Cited by 84Neurogenesis and neuroplasticity mechanismsNeuroinflammation and Neurodegeneration MechanismsMemory and Neural Mechanisms

Temporal dynamics of hippocampal neurogenesis in chronic neurodegeneration

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Gomez-Nicola, Diego, Suzzi, Stefano, Vargas-Caballero, Mariana, Fransen, Nina L., Al-Malki, Hussain, Cebrian-Silla, Arantxa, Garcia-Verdugo, Jose Manuel, Riecken, Kristoffer +2 more·2014·Brain

Abstract

The study of neurogenesis during chronic neurodegeneration is crucial in order to understand the intrinsic repair mechanisms of the brain, and key to designing therapeutic strategies. In this study, using an experimental model of progressive chronic neurodegeneration, murine prion disease, we define the temporal dynamics of the generation, maturation and integration of new neurons in the hippocampal dentate gyrus, using dual pulse-chase, multicolour γ-retroviral tracing, transmission electron microscopy and patch-clamp. We found increased neurogenesis during the progression of prion disease, which partially counteracts the effects of chronic neurodegeneration, as evidenced by blocking neurogenesis with cytosine arabinoside, and helps to preserve the hippocampal function. Evidence obtained from human post-mortem samples, of both variant Creutzfeldt-Jakob disease and Alzheimer's disease patients, also suggests increased neurogenic activity. These results open a new avenue into the exploration of the effects and regulation of neurogenesis during chronic neurodegeneration, and offer a new model to reproduce the changes observed in human neurodegenerative diseases.

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Authors
Gomez-Nicola, D., Suzzi, S., Vargas-Caballero, M., Fransen, N. L., Al-Malki, H., Cebrian-Silla, A., Garcia-Verdugo, J. M., Riecken, K., Fehse, B., & Perry, V. H.
Affiliations
University of Southampton (GB)
Venue
Brain
Published
2014-06-18
Volume
137
Issue
8
Pages
2312-2328
ISSN
  • 0006-8950 (ISSN-L)
  • 1460-2156
OpenAlex
W2093987055
Cited by
84
References
66
Citations by year
2026: 2 · 2025: 5 · 2024: 3 · 2023: 4 · 2022: 7 · 2021: 7 · 2020: 6 · 2019: 4 · 2018: 15 · 2017: 7 · 2016: 9 · 2015: 10 · 2014: 5
FWCI
3.60
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Brain (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • ePrints Soton (University of Southampton) (acceptedVersion)
Funders
  • European Commission
  • Ministerio de Economía y Competitividad
  • Medical Research Council (MR/K022687/1)
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
hippocampal neurogenesis, chronic neurodegeneration, prion disease, dentate gyrus, neural integration, variant Creutzfeldt-Jakob disease, Alzheimer's disease, cytarabine
MeSH terms
Adult, Aged, Alzheimer Disease, Animals, Antimetabolites, Antineoplastic, Chronic Disease, Cytarabine, Disease Models, Animal, Female, Genetic Vectors, Hippocampus, Humans, Creutzfeldt-Jakob Syndrome, Male, Mice, Inbred C57BL, Middle Aged, Neural Pathways, Prions, Time Factors, Tissue Banks, Prion Diseases, Patch-Clamp Techniques, Disease Progression, Dentate Gyrus, Mossy Fibers, Hippocampal, Neurodegenerative Diseases, Cell Proliferation, Mice, Neurogenesis, Young Adult, Neuroanatomical Tract-Tracing Techniques, Neural Stem Cells

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