The aging lung: Physiology, disease, and immunity

Clinical characteristics of coronavirus disease 2019 in China

Guan, W.-J., Ni, Z.-Y., Hu, Y., Liang, W.-H., Ou, C.-Q., He, J.-X., Liu, L., Shan, H., Lei, C.-L., Hui, D. S. C., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa2002032 · Cited by 30,246 · see citing works

Cancer statistics, 2020

Siegel, R. L., Miller, K. D., & Jemal, A. (2020) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21590 · Cited by 20,444 · see citing works

The Hallmarks of Aging

López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982 · see citing works

Frailty in elderly people

Clegg, A., Young, J., Iliffe, S., Rikkert, M. O., & Rockwood, K. (2013) · The Lancet · doi:10.1016/s0140-6736(12)62167-9 · Cited by 9,503 · see citing works

Aging: a theory based on free radical and radiation chemistry

Harman, D. (1956) · Journal of Gerontology · doi:10.1093/geronj/11.3.298 · Cited by 8,567 · see citing works

DNA methylation age of human tissues and cell types

Horvath, S. (2013) · Genome Biology · doi:10.1186/gb-2013-14-10-r115 · Cited by 7,075 · see citing works

Factors associated with COVID-19-related death using OpenSAFELY

Williamson, E. J., Walker, A. J., Bhaskaran, K., Bacon, S., Bates, C., Morton, C. E., Curtis, H. J., Mehrkar, A., Evans, D., Inglesby, P., et al. (2020) · Nature · doi:10.1038/s41586-020-2521-4 · Cited by 6,674 · see citing works

Inflamm‐aging: An Evolutionary Perspective on Immunosenescence

FRANCESCHI, C., BONAFÈ, M., VALENSIN, S., OLIVIERI, F., DE LUCA, M., OTTAVIANI, E., & DE BENEDICTIS, G. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06651.x · Cited by 5,358 · see citing works

The Effect of Vitamin E and Beta Carotene on the Incidence of Lung Cancer and Other Cancers in Male Smokers

(1994) · New England Journal of Medicine · doi:10.1056/nejm199404143301501 · Cited by 4,737 · see citing works

Comorbidity and its impact on 1590 patients with covid-19 in China: a nationwide analysis

Guan, W.-J., Liang, W.-H., Zhao, Y., Liang, H.-R., Chen, Z.-S., Li, Y.-M., Liu, X.-Q., Chen, R.-C., Tang, C.-L., Wang, T., et al. (2020) · European Respiratory Journal · doi:10.1183/13993003.00547-2020 · Cited by 3,680 · see citing works

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

Baker, D. J., Wijshake, T., Tchkonia, T., LeBrasseur, N. K., Childs, B. G., van de Sluis, B., Kirkland, J. L., & van Deursen, J. M. (2011) · Nature · doi:10.1038/nature10600 · Cited by 3,670 · cited 1× · see citing works

Autoantibodies against type I IFNs in patients with life-threatening COVID-19

Bastard, P., Rosen, L. B., Zhang, Q., Michailidis, E., Hoffmann, H.-H., Zhang, Y., Dorgham, K., Philippot, Q., Rosain, J., Béziat, V., et al. (2020) · Science · doi:10.1126/science.abd4585 · Cited by 2,662 · see citing works

The Achilles' heel of senescent cells: from transcriptome to senolytic drugs

Zhu, Y., Tchkonia, T., Pirtskhalava, T., Gower, A. C., Ding, H., Giorgadze, N., Palmer, A. K., Ikeno, Y., Hubbard, G. B., Lenburg, M., et al. (2015) · Aging Cell · doi:10.1111/acel.12344 · Cited by 2,562 · cited 1× · see citing works

SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes

HCA Lung Biological Network, Sungnak, W., Huang, N., Bécavin, C., Berg, M., Queen, R., Litvinukova, M., Talavera-López, C., Maatz, H., Reichart, D., et al. (2020) · Nature Medicine · doi:10.1038/s41591-020-0868-6 · Cited by 2,501 · see citing works

Adapting Proteostasis for Disease Intervention

Balch, W. E., Morimoto, R. I., Dillin, A., & Kelly, J. W. (2008) · Science · doi:10.1126/science.1141448 · Cited by 2,495 · see citing works

Cellular senescence in aging and age-related disease: from mechanisms to therapy

Childs, B. G., Durik, M., Baker, D. J., & van Deursen, J. M. (2015) · Nature Medicine · doi:10.1038/nm.4000 · Cited by 2,363 · see citing works

Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors

Gomez Perdiguero, E., Klapproth, K., Schulz, C., Busch, K., Azzoni, E., Crozet, L., Garner, H., Trouillet, C., de Bruijn, M. F., Geissmann, F., et al. (2015) · Nature · doi:10.1038/nature13989 · Cited by 2,339 · cited 1× · see citing works

Senolytics improve physical function and increase lifespan in old age

Xu, M., Pirtskhalava, T., Farr, J. N., Weigand, B. M., Palmer, A. K., Weivoda, M. M., Inman, C. L., Ogrodnik, M. B., Hachfeld, C. M., Fraser, D. G., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0092-9 · Cited by 2,287 · see citing works

SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues

Ziegler, C. G. K., Allon, S. J., Nyquist, S. K., Mbano, I. M., Miao, V. N., Tzouanas, C. N., Cao, Y., Yousif, A. S., Bals, J., Hauser, B. M., et al. (2020) · Cell · doi:10.1016/j.cell.2020.04.035 · Cited by 2,284 · see citing works

Mortality in Randomized Trials of Antioxidant Supplements for Primary and Secondary Prevention: Systematic Review and Meta-analysis

Bjelakovic, G., Nikolova, D., Gluud, L. L., Simonetti, R. G., & Gluud, C. (2007) · JAMA · doi:10.1001/jama.297.8.842 · Cited by 2,275 · see citing works

Inborn errors of type I IFN immunity in patients with life-threatening COVID-19

Zhang, Q., Bastard, P., Liu, Z., Le Pen, J., Moncada-Velez, M., Chen, J., Ogishi, M., Sabli, I. K. D., Hodeib, S., Korol, C., et al. (2020) · Science · doi:10.1126/science.abd4570 · Cited by 2,229 · see citing works

Autophagy and Aging

Rubinsztein, D. C., Mariño, G., & Kroemer, G. (2011) · Cell · doi:10.1016/j.cell.2011.07.030 · Cited by 2,107 · see citing works

Cellular mechanisms and physiological consequences of redox-dependent signalling

Holmström, K. M., & Finkel, T. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3801 · Cited by 2,093 · see citing works

Mammalian Sirtuins: Biological Insights and Disease Relevance

Haigis, M. C., & Sinclair, D. A. (2010) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev.pathol.4.110807.092250 · Cited by 2,085 · see citing works

Idiopathic Pulmonary Fibrosis

Lederer, D. J., & Martinez, F. J. (2018) · New England Journal of Medicine · doi:10.1056/nejmra1705751 · Cited by 2,056 · see citing works

