and mature mammalian CNS, we investigated the role of PrP c in neural development and in adult neurogenesis, which occurs constitutively in the dentate gyrus (DG) of the hippocampus and in the olfactory bulb from precursors in the subventricular zone (SVZ)/rostral migratory stream. In vivo , we find that PrP c is expressed immediately adjacent to the proliferative region of the SVZ but not in mitotic cells. In vivo and in vitro studies further find that PrP c is expressed in multipotent neural precursors and mature neurons but is not detectable in glia. Loss- and gain-of-function experiments demonstrate that PrP c levels correlate with differentiation of multipotent neural precursors into mature neurons in vitro and that PrP c levels positively influence neuronal differentiation in a dose-dependent manner. PrP c also increases cellular proliferation in vivo ; in the SVZ, PrP c overexpresser (OE) mice have more proliferating cells compared with wild-type (WT) or knockout (KO) mice; in the DG, PrP c OE and WT mice have more proliferating cells compared with KO mice. Our results demonstrate that PrP c plays an important role in neurogenesis and differentiation. Because the final number of neurons produced in the DG is unchanged by PrP c expression, other factors must control the ultimate fate of new neurons.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Prusiner, S. B. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.23.13363 · Cited by 5,373
More hippocampal neurons in adult mice living in an enriched environment
Kempermann, G., Kuhn, H. G., & Gage, F. H. (1997) · Nature · doi:10.1038/386493a0 · Cited by 3,511
Mice devoid of PrP are resistant to scrapie
Büeler, H., Aguzzi, A., Sailer, A., Greiner, R.-A., Autenried, P., Aguet, M., & Weissmann, C. (1993) · Cell · doi:10.1016/0092-8674(93)90360-3 · Cited by 2,100
Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein
Büeler, H., Fischer, M., Lang, Y., Bluethmann, H., Lipp, H.-P., DeArmond, S. J., Prusiner, S. B., Aguet, M., & Weissmann, C. (1992) · Nature · doi:10.1038/356577a0 · Cited by 1,655
A multipotent EGF-responsive striatal embryonic progenitor cell produces neurons and astrocytes
Reynolds, B., Tetzlaff, W., & Weiss, S. (1992) · The Journal of Neuroscience · doi:10.1523/jneurosci.12-11-04565.1992 · Cited by 1,509
Johe, K. K., Hazel, T. G., Muller, T., Dugich-Djordjevic, M. M., & McKay, R. D. (1996) · Genes & Development · doi:10.1101/gad.10.24.3129 · Cited by 1,154
Fischer, M., Rülicke, T., Raeber, A., Sailer, A., Moser, M., Oesch, B., Brandner, S., Aguzzi, A., & Weissmann, C. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00467.x · Cited by 877
Depleting Neuronal PrP in Prion Infection Prevents Disease and Reverses Spongiosis
Mallucci, G., Dickinson, A., Linehan, J., Klöhn, P.-C., Brandner, S., & Collinge, J. (2003) · Science · doi:10.1126/science.1090187 · Cited by 770
Anchorless Prion Protein Results in Infectious Amyloid Disease Without Clinical Scrapie
Chesebro, B., Trifilo, M., Race, R., Meade-White, K., Teng, C., LaCasse, R., Raymond, L., Favara, C., Baron, G., Priola, S., et al. (2005) · Science · doi:10.1126/science.1110837 · Cited by 652
Manson, J. C., Clarke, A. R., Hooper, M. L., Aitchison, L., McConnell, I., & Hope, J. (1994) · Molecular Neurobiology · doi:10.1007/bf02780662 · Cited by 581
Cited by
Physiology of the prion protein
Linden, R., Martins, V. R., Prado, M. A. M., Cammarota, M., Izquierdo, I., & Brentani, R. R. (2008) · Physiological Reviews · doi:10.1152/physrev.00007.2007 · Cited by 617
Prions and their partners in crime
Caughey, B., & Baron, G. S. (2006) · Nature · doi:10.1038/nature05294 · Cited by 295
Pathogenesis of prion diseases: current status and future outlook
Aguzzi, A., & Heikenwalder, M. (2006) · Nature Reviews Microbiology · doi:10.1038/nrmicro1492 · Cited by 207
Pavoni, S., Jarray, R., Nassor, F., Guyot, A.-C., Cottin, S., Rontard, J., Mikol, J., Mabondzo, A., Deslys, J.-P., & Yates, F. (2018) · PLOS ONE · doi:10.1371/journal.pone.0209150 · Cited by 97
Temporal dynamics of hippocampal neurogenesis in chronic neurodegeneration
Gomez-Nicola, D., Suzzi, S., Vargas-Caballero, M., Fransen, N. L., Al-Malki, H., Cebrian-Silla, A., Garcia-Verdugo, J. M., Riecken, K., Fehse, B., & Perry, V. H. (2014) · Brain · doi:10.1093/brain/awu155 · Cited by 84
Metadata
- Authors
- Steele, A. D., Emsley, J. G., Özdinler, P. H., Lindquist, S., & Macklis, J. D.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2006-02-21
- Volume
- 103
- Issue
- 9
- Pages
- 3416-3421
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1969758868
- Cited by
- 270
- References
- 25
- FWCI
- 6.15
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Prion protein (PrP c ) positively regulates neural precursor proliferation during developmental and adult mammalian neurogenesis. https://app.cochat.ai/papers/10.1073/pnas.0511290103
- The paper
- Steele, A. D., Emsley, J. G., Özdinler, P. H., Lindquist, S., & Macklis, J. D. (2006). Prion protein (PrP c ) positively regulates neural precursor proliferation during developmental and adult mammalian neurogenesis. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0511290103
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
