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DC-SIGNR, a DC-SIGN homologue expressed in endothelial cells, binds to human and simian immunodeficiency viruses and activates infection in trans
Open accessAbstract
DC-SIGN, a C-type lectin expressed on the surface of dendritic cells (DCs), efficiently binds and transmits HIVs and simian immunodeficiency viruses to susceptible cells in trans. A DC-SIGN homologue, termed DC-SIGNR, has recently been described. Herein we show that DC-SIGNR, like DC-SIGN, can bind to multiple strains of HIV-1, HIV-2, and simian immunodeficiency virus and transmit these viruses to both T cell lines and human peripheral blood mononuclear cells. Binding of virus to DC-SIGNR was dependent on carbohydrate recognition. Immunostaining with a DC-SIGNR-specific antiserum showed that DC-SIGNR was expressed on sinusoidal endothelial cells in the liver and on endothelial cells in lymph node sinuses and placental villi. The presence of this efficient virus attachment factor on multiple endothelial cell types indicates that DC-SIGNR could play a role in the vertical transmission of primate lentiviruses, in the enabling of HIV to traverse the capillary endothelium in some organs, and in the presentation of virus to CD4-positive cells in multiple locations including lymph nodes.
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Citations
Cited by
DC-SIGN (CD209) Mediates Dengue Virus Infection of Human Dendritic Cells
Tassaneetrithep, B., Burgess, T. H., Granelli-Piperno, A., Trumpfheller, C., Finke, J., Sun, W., Eller, M. A., Pattanapanyasat, K., Sarasombath, S., Birx, D. L., et al. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20021840 · Cited by 890
C-type lectin receptors on dendritic cells and langerhans cells
Figdor, C. G., van Kooyk, Y., & Adema, G. J. (2002) · Nature Reviews Immunology · doi:10.1038/nri723 · Cited by 842
Structural Basis for Selective Recognition of Oligosaccharides by DC-SIGN and DC-SIGNR
Feinberg, H., Mitchell, D. A., Drickamer, K., & Weis, W. I. (2001) · Science · doi:10.1126/science.1066371 · Cited by 676
A Novel Mechanism of Carbohydrate Recognition by the C-type Lectins DC-SIGN and DC-SIGNR
Mitchell, D. A., Fadden, A. J., & Drickamer, K. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104565200 · Cited by 502
Self- and nonself-recognition by C-type lectins on dendritic cells
Geijtenbeek, T. B. H., van Vliet, S. J., Engering, A., 't Hart, B. A., & van Kooyk, Y. (2004) · Annual Review of Immunology · doi:10.1146/annurev.immunol.22.012703.104558 · Cited by 503
Metadata
- Authors
- Pöhlmann, S., Soilleux, E. J., Baribaud, F., Leslie, G. J., Morris, L. S., Trowsdale, J., Lee, B., Coleman, N., & Doms, R. W.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2001-02-27
- Volume
- 98
- Issue
- 5
- Pages
- 2670-2675
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2093551242
- Cited by
- 324
- References
- 0
- FWCI
- 10.28
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: DC-SIGNR, a DC-SIGN homologue expressed in endothelial cells, binds to human and simian immunodeficiency viruses and activates infection in trans. https://app.cochat.ai/papers/10.1073/pnas.051631398
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- Pöhlmann, S., Soilleux, E. J., Baribaud, F., Leslie, G. J., Morris, L. S., Trowsdale, J., Lee, B., Coleman, N., & Doms, R. W. (2001). DC-SIGNR, a DC-SIGN homologue expressed in endothelial cells, binds to human and simian immunodeficiency viruses and activates infection in trans. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.051631398
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