IL-33, the IL-1-like cytokine ligand for ST2 receptor, is a chromatin-associated nuclear factor in vivo

Biologic basis for interleukin-1 in disease.

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Release of chromatin protein HMGB1 by necrotic cells triggers inflammation

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IL-33, an Interleukin-1-like Cytokine that Signals via the IL-1 Receptor-Related Protein ST2 and Induces T Helper Type 2-Associated Cytokines

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High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal

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Monocytic cells hyperacetylate chromatin protein HMGB1 to redirect it towards secretion

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Association of transcriptionally silent genes with Ikaros complexes at centromeric heterochromatin.

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HMG1 and 2, and related ‘architectural’ DNA-binding proteins

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Ikaros DNA-Binding Proteins Direct Formation of Chromatin Remodeling Complexes in Lymphocytes

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A critical role of IL-33 in experimental allergic rhinitis

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IL-33 Is Produced by Mast Cells and Regulates IgE-Dependent Inflammation

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Disordered IL-33/ST2 Activation in Decidualizing Stromal Cells Prolongs Uterine Receptivity in Women with Recurrent Pregnancy Loss

Salker, M. S., Nautiyal, J., Steel, J. H., Webster, Z., Šućurović, S., Nicou, M., Singh, Y., Lucas, E. S., Murakami, K., Chan, Y., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0052252 · Cited by 228

Production and functions of IL-33 in the central nervous system

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Nuclear Interleukin-33 Is Generally Expressed in Resting Endothelium but Rapidly Lost upon Angiogenic or Proinflammatory Activation

Küchler, A. M., Pollheimer, J., Balogh, J., Sponheim, J., Manley, L., Sørensen, D. R., Angelis, P. M. D., Scott, H., & Haraldsen, G. (2008) · American Journal Of Pathology · doi:10.2353/ajpath.2008.080014 · Cited by 221

The Interleukin-1α Precursor is Biologically Active and is Likely a Key Alarmin in the IL-1 Family of Cytokines

Kim, B., Lee, Y. M., Kim, E., Kwak, A., Ryoo, S., Bae, S. H., Azam, T., Kim, S., & Dinarello, C. A. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00391 · Cited by 231

Suppression of innate inflammation and immunity by interleukin‐37

Dinarello, C. A., Nold‐Petry, C. A., Nold, M. F., Fujita, M., Li, S., Kim, S., & Bufler, P. (2016) · European Journal of Immunology · doi:10.1002/eji.201545828 · Cited by 218

IL-33 Induces IL-13–Dependent Cutaneous Fibrosis

Rankin, A. L., Mumm, J. B., Murphy, E., Turner, S. P., Yu, N., McClanahan, T. K., Bourne, P. A., Pierce, R. H., KASTELEIN, R. A., & Pflanz, S. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0903306 · Cited by 222

Cytokine-Induced Modulation of Colorectal Cancer

Mager, L. F., Wasmer, M.-H., Rau, T. T., & Krebs, P. (2016) · Frontiers in Oncology · doi:10.3389/fonc.2016.00096 · Cited by 223

Danger Signals Activating the Immune Response after Trauma

Hirsiger, S., Simmen, H., Werner, C. M. L., Wanner, G. A., & Rittirsch, D. (2012) · Mediators of Inflammation · doi:10.1155/2012/315941 · Cited by 216

Induction of IL-33 expression and activity in central nervous system glia

Hudson, C. A., Christophi, G. P., Gruber, R. C., Wilmore, J. R., Lawrence, D. A., & Massa, P. T. (2008) · Journal of Leukocyte Biology · doi:10.1189/jlb.1207830 · Cited by 213

Damage-associated molecular patterns in trauma

Relja, B., & Land, W. G. (2019) · European Journal of Trauma and Emergency Surgery · doi:10.1007/s00068-019-01235-w · Cited by 225

Neutralisation of the interleukin-33/ST2 pathway ameliorates experimental colitis through enhancement of mucosal healing in mice

Sedhom, M. A. K., Pichery, M., Murdoch, J. R., Foligné, B., Ortéga, N., Normand, S., Mertz, K. D., Sanmugalingam, D., Brault, L., Grandjean, T., et al. (2012) · Gut · doi:10.1136/gutjnl-2011-301785 · Cited by 211

Inflammation in acute and chronic pancreatitis

Habtezion, A. (2015) · Current Opinion in Gastroenterology · doi:10.1097/mog.0000000000000195 · Cited by 210

