The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Lung development and repair: Contribution of the ciliated lineage
Open accessAbstract
The identity of the endogenous epithelial cells in the adult lung that are responsible for normal turnover and repair after injury is still controversial. In part, this is due to a paucity of highly specific genetic lineage tools to follow efficiently the fate of the major epithelial cell populations: the basal, secretory, ciliated, neuroendocrine, and alveolar cells. As part of a program to address this problem we have used a 1-kb FOXJ1 promoter to drive CreER in the ciliated cells of the embryonic and adult lung. Analysis of FOXJ1 - GFP transgenic lungs shows that labeled cells appear in a proximal-distal pattern during embryogenesis and that the promoter drives expression in all ciliated cells. Using FOXJ1CreER adult mice, we have followed the fate of ciliated cells after epithelial injury by naphthalene or sulfur dioxide. From quantitative analysis and confocal microscopy we conclude that ciliated cells transiently change their morphology in response to lung injury but do not proliferate or transdifferentiate as part of the repair process.
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Cites
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Morrisey, E. E., & Hogan, B. L. M. (2010) · Developmental Cell · doi:10.1016/j.devcel.2009.12.010 · Cited by 964
Self-citationRawlins, E. L., Okubo, T., Xue, Y., Brass, D. M., Auten, R. L., Hasegawa, H., Wang, F., & Hogan, B. L. M. (2009) · Cell Stem Cell · doi:10.1016/j.stem.2009.04.002 · Cited by 853
Self-citationThe aging lung: Physiology, disease, and immunity
Schneider, J. L., Rowe, J. H., Garcia-de-Alba, C., Kim, C. F., Sharpe, A. H., & Haigis, M. C. (2021) · Cell · doi:10.1016/j.cell.2021.03.005 · Cited by 500
Airway Epithelial Cells: Current Concepts and Challenges
Crystal, R. G., Randell, S. H., Engelhardt, J. F., Voynow, J., & Sunday, M. E. (2008) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200805-041hr · Cited by 375
Self-citationThe Id2+ distal tip lung epithelium contains individual multipotent embryonic progenitor cells
Rawlins, E. L., Clark, C. P., Xue, Y., & Hogan, B. L. M. (2009) · Development · doi:10.1242/dev.037317 · Cited by 371
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Metadata
- Authors
- Rawlins, E. L., Ostrowski, L. E., Randell, S. H., & Hogan, B. L. M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2007-01-09
- Volume
- 104
- Issue
- 2
- Pages
- 410-417
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1977431638
- Cited by
- 276
- References
- 1
- FWCI
- 10.20
- Type
- journal article
- Language
- en
- Open access
- green
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- Rawlins, E. L., Ostrowski, L. E., Randell, S. H., & Hogan, B. L. M. (2007). Lung development and repair: Contribution of the ciliated lineage. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0610770104
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