The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.
Host defense against oral microbiota by bone-damaging T cells
Open accessAbstract
The immune system evolved to efficiently eradicate invading bacteria and terminate inflammation through balancing inflammatory and regulatory T-cell responses. In autoimmune arthritis, pathogenic T H 17 cells induce bone destruction and autoimmune inflammation. However, whether a beneficial function of T-cell-induced bone damage exists is unclear. Here, we show that bone-damaging T cells have a critical function in the eradication of bacteria in a mouse model of periodontitis, which is the most common infectious disease. Bacterial invasion leads to the generation of specialized T H 17 cells that protect against bacteria by evoking mucosal immune responses as well as inducing bone damage, the latter of which also inhibits infection by removing the tooth. Thus, bone-damaging T cells, which may have developed to stop local infection by inducing tooth loss, function as a double-edged sword by protecting against pathogens while also inducing skeletal tissue degradation.
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Cites
The gut microbiota shapes intestinal immune responses during health and disease
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Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria
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Periodontitis: from microbial immune subversion to systemic inflammation
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Self-citationZhou, X., Bailey-Bucktrout, S. L., Jeker, L. T., Penaranda, C., Martínez-Llordella, M., Ashby, M., Nakayama, M., Rosenthal, W., & Bluestone, J. A. (2009) · Nature Immunology · doi:10.1038/ni.1774 · Cited by 1,370
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Matrix-embedded cells control osteoclast formation
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Cited by
Local and systemic mechanisms linking periodontal disease and inflammatory comorbidities
Hajishengallis, G., & Chavakis, T. (2021) · Nature Reviews Immunology · doi:10.1038/s41577-020-00488-6 · Cited by 1,871
Dutzan, N., Kajikawa, T., Abusleme, L., Greenwell-Wild, T., Zuazo, C. E., Ikeuchi, T., Brenchley, L., Abe, T., Hurabielle, C., Martin, D., et al. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aat0797 · Cited by 382
Polarized Macrophages in Periodontitis: Characteristics, Function, and Molecular Signaling
Sun, X., Gao, J., Meng, X., Lu, X., Zhang, L., & Chen, R. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.763334 · Cited by 291
RANKL as the master regulator of osteoclast differentiation
Takayanagi, H. (2021) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-020-01191-1 · Cited by 175
Self-citationPTH induces bone loss via microbial-dependent expansion of intestinal TNF+ T cells and Th17 cells
Yu, M., Malik Tyagi, A., Li, J.-Y., Adams, J., Denning, T. L., Weitzmann, M. N., Jones, R. M., & Pacifici, R. (2020) · Nature Communications · doi:10.1038/s41467-019-14148-4 · Cited by 148
Metadata
- Authors
- Tsukasaki, M., Komatsu, N., Nagashima, K., Nitta, T., Pluemsakunthai, W., Shukunami, C., Iwakura, Y., Nakashima, T., Okamoto, K., & Takayanagi, H.
- Venue
- Nature Communications
- Published
- 2018-02-16
- Volume
- 9
- Issue
- 1
- Pages
- 701-701
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2796965506
- Cited by
- 322
- References
- 57
- FWCI
- 27.78
- Type
- journal article
- Language
- en
- Open access
- gold
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