High endothelial venules (HEVs) in immunity, inflammation and cancer

Blanchard, L., & Girard, J. (2021) · Angiogenesis · doi:10.1007/s10456-021-09792-8 · Cited by 231

Interleukin-33 enhances adhesion, CD11b expression and survival in human eosinophils

Suzukawa, M., Koketsu, R., Iikura, M., Nakae, S., Matsumoto, K., Nagase, H., Saito, H., Matsushima, K., Ohta, K., Yamamoto, K., et al. (2008) · Laboratory Investigation · doi:10.1038/labinvest.2008.82 · Cited by 206

Interleukin-33 biology with potential insights into human diseases

Palmer, G., & Gabay, C. (2011) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2011.53 · Cited by 214

IL‐33: a tissue derived cytokine pathway involved in allergic inflammation and asthma

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IL-33 and IL-33 Receptors in Host Defense and Diseases

Oboki, K., Ohno, T., Kajiwara, N., Saito, H., & Nakae, S. (2010) · Allergology International · doi:10.2332/allergolint.10-rai-0186 · Cited by 210

Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease

Chapuis, J., Hot, D., Hansmannel, F., Kerdraon, O., Ferreira, S., Hubans, C., Maurage, C. A., Huot, L., Bensemain, F., Laumet, G., et al. (2009) · Molecular Psychiatry · doi:10.1038/mp.2009.10 · Cited by 201

Positive regulators of osteoclastogenesis and bone resorption in rheumatoid arthritis

Braun, T., & Zwerina, J. (2011) · Arthritis Research & Therapy · doi:10.1186/ar3380 · Cited by 208

The role of IL‐33 and mast cells in allergy and inflammation

Saluja, R., Khan, M., Church, M. K., & Maurer, M. (2015) · Clinical and Translational Allergy · doi:10.1186/s13601-015-0076-5 · Cited by 205

Overview of the interleukin-1 family of ligands and receptors

Dinarello, C. A. (2013) · Seminars in Immunology · doi:10.1016/j.smim.2013.10.001 · Cited by 198

Trefoil factor 2 rapidly induces interleukin 33 to promote type 2 immunity during allergic asthma and hookworm infection

Wills-Karp, M. A., Rani, R., Dienger, K. M., Lewkowich, I. P., Fox, J. G., Perkins, C. L., Lewis, L., Finkelman, F. D., Smith, D. E., Bryce, P. J., et al. (2012) · The Journal of Experimental Medicine · doi:10.1084/jem.20110079 · Cited by 187

IL-36R signalling activates intestinal epithelial cells and fibroblasts and promotes mucosal healing in vivo

Koop, K., Backert, I., Wirtz, S. J., Hueber, A. J., Schett, G. A., Vieth, M. W., Probst, H. C., Bopp, T., Neurath, M. F., & Neufert, C. F. (2016) · Gut · doi:10.1136/gutjnl-2015-310374 · Cited by 192

The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and stromal cells promotes metastasis through tumour-associated macrophages

Yang, Y., Andersson, P., Hosaka, K., Zhang, Y., Cao, R., Iwamoto, H., Yang, X., Nakamura, M., Wang, J., Zhuang, R., et al. (2016) · Nature Communications · doi:10.1038/ncomms11385 · Cited by 189

IL-33 Reduces Macrophage Foam Cell Formation

McLaren, J. E., Michael, D. R., Salter, R. C., Ashlin, T. G., Calder, C. J., Miller, A. M., Liew, F. Y., & Ramji, D. P. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1000520 · Cited by 186

IL-33, a recently identified interleukin-1 gene family member, is expressed in human adipocytes

Wood, I. S., Wang, B., & Trayhurn, P. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.04.081 · Cited by 187

The IL-1 receptor accessory protein (AcP) is required for IL-33 signaling and soluble AcP enhances the ability of soluble ST2 to inhibit IL-33

Palmer, G., Lipsky, B. P., Smithgall, M. D., Meininger, D. P., Siu, S., Talabot‐Ayer, D., Gabay, C., & Smith, D. E. (2008) · Cytokine · doi:10.1016/j.cyto.2008.03.008 · Cited by 181

Alarmins: Feel the Stress

Rider, P., Voronov, E., Dinarello, C. A., Apte, R. N., & Cohen, I. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1601342 · Cited by 186

Glioma-derived IL-33 orchestrates an inflammatory brain tumor microenvironment that accelerates glioma progression

