Regulation of neuronal nicotinic receptor traffic and expression
Abstract
Neuronal nicotinic acetylcholine receptors (nAChRs) are a family of cation channels widely distributed in the brain, whose subunit composition and biophysical properties vary depending on the subtype and the area of the brain in which they are found. Brain nAChRs are also the target of nicotine, the most widespread drug of abuse. Chronic nicotine exposure differentially affects the number, subunit composition, stoichiometry and functional state of some nAChR subtypes, leaving others substantially unaffected. In this review, we will summarise recent data concerning the nAChR subtypes expressed in the CNS, and how they are regulated by means of chronic nicotine and/or nicotinic drugs. We will particularly focus on the possible mechanisms involved in the up-regulation of nAChRs.
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Heteromeric nAChRs in the cortex are almost exclusively made up of the α4β2 subtype, which is the subtype most readily upregulated following chronic administration of nicotine.
“Heteromeric nAChRs in the cortex are almost exclusively made up of the α4β2 subtype, which is the subtype most readily upregulated following chronic administration of nicotine”
From Parallel Anxiolytic-Like Effects and Upregulation of Neuronal Nicotinic Acetylcholine Receptors Following Chronic Nicotine and Varenicline (2011) · cites this paper as Gaimarri et al., 2007
Cites
Neuronal nicotinic receptors: from structure to pathology
Gotti, C., & Clementi, F. (2004) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2004.09.006 · Cited by 970 · see citing works
Self-citationBrain nicotinic acetylcholine receptors: native subtypes and their relevance
Gotti, C., Zoli, M., & Clementi, F. (2006) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2006.07.004 · Cited by 882 · see citing works
Self-citationNicotinic Receptors at the Amino Acid Level
Corringer, P., Novère, N. G. L., & Changeux, J. (2000) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.40.1.431 · Cited by 823 · see citing works
Celie, P. H. N., van Rossum-Fikkert, S. E., van Dijk, W. J., Brejc, K., Smit, A. B., & Sixma, T. K. (2004) · Neuron · doi:10.1016/s0896-6273(04)00115-1 · Cited by 781 · see citing works
Nicotine activates and desensitizes midbrain dopamine neurons
Pidoplichko, V. I., DeBiasi, M., Williams, J. T., & Dani, J. A. (1997) · Nature · doi:10.1038/37120 · Cited by 769 · see citing works
Hansen, S. B., Sulzenbacher, G., Huxford, T., Marchot, P., Taylor, P., & Bourne, Y. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600828 · Cited by 643 · see citing works
Nicotinic acetylcholine receptors and the regulation of neuronal signalling
Dajas‐Bailador, F., & Wonnacott, S. (2004) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2004.04.006 · Cited by 618 · see citing works
Nicotine binding and nicotinic receptor subunit RNA after chronic nicotine treatment
Marks, M., Pauly, Jr., Gross, S., Deneris, E., Hermans-Borgmeyer, I., Heinemann, S., & Collins, A. (1992) · The Journal of Neuroscience · doi:10.1523/jneurosci.12-07-02765.1992 · Cited by 551 · see citing works
Jensen, A. A., Frølund, B., Liljefors, T., & Krogsgaard‐Larsen, P. (2005) · Journal of Medicinal Chemistry · doi:10.1021/jm040219e · Cited by 541 · see citing works
Nicotinic acetylcholine receptors: from structure to brain function
Hogg, R. C., Raggenbass, M., & Bertrand, D. (2003) · Springer eBooks · doi:10.1007/s10254-003-0005-1 · Cited by 529 · see citing works
Recent advances in Cys-loop receptor structure and function
Sine, S. M., & Engel, A. G. (2006) · Nature · doi:10.1038/nature04708 · Cited by 521 · see citing works
Champtiaux, N., Gotti, C., Cordero‐Erausquin, M., David, D. J. P., Przybylski, C., Léna, C., Clementi, F., Moretti, M., Rossi, F., Novère, N. G. L., et al. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-21-07820.2003 · Cited by 509 · see citing works
Self-citationThe neurobiology of nicotine addiction: bridging the gap from molecules to behaviour
Laviolette, S. R., & van der Kooy, D. (2004) · Nature reviews. Neuroscience · doi:10.1038/nrn1298 · Cited by 452 · see citing works
Allosteric Receptors after 30 Years
Changeux, J., & Edelstein, S. J. (1998) · Neuron · doi:10.1016/s0896-6273(00)80616-9 · Cited by 426 · see citing works
Alternate stoichiometries of α4β2 nicotinic acetylcholine receptors
