A common variant associated with prostate cancer in European and African populations
Abstract
With the increasing incidence of prostate cancer, identifying common genetic variants that confer risk of the disease is important. Here we report such a variant on chromosome 8q24, a region initially identified through a study of Icelandic families. Allele -8 of the microsatellite DG8S737 was associated with prostate cancer in three case-control series of European ancestry from Iceland, Sweden and the US. The estimated odds ratio (OR) of the allele is 1.62 (P = 2.7 x 10(-11)). About 19% of affected men and 13% of the general population carry at least one copy, yielding a population attributable risk (PAR) of approximately 8%. The association was also replicated in an African American case-control group with a similar OR, in which 41% of affected individuals and 30% of the population are carriers. This leads to a greater estimated PAR (16%) that may contribute to higher incidence of prostate cancer in African American men than in men of European ancestry.
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Many associations implicate non-protein-coding regions; examples include 8q24 associated with prostate, breast, and colon cancer, 300 kb from the nearest gene, and 9q21 associated with myocardial infarction and T2D, 150 kb from CDKN2A/CDKN2B.
“Examples include the region at 8q24 associated with prostate, breast, and colon cancer, 300 kb from the nearest gene (103, 104), and the region at 9q21 associated with myocardial infarction and T2D, 150 kb from the nearest genes encoding CDKN2A and CDKN2B (99–101, 105–107).”
From Genetic Mapping in Human Disease (2008) · cites this paper as [103]
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- Authors
- Amundadottir, L. T., Sulem, P., Gudmundsson, J., Helgason, A., Baker, A., Agnarsson, B. A., Sigurdsson, A., Benediktsdottir, K. R., Cazier, J.-B., Sainz, J., Jakobsdottir, M., Kostic, J., Magnusdottir, D. N., Ghosh, S., Agnarsson, K., Birgisdottir, B., Le Roux, L., Olafsdottir, A., Blondal, T., Andresdottir, M., Gretarsdottir, O. S., Bergthorsson, J. T., Gudbjartsson, D., Gylfason, A., Thorleifsson, G., Manolescu, A., Kristjansson, K., Geirsson, G., Isaksson, H., Douglas, J., Johansson, J.-E., Bälter, K., Wiklund, F., Montie, J. E., Yu, X., Suarez, B. K., Ober, C., Cooney, K. A., Gronberg, H., Catalona, W. J., Einarsson, G. V., Barkardottir, R. B., Gulcher, J. R., Kong, A., Thorsteinsdottir, U., & Stefansson, K.
- Affiliations
- deCODE Genetics (Iceland) (IS)
- National University Hospital of Iceland (IS)
- University of Michigan (US)
- Örebro University Hospital (SE)
- Karolinska Institutet (SE)
- Northwestern University (US)
- Washington University in St. Louis (US)
- University of Chicago (US)
- ORCID
- Venue
- Nature Genetics
- Published
- 2006-05-07
- Volume
- 38
- Issue
- 6
- Pages
- 652-658
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- OpenAlex
- W2164716330
- Cited by
- 787
- References
- 29
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 10 · 2023: 23 · 2022: 21 · 2021: 16 · 2020: 16 · 2019: 11 · 2018: 13 · 2017: 24 · 2016: 23 · 2015: 30 · 2014: 39 · 2013: 50 · 2012: 57
- FWCI
- 56.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Genetics (publishedVersion)
- PubMed (publishedVersion)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
- Hirsla (Landspítali University Hospital) (submittedVersion)
- Funders
- Swedish Cancer Foundation
- Landspítali Háskólasjúkrahús
- National Cancer Institute (R01CA105055)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Prostate Cancer Treatment and Research
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Prostate Cancer Diagnosis and Treatment
- Keywords
- prostate cancer, chromosome 8q24, microsatellite polymorphism, genetic susceptibility, population attributable risk, African American men, European ancestry, genetic association, cancer risk
- MeSH terms
- Alleles, Black or African American, Humans, Male, Prostatic Neoplasms, Microsatellite Repeats, Polymorphism, Single Nucleotide, Black People, White People
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