Epigenetic inactivation of the premature aging Werner syndrome gene in human cancer

Agrelo, Ruben, Cheng, Wen-Hsing, Setien, Fernando, Ropero, Santiago, Espada, Jesus, Fraga, Mario F., Herranz, Michel, Paz, Maria F., Sanchez-Cespedes, Montserrat, Artiga, Maria Jesus, Guerrero, David, Castells, Antoni, von Kobbe, Cayetano, Bohr, Vilhelm A., Esteller, Manel·2006·Proceedings of the National Academy of Sciences

Cited by (263)

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  1. The Human Epigenome—Implications for the Understanding of Human Disease
    Manel Esteller · 2017 · Elsevier eBooks
  2. [Epigenetic research progress of anti-tumor drugs].
    Mouze Liu, Fazhong He, Wei Zhang · 2013 · PubMed
  3. The epigenome of colorectal cancer
    Minoru Toyota, Hiromu Suzuki, Yasuhisa Shinomura · 2009 · Current Colorectal Cancer Reports
  4. Epigenetic Primer for Diagnostic Applications: A window into Personalized Medicine
    Beth A. McNally, Mark W. Linder, Roland Valdes · 2014 · Personalized Medicine
  5. The Role of DNA Methylation in Cancer
    Sepideh Shahkarami, Samaneh Zoghi, Nima Rezaei · 2020 · Springer eBooks
  6. Epigenetic Silencing of Progeroid Syndromes
    Rubén Agrelo · 2009 · Springer eBooks
  7. The Biological Basis of Aging
    Junko Oshima, George M. Martin, Fuki Marie Hisama · 2013 · Elsevier eBooks
  8. Epigenetic Mechanisms in Cancer Formation and Progression
    Elisabetta Fratta, Luca Sigalotti, Alessia Covre, Giulia Parisi, Riccardo Danielli, Hugues J. M. Nicolay, Sandra Coral, Michele Maio · 2011 · Wiley eBooks
  9. The Age of Cancer
    Mitch Leslie · 2006 · Science of Aging Knowledge Environment
  10. Maintaining the unmethylated state
    Steven S. Smith · 2013 · Clinical Epigenetics
  11. The Biological Basis of Aging: Implications for Medical Genetics
    Junko Oshima, George M. Martin, Fuki Marie Hisama · 2014 · Elsevier eBooks
  12. The Influence of Aging and Cellular Senescence on Metastasis
    Futoshi Okada, Hiroshi Kobayashi · 2011 · Cambridge University Press eBooks
  13. Methylation Changes in Neoplasia
    Tim Crook, Eleftheria ChR. Hatzimichael, Justin Stebbing · 2008 · CRC Press eBooks
  14. Chapter 18 – The Biological Basis of Aging: Implications for Medical Genetics
    Junko Oshima, George M. Martin, Fuki Marie Hisama · 2013
  15. The Human Epigenome: Implications for the Understanding of Human Disease
    María Berdasco, Manel Esteller · 2009 · Elsevier eBooks
  16. Promoter CpG island methylation in colorectal cancer:
    Sarah Derks A, Manon van Engeland · 2012 · Cambridge University Press eBooks
  17. Biomarkers in Metastatic Colorectal Cancer
    Connie Irene Diakos, Kellie A. Charles, Wei Ming Chua, Viive Maarika Howell, Stephen John Clarke · 2015 · Biomarkers in disease
  18. Werner syndrome: a rare mutation
    Alberto Castagna, Pietro Gareri, Francesca Falvo, Simona Sestito, Maurizio Rocca, Licia Pensabene, Daniela Concolino, Giuseppe Coppolino, Giovanni Ruotolo · 2018 · Aging Clinical and Experimental Research
  19. WPŁYW METYLACJI DNA NA FUNKCJONOWANIE GENOMU
    Marcin Łukasik, Jolanta Karmalska, Mirosław M. Szutowski, Jacek Łukaszkiewicz · 2009 · Prospects in Pharmaceutical Sciences
  20. Alcohol consumption as a risk factor for colorectal cancer : an epidemiological study on genetic susceptibility and molecular endpoints
    Brenda W. C. Bongaerts · 2008
  21. DNA Helicase Deficiency Disorders
    Julia M. Sidorova, Raymond J. Monnat · 2018 · Wiley eBooks
  22. Gene expression changes in normal haematopoietic cells
    Jack M. Lionberger, Derek L. Stirewalt · 2009 · Best Practice & Research Clinical Haematology
  23. Telomere biology: Implications for radiation carcinogenesis
    Seiji Kodama, Kentaro Ariyoshi, Sanae Watanabe, Kazunori Shiraishi, Masami Watanabe · 2007 · International Congress Series
  24. Epigenetics in Brain Development and Disease
    Elisabeth J. Radford, Anne C. Ferguson‐Smith, Sacri R. Ferrón · 2017 · Wiley eBooks
  25. Contribución de la epigenética al manejo personalizado del cáncer
    Verónica Dávalos, Manel Esteller · 2010 · Elsevier eBooks
  26. Methylation in Tumorigenesis
    A. Melissa, P. Pashayar, Drew R., Adam Mark · 2012 · InTech eBooks
  27. (Epi-) genetic profiling of colorectal cancer : prognostic and biological relevance, with emphasis on tumor-hypoxia
    Arjen H.G. Cleven · 2012
  28. Pharmaco-Epigenomics to Improve Cancer Therapies
    Bart Claes, Bernard Siebens, Diether Lambrechts · 2012 · Encyclopedia of Molecular Cell Biology and Molecular Medicine
  29. Análise epigenética e de polimorfismos em tumores extra-axiais do sistema nervoso
