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Cited by 314

The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.

Coupling of STIM1 to store-operated Ca 2+ entry through its constitutive and inducible movement in the endoplasmic reticulum

Open access
Baba, Yoshihiro, Hayashi, Kenji, Fujii, Yoko, Mizushima, Akiko, Watarai, Hiroshi, Wakamori, Minoru, Numaga, Takuro, Mori, Yasuo, Iino, Masamitsu, Hikida, Masaki, Kurosaki, Tomohiro·2006·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.0608358103
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Abstract

Depletion of intracellular calcium (Ca 2+ ) stores induces store-operated Ca 2+ (SOC) entry across the plasma membrane (PM). STIM1, a putative Ca 2+ sensor in the endoplasmic reticulum (ER), has been recently shown to be necessary for SOC channel activation. Here we show that STIM1 dynamically moves in tubulovesicular shape on the ER and its subcompartment in resting living cells, whereas, upon Ca 2+ store depletion, it is rapidly redistributed into discrete puncta that are located underneath, but not inserted into the PM. Normal constitutive movement of STIM1 is mediated through the coiled-coil and Ser/Thr-rich C-terminal domains in the cytoplasmic region of STIM1, whereas subsequent inducible puncta formation further requires the sterile α motif domain protruding into the ER lumen. Each of these three domains (coiled-coil, Ser/Thr-rich, and sterile α motif) was essential for activating SOC channels. Hence, our findings based on structure–function experiments suggest that constitutive dynamic movement of STIM1 in the ER and its subcompartment is obligatory for subsequent depletion-dependent redistribution of STIM1 into puncta underneath the PM and activation of SOC channels.

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Research works printed but not linked: 2

  1. 10.1016/j.bcp.2005.01.011 · doi:10.1016/j.bcp.2005.01.011
  2. 10.1083/jcb.200103002 · doi:10.1083/jcb.200103002

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Metadata

Authors
Baba, Y., Hayashi, K., Fujii, Y., Mizushima, A., Watarai, H., Wakamori, M., Numaga, T., Mori, Y., Iino, M., Hikida, M., & Kurosaki, T.
Venue
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Published
2006-11-07
Volume
103
Issue
45
Pages
16704-16709
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.0608358103
OpenAlex
W2041474455
Cited by
314
References
38
FWCI
11.25
Type
journal article
Language
en
Open access
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CoChat. (2026). Citation check: Coupling of STIM1 to store-operated Ca 2+ entry through its constitutive and inducible movement in the endoplasmic reticulum. https://app.cochat.ai/papers/10.1073/pnas.0608358103
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Baba, Y., Hayashi, K., Fujii, Y., Mizushima, A., Watarai, H., Wakamori, M., Numaga, T., Mori, Y., Iino, M., Hikida, M., & Kurosaki, T. (2006). Coupling of STIM1 to store-operated Ca 2+ entry through its constitutive and inducible movement in the endoplasmic reticulum. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0608358103

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