The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Single factors direct the differentiation of stem cells from the fetal and adult central nervous system.
Open accessAbstract
Identifying the signals that regulate stem cell differentiation is fundamental to understanding cellular diversity in the brain. In this paper we identify factors that act in an instructive fashion to direct the differentiation of multipotential stem cells derived from the embryonic central nervous system (CNS). CNS stem cell clones differentiate to multiple fates: neurons, astrocytes, and oligodendrocytes. The differentiation of cells in a clone is influenced by extracellular signals: Platelet-derived growth factor (PDGF-AA, -AB, and -BB) supports neuronal differentiation. In contrast, ciliary neurotrophic factor and thyroid hormone T3 act instructively on stem cells to generate clones of astrocytes and oligodendrocytes, respectively. Adult stem cells had remarkably similar responses to these growth factors. These results support a simple model in which transient exposure to extrinsic factors acting through known pathways initiates fate decisions by multipotential CNS stem cells.
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Cites
Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats
Altman, J., & Das, G. D. (1965) · Journal of Comparative Neurology · doi:10.1002/cne.901240303 · Cited by 3,592
Monyer, H., Burnashev, N., Laurie, D. J., Sakmann, B., & Seeburg, P. H. (1994) · Neuron · doi:10.1016/0896-6273(94)90210-0 · Cited by 3,535
Cited by
Gage, F. H. (2000) · Science · doi:10.1126/science.287.5457.1433 · Cited by 4,786
Subventricular zone astrocytes are neural stem cells in the adult mammalian brain
Doetsch, F., Caillé, I., Lim, D. A., García-Verdugo, J. M., & Alvarez-Buylla, A. (1999) · Cell · doi:10.1016/s0092-8674(00)80783-7 · Cited by 3,898
Biology of Oligodendrocyte and Myelin in the Mammalian Central Nervous System
Baumann, N., & Pham-Dinh, D. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.871 · Cited by 1,828
Reactive astrocytes: cellular and molecular cues to biological function
Ridet, J. L., Privat, A., Malhotra, S. K., & Gage, F. H. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(97)01139-9 · Cited by 1,766
Efficient generation of midbrain and hindbrain neurons from mouse embryonic stem cells
Lee, S.-H., Lumelsky, N., Studer, L., Auerbach, J. M., & McKay, R. D. (2000) · Nature Biotechnology · doi:10.1038/76536 · Cited by 1,257
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Metadata
- Authors
- Johe, K. K., Hazel, T. G., Muller, T., Dugich-Djordjevic, M. M., & McKay, R. D.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1996-12-15
- Volume
- 10
- Issue
- 24
- Pages
- 3129-3140
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2020539766
- Cited by
- 1,154
- References
- 2
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Johe, K. K., Hazel, T. G., Muller, T., Dugich-Djordjevic, M. M., & McKay, R. D. (1996). Single factors direct the differentiation of stem cells from the fetal and adult central nervous system. Genes & Development. https://doi.org/10.1101/gad.10.24.3129
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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