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Cited by 425

The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.

Dual growth factor releasing multi-functional nanofibers for wound healing

Open access
Xie, Zhiwei, Paras, Christian B., Weng, Hong, Punnakitikashem, Primana, Su, Lee-Chun, Vu, Khanh, Tang, Liping, Yang, Jian, Nguyen, Kytai T.·2013·Acta Biomaterialia
DOI 10.1016/j.actbio.2013.07.030
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Abstract

The objective of this research is to develop a dual growth factor-releasing nanoparticle-in-nanofiber system for wound healing applications. In order to mimic and promote the natural healing procedure, chitosan and poly(ethylene oxide) were electrospun into nanofibrous meshes as mimics of extracellular matrix. Vascular endothelial growth factor (VEGF) was loaded within nanofibers to promote angiogenesis in the short term. In addition, platelet-derived growth factor-BB (PDGF-BB) encapsulated poly(lactic-co-glycolic acid) nanoparticles were embedded inside nanofibers to generate a sustained release of PDGF-BB for accelerated tissue regeneration and remodeling. In vitro studies revealed that our nanofibrous composites delivered VEGF quickly and PDGF-BB in a relayed manner, supported fibroblast growth and exhibited anti-bacterial activities. A preliminary in vivo study performed on normal full thickness rat skin wound models demonstrated that nanofiber/nanoparticle scaffolds significantly accelerated the wound healing process by promoting angiogenesis, increasing re-epithelialization and controlling granulation tissue formation. For later stages of healing, evidence also showed quicker collagen deposition and earlier remodeling of the injured site to achieve a faster full regeneration of skin compared to the commercial Hydrofera Blue® wound dressing. These results suggest that our nanoparticle-in-nanofiber system could provide a promising treatment for normal and chronic wound healing.

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Metadata

Authors
Xie, Z., Paras, C. B., Weng, H., Punnakitikashem, P., Su, L.-C., Vu, K., Tang, L., Yang, J., & Nguyen, K. T.
Venue
Acta Biomaterialia
Publisher
Elsevier BV
Published
2013-12
Volume
9
Issue
12
Pages
9351-9359
ISSN
1742-7061 (ISSN-L)
DOI
10.1016/j.actbio.2013.07.030
OpenAlex
W2039229322
Cited by
425
References
45
FWCI
8.75
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Dual growth factor releasing multi-functional nanofibers for wound healing. https://app.cochat.ai/papers/10.1016/j.actbio.2013.07.030
The paper
Xie, Z., Paras, C. B., Weng, H., Punnakitikashem, P., Su, L.-C., Vu, K., Tang, L., Yang, J., & Nguyen, K. T. (2013). Dual growth factor releasing multi-functional nanofibers for wound healing. Acta Biomaterialia. https://doi.org/10.1016/j.actbio.2013.07.030

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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.