Nelson, M. E., Kuryatov, A., Choi, C. H., Zhou, Y., & Lindstrom, J. (2003) · Molecular Pharmacology · doi:10.1124/mol.63.2.332 · Cited by 423 · see citing works
Le Novère, N., Corringer, P., & Changeux, J. (2002) · Journal of Neurobiology · doi:10.1002/neu.10153 · Cited by 411 · see citing works
Chavez-Noriega, L. E., Crona, J. H., Washburn, M. S., Urrutia, A., Elliott, K. J., & Johnson, E. C. (1997) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)36376-1 · Cited by 405 · see citing works
Chavez-Noriega, L. E., Crona, J. H., Washburn, M. S., Urrutia, A., Elliott, K. J., & Johnson, E. C. (1997) · PubMed · Cited by 392 · see citing works
Increased nicotinic receptors in brains from smokers: membrane binding and autoradiography studies
Perry, D. C., Dávila-Garcı́a, M. I., Stockmeier, C. A., & Kellar, K. J. (1999) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)38304-1 · Cited by 362 · see citing works
Chronic Exposure to Nicotine Upregulates the Human α4β2 Nicotinic Acetylcholine Receptor Function
Buisson, B., & Bertrand, D. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-06-01819.2001 · Cited by 361 · see citing works
Nicotinic receptors in the brain. Links between molecular biology and behavior
Picciotto, M. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00146-3 · Cited by 354 · see citing works
Ca2+ permeability of nicotinic acetylcholine receptors
Fucile, S. (2003) · Cell Calcium · doi:10.1016/j.ceca.2003.08.006 · Cited by 320 · see citing works
Moroni, M., Zwart, R., Sher, E., Cassels, B. K., & Bermúdez, I. (2006) · Molecular Pharmacology · doi:10.1124/mol.106.023044 · Cited by 286 · see citing works
Nicotine acts as a pharmacological chaperone to up-regulate human α4β2 acetylcholine receptors
Kuryatov, A., Luo, J., Cooper, J., & Lindstrom, J. (2005) · Molecular Pharmacology · doi:10.1124/mol.105.012419 · Cited by 275 · see citing works
Nicotine upregulates its own receptors through enhanced intracellular maturation
Sallette, J., Pons, S., Devillers-Thiery, A., Soudant, M., Prado de Carvalho, L., Changeux, J.-P., & Corringer, P. J. (2005) · Neuron · doi:10.1016/j.neuron.2005.03.029 · Cited by 261 · see citing works
Nicotine as a modulator of behavior: beyond the inverted U
Picciotto, M. R. (2003) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(03)00230-x · Cited by 257 · see citing works
THE PHARMACOLOGICAL ACTIONS OF POLYMETHYLENE BISTRIMETHYLAMMONIUM SALTS
Paton, W. D. M., & ZAIMIS, E. J. (1997) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1997.tb06777.x · Cited by 244 · see citing works
Regulation of Nicotinic Acetylcholine Receptor Numbers and Function by Chronic Nicotine Exposure
Gentry, C., & Lukas, R. (2002) · Current Drug Target -CNS & Neurological Disorders · doi:10.2174/1568007023339184 · Cited by 232 · see citing works
Vincler, M. A., Wittenauer, S., Parker, R., Ellison, M., Olivera, B. M., & McIntosh, J. M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0608715103 · Cited by 231 · see citing works
Picciotto, M. R., Caldarone, B. J., Brunzell, D. H., Zachariou, V., Stevens, T. R., & King, S. L. (2001) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(01)00161-9 · Cited by 221 · see citing works
Khiroug, S. S., Harkness, P. C., Lamb, P. W., Sudweeks, S. N., Khiroug, L. S., Millar, N. S., & Yakel, J. L. (2002) · The Journal of Physiology · doi:10.1113/jphysiol.2001.013847 · Cited by 215 · see citing works
THE PHARMACOLOGICAL ACTIONS OF POLYMETHYLENE BISTRIMETHYLAMMONIUM SALTS
Paton, W. D. M., & ZAIMIS, E. J. (1949) · British Journal of Pharmacology and Chemotherapy · doi:10.1111/j.1476-5381.1949.tb00565.x · Cited by 212 · see citing works
Chronic Nicotine Exposure Upregulates Nicotinic Receptors by a Novel Mechanism
Vallejo, Y. F. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.5240-04.2005 · Cited by 201 · see citing works
Peng, X.-D., Gerzanich, V., Anand, R., Wang, F., & Lindstrom, J. M. (1997) · Molecular Pharmacology · doi:10.1124/mol.51.5.776 · Cited by 191 · see citing works
Nashmi, R., Dickinson, M. E., McKinney, S., Jareb, M., Labarca, C., Fraser, S. E., & Lester, H. A. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-37-11554.2003 · Cited by 188 · see citing works
Wang, F., Nelson, M. E., Kuryatov, A., Olale, F., Cooper, J., Keyser, K., & Lindstrom, J. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.44.28721 · Cited by 187 · see citing works
