The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Hematopoiesis-restricted minor histocompatibility antigens HA-1- or HA-2-specific T cells can induce complete remissions of relapsed leukemia
Open accessAbstract
Donor lymphocyte infusion (DLI) into patients with a relapse of their leukemia or multiple myeloma after allogeneic stem cell transplantation (alloSCT) has been shown to be a successful treatment approach. The hematopoiesis-restricted minor histocompatibility antigens (mHAgs) HA-1 or HA-2 expressed on malignant cells of the recipient may serve as target antigens for alloreactive donor T cells. Recently we treated three mHAg HA-1- and/or HA-2-positive patients with a relapse of their disease after alloSCT with DLI from their mHAg HA-1- and/or HA-2-negative donors. Using HLA-A2/HA-1 and HA-2 peptide tetrameric complexes we showed the emergence of HA-1- and HA-2-specific CD8+T cells in the blood of the recipients 5–7 weeks after DLI. The appearance of these tetramer-positive cells was followed immediately by a complete remission of the disease and restoration of 100% donor chimerism in each of the patients. Furthermore, cloned tetramer-positive T cells isolated during the clinical response specifically recognized HA-1 and HA-2 expressing malignant progenitor cells of the recipient and inhibited the growth of leukemic precursor cells in vitro. Thus, HA-1- and HA-2-specific cytotoxic T lymphocytes emerging in the blood of patients after DLI demonstrate graft-versus-leukemia or myeloma reactivity resulting in a durable remission. This finding implies that in vitro generated HA-1- and HA-2-specific cytotoxic T lymphocytes could be used as adoptive immunotherapy to treat hematological malignances relapsing after alloSCT.
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Miklos, D. B., Kim, H. T., Miller, K. H., Guo, L., Zorn, E., Lee, S. J., Hochberg, E. P., Wu, C. J., Alyea, E. P., Cutler, C., et al. (2005) · Blood · doi:10.1182/blood-2004-09-3660 · Cited by 406
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Minor Histocompatibility Antigen-Specific T Cells
Summers, C., Sheth, V. S., & Bleakley, M. (2020) · Frontiers in Pediatrics · doi:10.3389/fped.2020.00284 · Cited by 37
Metadata
- Authors
- Marijt, W. A. E., Heemskerk, M. H. M., Kloosterboer, F. M., Goulmy, E., Kester, M. G. D., van der Hoorn, M. A. W. G., van Luxemburg-Heys, S. A. P., Hoogeboom, M., Mutis, T., Drijfhout, J. W., van Rood, J. J., Willemze, R., & Falkenburg, J. H. F.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2003-02-24
- Volume
- 100
- Issue
- 5
- Pages
- 2742-2747
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2102516973
- Cited by
- 408
- References
- 38
- FWCI
- 21.13
- Type
- journal article
- Language
- en
- Open access
- green
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- Marijt, W. A. E., Heemskerk, M. H. M., Kloosterboer, F. M., Goulmy, E., Kester, M. G. D., van der Hoorn, M. A. W. G., van Luxemburg-Heys, S. A. P., Hoogeboom, M., Mutis, T., Drijfhout, J. W., van Rood, J. J., Willemze, R., & Falkenburg, J. H. F. (2003). Hematopoiesis-restricted minor histocompatibility antigens HA-1- or HA-2-specific T cells can induce complete remissions of relapsed leukemia. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0530192100
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