Genomewide Association Study of Severe Covid-19 with Respiratory Failure

The Severe Covid-19 GWAS Group (2020) · New England Journal of Medicine · doi:10.1056/nejmoa2020283 · Cited by 1,986 · see citing works

Type 2 alveolar cells are stem cells in adult lung

Barkauskas, C. E., Cronce, M. J., Rackley, C. R., Bowie, E. J., Keene, D. R., Stripp, B. R., Randell, S. H., Noble, P. W., & Hogan, B. L. M. (2013) · Journal of Clinical Investigation · doi:10.1172/jci68782 · Cited by 1,776 · cited 2× · see citing works

High burden and pervasive positive selection of somatic mutations in normal human skin

Martincorena, I., Roshan, A., Gerstung, M., Ellis, P., Van Loo, P., McLaren, S., Wedge, D. C., Fullam, A., Alexandrov, L. B., Tubio, J. M., et al. (2015) · Science · doi:10.1126/science.aaa6806 · Cited by 1,770 · see citing works

A molecular cell atlas of the human lung from single-cell RNA sequencing

Travaglini, K. J., Nabhan, A. N., Penland, L., Sinha, R., Gillich, A., Sit, R. V., Chang, S., Conley, S. D., Mori, Y., Seita, J., et al. (2020) · Nature · doi:10.1038/s41586-020-2922-4 · Cited by 1,657 · see citing works

Cellular senescence mediates fibrotic pulmonary disease

Schafer, M. J., White, T. A., Iijima, K., Haak, A. J., Ligresti, G., Atkinson, E. J., Oberg, A. L., Birch, J., Salmonowicz, H., Zhu, Y., et al. (2017) · Nature Communications · doi:10.1038/ncomms14532 · Cited by 1,613 · cited 5× · see citing works

Effects of intermittent fasting on health, aging, and disease

de Cabo, R., & Mattson, M. P. (2019) · New England Journal of Medicine · doi:10.1056/nejmra1905136 · Cited by 1,605 · see citing works

Basal cells as stem cells of the mouse trachea and human airway epithelium

Rock, J. R., Onaitis, M. W., Rawlins, E. L., Lu, Y., Clark, C. P., Xue, Y., Randell, S. H., & Hogan, B. L. M. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0906850106 · Cited by 1,568 · see citing works

Safety and Immunogenicity of SARS-CoV-2 mRNA-1273 Vaccine in Older Adults

Anderson, E. J., Rouphael, N. G., Widge, A. T., Jackson, L. A., Roberts, P. C., Makhene, M., Chappell, J. D., Denison, M. R., Stevens, L. J., Pruijssers, A. J., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa2028436 · Cited by 1,523 · see citing works

Alveolar macrophages: plasticity in a tissue-specific context

Hussell, T., & Bell, T. J. (2014) · Nature Reviews Immunology · doi:10.1038/nri3600 · Cited by 1,377 · see citing works

Telomerase Mutations in Families with Idiopathic Pulmonary Fibrosis

Armanios, M. Y., Chen, J. J.-L., Cogan, J. D., Alder, J. K., Ingersoll, R. G., Markin, C., Lawson, W. E., Xie, M., Vulto, I., Phillips, J. A., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa066157 · Cited by 1,357 · see citing works

A proteomic atlas of senescence-associated secretomes for aging biomarker development

Basisty, N., Kale, A., Jeon, O. H., Kuehnemann, C., Payne, T., Rao, C., Holtz, A., Shah, S., Sharma, V., Ferrucci, L., et al. (2020) · PLOS Biology · doi:10.1371/journal.pbio.3000599 · Cited by 1,348 · see citing works

A Multidimensional Index and Staging System for Idiopathic Pulmonary Fibrosis

Ley, B., Ryerson, C. J., Vittinghoff, E., Ryu, J. H., Tomassetti, S., Lee, J. S., Poletti, V., Buccioli, M., Elicker, B. M., Jones, K. D., et al. (2012) · Annals of Internal Medicine · doi:10.7326/0003-4819-156-10-201205150-00004 · Cited by 1,308 · see citing works

Lung-Function Trajectories Leading to Chronic Obstructive Pulmonary Disease

Lange, P., Celli, B., Agustí, A., Boje Jensen, G., Divo, M., Faner, R., Guerra, S., Marott, J. L., Martinez, F. D., Martinez-Camblor, P., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1411532 · Cited by 1,284 · see citing works

Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study

Justice, J. N., Nambiar, A. M., Tchkonia, T., LeBrasseur, N. K., Pascual, R., Hashmi, S. K., Prata, L., Masternak, M. M., Kritchevsky, S. B., Musi, N., et al. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2018.12.052 · Cited by 1,261 · cited 1× · see citing works

The twilight of immunity: emerging concepts in aging of the immune system

Nikolich-Žugich, J. (2018) · Nature Immunology · doi:10.1038/s41590-017-0006-x · Cited by 1,240 · see citing works

A revised airway epithelial hierarchy includes CFTR-expressing ionocytes

Montoro, D. T., Haber, A. L., Biton, M., Vinarsky, V., Lin, B., Birket, S. E., Yuan, F., Chen, S., Leung, H. M., Villoria, J., et al. (2018) · Nature · doi:10.1038/s41586-018-0393-7 · Cited by 1,206 · see citing works

A Common MUC5B Promoter Polymorphism and Pulmonary Fibrosis

Seibold, M. A., Wise, A. L., Speer, M. C., Steele, M. P., Brown, K. M., Loyd, J. E., Fingerlin, T. E., Zhang, W., Guðmundsson, G., Groshong, S. D., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1013660 · Cited by 1,203 · see citing works

SARS-CoV-2 Entry Genes Are Most Highly Expressed in Nasal Goblet and Ciliated Cells within Human Airways.Preprint

Sungnak, W., Huang, N., Bécavin, C., & Berg, M. (2020) · PubMed · Cited by 1,196 · see citing works

Why does COVID-19 disproportionately affect older people?