Conservation within the RIC-3 Gene Family
Halevi, S., Yassin, L., Eshel, M., Sala, F., Sala, S., Criado, M., & Treinin, M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300170200 · Cited by 181 · see citing works
Green, W. N., & Millar, N. S. (1995) · PubMed · Cited by 180 · see citing works
Lansdell, S. J., Gee, V. J., Harkness, P. C., Doward, A. I., Baker, E. R., Gibb, A. J., & Millar, N. S. (2005) · Molecular Pharmacology · doi:10.1124/mol.105.017459 · Cited by 156 · see citing works
The Chaperone Protein 14-3-3η Interacts with the Nicotinic Acetylcholine Receptor α4 Subunit
Jeanclos, E. M., Lin, L., Treuil, M. W., Rao, J., DeCoster, M. A., & Anand, R. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m011549200 · Cited by 155 · see citing works
Williams, M. E., Burton, B., Urrutia, A., Shcherbatko, A., Chavez-Noriega, L. E., Cohen, C. J., & Aiyar, J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m410039200 · Cited by 152 · see citing works
Green, W. N., & Millar, N. S. (1995) · Trends in Neurosciences · doi:10.1016/0166-2236(95)80009-q · Cited by 146 · see citing works
Gotti, C., Moretti, M., Clementi, F., Riganti, L., McIntosh, J. M., Collins, A. C., Marks, M. J., & Whiteaker, P. (2005) · Molecular Pharmacology · doi:10.1124/mol.105.011940 · Cited by 133 · see citing works
Self-citationWilliams, B. M., Temburni, M. K., Levey, M. S., Bertrand, S., Bertrand, D., & Jacob, M. H. (1998) · Nature Neuroscience · doi:10.1038/2792 · Cited by 132 · see citing works
Marks, M. J., Whiteaker, P., Calcaterra, J., Stitzel, J. A., Bullock, A. E., Grady, S. R., Picciotto, M. R., Changeux, J., & Collins, A. C. (1999) · PubMed · Cited by 126 · see citing works
Marks, M. J., Farnham, D. A., Grady, S. R., & Collins, A. C. (1993) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)10175-4 · Cited by 112 · see citing works
Lai, A., Parameswaran, N., Khwaja, M., Whiteaker, P., Lindstrom, J. M., Fan, H., McIntosh, J. M., Grady, S. R., & Quik, M. (2005) · Molecular Pharmacology · doi:10.1124/mol.104.006429 · Cited by 112 · see citing works
Lin, L., Jeanclos, E. M., Treuil, M. W., Braunewell, K., Gundelfinger, E. D., & Anand, R. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206857200 · Cited by 105 · see citing works
Parker, S. L., Fu, Y., McAllen, K., Luo, J., McIntosh, J. M., Lindstrom, J. M., & Sharp, B. M. (2004) · Molecular Pharmacology · doi:10.1124/mol.65.3.611 · Cited by 105 · see citing works
Identification of Sequence Motifs That Target Neuronal Nicotinic Receptors to Dendrites and Axons
Xu, J., Zhu, Y., & Heinemann, S. F. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.0840-06.2006 · Cited by 96 · see citing works
Boido, C. C., Tasso, B., Boido, V., & Sparatore, F. (2003) · Il Farmaco · doi:10.1016/s0014-827x(03)00017-x · Cited by 93 · see citing works
The Structures of Neuronal Nicotinic Receptors
Lindstrom, J. M. (2000) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-57079-7_6 · Cited by 91 · see citing works
Yu, Z. J., & Wecker, L. (1994) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1994.63010186.x · Cited by 90 · see citing works
Champtiaux, N., & Changeux, J. (2002) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1568007023339247 · Cited by 89 · see citing works
Moretti, M., Vailati, S., Zoli, M., Lippi, G., Riganti, L., Longhi, R., Viegi, A., Clementi, F., & Gotti, C. (2004) · Molecular Pharmacology · doi:10.1124/mol.66.1.85 · Cited by 89 · see citing works
Self-citationQuik, M., Vailati, S., Bordia, T., Kulak, J. M., Fan, H., McIntosh, J. M., Clementi, F., & Gotti, C. (2004) · Molecular Pharmacology · doi:10.1124/mol.104.006015 · Cited by 86 · see citing works
Self-citationEvidence for Functional Activity of Up‐Regulated Nicotine Binding Sites in Rat Striatal Synaptosomes
Rowell, P. P., & Wonnacott, S. (1990) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1990.tb05802.x · Cited by 84 · see citing works
Nguyen, H. N., Rasmussen, B. A., & Perry, D. C. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02482.x · Cited by 83 · see citing works
Marks, M. J., Rowell, P. P., Cao, J., Grady, S. R., McCallum, S. E., & Collins, A. C. (2004) · Neuropharmacology · doi:10.1016/j.neuropharm.2004.02.009 · Cited by 81 · see citing works
Sallette, J., Bohler, S., Benoit, P., Soudant, M., Pons, S., Le Novère, N., Changeux, J.-P., & Corringer, P. J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m308260200 · Cited by 80 · see citing works