Boeck, A. D., Ahn, B. Y., D’Mello, C., Lun, X. Q., Menon, S. V., Alshehri, M. M., Szulzewsky, F., Shen, Y., Khan, L., Dang, N. H., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-18569-4 · Cited by 191

IL-33 in T Cell Differentiation, Function, and Immune Homeostasis

Peine, C., Marek, R. M., & Löhning, M. (2016) · Trends in Immunology · doi:10.1016/j.it.2016.03.007 · Cited by 187

Decoding asthma: Translating genetic variation in IL33 and IL1RL1 into disease pathophysiology

Grotenboer, N. S., Ketelaar, M. E., Koppelman, G. H., & Nawijn, M. C. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2012.11.028 · Cited by 182

Molecular and bioenergetic differences between cells with African versus European inherited mitochondrial DNA haplogroups: Implications for population susceptibility to diseases

Kenney, M. C., Chwa, M., Atilano, S. R., Falatoonzadeh, P., Ramírez, C., Malik, D., Tarek, M., Cáceres‐del‐Carpio, J., Nesburn, A. B., Boyer, D. S., et al. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.10.016 · Cited by 177

The IL-33/ST2 axis: Role in health and disease

la Fuente, M. D., MacDonald, T. T., & Hermoso, M. A. (2015) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2015.07.017 · Cited by 171

IL-10-producing regulatory B cells induced by IL-33 (BregIL-33) effectively attenuate mucosal inflammatory responses in the gut

Sattler, S., Ling, G., Xu, D., Hussaarts, L., Romaine, A., Zhao, H., Fossati‐Jimack, L., Malik, T. H., Cook, H. T., Botto, M., et al. (2014) · Journal of Autoimmunity · doi:10.1016/j.jaut.2014.01.032 · Cited by 187

Serum levels of IL-33 and soluble ST2 and their association with disease activity in systemic lupus erythematosus

Mok, M. Y., Huang, F., Ip, W., Lo, Y., Wong, F. Y., Chan, E. Y. T., Lam, K. F., & Xu, D. (2009) · Lara D. Veeken · doi:10.1093/rheumatology/kep402 · Cited by 172

IL-1 family cytokines trigger sterile inflammatory disease

Lukens, J. R., Gross, J. M., & Kanneganti, T. (2012) · Frontiers in Immunology · doi:10.3389/fimmu.2012.00315 · Cited by 178

Ozone exposure induces respiratory barrier biphasic injury and inflammation controlled by IL-33

Michaudel, C., Mackowiak, C., Maillet, I., Fauconnier, L., Akdiş, C. A., Sokołowska, M., Dreher, A., Tan, H. T., Quesniaux, V. F. J., Ryffel, B., et al. (2018) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2017.11.044 · Cited by 172

The IL-33/ST2 axis augments effector T-cell responses during acute GVHD

Reichenbach, D. K., Schwarze, V., Matta, B. M., Tkachev, V., Lieberknecht, E., Liu, Q., Koehn, B. H., Pfeifer, D., Taylor, P. A., Prinz, G., et al. (2015) · Blood · doi:10.1182/blood-2014-10-606830 · Cited by 173

Altered subcellular localization of IL-33 leads to non-resolving lethal inflammation

Bessa, J., Meyer, C. A., Mudry, M. C. D. V., Schlicht, S., Smith, S. H., Iglesias, A. H., & Cote-Sierra, J. (2014) · Journal of Autoimmunity · doi:10.1016/j.jaut.2014.02.012 · Cited by 182

Respiratory Syncytial Virus Disease Is Mediated by Age-Variable IL-33

Saravia, J., You, D., Shrestha, B., Jaligama, S., Siefker, D. T., Lee, G. I., Harding, J. N., Jones, T. L., Rovnaghi, C. R., Bagga, B., et al. (2015) · PLoS Pathogens · doi:10.1371/journal.ppat.1005217 · Cited by 170

Increased Levels of Interleukin 33 in Sera and Synovial Fluid from Patients with Active Rheumatoid Arthritis

Matsuyama, Y., Okazaki, H., Tamemoto, H., KIMURA, H., Kamata, Y., Nagatani, K., Nagashima, T., Hayakawa, M., Iwamoto, M., Yoshio, T., et al. (2009) · The Journal of Rheumatology · doi:10.3899/jrheum.090492 · Cited by 169

New Cytokines in the Pathogenesis of Atopic Dermatitis—New Therapeutic Targets

Klonowska, J., Gleń, J., Nowicki, R. J., & Trzeciak, M. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19103086 · Cited by 174

