The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Characterization of the nanoscale properties of individual amyloid fibrils
Open accessAbstract
We report the detailed mechanical characterization of individual amyloid fibrils by atomic force microscopy and spectroscopy. These self-assembling materials, formed here from the protein insulin, were shown to have a strength of 0.6 ± 0.4 GPa, comparable to that of steel (0.6–1.8 GPa), and a mechanical stiffness, as measured by Young's modulus, of 3.3 ± 0.4 GPa, comparable to that of silk (1–10 GPa). The values of these parameters reveal that the fibrils possess properties that make these structures highly attractive for future technological applications. In addition, analysis of the solution-state growth kinetics indicated a breakage rate constant of 1.7 ± 1.3 × 10 −8 s −1 , which reveals that a fibril 10 μm in length breaks spontaneously on average every 47 min, suggesting that internal fracturing is likely to be of fundamental importance in the proliferation of amyloid fibrils and therefore for understanding the progression of their associated pathogenic disorders.
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Self-citationStructure of the cross-β spine of amyloid-like fibrils
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Cited by
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Knowles, T. P. J., Vendruscolo, M., & Dobson, C. M. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3810 · Cited by 2,382
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Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation
Galvagnion, C., Buell, A. K., Meisl, G., Michaels, T. C. T., Vendruscolo, M., Knowles, T. P. J., & Dobson, C. M. (2015) · Nature Chemical Biology · doi:10.1038/nchembio.1750 · Cited by 661
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Factors affecting the physical stability (aggregation) of peptide therapeutics
Zapadka, K. L., Becher, F. J., Gomes dos Santos, A. L., & Jackson, S. E. (2017) · Interface Focus · doi:10.1098/rsfs.2017.0030 · Cited by 401
Metadata
- Authors
- Smith, J. F., Knowles, T. P. J., Dobson, C. M., MacPhee, C. E., & Welland, M. E.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2006-10-24
- Volume
- 103
- Issue
- 43
- Pages
- 15806-15811
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2034951358
- Cited by
- 640
- References
- 38
- FWCI
- 21.69
- Type
- journal article
- Language
- en
- Open access
- green
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- Smith, J. F., Knowles, T. P. J., Dobson, C. M., MacPhee, C. E., & Welland, M. E. (2006). Characterization of the nanoscale properties of individual amyloid fibrils. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0604035103
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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