Marks, M. J., Whiteaker, P., Calcaterra, J., Stitzel, J. A., Bullock, A. E., Grady, S. R., Picciotto, M. R., Changeux, J.-P., & Collins, A. C. (1999) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)38240-0 · Cited by 79 · see citing works
Nicotinic Acetylcholine Receptors Assembled from the α7 and β3 Subunits
Palma, E., Maggi, L., Barabino, B., Eusebi, F., & Ballivet, M. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.26.18335 · Cited by 78 · see citing works
Darsow, T., Booker, T. K., Piña-Crespo, J. C., & Heinemann, S. F. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m501157200 · Cited by 76 · see citing works
Synthesis and preliminary pharmacological evaluation of some cytisine derivatives
Boido, C. C., & Sparatore, F. (1999) · Il Farmaco · doi:10.1016/s0014-827x(99)00049-x · Cited by 74 · see citing works
Harkness, P. C., & Millar, N. S. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-23-10172.2002 · Cited by 74 · see citing works
Tumkosit, P., Kuryatov, A., Luo, J., & Lindstrom, J. (2006) · Molecular Pharmacology · doi:10.1124/mol.106.027326 · Cited by 73 · see citing works
Neuronal nicotinic receptors: insights gained from gene knockout an knocking mutant mice
Drago, J., McColl, C. D., Horne, M. K., Finkelstein, D. I., & Ross, S. A. (2003) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-003-2259-9 · Cited by 68 · see citing works
Grilli, M., Parodi, M., Raiteri, M., & Marchi, M. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03126.x · Cited by 65 · see citing works
Mugnaini, M., Garzotti, M., Sartori, I., Pilla, M. A., Repeto, P., Heidbreder, C. A., & Tessari, M. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.09.008 · Cited by 64 · see citing works
Structural determinants of α4β2 nicotinic acetylcholine receptor trafficking
Ren, X.-Q., Cheng, S.-B., Treuil, M. W., Mukherjee, J., Rao, J., Braunewell, K. H., Lindstrom, J. M., & Anand, R. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.1079-05.2005 · Cited by 61 · see citing works
Broadbent, S. D., Groot‐Kormelink, P. J., Krashia, P., Harkness, P. C., Millar, N. S., Beato, M., & Sivilotti, L. G. (2006) · Molecular Pharmacology · doi:10.1124/mol.106.026682 · Cited by 60 · see citing works
Ubiquilin-1 Regulates Nicotine-induced Up-regulation of Neuronal Nicotinic Acetylcholine Receptors
Ficklin, M. B., Zhao, S., & Feng, G. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m506781200 · Cited by 59 · see citing works
Nitrogen substitution modifies the activity of cytisine on neuronal nicotinic receptor subtypes
Carbonnelle, E., Sparatore, F., Canu, C., Salvagno, C., Baldani‐Guerra, B., Terstappen, G. C., Zwart, R., Vijverberg, H. P. M., Clementi, F., & Gotti, C. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(03)01817-x · Cited by 54 · see citing works
Self-citationNeurotransmitter Receptor Trafficking and the Regulation of Synaptic Strength
Kittler, J. T., & Moss, S. J. (2001) · Traffic · doi:10.1034/j.1600-0854.2001.20702.x · Cited by 40 · see citing works
Riganti, L., Matteoni, C., Angelantonio, S. D., Nistri, A., Gaimarri, A., Sparatore, F., Canu, C., Clementi, F., & Gotti, C. (2005) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706434 · Cited by 27 · see citing works
Self-citationVillarroya, M., Gandı́a, L., López, M. G., Garcı́a, A. G., Cueto, S., Garcı́a-Navı́o, J. L., & Álvarez‐Buílla, J. (1996) · Bioorganic & Medicinal Chemistry · doi:10.1016/0968-0896(96)00108-3 · Cited by 14 · see citing works
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Sorted by citations
Structural and functional diversity of native brain neuronal nicotinic receptors
Gotti, C., Clementi, F., Fornari, A., Gaimarri, A., Guiducci, S., Manfredi, I., Moretti, M., Pedrazzi, P., Pucci, L., & Zoli, M. (2009) · Biochemical Pharmacology · doi:10.1016/j.bcp.2009.05.024 · Cited by 469 · see citing works
Self-citationReward, addiction, withdrawal to nicotine
De Biasi, M., & Dani, J. A. (2011) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-061010-113734 · Cited by 366 · see citing works
“…differs among the diverse subtypes, varies among brain regions for the same nAChR subtype, and depends on the contingency of nicotine administration (Gaimarri et al. 2007, Marks et al. 1983, McCallum et al. 2006, Metaxas et al. 2010, Nguyen et al. 2004, Pauly et al. 1996, Schwartz & Kellar 1983).”