Mueller, A. L., McNamara, M. S., & Sinclair, D. A. (2020) · Aging · doi:10.18632/aging.103344 · Cited by 1,128 · see citing works

Macrophage death and defective inflammation resolution in atherosclerosis

Tabas, I. (2010) · Nature Reviews Immunology · doi:10.1038/nri2675 · Cited by 1,120 · see citing works

Somatic mutant clones colonize the human esophagus with age

Martincorena, I., Fowler, J. C., Wabik, A., Lawson, A. R. J., Abascal, F., Hall, M. W. J., Cagan, A., Murai, K., Mahbubani, K., Stratton, M. R., et al. (2018) · Science · doi:10.1126/science.aau3879 · Cited by 1,113 · see citing works

Senolytic CAR T cells reverse senescence-associated pathologies

Amor, C., Feucht, J., Leibold, J., Ho, Y.-J., Zhu, C., Alonso-Curbelo, D., Mansilla-Soto, J., Boyer, J. A., Li, X., Giavridis, T., et al. (2020) · Nature · doi:10.1038/s41586-020-2403-9 · Cited by 1,098 · see citing works

Renin–Angiotensin–Aldosterone System Blockers and the Risk of Covid-19

Mancia, G., Rea, F., Ludergnani, M., Apolone, G., & Corrao, G. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa2006923 · Cited by 1,071 · see citing works

Age-dependent dysregulation of innate immunity

Shaw, A. C., Goldstein, D. R., & Montgomery, R. R. (2013) · Nature Reviews Immunology · doi:10.1038/nri3547 · Cited by 1,061 · see citing works

Effect of aging on respiratory system physiology and immunology

Sharma, G., & Goodwin, J. (2006) · Clinical Interventions in Aging · doi:10.2147/ciia.2006.1.3.253 · Cited by 1,037 · see citing works

Rescue of exhausted CD8 T cells by PD-1–targeted therapies is CD28-dependent

Kamphorst, A. O., Wieland, A., Nasti, T., Yang, S., Zhang, R., Barber, D. L., Konieczny, B. T., Daugherty, C. Z., Koenig, L., Yu, K., et al. (2017) · Science · doi:10.1126/science.aaf0683 · Cited by 1,015 · see citing works

Undulating changes in human plasma proteome profiles across the lifespan

Lehallier, B., Gate, D., Schaum, N., Nanasi, T., Lee, S. E., Yousef, H., Moran Losada, P., Berdnik, D., Keller, A., Verghese, J., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0673-2 · Cited by 981 · see citing works

The RNA component of telomerase is mutated in autosomal dominant dyskeratosis congenita

Vulliamy, T., Marrone, A., Goldman, F., Dearlove, A., Bessler, M., Mason, P. J., & Dokal, I. (2001) · Nature · doi:10.1038/35096585 · Cited by 960 · see citing works

The role of macrophages in the resolution of inflammation

Watanabe, S., Alexander, M., Misharin, A. V., & Budinger, G. R. S. (2019) · Journal of Clinical Investigation · doi:10.1172/jci124615 · Cited by 925 · see citing works

Sex-Based Differences in Susceptibility to Severe Acute Respiratory Syndrome Coronavirus Infection

Channappanavar, R., Fett, C., Mack, M., Eyck, P. T., Meyerholz, D. K., & Perlman, S. M. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1601896 · Cited by 896 · see citing works

A low level of reactive oxygen species selects for primitive hematopoietic stem cells that may reside in the low-oxygenic niche

Jang, Y.-Y., & Sharkis, S. J. (2007) · Blood · doi:10.1182/blood-2007-05-087759 · Cited by 894 · see citing works

Antioxidants Accelerate Lung Cancer Progression in Mice

Sayin, V. I., Ibrahim, M. X., Larsson, E., Nilsson, J. A., Lindahl, P., & Bergo, M. O. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3007653 · Cited by 867 · see citing works

The Role of Scgb1a1+ Clara Cells in the Long-Term Maintenance and Repair of Lung Airway, but Not Alveolar, Epithelium

Rawlins, E. L., Okubo, T., Xue, Y., Brass, D. M., Auten, R. L., Hasegawa, H., Wang, F., & Hogan, B. L. M. (2009) · Cell stem cell · doi:10.1016/j.stem.2009.04.002 · Cited by 855 · see citing works

Short telomeres are a risk factor for idiopathic pulmonary fibrosis

Alder, J. K., Chen, J. J.-L., Lancaster, L., Danoff, S., Su, S.-C., Cogan, J. D., Vulto, I., Xie, M., Qi, X., Tuder, R. M., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804280105 · Cited by 805 · see citing works

The Critical Role of Metabolic Pathways in Aging

Barzilai, N., Huffman, D. M., Muzumdar, R. H., & Bartke, A. (2012) · Diabetes · doi:10.2337/db11-1300 · Cited by 803 · see citing works

The PD-1 expression balance between effector and regulatory T cells predicts the clinical efficacy of PD-1 blockade therapies

Kumagai, S., Togashi, Y., Kamada, T., Sugiyama, E., Nishinakamura, H., Takeuchi, Y., Kochin, V., Itahashi, K., Maeda, Y., Matsui, S., et al. (2020) · Nature Immunology · doi:10.1038/s41590-020-0769-3 · Cited by 794 · see citing works

Telomere Diseases

Calado, R. T., & Young, N. S. (2009) · New England Journal of Medicine · doi:10.1056/nejmra0903373 · Cited by 783 · see citing works

A New Theory on the Cancer-inducing Mechanism

Nordling, C. O. (1953) · British Journal of Cancer · doi:10.1038/bjc.1953.8 · Cited by 779 · see citing works

Regeneration of the lung alveolus by an evolutionarily conserved epithelial progenitor

Zacharias, W. J., Frank, D. B., Zepp, J. A., Morley, M. P., Alkhaleel, F. A., Kong, J., Zhou, S., Cantu, E., & Morrisey, E. E. (2018) · Nature · doi:10.1038/nature25786 · Cited by 742 · see citing works

Single-cell Wnt signaling niches maintain stemness of alveolar type 2 cells

Nabhan, A. N., Brownfield, D., Harbury, P. B., Krasnow, M. A., & Desai, T. (2018) · Science · doi:10.1126/science.aam6603 · Cited by 731 · see citing works

Cell number and cell characteristics of the normal human lung.

Crapo, J. D., Barry, B. E., Gehr, P., Bachofen, M., & Weibel, E. R. (1982) · PubMed · doi:10.1164/arrd.1982.125.6.740 · Cited by 730 · see citing works

Airway basal stem cells: a perspective on their roles in epithelial homeostasis and remodeling

Rock, J. R., Randell, S. H., & Hogan, B. L. M. (2010) · Disease Models & Mechanisms · doi:10.1242/dmm.006031 · Cited by 724 · see citing works

Pathogenesis, treatment, and prevention of pneumococcal pneumonia

van der Poll, T., & Opal, S. M. (2009) · The Lancet · doi:10.1016/s0140-6736(09)61114-4 · Cited by 713 · see citing works

Reversal of persistent fibrosis in aging by targeting Nox4-Nrf2 redox imbalance

Hecker, L., Logsdon, N. J., Kurundkar, D., Kurundkar, A., Bernard, K., Hock, T., Meldrum, E., Sanders, Y. Y., & Thannickal, V. J. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3008182 · Cited by 686 · see citing works

An atlas of the aging lung mapped by single cell transcriptomics and deep tissue proteomics

Angelidis, I., Simon, L. M., Fernandez, I. E., Strunz, M., Mayr, C. H., Greiffo, F. R., Tsitsiridis, G., Ansari, M., Graf, E., Strom, T.-M., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-08831-9 · Cited by 637 · see citing works

Disruption of the beclin 1–BCL2 autophagy regulatory complex promotes longevity in mice

