The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
MicroRNA fingerprints during human megakaryocytopoiesis
Abstract
microRNAs are a highly conserved class of noncoding RNAs with important regulatory functions in proliferation, apoptosis, development, and differentiation. To discover novel regulatory pathways during megakaryocytic differentiation, we performed microRNA expression profiling of in vitro -differentiated megakaryocytes derived from CD34 + hematopoietic progenitors. The main finding was down-regulation of miR-10a , miR-126 , miR-106 , miR-10b , miR-17 and miR-20 . Hypothetically, the down-regulation of microRNAs unblocks target genes involved in differentiation. We confirmed in vitro and in vivo that miR-130a targets the transcription factor MAFB , which is involved in the activation of the GPIIB promoter, a key protein for platelet physiology. In addition, we found that miR-10a expression in differentiated megakaryocytes is inverse to that of HOXA1 , and we showed that HOXA1 is a direct target of miR-10a . Finally, we compared the microRNA expression of megakaryoblastic leukemic cell lines with that of in vitro differentiated megakaryocytes and CD34 + progenitors. This analysis revealed up-regulation of miR-101 , miR-126 , miR-99a , miR-135 , and miR-20 . Our data delineate the expression of microRNAs during megakaryocytopoiesis and suggest a regulatory role of microRNAs in this process by targeting megakaryocytic transcription factors.
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Bartel (2004) · doi:10.1016/s0092-8674(04)00045-5 · Cited by 34,714
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Ambros, V. (2004) · Nature · doi:10.1038/nature02871 · Cited by 10,728
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Self-citationA pancreatic islet-specific microRNA regulates insulin secretion
Poy, M. N., Eliasson, L., Krutzfeldt, J., Kuwajima, S., Ma, X., MacDonald, P. E., Pfeffer, S., Tuschl, T., Rajewsky, N., Rorsman, P., et al. (2004) · Nature · doi:10.1038/nature03076 · Cited by 2,102
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An oligonucleotide microchip for genome-wide microRNA profiling in human and mouse tissues
Liu, C.-G., Calin, G. A., Meloon, B., Gamliel, N., Sevignani, C., Ferracin, M., Dumitru, C. D., Shimizu, M., Zupo, S., Dono, M., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403293101 · Cited by 948
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Ma, L., Teruya-Feldstein, J., & Weinberg, R. A. (2007) · Nature · doi:10.1038/nature06174 · Cited by 2,605
The Endothelial-Specific MicroRNA miR-126 Governs Vascular Integrity and Angiogenesis
Wang, S., Aurora, A. B., Johnson, B. A., Qi, X., McAnally, J., Hill, J. A., Richardson, J. A., Bassel-Duby, R., & Olson, E. N. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.07.002 · Cited by 1,617
MicroRNA: Biogenesis, Function and Role in Cancer
MacFarlane, L.-A., & R. Murphy, P. (2010) · Current Genomics · doi:10.2174/138920210793175895 · Cited by 1,584
Detection of microRNA Expression in Human Peripheral Blood Microvesicles
Hunter, M. P., Ismail, N., Zhang, X., Aguda, B. D., Lee, E. J., Yu, L., Xiao, T., Schafer, J., Lee, M.-L. T., Schmittgen, T. D., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003694 · Cited by 1,452
MicroRNA-10a binds the 5’UTR of ribosomal protein mRNAs and enhances their translation
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Metadata
- Authors
- Garzon, R., Pichiorri, F., Palumbo, T., Iuliano, R., Cimmino, A., Aqeilan, R., Volinia, S., Bhatt, D., Alder, H., Marcucci, G., Calin, G. A., Liu, C.-G., Bloomfield, C. D., Andreeff, M., & Croce, C. M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2006-03-20
- Volume
- 103
- Issue
- 13
- Pages
- 5078-5083
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W4245652485
- Cited by
- 414
- References
- 6
- FWCI
- 21.61
- Type
- journal article
- Language
- en
- Open access
- closed
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- Garzon, R., Pichiorri, F., Palumbo, T., Iuliano, R., Cimmino, A., Aqeilan, R., Volinia, S., Bhatt, D., Alder, H., Marcucci, G., Calin, G. A., Liu, C.-G., Bloomfield, C. D., Andreeff, M., & Croce, C. M. (2006). MicroRNA fingerprints during human megakaryocytopoiesis. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0600587103
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