IL‐33 induces skin inflammation with mast cell and neutrophil activation

Hueber, A. J., Alves-Filho, J. C., Asquith, D. L., Michels, C., Millar, N. L., Reilly, J. H., Graham, G. J., Liew, F. Y., Miller, A. M., & McInnes, I. B. (2011) · European Journal of Immunology · doi:10.1002/eji.201041360 · Cited by 169

The IL-33/ST2 pathway — A new therapeutic target in cardiovascular disease

Miller, A. M., & Liew, F. Y. (2011) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2011.02.005 · Cited by 168

Components of the interleukin-33/ST2 system are differentially expressed and regulated in human cardiac cells and in cells of the cardiac vasculature

Demyanets, S., Kaun, C., Pentz, R., Krychtiuk, K. A., Rauscher, S., Pfaffenberger, S., Zuckermann, A. O., Aliabadi, A. Z., Gröger, M., Maurer, G., et al. (2013) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2013.03.020 · Cited by 168

New Insights in the Immunobiology of IL-1 Family Members

van de Veerdonk, F. L., & Netea, M. G. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00167 · Cited by 170

Role of Proinflammatory Cytokines IL-18 and IL-1β in Bleomycin-Induced Lung Injury in Humans and Mice

Hoshino, T., Okamoto, M., Sakazaki, Y., Kato, S., Young, H. A., & Aizawa, H. (2009) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2008-0182oc · Cited by 164

Epithelial-Derived Cytokines in Asthma

Mitchell, P. D., & O’Byrne, P. M. (2016) · CHEST Journal · doi:10.1016/j.chest.2016.10.042 · Cited by 171

Cytokine inhibition in the treatment of COPD

Chung, K. F., Caramori, G., Adcock, I. M., & Stefano, A. D. (2014) · International Journal of COPD · doi:10.2147/copd.s42544 · Cited by 173

IL-33 Exacerbates Acute Kidney Injury

Akçay, A., Nguyen, Q., He, Z., Türkmen, K., Lee, D. W., Andrés-Hernando, A., Altmann, C. J., Toker, A., Pačić, A., Ljubanović, D. G., et al. (2011) · Journal of the American Society of Nephrology · doi:10.1681/asn.2010091011 · Cited by 166

The Interleukin-1 Family

Yazdi, A. S., & Ghoreschi, K. (2016) · Advances in experimental medicine and biology · doi:10.1007/978-94-024-0921-5_2 · Cited by 174

Myocardial pressure overload induces systemic inflammation through endothelial cell IL-33

Chen, W., Hong, J., Gannon, J., Kakkar, R. K., & Lee, R. T. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1424236112 · Cited by 162

Interleukin-33 and the function of innate lymphoid cells

Mirchandani, A. S., Salmond, R. J., & Liew, F. Y. (2012) · Trends in Immunology · doi:10.1016/j.it.2012.04.005 · Cited by 164

Caspase-1, Caspase-8, and Calpain Are Dispensable for IL-33 Release by Macrophages

Ohno, T., Oboki, K., Kajiwara, N., Morii, E., Aozasa, K., Flavell, R. A., Okumura, K., Saito, H., & Nakae, S. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0802449 · Cited by 160

Regulation and Function of the IL-1 Family Cytokine IL-1F9 in Human Bronchial Epithelial Cells

Chustz, R. T., Nagarkar, D. R., Poposki, J. A., Favoreto, S., Avila, P. C., Schleimer, R. P., & Kato, A. (2010) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2010-0075oc · Cited by 157

Interleukin-1α

Rider, P., Carmi, Y., Voronov, E., & Apte, R. N. (2013) · Seminars in Immunology · doi:10.1016/j.smim.2013.10.005 · Cited by 155

IL-33 activates tumor stroma to promote intestinal polyposis

Maywald, R. L., Doerner, S. K., Pastorelli, L., Salvo, C. D., Benton, S. M., Dawson, E. P., Lanza, D. G., Berger, N. A., Markowitz, S. D., Lenz, H., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1422445112 · Cited by 159

Alternative splicing of interleukin-33 and type 2 inflammation in asthma

Gordon, E. D., Simpson, L. J., Rios, C. L., Ringel, L., Lachowicz-Scroggins, M. E., Peters, M. C., Wesolowska‐Andersen, A., Gonzalez, J. R., MacLeod, H. J., Christian, L. S., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1601914113 · Cited by 160

Type 2 innate immune responses and the natural helper cell

Koyasu, S., & Moro, K. (2011) · Immunology · doi:10.1111/j.1365-2567.2011.03413.x · Cited by 155

