The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Controlling interlayer diffusion to achieve sustained, multiagent delivery from layer-by-layer thin films
Open accessAbstract
We present the fabrication of conformal, hydrolytically degradable thin films capable of administering sustained, multiagent release profiles. Films are constructed one molecular layer at a time by using the layer-by-layer, directed-deposition technique; the subsequent hydrolytic surface erosion of these systems results in the release of incorporated materials in a sequence that reflects their relative positions in the film. The position of each species is determined by its ability to diffuse throughout the film architecture, and, as such, the major focus of this work is to define strategies that physically block interlayer diffusion during assembly to create multicomponent, stratified films. By using a series of radiolabeled polyelectrolytes as experimental probes, we show that covalently crosslinked barriers can effectively block interlayer diffusion, leading to compartmentalized structures, although even very large numbers of ionically crosslinked (degradable or nondegradable) barrier layers cannot block interlayer diffusion. By using these principles, we designed degradable films capable of extended release as well as both parallel and serial multiagent release. The ability to fabricate multicomponent thin films with nanoscale resolution may lead to a host of new materials and applications.
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Cites
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Kumar, R., Santa Chalarca, C. F., Bockman, M. R., Bruggen, C. V., Grimme, C. J., Dalal, R. J., Hanson, M. G., Hexum, J. K., & Reineke, T. M. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.0c00997 · Cited by 365
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Metadata
- Authors
- Wood, K. C., Chuang, H. F., Batten, R. D., Lynn, D. M., & Hammond, P. T.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2006-07-05
- Volume
- 103
- Issue
- 27
- Pages
- 10207-10212
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1995723522
- Cited by
- 270
- References
- 17
- FWCI
- 11.32
- Type
- journal article
- Language
- en
- Open access
- green
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- Wood, K. C., Chuang, H. F., Batten, R. D., Lynn, D. M., & Hammond, P. T. (2006). Controlling interlayer diffusion to achieve sustained, multiagent delivery from layer-by-layer thin films. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0602884103
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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