BackgroundThe structural basis of function in Cys-loop receptors
Thompson, A. J., Lester, H. A., & Lummis, S. C. R. (2010) · Quarterly Reviews of Biophysics · doi:10.1017/s0033583510000168 · Cited by 340 · see citing works
Smoking, nicotine and neuropsychiatric disorders
Döme, P., Lazáry, J., Kalapos, M. P., & Rihmer, Z. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.07.013 · Cited by 215 · see citing works
Costas‐Ferreira, C., & Faro, L. R. F. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22168413 · Cited by 156 · see citing works
Nicotine self‐medication of cognitive‐attentional processing
Evans, D. E., & Drobes, D. J. (2008) · Addiction Biology · doi:10.1111/j.1369-1600.2008.00130.x · Cited by 150 · see citing works
Basal forebrain cholinergic signalling: development, connectivity and roles in cognition
Ananth, M. R., Rajebhosale, P., Kim, R., Talmage, D. A., & Role, L. W. (2023) · Nature Reviews Neuroscience · doi:10.1038/s41583-023-00677-x · Cited by 148 · see citing works
Assembly and trafficking of nicotinic acetylcholine receptors (Review)
Millar, N. S., & Harkness, P. C. (2008) · Molecular Membrane Biology · doi:10.1080/09687680802035675 · Cited by 142 · see citing works
Rose, J., Mukhin, A., Lokitz, S., Turkington, T., Herskovic, J., Behm, F., Garg, S., & Garg, P. (2010) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.0909184107 · Cited by 134 · see citing works
Pistillo, F., Clementi, F., Zoli, M., & Gotti, C. (2014) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2014.10.002 · Cited by 113 · see citing works
Self-citationNicotine regulates multiple synaptic proteins by inhibiting proteasomal activity
Rezvani, K., Teng, Y., Shim, D., & De Biasi, M. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.3353-07.2007 · Cited by 113 · see citing works
Görlich, A., Antolin‐Fontes, B., Ables, J. L., Frahm, S., Ślimak, M. A., Dougherty, J. D., & Ibáñez-Tallon, I. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1313103110 · Cited by 109 · see citing works
Turner, J. R., Castellano, L. M., & Blendy, J. A. (2011) · Nicotine & Tobacco Research · doi:10.1093/ntr/ntq206 · Cited by 78 · see citing works
Colomer, C., Olivos-Oré, L. A., Vincent, A., McIntosh, J. M., Artalejo, A. R., & Guérineau, N. C. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.4997-09.2010 · Cited by 74 · see citing works
Greenbaum, L., & Lerer, B. (2009) · Molecular Psychiatry · doi:10.1038/mp.2009.59 · Cited by 73 · see citing works
Lifetime cigarette smoking is associated with striatal volume measures
Das, D., Cherbuin, N., Anstey, K. J., Sachdev, P. S., & Easteal, S. (2011) · Addiction Biology · doi:10.1111/j.1369-1600.2010.00301.x · Cited by 72 · see citing works
Fattore, L., Spano, M. S., Cossu, G., Scherma, M., Fratta, W., & Fadda, P. (2009) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2009.01.007 · Cited by 67 · see citing works
Associations of Variants in CHRNA5/A3/B4 Gene Cluster with Smoking Behaviors in a Korean Population
Li, M. D., Yoon, D., Lee, J., Han, B., Niu, T., Payne, T. J., Ma, J. Z., & Park, T. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012183 · Cited by 64 · see citing works
Li, M. D., Xu, Q., Lou, X., Payne, T. J., Niu, T., & Ma, J. Z. (2009) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.31043 · Cited by 60 · see citing works
Recent advances in understanding the structure of nicotinic acetylcholine receptors
Zouridakis, M., Zisimopoulou, P., Poulas, K. A., & Tzartos, S. J. (2009) · IUBMB Life · doi:10.1002/iub.170 · Cited by 60 · see citing works
Moretti, M., Mugnaini, M., Tessari, M., Zoli, M., Gaimarri, A., Manfredi, I., Pistillo, F., Clementi, F., & Gotti, C. (2010) · Molecular Pharmacology · doi:10.1124/mol.110.064071 · Cited by 58 · see citing works
Self-citationNicotinic receptor-based therapeutics and candidates for smoking cessation
Dwoskin, L. P., Smith, A. M., Wooters, T. E., Zhang, Z., Crooks, P. A., & Bardo, M. T. (2009) · Biochemical Pharmacology · doi:10.1016/j.bcp.2009.06.002 · Cited by 56 · see citing works
Neurophysiology of Nicotine Addiction
Dani, J. A., Jenson, D., & Broussard, J. I. (2012) · Journal of Addiction Research & Therapy · doi:10.4172/2155-6105.s1-001 · Cited by 53 · see citing works
Respiratory dysfunctions induced by prenatal nicotine exposure
Campos, M., Bravo, E., & Eugenín, J. L. (2009) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2009.05214.x · Cited by 47 · see citing works
