The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Ultrashort antibacterial and antifungal lipopeptides
Open accessAbstract
Host-defense cationic antimicrobial peptides (≈12–50 aa long) play an essential protective role in the innate immune system of all organisms. Lipopeptides, however, are produced only in bacteria and fungi during cultivation, and they are composed of specific lipophilic moieties attached to anionic peptides (six to seven amino acids). Here we report the following. ( i ) The attachment of an aliphatic chain to otherwise inert, cationic D,L tetrapeptides endows them with potent activity against various microorganisms including antibiotic resistance strains. ( ii ) Cell specificity is determined by the sequence of the short peptidic chain and the length of the aliphatic moiety. ( iii ) Despite the fact that the peptidic chains are very short, their mode of action involves permeation and disintegration of membranes, similar to that of many long antimicrobial peptides. Besides adding important information on the parameters necessary for host-defense lipopeptides to kill microorganisms, the simple composition of these lipopeptides and their diverse specificities should make them economically available, innate immunity-mimicking antimicrobial and antifungal compounds for various applications.
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Cites
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Self-citationPeptide Antibiotics and Their Role in Innate Immunity
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Cited by
A brief history of the antibiotic era: lessons learned and challenges for the future
Aminov, R. I. (2010) · Frontiers in Microbiology · doi:10.3389/fmicb.2010.00134 · Cited by 1,628
Ageitos, J. M., Sánchez-Pérez, A., Calo-Mata, P., & Villa, T. G. (2017) · Biochemical Pharmacology · doi:10.1016/j.bcp.2016.09.018 · Cited by 614
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Zaman, M., & Toth, I. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00318 · Cited by 90
Sporicidal Activity of Synthetic Antifungal Undecapeptides and Control of Penicillium Rot of Apples
Badosa, E., Ferré, R., Francés, J., Bardají, E., Feliu, L., Planas, M., & Montesinos, E. (2009) · Applied and Environmental Microbiology · doi:10.1128/aem.00711-09 · Cited by 67
Metadata
- Authors
- Makovitzki, A., Avrahami, D., & Shai, Y.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2006-10-24
- Volume
- 103
- Issue
- 43
- Pages
- 15997-16002
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2010666335
- Cited by
- 468
- References
- 38
- FWCI
- 10.18
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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