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Admixture mapping identifies 8q24 as a prostate cancer risk locus in African-American men
Open accessAbstract
A whole-genome admixture scan in 1,597 African Americans identified a 3.8 Mb interval on chromosome 8q24 as significantly associated with susceptibility to prostate cancer [logarithm of odds (LOD) = 7.1]. The increased risk because of inheriting African ancestry is greater in men diagnosed before 72 years of age ( P < 0.00032) and may contribute to the epidemiological observation that the higher risk for prostate cancer in African Americans is greatest in younger men (and attenuates with older age). The same region was recently identified through linkage analysis of prostate cancer, followed by fine-mapping. We strongly replicated this association ( P < 4.2 × 10 −9 ) but find that the previously described alleles do not explain more than a fraction of the admixture signal. Thus, admixture mapping indicates a major, still-unidentified risk gene for prostate cancer at 8q24, motivating intense work to find it.
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Self-citation
Metadata
- Authors
- Freedman, M. L., Haiman, C. A., Patterson, N., McDonald, G. J., Tandon, A., Waliszewska, A., Penney, K., Steen, R. G., Ardlie, K., John, E. M., Oakley-Girvan, I., Whittemore, A. S., Cooney, K. A., Ingles, S. A., Altshuler, D., Henderson, B. E., & Reich, D.
- Affiliations
- Broad Institute (US)
- University of Southern California (US)
- Harvard University (US)
- Cancer Prevention Institute of California (US)
- Stanford Medicine (US)
- University of Michigan (US)
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2006-09-19
- Volume
- 103
- Issue
- 38
- Pages
- 14068-14073
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC1599913
- OpenAlex
- W1995404520
- Cited by
- 612
- References
- 26
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 14 · 2023: 18 · 2022: 15 · 2021: 20 · 2020: 33 · 2019: 13 · 2018: 17 · 2017: 25 · 2016: 21 · 2015: 22 · 2014: 27 · 2013: 29 · 2012: 37
- FWCI
- 36.26
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- University Libraries (University of Maryland) (submittedVersion)
- Digital Repository at the University of Maryland (University of Maryland College Park)
- Funders
- U.S. Department of Defense (CA63464)
- University of Southern California (CA63464)
- Rockefeller Brothers Fund
- University of Michigan
- Broad Institute
- National Institutes of Health (CA63464, CA69568, CA79596)
- University of Michigan Comprehensive Cancer Center
- National Human Genome Research Institute (K01HG002758, HG02758)
- National Cancer Institute (CA 69568, CA63464, U01CA063464, CA79596, CA67044, R01CA067044, R01CA079596, R01CA063464, P50CA069568, U01CA067044)
- National Center for Research Resources
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Prostate Cancer Treatment and Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Forensic and Genetic Research
- Keywords
- prostate cancer, 8q24, African American men, admixture mapping, genetic susceptibility, African ancestry, age at diagnosis
- MeSH terms
- Aged, Alleles, Black or African American, Chromosome Mapping, Chromosomes, Human, Pair 8, Genetic Markers, Genotype, Humans, Male, Middle Aged, Neoplasm Staging, Phenotype, Prostatic Neoplasms, Risk Factors, Genetic Predisposition to Disease
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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