The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
Airway Epithelial Cells: Current Concepts and Challenges
Open accessAbstract
The adult human bronchial tree is covered with a continuous layer of epithelial cells that play a critical role in maintaining the conduit for air, and which are central to the defenses of the lung against inhaled environmental concomitants. The epithelial sheet functions as an interdependent unit with the other lung components. Importantly, the structure and/or function of airway epithelium is deranged in major lung disorders, including chronic obstructive pulmonary disease, asthma, and bronchogenic carcinoma. Investigations regarding the airway epithelium have led to many advances over the past few decades, but new developments in genetics and stem cell/progenitor cell biology have opened the door to understanding how the airway epithelium is developed and maintained, and how it responds to environmental stress. This article provides an overview of the current state of knowledge regarding airway epithelial stem/progenitor cells, gene expression, cell–cell interactions, and less frequent cell types, and discusses the challenges for future areas of investigation regarding the airway epithelium in health and disease.
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Citations
Cites
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Adult pancreatic β-cells are formed by self-duplication rather than stem-cell differentiation
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Identification of Bronchioalveolar Stem Cells in Normal Lung and Lung Cancer
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The stem-cell niche as an entity of action
Scadden, D. T. (2006) · Nature · doi:10.1038/nature04957 · Cited by 1,856
Socializing with the Neighbors
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Self-citationIncreased airway epithelial Na+ absorption produces cystic fibrosis-like lung disease in mice
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Cited by
Studies on expression and function of the TMEM16A calcium-activated chloride channel
Huang, F., Rock, J. R., Harfe, B. D., Cheng, T., Huang, X., Jan, Y. N., & Jan, L. Y. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911935106 · Cited by 310
Mastorakos, P., da Silva, A. L., Chisholm, J., Song, E., Choi, W. K., Boyle, M. P., Morales, M. M., Hanes, J., & Suk, J. S. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1502281112 · Cited by 210
Metabolic reprogramming in tumors: Contributions of the tumor microenvironment
Lane, A. N., Higashi, R. M., & Fan, T. W.-M. (2020) · Genes & Diseases · doi:10.1016/j.gendis.2019.10.007 · Cited by 91
Smoking accelerates aging of the small airway epithelium
Walters, M. S., De, B. P., Salit, J., Buro-Auriemma, L. J., Wilson, T., Rogalski, A. M., Lief, L., Hackett, N. R., Staudt, M. R., Tilley, A. E., et al. (2014) · Respiratory Research · doi:10.1186/s12931-014-0094-1 · Cited by 87
Self-citationEmerging Roles of Airway Epithelial Cells in Idiopathic Pulmonary Fibrosis
Chakraborty, A., Mastalerz, M., Ansari, M., Schiller, H. B., & Staab-Weijnitz, C. A. (2022) · Cells · doi:10.3390/cells11061050 · Cited by 68
Metadata
- Authors
- Crystal, R. G., Randell, S. H., Engelhardt, J. F., Voynow, J., & Sunday, M. E.
- Venue
- Proceedings of the American Thoracic Society
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-09
- Volume
- 5
- Issue
- 7
- Pages
- 772-777
- ISSN
- 1546-3222 (ISSN-L)
- 1943-5665
- OpenAlex
- W2022751366
- Cited by
- 375
- References
- 47
- FWCI
- 10.85
- Type
- journal article
- Language
- en
- Open access
- green
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- Crystal, R. G., Randell, S. H., Engelhardt, J. F., Voynow, J., & Sunday, M. E. (2008). Airway Epithelial Cells: Current Concepts and Challenges. Proceedings of the American Thoracic Society. https://doi.org/10.1513/pats.200805-041hr
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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