    Luciana O. Almeida · 2009
  30. Epigenetics and Tumor Suppressor Genes
    Mingzhou Guo, Xuefeng Liu, Weimin Zhang · 2012 · InTech eBooks
  31. Epigenetic Drivers of Genetic Alterations in Cancer
    Hiromu Suzuki · 2012 · Wiley eBooks
  32. Predicting chemotherapeutic response and toxicity in colorectal cancer
    Connie Irene Diakos, Wei Ming Chua, Kellie A. Charles, Viive Maarika Howell, Stephen John Clarke · 2013 · Colorectal Cancer
  33. Genetics and epigenetics in human cancer
    Jie Lv, Hui Liu, Hongbo Liu, Qiong Wu, Yan Zhang · 2014 · Cancer Genetics and Epigenetics
  34. Regulation of WRN Function by Acetylation and SIRT1-Mediated Deacetylation in Response to DNA Damage: A Dissertation
    Kai Li · 2010 · eScholarship@UMassChan
  35. Utilization of Werner syndrome mouse model in studying premature aging and tumor
    Shuting Jia, Shihua Yang, Ying Luo · 2009 · Hereditas (Beijing)
  36. Recapitulation of Werner syndrome sensitivity to camptothecin by limited knockdown of the WRN
    Andreas Bachler, Stephanie W. Cox · 2012
  37. Werner syndrome: association of premature aging and cancer predisposition
    Byungchan Ahn, Tinna Stevnsner, Vilhelm A. Bohr · 2013 · Cambridge University Press eBooks
  38. TYPES OF DNA DAMAGE
    2013 · CRC Press eBooks
  39. Age-related epigenetic changes at base excision repair genes and their modulation by dietary restriction in mice
    Joanna Gorniak · 2015
  40. Genetics: Clues, Not Answers, to the Mysteries of Precision Medicine
    Jules J. Berman · 2018 · Elsevier eBooks
  41. The Human Epigenome
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    Jules J. Berman · 2019 · Elsevier eBooks
  43. Analyse globale des altérations abberantes de la méthylation de l'ADN dans le cancer de l'ovaire
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  44. Biomarkers in Metastatic Colorectal Cancer
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    Rohan Aananth, Meera Chopra, Esra Rakab · 2021 · The Meducator
  46. Werner Syndrome
    Maria Stylianou, Xenia Anastassiou‐Hadjicharalambous · 2011 · Springer eBooks
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    Yuslina Mat Yusoff, Fadly Ahid, Zahidah Abu Seman, Julia Abdullah, Nor Rizan Kamaluddin, Ezalia Esa, Zubaidah Zakaria · 2021 · Research Square
  48. Glossary
    2014 · Elsevier eBooks
  49. Pathoprofile
    Rohan Aananth, Meera Chopra, Esra Rakab · 2020 · The Meducator
  50. DNA Helicase‐deficiency Disorders
    Julia M. Sidorova, Raymond J. Monnat · 2010 · Wiley eBooks
  51. In Brief
    2006 · Nature reviews. Cancer
  52. Prognostic significance of aberrant CpG islands methylation in human follicular and diffuse large B-cell lymphoma
    Milena Krajnović · 2013
  53. Faculty Opinions recommendation of WRN Promoter CpG Island Hypermethylation Does Not Predict More Favorable Outcomes for Patients with Metastatic Colorectal Cancer Treated with Irinotecan-Based Therapy.
    Vilhelm A. Bohr · 2017 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  54. Epigenetic therapy and DNA damage response
    Marina Baretti, Nilofer Saba Azad · 2022 · Elsevier eBooks
  55. Supplementary Figure 1 from RECQL1 and WRN Proteins Are Potential Therapeutic Targets in Head and Neck Squamous Cell Carcinoma
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  56. Epigenetic Contributions to Human Cancer
    James Gordon Herman, Stephen B. Baylin · 2017 · Wiley eBooks
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    Raymond J. Monnat · 2024 · Cells
  58. Whole Exome Sequencing Identifies a Novel Frameshift Mutation of the WRN Gene in a Werner Syndrome Family and Functional Analysis
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    Pooja Gupta, Mrityunjay Tyagi, Ananda Guha Majumdar, Ganesh Pai Bellare, Saikat Chakraborty, Shambhavi Mishra, Megha Tawate, Avik Chakraborty, Sujit K. Bhutia, Birija Sankar Patro · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  60. Etude de la régulation de l’expression de PLAGL1 dans les sarcomes
    Anne-Lise Peille · 2010 · theses.fr (ABES)
  61. Réparation des cassures double brin de l'adn chez les mammifères : rôle des protéines MRE11 et BLM dans l’initiation de la ligature d’extrémités non homologues (NHEJ )
    Anastazja Grabarz · 2011 · theses.fr (ABES)
  62. The interplay between genetics and epigenetics in colorectal cancer
    Sarah Derks · 2009 · Research Publications (Maastricht University)
  63. The epigenetic regulation of chemotherapy resistance in melanoma
    Hussein Abdul-Hassan Tawbi · 2011 · D-Scholarship@Pitt (University of Pittsburgh)