Reward Sensitization: Effects of Repeated Nicotine Exposure and Withdrawal in Mice
Hilário, M. R. F., Turner, J. R., & Blendy, J. A. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.130 · Cited by 48 · see citing works
Singh, S., Singh, K., Patel, D. K., Singh, C., Nath, C., Singh, V. K., Singh, R. K., & Singh, M. P. (2009) · Rejuvenation Research · doi:10.1089/rej.2009.0850 · Cited by 47 · see citing works
An Accessory Agonist Binding Site Promotes Activation of α4β2* Nicotinic Acetylcholine Receptors
Wang, J., Kuryatov, A., Sriram, A., Jin, Z., Kamenecka, T. M., Kenny, P. J., & Lindstrom, J. M. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.646786 · Cited by 40 · see citing works
Pharmacogenetics of smoking cessation: role of nicotine target and metabolism genes
Gold, A. B., & Lerman, C. E. (2012) · Human Genetics · doi:10.1007/s00439-012-1143-9 · Cited by 40 · see citing works
Santos, N., Chatterjee, S., Henry, A., Holgate, J. Y., & Bartlett, S. E. (2012) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.12009 · Cited by 40 · see citing works
Nicotine and ethanol interact during adolescence: Effects on the central cholinergic systems
Ribeiro‐Carvalho, A., Lima, C. S., Filgueiras, C. C., Manhães, A. C., & Abreu‐Villaça, Y. (2008) · Brain Research · doi:10.1016/j.brainres.2008.07.062 · Cited by 39 · see citing works
Huang, Y.-Y., Kandel, E. R., & Levine, A. A. (2008) · Learning & Memory · doi:10.1101/lm.975308 · Cited by 40 · see citing works
Chatterjee, S., Santos, N., Holgate, J. Y., Haass‐Koffler, C. L., Hopf, F. W., Kharazia, V., Lester, H. A., Bonci, A., & Bartlett, S. E. (2013) · PLoS ONE · doi:10.1371/journal.pone.0068300 · Cited by 39 · see citing works
Structural answers and persistent questions about how nicotinic receptors work
Gregg, B. W. (2008) · Frontiers in bioscience · doi:10.2741/3094 · Cited by 37 · see citing works
Xiao, C., Srinivasan, R., Drenan, R. M., Mackey, E. D. W., McIntosh, J. M., & Lester, H. A. (2011) · Biochemical Pharmacology · doi:10.1016/j.bcp.2011.05.005 · Cited by 37 · see citing works
Cellular distribution of the nicotinic acetylcholine receptor α7 subunit in rat hippocampus
Mielke, J. G., & Mealing, G. A. R. (2009) · Neuroscience Research · doi:10.1016/j.neures.2009.08.003 · Cited by 36 · see citing works
Nicotine and estrogen synergistically exacerbate cerebral ischemic injury
Raval, A. P., Hirsch, N., Dave, K. R., Yavagal, D. R., Bramlett, H. M., & Saul, I. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.02.036 · Cited by 36 · see citing works
Garcia‐Ratés, S., Camarasa, J., Sánchez-García, A. I., Gandı́a, L., Escubedo, E., & Pubill, D. (2010) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2010.01.014 · Cited by 32 · see citing works
Developmental Sex Differences in Nicotinic Currents of Prefrontal Layer VI Neurons in Mice and Rats
Alves, N. C., Bailey, C. D. C., Nashmi, R., & Lambe, E. K. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009261 · Cited by 29 · see citing works
Arunrungvichian, K., Fokin, V. V., Vajragupta, O., & Taylor, P. (2015) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.5b00058 · Cited by 30 · see citing works
Jiang, Y., Dai, A., Zhou, Y., Peng, G., Hu, G., Li, B., Sham, J. S. K., & Ran, P. (2014) · Cellular Physiology and Biochemistry · doi:10.1159/000356678 · Cited by 27 · see citing works
Coddou, C., Bravo, E., & Eugenín, J. L. (2009) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2009.0078 · Cited by 27 · see citing works
Uchida, S., & Hotta, H. (2009) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.32.341 · Cited by 27 · see citing works
Abbas, M., & Rahman, S. (2016) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2016.05.003 · Cited by 25 · see citing works
Nicotine inhibits LPS-induced cytokine production and leukocyte infiltration in rat placenta
Bao, J., Liu, Y., Yang, J., Gao, Q., Shi, S.-Q., Garfield, R. E., & Liu, H. (2016) · Placenta · doi:10.1016/j.placenta.2016.01.015 · Cited by 24 · see citing works
Koul, S., Schaal, V. L., Chand, S., Pittenger, S. T., Vellichirammal, N. N., Kumar, V., Guda, C., Bevins, R. A., Yelamanchili, S. V., & Pendyala, G. (2020) · Cells · doi:10.3390/cells9081883 · Cited by 23 · see citing works
Involvement of Nicotinic Receptors in Methamphetamine- and Mdma-Induced Neurotoxicity
Escubedo, E., Camarasa, J., Chipana, C., Garcia‐Ratés, S., & Pubill, D. (2009) · International review of neurobiology · doi:10.1016/s0074-7742(09)88006-9 · Cited by 22 · see citing works
