The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Molecular mechanism for analgesia involving specific antagonism of α9α10 nicotinic acetylcholine receptors
Open accessAbstract
α9α10 nicotinic acetylcholine receptors (nAChRs) have been identified in a variety of tissues including lymphocytes and dorsal root ganglia; except in the case of the auditory system, the function of α9α10 nAChRs is not known. Here we show that selective block (rather than stimulation) of α9α10 nAChRs is analgesic in an animal model of nerve injury pain. In addition, blockade of this nAChR subtype reduces the number of choline acetyltransferase-positive cells, macrophages, and lymphocytes at the site of injury. Chronic neuropathic pain is estimated to affect up to 8% of the world's population; the numerous analgesic compounds currently available are largely ineffective and act through a small number of pharmacological mechanisms. Our findings not only suggest a molecular mechanism for the treatment of neuropathic pain but also demonstrate the involvement of α9α10 nAChRs in the pathophysiology of peripheral nerve injury.
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Cites
A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man
Bennett, G. J., & Xie, Y.-K. (1988) · Pain · doi:10.1016/0304-3959(88)90209-6 · Cited by 5,376
Nicotinic acetylcholine receptor α7 subunit is an essential regulator of inflammation
Wang, H., Yu, M., Ochani, M., Amella, C. A., Tanovic, M., Susarla, S., Li, J. H., Wang, H., Yang, H., Ulloa, L., et al. (2003) · Nature · doi:10.1038/nature01339 · Cited by 3,228
de Jonge, W. J., van der Zanden, E. P., The, F. O., Bijlsma, M. F., van Westerloo, D. J., Bennink, R. J., Berthoud, H.-R., Uematsu, S., Akira, S., van den Wijngaard, R. M., et al. (2005) · Nature Immunology · doi:10.1038/ni1229 · Cited by 1,074
Neuronal nicotinic receptors: from structure to pathology
Gotti, C., & Clementi, F. (2004) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2004.09.006 · Cited by 970
The Vagus Nerve and Nicotinic Receptors Modulate Experimental Pancreatitis Severity in Mice
van Westerloo, D. J., Giebelen, I. A., Florquin, S., Bruno, M. J., LaRosa, G. J., Ulloa, L., Tracey, K. J., & van der Poll, T. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.02.022 · Cited by 377
Cited by
Nicotinic acetylcholine receptors: From basic science to therapeutics
Hurst, R., Rollema, H., & Bertrand, D. (2013) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2012.08.012 · Cited by 522
Diversity of vertebrate nicotinic acetylcholine receptors
Millar, N. S., & Gotti, C. (2009) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.07.041 · Cited by 441
Discovery, Synthesis, and Structure–Activity Relationships of Conotoxins
Akondi, K. B., Muttenthaler, M., Dutertre, S., Kaas, Q., Craik, D. J., Lewis, R. J., & Alewood, P. F. (2014) · Chemical Reviews · doi:10.1021/cr400401e · Cited by 323
Regulation of neuronal nicotinic receptor traffic and expression
Gaimarri, A., Moretti, M., Riganti, L., Zanardi, A., Clementi, F., & Gotti, C. (2007) · Brain Research Reviews · doi:10.1016/j.brainresrev.2007.02.005 · Cited by 89
Metadata
- Authors
- Vincler, M., Wittenauer, S., Parker, R., Ellison, M., Olivera, B. M., & McIntosh, J. M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2006-11-21
- Volume
- 103
- Issue
- 47
- Pages
- 17880-17884
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2128043404
- Cited by
- 227
- References
- 5
- FWCI
- 7.65
- Type
- journal article
- Language
- en
- Open access
- green
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- Vincler, M., Wittenauer, S., Parker, R., Ellison, M., Olivera, B. M., & McIntosh, J. M. (2006). Molecular mechanism for analgesia involving specific antagonism of α9α10 nicotinic acetylcholine receptors. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0608715103
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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