Fernández, Á. F., Sebti, S., Wei, Y., Zou, Z., Shi, M., McMillan, K. L., He, C., Ting, T., Liu, Y., Chiang, W.-C., et al. (2018) · Nature · doi:10.1038/s41586-018-0162-7 · Cited by 630 · see citing works

PINK1 deficiency impairs mitochondrial homeostasis and promotes lung fibrosis

Bueno, M., Lai, Y.-C., Romero, Y., Brands, J., St. Croix, C. M., Kamga, C., Corey, C., Herazo-Maya, J. D., Sembrat, J., Lee, J. S., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci74942 · Cited by 627 · see citing works

Cutting edge: impaired toll-like receptor expression and function in aging

Renshaw, M., Rockwell, J., Engleman, C., Gewirtz, A., Katz, J., & Sambhara, S. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.9.4697 · Cited by 626 · see citing works

Mitophagy-dependent necroptosis contributes to the pathogenesis of COPD

Mizumura, K., Cloonan, S. M., Nakahira, K., Bhashyam, A. R., Cervo, M., Kitada, T., Glass, K., Owen, C. A., Mahmood, A., Washko, G. R., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci74985 · Cited by 611 · see citing works

Interventions to slow aging in humans: are we ready?

Longo, V. D., Antebi, A., Bartke, A., Barzilai, N., Brown‐Borg, H. M., Caruso, C., Curiel, T. J., Cabo, R., Franceschi, C., Gems, D., et al. (2015) · Aging Cell · doi:10.1111/acel.12338 · Cited by 592 · see citing works

Spatial map of human T cell compartmentalization and maintenance over decades of life

Thome, J. J. C., Yudanin, N., Ohmura, Y., Kubota, M., Grinshpun, B., Sathaliyawala, T., Kato, T., Lerner, H., Shen, Y., & Farber, D. L. (2014) · Cell · doi:10.1016/j.cell.2014.10.026 · Cited by 587 · see citing works

Sexual-dimorphism in human immune system aging

Márquez, E. J., Chung, C.-H., Marches, R., Rossi, R. J., Nehar-Belaid, D., Eroglu, A., Mellert, D. J., Kuchel, G. A., Banchereau, J., & Ucar, D. (2020) · Nature Communications · doi:10.1038/s41467-020-14396-9 · Cited by 584 · see citing works

BACH1 Stabilization by Antioxidants Stimulates Lung Cancer Metastasis

Wiel, C., Le Gal, K., Ibrahim, M. X., Jahangir, C. A., Kashif, M., Yao, H., Ziegler, D. V., Xu, X., Ghosh, T., Mondal, T., et al. (2019) · Cell · doi:10.1016/j.cell.2019.06.005 · Cited by 579 · see citing works

Nrf2 Activation Promotes Lung Cancer Metastasis by Inhibiting the Degradation of Bach1

Lignitto, L., LeBoeuf, S. E., Homer, H., Jiang, S., Askenazi, M., Karakousi, T. R., Pass, H. I., Bhutkar, A. J., Tsirigos, A., Ueberheide, B., et al. (2019) · Cell · doi:10.1016/j.cell.2019.06.003 · Cited by 573 · see citing works

Mechanisms of cross‐talk between the ubiquitin‐proteasome and autophagy‐lysosome systems

Korolchuk, V. I., Menzies, F. M., & Rubinsztein, D. C. (2009) · FEBS Letters · doi:10.1016/j.febslet.2009.12.047 · Cited by 565 · see citing works

Age-associated decrease in TLR function in primary human dendritic cells predicts influenza vaccine response

Panda, A., Qian, F., Mohanty, S., van Duin, D., Newman, F. K., Zhang, L., Chen, S., Towle, V., Belshe, R. B., Fikrig, E., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0901022 · Cited by 548 · cited 1× · see citing works

Telomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancer

Bernardes de Jesus, B., Vera, E., Schneeberger, K., Tejera, A. M., Ayuso, E., Bosch, F., & Blasco, M. A. (2012) · EMBO Molecular Medicine · doi:10.1002/emmm.201200245 · Cited by 548 · see citing works

Rapalogs and mTOR inhibitors as anti-aging therapeutics

Lamming, D. W., Ye, L., Sabatini, D. M., & Baur, J. A. (2013) · Journal of Clinical Investigation · doi:10.1172/jci64099 · Cited by 531 · see citing works

Oxidative stress and pulmonary fibrosis

Cheresh, P., Kim, S.-J., Tulasiram, S., & Kamp, D. W. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2012.11.021 · Cited by 527 · see citing works

Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function

Zhang, C., & Cuervo, A. M. (2008) · Nature Medicine · doi:10.1038/nm.1851 · Cited by 520 · see citing works

A clinically meaningful metric of immune age derived from high-dimensional longitudinal monitoring

Alpert, A., Pickman, Y., Leipold, M., Rosenberg-Hasson, Y., Ji, X., Gaujoux, R., Rabani, H., Starosvetsky, E., Kveler, K., Schaffert, S., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0381-y · Cited by 513 · see citing works

Lung regeneration: mechanisms, applications and emerging stem cell populations

Kotton, D. N., & Morrisey, E. E. (2014) · Nature Medicine · doi:10.1038/nm.3642 · Cited by 512 · see citing works

Epithelial Endoplasmic Reticulum Stress and Apoptosis in Sporadic Idiopathic Pulmonary Fibrosis

Korfei, M., Ruppert, C., Mahavadi, P., Henneke, I., Markart, P., Koch, M., Lang, G., Fink, L., Bohle, R.-M., Seeger, W., et al. (2008) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200802-313oc · Cited by 508 · see citing works

Clara Cell Secretory Protein–Expressing Cells of the Airway Neuroepithelial Body Microenvironment Include a Label-Retaining Subset and Are Critical for Epithelial Renewal after Progenitor Cell Depletion

Hong, K. U., Reynolds, S. D., Giangreco, A., Hurley, C. M., & Stripp, B. R. (2001) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.24.6.4498 · Cited by 486 · see citing works

A SARS-CoV-2 Infection Model in Mice Demonstrates Protection by Neutralizing Antibodies

Hassan, A. O., Case, J. B., Winkler, E. S., Thackray, L. B., Kafai, N. M., Bailey, A. L., McCune, B. T., Fox, J. M., Chen, R. E., Alsoussi, W. B., et al. (2020) · Cell · doi:10.1016/j.cell.2020.06.011 · Cited by 477 · see citing works

Three Unique Interstitial Macrophages in the Murine Lung at Steady State

Gibbings, S. L., Thomas, S. M., Atif, S. M., McCubbrey, A. L., Desch, A. N., Danhorn, T., Leach, S. M., Bratton, D. L., Henson, P. M., Janssen, W. J., et al. (2017) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2016-0361oc · Cited by 476 · see citing works