Interleukin-33 Induces Expression of Adhesion Molecules and Inflammatory Activation in Human Endothelial Cells and in Human Atherosclerotic Plaques

Demyanets, S., Kónya, V., Kastl, S., Kaun, C., Rauscher, S., Niessner, A., Pentz, R., Pfaffenberger, S., Rychli, K., Lemberger, C. E., et al. (2011) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.111.231431 · Cited by 156

The paracrine effect of cancer‐associated fibroblast‐induced interleukin‐33 regulates the invasiveness of head and neck squamous cell carcinoma

Chen, S.-F., Nieh, S., Jao, S., Wu, M.-Z., Liu, C., Chang, Y., & Lin, Y. (2013) · The Journal of Pathology · doi:10.1002/path.4226 · Cited by 152

IL-33 Enhances Lipopolysaccharide-Induced Inflammatory Cytokine Production from Mouse Macrophages by Regulating Lipopolysaccharide Receptor Complex

Espinassous, Q., Paco, E. G. D., García-Verdugo, I., Synguélakis, M., von Aulock, S., Sallenave, J., McKenzie, A. N. J., & Kanellopoulos, J. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803067 · Cited by 158

Soluble ST2: A complex and diverse role in several diseases

Homšak, E., & Gruson, D. (2020) · Clinica Chimica Acta · doi:10.1016/j.cca.2020.04.011 · Cited by 151

Inflammatory Bowel Disease-Associated Interleukin-33 Is Preferentially Expressed in Ulceration-Associated Myofibroblasts

Sponheim, J., Pollheimer, J., Olsen, T., Balogh, J., Hammarström, C. L., Loos, T., Kasprzycka, M., Sørensen, D. R., Nilsen, H. R., Küchler, A. M., et al. (2010) · American Journal Of Pathology · doi:10.2353/ajpath.2010.100378 · Cited by 158

Alarmin IL-33 Acts as an Immunoadjuvant to Enhance Antigen-Specific Tumor Immunity

Villarreal, D. O., Wise, M. C., Walters, J. N., Reuschel, E. L., Choi, M. J., Obeng-Adjei, N., Yan, J., Morrow, M. P., & Weiner, D. B. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-2729 · Cited by 147

The central role of IL-33/IL-1RL1 pathway in asthma: From pathogenesis to intervention

Jayalatha, A. K. S., Hesse, L., Ketelaar, M. E., Koppelman, G. H., & Nawijn, M. C. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107847 · Cited by 150

IL-33 Activates Unprimed Murine Basophils Directly In Vitro and Induces Their In Vivo Expansion Indirectly by Promoting Hematopoietic Growth Factor Production

Schneider, E., Petit-Bertron, A.-F., Rignault‐Bricard, R., Levasseur, M., Ramadan, A., Girard, J., Herbelin, A., & Dy, M. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0900328 · Cited by 152

Interleukin-33 treatment reduces secondary injury and improves functional recovery after contusion spinal cord injury

Pomeshchik, Y., Kidin, I., Korhonen, P., Savchenko, E., Jaronen, M., Lehtonen, Š., Wojciechowski, S., Kanninen, K. M., Koıstınaho, J., & Malm, T. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.08.002 · Cited by 143

Interleukin-33 is expressed in differentiated osteoblasts and blocks osteoclast formation from bone marrow precursor cells

Schulze, J., Bickert, T., Beil, F. T., Zaiss, M. M., Albers, J., Wintges, K., Streichert, T., Klaetschke, K., Keller, J., Hißnauer, T.-N., et al. (2010) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.269 · Cited by 146

Airway epithelial dual oxidase 1 mediates allergen-induced IL-33 secretion and activation of type 2 immune responses

Hristova, M., Habibovic, A., Veith, C., Janssen-Heininger, Y. M. W., Dixon, A. E., Geiszt, M., & van der Vliet, A. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.10.003 · Cited by 141

A network map of IL-33 signaling pathway

Pinto, S. M., Subbannayya, Y., Balaya, R. D. A., Raju, R., Chatterjee, O., Advani, J., Radhakrishnan, A., Prasad, T. S. K., Wani, M. R., & Pandey, A. (2018) · Journal of Cell Communication and Signaling · doi:10.1007/s12079-018-0464-4 · Cited by 141

Sounding the alarmins—The role of alarmin cytokines in asthma

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A rare IL33 loss-of-function mutation reduces blood eosinophil counts and protects from asthma

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