Rahman, S., Zhang, Z., Papke, R. L., Crooks, P. A., Dwoskin, L. P., & Bardo, M. T. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707612 · Cited by 22 · see citing works
Nicotinic receptors in airway disease
Borkar, N. A., Thompson, M. A., Bartman, C. M., Khalfaoui, L., Sine, S. M., Sathish, V., Prakash, Y. S., & Pabelick, C. M. (2023) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00268.2023 · Cited by 19 · see citing works
Talboom, J. S., Engler-Chiurazzi, E. B., Whiteaker, P., Simard, A. R., Lukas, R. J., Acosta, J. I., Prókai, L., & Bimonte‐Nelson, H. A. (2010) · Hormones and Behavior · doi:10.1016/j.yhbeh.2010.09.002 · Cited by 20 · see citing works
Ciudad‐Roberts, A., Camarasa, J., Pubill, D., & Escubedo, E. (2013) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2013.02.013 · Cited by 19 · see citing works
Associations of rare nicotinic cholinergic receptor gene variants to nicotine and alcohol dependence
Zuo, L., Tan, Y., Li, C.-S. R., Wang, Z., Wang, K., Zhang, X., Lin, X., Chen, X., Zhong, C., Wang, X., et al. (2016) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32476 · Cited by 18 · see citing works
Nicotinic Receptors Underlying Nicotine Dependence: Evidence from Transgenic Mouse Models
Gipson, C. D., & Fowler, C. D. (2020) · Current topics in behavioral neurosciences · doi:10.1007/7854_2020_134 · Cited by 18 · see citing works
Pubill, D., Garcia‐Ratés, S., Camarasa, J., & Escubedo, E. (2012) · NeuroToxicology · doi:10.1016/j.neuro.2012.11.008 · Cited by 15 · see citing works
Wang, J., Kuryatov, A., Jin, Z., Norleans, J., Kamenecka, T. M., Kenny, P. J., & Lindstrom, J. M. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.676551 · Cited by 15 · see citing works
Impact of Electronic Cigarette Vaping on Cerebral Ischemia: What We Know So Far
Siegel, J., Patel, S. H., Mankaliye, B., & Raval, A. P. (2022) · Translational Stroke Research · doi:10.1007/s12975-022-01011-w · Cited by 13 · see citing works
Gene expression profiling of midbrain dopamine neurons upon gestational nicotine exposure
Kanlikilicer, P., Zhang, D., Dragomir, A., Akay, Y. M., & Akay, M. (2016) · Medical & Biological Engineering & Computing · doi:10.1007/s11517-016-1531-8 · Cited by 12 · see citing works
Noda, Y., Uchida, M., Mouri, A., Yamada, S., Goto, S., Kitagaki, S., Mamiya, T., Kushima, I., Arioka, Y., Ozaki, N., et al. (2020) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2020.10.001 · Cited by 10 · see citing works
Differential regulation of alcohol taking and seeking by antagonism at α4β2 and α3β4 nAChRs
Cippitelli, A., Brunori, G., Schoch, J., Armishaw, C. J., Wu, J., Zaveri, N. T., Giulianotti, M. A., Welmaker, G. S., & Toll, L. (2018) · Psychopharmacology · doi:10.1007/s00213-018-4883-y · Cited by 9 · see citing works
Biaggi-Labiosa, N. M., Avilés-Pagán, E. E., Caballero‐Rivera, D., Báez-Pagán, C. A., & Lasalde‐Dominicci, J. A. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.04.022 · Cited by 9 · see citing works
Chaity, N. I., & Apu, M. N. H. (2022) · Heliyon · doi:10.1016/j.heliyon.2022.e09947 · Cited by 8 · see citing works
Rosa, J., Myskiw, J. D. C., Fiorenza, N. G., Furini, C. R. G., Sapiras, G. G., & Izquierdo, I. (2022) · Behavioural Brain Research · doi:10.1016/j.bbr.2022.114129 · Cited by 7 · see citing works
Li, R., Li, X., Jiang, J., Tian, Y., Liu, D., Zhangsun, D., Fu, Y., Wu, Y., & Luo, S. (2019) · Journal of Molecular Graphics and Modelling · doi:10.1016/j.jmgm.2019.06.020 · Cited by 5 · see citing works
Noda, Y., Soeda, K., Uchida, M., Goto, S., Ito, T., Kitagaki, S., Mamiya, T., Yoshimi, A., Ozaki, N., & Mouri, A. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113284 · Cited by 5 · see citing works
Alterations of Neurotransmitter Receptors in Schizophrenia: Evidence from Postmortem Studies
Kristiansen, L. V., Cowell, R. M., Biscaia, M., McCullumsmith, R. E., & Meador‐Woodruff, J. H. (2009) · Springer eBooks · doi:10.1007/978-0-387-30410-6_14 · Cited by 5 · see citing works
Pubill, D., Garcia‐Ratés, S., Camarasa, J., & Escubedo, E. (2011) · Pharmaceuticals · doi:10.3390/ph4060822 · Cited by 4 · see citing works
Fu, C., Huang, C.-H., Tong, S., Chu, C., & Chou, M. (2023) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.164876 · Cited by 4 · see citing works
Presynaptic Nicotinic Acetylcholine Receptors and the Modulation of Circuit Excitability