Notch-Dependent Differentiation of Adult Airway Basal Stem Cells

Rock, J. R., Gao, X., Xue, Y., Randell, S. H., Kong, Y., & Hogan, B. L. M. (2011) · Cell stem cell · doi:10.1016/j.stem.2011.04.003 · Cited by 459 · see citing works

Egr-1 Regulates Autophagy in Cigarette Smoke-Induced Chronic Obstructive Pulmonary Disease

Chen, Z.-H., Kim, H. P., Sciurba, F. C., Lee, S.-J., Feghali-Bostwick, C., Stolz, D. B., Dhir, R., Landreneau, R. J., Schuchert, M. J., Yousem, S. A., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003316 · Cited by 459 · see citing works

SIRT4 Has Tumor-Suppressive Activity and Regulates the Cellular Metabolic Response to DNA Damage by Inhibiting Mitochondrial Glutamine Metabolism

Jeong, S. M., Xiao, C., Finley, L. W. S., Lahusen, T., Souza, A. L., Pierce, K., Li, Y.-H., Wang, X., Laurent, G., German, N. J., et al. (2013) · Cancer Cell · doi:10.1016/j.ccr.2013.02.024 · Cited by 445 · see citing works

Altered innate immune functioning of dendritic cells in elderly humans: a role of phosphoinositide 3-kinase-signaling pathway

Agrawal, A., Agrawal, S., Cao, J.-N., Su, H., Osann, K., & Gupta, S. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.11.6912 · Cited by 435 · see citing works

Mitochondrial Biogenesis and Proteome Remodeling Promote One-Carbon Metabolism for T Cell Activation

Ron-Harel, N., Santos, D., Ghergurovich, J. M., Sage, P. T., Reddy, A., Lovitch, S. B., Dephoure, N., Satterstrom, F. K., Sheffer, M., Spinelli, J. B., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.06.007 · Cited by 429 · see citing works

Endoplasmic reticulum stress in alveolar epithelial cells is prominent in IPF: association with altered surfactant protein processing and herpesvirus infection

Lawson, W. E., Crossno, P. F., Polosukhin, V. V., Roldan, J., Cheng, D., Lane, K. B., Blackwell, T. R., Xu, C., Markin, C. R., Ware, L. B., et al. (2008) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00382.2007 · Cited by 428 · see citing works

The innate immune function of airway epithelial cells in inflammatory lung disease

Hiemstra, P. S., McCray, P. B., & Bals, R. (2015) · European Respiratory Journal · doi:10.1183/09031936.00141514 · Cited by 425 · see citing works

Age- and gender-related difference of ACE2 expression in rat lung

Xudong, X., Junzhu, C., Xingxiang, W., Furong, Z., & Yanrong, L. (2006) · Life Sciences · doi:10.1016/j.lfs.2005.09.038 · Cited by 410 · see citing works

Senolytic drugs target alveolar epithelial cell function and attenuate experimental lung fibrosis <i>ex vivo</i>

Lehmann, M., Korfei, M., Mutze, K., Klee, S., Skronska-Wasek, W., Alsafadi, H. N., Ota, C., Costa, R., Schiller, H. B., Lindner, M., et al. (2017) · European Respiratory Journal · doi:10.1183/13993003.02367-2016 · Cited by 403 · cited 1× · see citing works

Emerging therapies for idiopathic pulmonary fibrosis, a progressive age-related disease

Mora, A. L., Rojas, M., Pardo, A., & Selman, M. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2017.170 · Cited by 403 · see citing works

Axis of ageing: telomeres, p53 and mitochondria

Sahin, E., & DePinho, R. A. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3352 · Cited by 380 · see citing works

In vivo differentiation potential of tracheal basal cells: evidence for multipotent and unipotent subpopulations

Hong, K. U., Reynolds, S. D., Watkins, S. C., Fuchs, E. V., & Stripp, B. R. (2004) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00155.2003 · Cited by 375 · see citing works

Phosphoinositide 3-kinase inhibition restores neutrophil accuracy in the elderly: toward targeted treatments for immunosenescence

Sapey, E., Greenwood, H., Walton, G., Mann, E., Love, A., Aaronson, N., Insall, R. H., Stockley, R. A., & Lord, J. M. (2014) · Blood · doi:10.1182/blood-2013-08-519520 · Cited by 358 · see citing works

SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice

Yao, H., Chung, S., Hwang, J.-W., Rajendrasozhan, S., Sundar, I. K., Dean, D. A., McBurney, M. W., Guarente, L., Gu, W., Rönty, M., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci60132 · Cited by 358 · see citing works

Age-Associated Defect in Human TLR-1/2 Function

van Duin, D., Mohanty, S., Thomas, V., Ginter, S., Montgomery, R. R., Fikrig, E., Allore, H. G., Medzhitov, R., & Shaw, A. C. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.2.970 · Cited by 352 · see citing works

Decline in miR-181a expression with age impairs T cell receptor sensitivity by increasing DUSP6 activity

Li, G., Yu, M., Lee, W.-W., Tsang, M., Krishnan, E., Weyand, C. M., & Goronzy, J. J. (2012) · Nature Medicine · doi:10.1038/nm.2963 · Cited by 349 · see citing works

The Shock of Aging: Molecular Chaperones and the Heat Shock Response in Longevity and Aging – A Mini-Review

Calderwood, S. K., Murshid, A., & Prince, T. L. (2009) · Gerontology · doi:10.1159/000225957 · Cited by 343 · see citing works

Mitochondrial Sirtuin Network Reveals Dynamic SIRT3-Dependent Deacetylation in Response to Membrane Depolarization

Yang, W., Nagasawa, K., Münch, C., Xu, Y., Satterstrom, F. K., Jeong, S., Hayes, S., Jedrychowski, M. P., Vyas, F. S., Zaganjor, E., et al. (2016) · Cell · doi:10.1016/j.cell.2016.10.016 · Cited by 341 · see citing works

Accelerated ageing of the lung in COPD: new concepts

Mercado, N., Ito, K., & Barnes, P. J. (2015) · Thorax · doi:10.1136/thoraxjnl-2014-206084 · Cited by 340 · see citing works

Incidence and prevalence of idiopathic pulmonary fibrosis in US adults 18–64 years old

Raghu, G., Chen, S., Hou, Q., Yeh, W., & Collard, H. R. (2016) · European Respiratory Journal · doi:10.1183/13993003.01653-2015 · Cited by 338 · see citing works

Aging Down-Regulates the Transcription Factor E2A, Activation-Induced Cytidine Deaminase, and Ig Class Switch in Human B Cells

Frasca, D., Landin, A. M., Lechner, S. C., Ryan, J. G., Schwartz, R., Riley, R. L., & Blomberg, B. B. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.8.5283 · Cited by 333 · see citing works

Cigarette smoke-induced autophagy impairment accelerates lung aging, COPD-emphysema exacerbations and pathogenesis

Vij, N., Chandramani-Shivalingappa, P., Westphal, C. V., Hole, R., & Bodas, M. (2016) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00110.2016 · Cited by 333 · see citing works

