The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Differential detection of dual traps improves the spatial resolution of optical tweezers
Open accessAbstract
The drive toward more sensitive single-molecule manipulation techniques has led to the recent development of optical tweezers capable of resolving the motions of biological systems at the subnanometer level, approaching the fundamental limit set by Brownian fluctuations. One successful approach has been the dual-trap optical tweezers, in which the system of study is held at both ends by microspheres in two separate optical traps. We present here a theoretical description of the Brownian limit on the spatial resolution of such systems and verify these predictions by direct measurement in a Brownian noise-limited dual-trap optical tweezers. We find that by detecting the positions of both trapped microspheres, correlations in their motions can be exploited to maximize the resolving power of the instrument. Remarkably, we show that the spatial resolution of dual optical traps with dual-trap detection is always superior to that of more traditional, single-trap designs, despite the added Brownian noise of the second trapped microsphere.
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Cites
Observation of a single-beam gradient force optical trap for dielectric particles
Ashkin, A., Dziedzic, J. M., Bjorkholm, J. E., & Chu, S. (1986) · Optics Letters · doi:10.1364/ol.11.000288 · Cited by 7,030
A theory of the linear viscoelastic properties of dilute solutions of coiling polymers
Rouse, P. E. (1953) · The Journal of Chemical Physics · doi:10.1063/1.1699180 · Cited by 4,203
Entropic Elasticity of λ-Phage DNA
Bustamante, C., Marko, J. F., Siggia, E. D., & Smith, S. (1994) · Science · doi:10.1126/science.8079175 · Cited by 2,154
Self-citationSingle myosin molecule mechanics: piconewton forces and nanometre steps
Finer, J. T., Simmons, R. M., & Spudich, J. A. (1994) · Nature · doi:10.1038/368113a0 · Cited by 1,915
Biological Applications of Optical Forces
Svoboda, K., & Block, S. M. (1994) · Annual Review of Biophysics and Biomolecular Structure · doi:10.1146/annurev.bb.23.060194.001335 · Cited by 1,792
Stretching DNA with optical tweezers
Wang, M. D., Yin, H., Landick, R., Gelles, J., & Block, S. M. (1997) · Biophysical Journal · doi:10.1016/s0006-3495(97)78780-0 · Cited by 1,481
Ten years of tension: single-molecule DNA mechanics
Bustamante, C., Bryant, Z., & Smith, S. B. (2003) · Nature · doi:10.1038/nature01405 · Cited by 1,303
Self-citationLiphardt, J., Dumont, S., Smith, S. B., Tinoco, I., & Bustamante, C. (2002) · Science · doi:10.1126/science.1071152 · Cited by 1,243
Self-citationVerification of the Crooks fluctuation theorem and recovery of RNA folding free energies
Collin, D., Ritort, F., Jarzynski, C., Smith, S. B., Tinoco, I., & Bustamante, C. (2005) · Nature · doi:10.1038/nature04061 · Cited by 1,049
Self-citationWang, G. M., Sevick, E. M., Mittag, E., Searles, D. J., & Evans, D. J. (2002) · Physical Review Letters · doi:10.1103/physrevlett.89.050601 · Cited by 936
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Recent Advances in Optical Tweezers
Moffitt, J. R., Chemla, Y. R., Smith, S. B., & Bustamante, C. (2008) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.77.043007.090225 · Cited by 1,084
Self-citationThe Complex Folding Network of Single Calmodulin Molecules
Stigler, J., Ziegler, F., Gieseke, A., Gebhardt, J. C. M., & Rief, M. (2011) · Science · doi:10.1126/science.1207598 · Cited by 372
Nucleosomal Elements that Control the Topography of the Barrier to Transcription
Bintu, L., Ishibashi, T., Dangkulwanich, M., Wu, Y.-Y., Lubkowska, L., Kashlev, M., & Bustamante, C. (2012) · Cell · doi:10.1016/j.cell.2012.10.009 · Cited by 192
Self-citationRevisiting the central dogma one molecule at a time
Bustamante, C., Cheng, W., & Mejia, Y. X. (2011) · Cell · doi:10.1016/j.cell.2011.01.033 · Cited by 173
Self-citationNascent RNA structure modulates the transcriptional dynamics of RNA polymerases
Zamft, B., Bintu, L., Ishibashi, T., & Bustamante, C. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1205063109 · Cited by 117
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Metadata
- Authors
- Moffitt, J. R., Chemla, Y. R., Izhaky, D., & Bustamante, C.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2006-06-13
- Volume
- 103
- Issue
- 24
- Pages
- 9006-9011
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2156300176
- Cited by
- 284
- References
- 27
- FWCI
- 10.52
- Type
- journal article
- Language
- en
- Open access
- green
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- Moffitt, J. R., Chemla, Y. R., Izhaky, D., & Bustamante, C. (2006). Differential detection of dual traps improves the spatial resolution of optical tweezers. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0603342103
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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