Zhong, C., López‐Hernández, G. Y., Talmage, D. A., & Role, L. W. (2014) · The Receptors · doi:10.1007/978-1-4939-1167-7_7 · Cited by 4 · see citing works
Effects of ethanol and nicotine on human CNS development
Robles, N., & Sabrià, J. (2011) · Elsevier eBooks · doi:10.1016/b978-0-12-382032-7.10025-6 · Cited by 3 · see citing works
Mousavi, S. L., Rezayof, A., Alijanpour, S., Delphi, L., & Sahafi, O. H. (2023) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2023.173650 · Cited by 3 · see citing works
Cholinergic Vasodilative System in the Cerebral Cortex: Effects of Acupuncture and Aging
Uchida, S. (2014) · Journal of Acupuncture and Meridian Studies · doi:10.1016/j.jams.2014.02.006 · Cited by 3 · see citing works
Ciudad‐Roberts, A., Camarasa, J., Pubill, D., & Escubedo, E. (2014) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2014.02.014 · Cited by 2 · see citing works
Uchida, S., & Kagitani, F. (2024) · The Journal of Physiological Sciences · doi:10.1186/s12576-024-00913-8 · Cited by 2 · see citing works
Molecular Underpinnings of Neuronal Nicotinic Acetylcholine Receptor Expression
Scofield, M. D., & Gardner, P. D. (2014) · The Receptors · doi:10.1007/978-1-4939-1167-7_3 · Cited by 2 · see citing works
Arunrungvichian, K., Khongkaew, P., Panyasang, S., & Sarasamkan, J. (2018) · Pharmaceutical Sciences Asia · doi:10.29090/psa.2019.03.018.0043 · Cited by 2 · see citing works
Nicotine Addiction and Alpha4beta2* Nicotinic Acetylcholine Receptors
Maurer, J. J., & Schmidt, H. D. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813035-3.00031-9 · Cited by 1 · see citing works
Postsynaptic Mechanisms of Trophic Factor-Induced Excitatory Synapse Formation in Lymnaea stagnalis
Flynn, N. (2015) · Libraries and Cultural Resources (University of Calgary) · doi:10.11575/prism/27390 · Cited by 1 · see citing works
Interacció dels derivats amfetamínics amb els receptors nicotínics: Aspectes moleculars i funcionals
Garcia‐Ratés, S. (2011) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)
ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTOR REGULATION IN EXPERIMENTAL NEURODEGENERATIVE DISEASE
Charriez, C. M. (2010) · UKnowledge (University of Kentucky)
Sigara İçme ve Alzheimer Hastalığı Arasındaki İlişki
Sharma, V. (2014) · Arşiv Kaynak Tarama Dergisi · doi:10.17827/aktd.88989
Potaros, T., Phornchirasilp, S., McKay, S. B., González-Cestari, T. F., Boyd, R. T., & McKay, D. B. (2010) · Neuroscience Letters · doi:10.1016/j.neulet.2010.11.075
Nicotinic Acetylcholine Receptors and the Roles of the Alpha7 Subunit
Paolini, M. A., Biasi, M. D., & Dani, J. A. (2014) · The Receptors · doi:10.1007/978-1-4939-1167-7_13
ΠANEΠIΣTHMIO ΠATPΩN ΣXOΛH EΠIΣTHMΩN YΓEIAΣ TMHMA IATPIKHΣ
Kai, T. P. (2009)
The Roles of a5-Containing nAChRs in the Brain
Wang, J. W. Y. (2014) · Biochemistry & Pharmacology Open Access · doi:10.4172/2167-0501.1000129
Litvin, E. B., Ditre, J. W., Heckman, B. W., & Brandon, T. H. (2012) · Springer eBooks · doi:10.1007/978-1-4614-3375-0_10
Uchida, M., Kano, M., Ozaki, N., Yoshimi, A., & Noda, Y. (2026) · Neurochemistry International · doi:10.1016/j.neuint.2026.106121 · Cited by 1 · see citing works
PREDICTING BITTER TASTE OF SELE CTED QUINOLIZIDINE ALKALOIDS
Kikut‐Ligaj, D. (2014) · Zywnosc-nauka Technologia Jakosc · doi:10.15193/zntj/2014/97/182-196
- Authors
- Gaimarri, A., Moretti, M., Riganti, L., Zanardi, A., Clementi, F., & Gotti, C.
- Affiliations
- University of Milan (IT)
- University of Modena and Reggio Emilia (IT)
- Corresponding author
- Clementi, Francesco
- ORCID
- Gotti, Cecilia
- Venue
- Brain Research Reviews
- Publisher
- Elsevier BV
- Published
- 2007-08
- Volume
- 55
- Issue
- 1
- Pages
- 134-143
- ISSN
- 0165-0173 (ISSN-L)
- OpenAlex
- W2092827457
- Cited by
- 89
- References
- 76
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 4 · 2022: 3 · 2021: 2 · 2020: 3 · 2019: 2 · 2018: 2 · 2016: 4 · 2015: 5 · 2014: 10 · 2013: 3 · 2012: 6
- FWCI
- 0.92
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research Reviews (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- neuronal nicotinic acetylcholine receptors, nAChR subtypes, receptor trafficking, receptor regulation, chronic nicotine exposure, nicotinic agonists, receptor up-regulation, receptor stoichiometry, subunit composition
- MeSH terms
- Animals, Brain, Gene Expression Regulation, Neurons, Receptors, Nicotinic, Nicotinic Antagonists, Protein Transport
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