Sex Differences in Mortality From COVID-19 Pandemic

Sharma, G. V., Volgman, A. S., & Michos, E. D. (2020) · JACC Case Reports · doi:10.1016/j.jaccas.2020.04.027 · Cited by 332 · see citing works

Exacerbated Innate Host Response to SARS-CoV in Aged Non-Human Primates

Smits, S. L., de Lang, A., van den Brand, J. M. A., Leijten, L. M. E., van IJcken, W. F. J., Eijkemans, M. J. C., van Amerongen, G., Kuiken, T., Andeweg, A. C., Osterhaus, A. D. M. E., et al. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1000756 · Cited by 331 · see citing works

Early local immune defences in the respiratory tract

Iwasaki, A., Foxman, E. F., & Molony, R. D. (2016) · Nature reviews. Immunology · doi:10.1038/nri.2016.117 · Cited by 331 · see citing works

Insufficient autophagy in idiopathic pulmonary fibrosis

Araya, J., Kojima, J., Takasaka, N., Ito, S., Fujii, S., Hara, H., Yanagisawa, H., Kobayashi, K., Tsurushige, C., Kawaishi, M., et al. (2012) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00213.2012 · Cited by 326 · see citing works

Aging promotes reorganization of the CD4 T cell landscape toward extreme regulatory and effector phenotypes

Elyahu, Y., Hekselman, I., Eizenberg-Magar, I., Berner, O., Strominger, I., Schiller, M., Mittal, K., Nemirovsky, A., Eremenko, E., Vital, A., et al. (2019) · Science Advances · doi:10.1126/sciadv.aaw8330 · Cited by 324 · see citing works

Mitochondria in lung disease

Cloonan, S. M., & Choi, A. M. K. (2016) · Journal of Clinical Investigation · doi:10.1172/jci81113 · Cited by 322 · cited 1× · see citing works

CXCR6 regulates localization of tissue-resident memory CD8 T cells to the airways

Wein, A. N., Mcmaster, S., Takamura, S., Dunbar, P., Cartwright, E. K., Hayward, S. L., McManus, D. T., Shimaoka, T., Ueha, S., Tsukui, T., et al. (2019) · Journal of Experimental Medicine · doi:10.1084/jem.20181308 · Cited by 314 · see citing works

Regulation of Yeast Chronological Life Span by TORC1 via Adaptive Mitochondrial ROS Signaling

Pan, Y., Schroeder, E. A., Ocampo, A., Barrientos, A., & Shadel, G. S. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.03.018 · Cited by 313 · see citing works

Ciliated epithelial cell lifespan in the mouse trachea and lung

Rawlins, E. L., & Hogan, B. L. M. (2008) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.90209.2008 · Cited by 304 · see citing works

Limited efficacy of inactivated influenza vaccine in elderly individuals is associated with decreased production of vaccine-specific antibodies

Sasaki, S., Sullivan, M., Narvaez, C. F., Holmes, T. H., Furman, D., Zheng, N.-Y., Nishtala, M., Wrammert, J., Smith, K., James, J. A., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci57834 · Cited by 300 · see citing works

Impaired neutrophil extracellular trap formation: a novel defect in the innate immune system of aged individuals

Hazeldine, J., Harris, P., Chapple, I., Grant, M. M., Greenwood, H. L., Livesey, A., Sapey, E., & Lord, J. M. (2014) · Aging Cell · doi:10.1111/acel.12222 · Cited by 297 · see citing works

The Senile Lung

Verbeken, E. K., Cauberghs, M., Mertens, I., Clement, J., Lauweryns, J. M., & Van de Woestijne, K. P. (1992) · Chest · doi:10.1378/chest.101.3.793 · Cited by 289 · see citing works

Proteostasis and the Aging Proteome in Health and Disease

Morimoto, R. I., & Cuervo, A. M. (2014) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glu049 · Cited by 277 · see citing works

Developmental origin of lung macrophage diversity

Tan, S. Y., & Krasnow, M. A. (2016) · Development · doi:10.1242/dev.129122 · Cited by 274 · see citing works

Lung development and repair: Contribution of the ciliated lineage

Rawlins, E. L., Ostrowski, L. E., Randell, S. H., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610770104 · Cited by 272 · see citing works

Genetic mutations in surfactant protein C are a rare cause of sporadic cases of IPF

Lawson, W. E. (2004) · Thorax · doi:10.1136/thx.2004.026336 · Cited by 272 · see citing works

Telomere dysfunction in alveolar epithelial cells causes lung remodeling and fibrosis

Naikawadi, R. P., Disayabutr, S., Mallavia, B., Donne, M. L., Green, G., La, J. L., Rock, J. R., Looney, M. R., & Wolters, P. J. (2016) · JCI Insight · doi:10.1172/jci.insight.86704 · Cited by 267 · see citing works

Age-related increases in PGD2 expression impair respiratory DC migration, resulting in diminished T cell responses upon respiratory virus infection in mice

Zhao, J., Zhao, J., Legge, K., & Perlman, S. (2011) · Journal of Clinical Investigation · doi:10.1172/jci59777 · Cited by 265 · see citing works

Time- and compartment-resolved proteome profiling of the extracellular niche in lung injury and repair

Schiller, H. B., Fernandez, I. E., Burgstaller, G., Schaab, C., Scheltema, R. A., Schwarzmayr, T., Strom, T. M., Eickelberg, O., & Mann, M. (2015) · Molecular Systems Biology · doi:10.15252/msb.20156123 · Cited by 261 · see citing works

Association Between Younger Age and Targetable Genomic Alterations and Prognosis in Non–Small-Cell Lung Cancer

Sacher, A. G., Dahlberg, S. E., Heng, J. C., Mach, S. L., Janne, P. A., & Oxnard, G. R. (2015) · JAMA Oncology · doi:10.1001/jamaoncol.2015.4482 · Cited by 259 · see citing works

Lung Homeostasis: Influence of Age, Microbes, and the Immune System

Lloyd, C. M., & Marsland, B. J. (2017) · Immunity · doi:10.1016/j.immuni.2017.04.005 · Cited by 254 · see citing works

Aging Impairs Alveolar Macrophage Phagocytosis and Increases Influenza-Induced Mortality in Mice

Wong, C. K., Smith, C. A., Sakamoto, K., Kaminski, N., Koff, J. L., & Goldstein, D. R. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1700397 · Cited by 246 · see citing works

The Human Lung Cell Atlas: A High-Resolution Reference Map of the Human Lung in Health and Disease

Schiller, H. B., Montoro, D. T., Simon, L. M., Rawlins, E. L., Meyer, K. B., Strunz, M., Vieira Braga, F. A., Timens, W., Koppelman, G. H., Budinger, G. R. S., et al. (2019) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2018-0416tr · Cited by 245 · see citing works

Age-related CD8 T Cell Clonal Expansions Constrict CD8 T Cell Repertoire and Have the Potential to Impair Immune Defense

Messaoudi, I., LeMaoult, J., Guevara-Patino, J. A., Metzner, B. M., & Nikolich‐Žugich, J. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20040437 · Cited by 243 · see citing works

Senolytic therapies for healthy longevity.

van Deursen, J. M. (2019) · Science · doi:10.1126/science.aaw1299 · Cited by 237 · see citing works

Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation

Plate, L., Cooley, C. B., Chen, J. J.-W., Paxman, R. J., Gallagher, C. M., Madoux, F., Genereux, J. C., Dobbs, W., Garza, D., Spicer, T., et al. (2016) · eLife · doi:10.7554/elife.15550 · Cited by 234 · see citing works

Efficacy of PD-1 &amp; PD-L1 inhibitors in older adults: a meta-analysis

Elias, R., Giobbie-Hurder, A., McCleary, N. J., Ott, P., Hodi, F. S., & Rahma, O. (2018) · Journal for ImmunoTherapy of Cancer · doi:10.1186/s40425-018-0336-8 · Cited by 218 · see citing works

Resident Cellular Components of the Human Lung: Current Knowledge and Goals for Research on Cell Phenotyping and Function

Franks, T. J., Colby, T. V., Travis, W. D., Tuder, R. M., Reynolds, H. Y., Brody, A. R., Cardoso, W. V., Crystal, R. G., Drake, C. J., Engelhardt, J. F., et al. (2008) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200803-025hr · Cited by 213 · see citing works

Mitochondrial Dysfunction in Aging and Diseases of Aging

Haas, R. (2019) · Biology · doi:10.3390/biology8020048 · Cited by 205 · see citing works

The lung microbiome in health and disease

Moffatt, M. F., & Cookson, W. (2017) · Clinical Medicine · doi:10.7861/clinmedicine.17-6-525 · Cited by 204 · see citing works

The pathophysiological role of mitochondrial oxidative stress in lung diseases

Liu, X., & Chen, Z. (2017) · Journal of Translational Medicine · doi:10.1186/s12967-017-1306-5 · Cited by 202 · see citing works

Role of Endoplasmic Reticulum Stress in Epithelial–Mesenchymal Transition of Alveolar Epithelial Cells

Zhong, Q., Zhou, B., Ann, D. K., Minoo, P., Liu, Y., Banfalvi, A., Krishnaveni, M. S., Dubourd, M., DeMaio, L., Willis, B. C., et al. (2010) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2010-0347oc · Cited by 201 · see citing works

Cellular senescence-like features of lung fibroblasts derived from idiopathic pulmonary fibrosis patients

Yanai, H., Shteinberg, A., Porat, Z., Budovsky, A., Braiman, A., Zeische, R., & Fraifeld, V. E. (2015) · Aging · doi:10.18632/aging.100807 · Cited by 198 · see citing works

Telomerase mutations in smokers with severe emphysema

Stanley, S. E., Chen, J. J. L., Podlevsky, J. D., Alder, J. K., Hansel, N. N., Mathias, R. A., Qi, X., Rafaels, N. M., Wise, R. A., Silverman, E. K., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci78554 · Cited by 196 · see citing works

Covid-19 and Immunity in Aging Populations — A New Research Agenda

Koff, W. C., & Williams, M. A. (2020) · New England Journal of Medicine · doi:10.1056/nejmp2006761 · Cited by 196 · see citing works

Is there more to aging than mitochondrial DNA and reactive oxygen species?

ALEXEYEV, M. F. (2009) · FEBS Journal · doi:10.1111/j.1742-4658.2009.07269.x · Cited by 194 · see citing works

Pink1 regulates the oxidative phosphorylation machinery via mitochondrial fission

Liu, W., Acín-Peréz, R., Geghman, K. D., Manfredi, G., Lu, B., & Li, C. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1107332108 · Cited by 190 · see citing works

mTORC 1 activation decreases autophagy in aging and idiopathic pulmonary fibrosis and contributes to apoptosis resistance in IPF fibroblasts

Romero, Y., Bueno, M., Ramı́rez, R., Álvarez, D., Sembrat, J., Goncharova, E. A., Rojas, M. M., Selman, M., Mora, A. L., & Pardo, A. (2016) · Aging Cell · doi:10.1111/acel.12514 · Cited by 190 · see citing works

Global analyses revealed age‐related alterations in innate immune responses after stimulation of pathogen recognition receptors

Metcalf, T. U., Cubas, R. A., Ghneim, K., Cartwright, M. J., Grevenynghe, J. V., Richner, J. M., Olagnier, D. P., Wilkinson, P. A., Cameron, M. J., Park, B. S., et al. (2015) · Aging Cell · doi:10.1111/acel.12320 · Cited by 189 · see citing works

Clinical consequences of clonal hematopoiesis of indeterminate potential

Steensma, D. P. (2018) · Hematology · doi:10.1182/asheducation-2018.1.264 · Cited by 188 · see citing works

Influenza-specific lung-resident memory T cells are proliferative and polyfunctional and maintain diverse TCR profiles

Pizzolla, A., Nguyen, T. H. O., Sant, S. A., Jaffar, J., Loudovaris, T., Mannering, S. I., Thomas, P. G., Westall, G. P., Kedzierska, K., & Wakim, L. M. (2018) · Journal of Clinical Investigation · doi:10.1172/jci96957 · Cited by 181 · see citing works

Neutrophils and low-grade inflammation in the seemingly normal aging human lung

Meyer, K. C., Rosenthal, N. S., Soergel, P., & Peterson, K. (1998) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(98)00065-7 · Cited by 179 · see citing works

Circulating CXCR5+PD-1+ Response Predicts Influenza Vaccine Antibody Responses in Young Adults but not Elderly Adults

Herati, R. S., Reuter, M. A., Dolfi, D. V., Mansfield, K. D., Aung, H., Badwan, O. Z., Kurupati, R. K., Kannan, S., Ertl, H., Schmader, K. E., et al. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1302503 · Cited by 177 · see citing works

Autophagy inhibition-mediated epithelial–mesenchymal transition augments local myofibroblast differentiation in pulmonary fibrosis

Hill, C. N., Li, J., Liu, D., Conforti, F., Brereton, C. J., Yao, L., Zhou, Y., Alzetani, A., Chee, S., Marshall, B. G., et al. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-1820-x · Cited by 177 · see citing works

The lung microenvironment shapes a dysfunctional response of alveolar macrophages in aging

McQuattie-Pimentel, A. C., Ren, Z., Joshi, N., Watanabe, S., Stoeger, T., Chi, M., Lu, Z., Sichizya, L., Aillon, R. P., Chen, C.-I., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci140299 · Cited by 177 · see citing works

Deregulation of selective autophagy during aging and pulmonary fibrosis: the role of TGF β1

Sosulski, M. L., Góngora, R., Danchuk, S. D., Dong, C., Luo, F., & Sánchez, C. G. (2015) · Aging Cell · doi:10.1111/acel.12357 · Cited by 176 · see citing works

Oxidative stress dependent microRNA-34a activation via PI3Kα reduces the expression of sirtuin-1 and sirtuin-6 in epithelial cells

Baker, J. R., Vuppusetty, C., Colley, T., Papaioannou, A. Ι., Fenwick, P. S., Donnelly, L., Ito, K., & Barnes, P. J. (2016) · Scientific Reports · doi:10.1038/srep35871 · Cited by 175 · see citing works

Inhibition of LTβR signalling activates WNT-induced regeneration in lung

Conlon, T. M., John-Schuster, G., Heide, D., Pfister, D. R., Lehmann, M., Hu, Y., Ertüz, Z., Lopez, M., Ansari, M., Strunz, M., et al. (2020) · Nature · doi:10.1038/s41586-020-2882-8 · Cited by 174 · see citing works

TNF Drives Monocyte Dysfunction with Age and Results in Impaired Anti-pneumococcal Immunity

Puchta, A., Naidoo, A., Verschoor, C. P., Loukov, D., Thevaranjan, N., Mandur, T. S., Nguyen, P.-S., Jordana, M., Loeb, M. B., Xing, Z., et al. (2016) · PLoS Pathogens · doi:10.1371/journal.ppat.1005368 · Cited by 173 · see citing works

Aging and anatomical variations in lung tissue stiffness

Sicard, D., Haak, A. J., Choi, K. M., Craig, A. R., Fredenburgh, L. E., & Tschumperlin, D. J. (2018) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00415.2017 · Cited by 172 · see citing works

A Measurable Increase in Oxidative Damage Due to Reduction in Superoxide Detoxification Fails to Shorten the Life Span of Long-Lived Mitochondrial Mutants of Caenorhabditis elegans

Yang, W., Li, J., & Hekimi, S. (2007) · Genetics · doi:10.1534/genetics.107.080788 · Cited by 171 · see citing works

Grp78 Loss in Epithelial Progenitors Reveals an Age-linked Role for Endoplasmic Reticulum Stress in Pulmonary Fibrosis

Borok, Z., Horie, M., Flodby, P., Wang, H., Liu, Y., Ganesh, S., Firth, A. L., Minoo, P., Li, C., Beers, M. F., et al. (2019) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201902-0451oc · Cited by 171 · see citing works

Beyond macrophages: the diversity of mononuclear cells in tuberculosis

Srivastava, S., Ernst, J., & Desvignes, L. (2014) · Immunological Reviews · doi:10.1111/imr.12217 · Cited by 167 · see citing works

Fibroblast senescence in the pathology of idiopathic pulmonary fibrosis

Waters, D. W., Blokland, K. E. C., Pathinayake, P. S., Burgess, J. K., Mutsaers, S. E., Prêle, C. M., Schuliga, M. J., Grainge, C., & Knight, D. A. (2018) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00037.2018 · Cited by 167 · see citing works

B cell maintenance and function in aging

Kogut, I., Scholz, J. L., Cancro, M. P., & Cambier, J. C. (2012) · Seminars in Immunology · doi:10.1016/j.smim.2012.04.004 · Cited by 166 · see citing works

Essential role for the ATG4B protease and autophagy in bleomycin-induced pulmonary fibrosis

Cabrera, S., Maciel, M., Herrera, I., Nava, T., Vergara, F., Gaxiola, M., López-Otín, C., Selman, M., & Pardo, A. (2015) · Autophagy · doi:10.1080/15548627.2015.1034409 · Cited by 163 · see citing works

Effects of aging on B cell function

Frasca, D., & Blomberg, B. B. (2009) · Current Opinion in Immunology · doi:10.1016/j.coi.2009.06.001 · Cited by 161 · see citing works

Innate immune responses in the ageing lung.

Boe, D. M., Boule, L. A., & Kovacs, E. J. (2016) · Clinical and Experimental Immunology · doi:10.1111/cei.12881 · Cited by 156 · see citing works

Aging impairs both primary and secondary RIG-I signaling for interferon induction in human monocytes

Molony, R. D., Nguyen, J. T., Kong, Y., Montgomery, R. R., Shaw, A. C., & Iwasaki, A. (2017) · Science Signaling · doi:10.1126/scisignal.aan2392 · Cited by 154 · see citing works

Mechanisms and consequences of oxidative stress in lung disease: therapeutic implications for an aging populace

Hecker, L. (2018) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00275.2017 · Cited by 153 · see citing works

Myoepithelial Cells of Submucosal Glands Can Function as Reserve Stem Cells to Regenerate Airways after Injury

Tata, A., Kobayashi, Y., Chow, R. D.-W., Tran, J., Desai, A. P., Massri, A. J., McCord, T. J., Gunn, M. D., & Tata, P. R. (2018) · Cell stem cell · doi:10.1016/j.stem.2018.03.018 · Cited by 152 · see citing works

Molecular basis of age-associated cytokine dysregulation in LPS-stimulated macrophages

Chelvarajan, R. L., Liu, Y., Popa, D., Getchell, M. L., Getchell, T. V., Stromberg, A. J., & Bondada, S. (2006) · Journal of Leukocyte Biology · doi:10.1189/jlb.0106024 · Cited by 151 · see citing works

IMPAIRED PULMONARY FUNCTION AS A RISK FACTOR FOR MORTALITY

BEATY, T. H., COHEN, B. H., NEWILL, C. A., MENKERS, H. A., DIAMOND, E. L., & CHEN, C. J. (1982) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a113385 · Cited by 149 · cited 1× · see citing works

SIRT3 diminishes inflammation and mitigates endotoxin-induced acute lung injury

Kurundkar, D., Kurundkar, A., Bone, N. B., Becker, E., Liu, W., Chacko, B. K., Darley-Usmar, V. M., Zmijewski, J. W., & Thannickal, V. J. (2019) · JCI Insight · doi:10.1172/jci.insight.120722 · Cited by 149 · see citing works

A randomised, placebo-controlled study of omipalisib (PI3K/mTOR) in idiopathic pulmonary fibrosis

Lukey, P. T., Harrison, S. A., Yang, S., Man, Y., Holman, B. F., Rashidnasab, A., Azzopardi, G., Grayer, M., Simpson, J. K., Bareille, P. J., et al. (2019) · European Respiratory Journal · doi:10.1183/13993003.01992-2018 · Cited by 146 · see citing works

Proteomic Analysis of Altered Extracellular Matrix Turnover in Bleomycin-induced Pulmonary Fibrosis

Decaris, M. L., Gatmaitan, M., FlorCruz, S., Luo, F., Li, K. W., Holmes, W. E., Hellerstein, M. K., Turner, S., & Emson, C. L. (2014) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m113.037267 · Cited by 145 · see citing works

Bone Marrow Microenvironmental Changes Underlie Reduced RAG-mediated Recombination and B Cell Generation in Aged Mice

Labrie, J. E., Sah, A. P., Allman, D. M., Cancro, M. P., & Gerstein, R. M. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20040845 · Cited by 145 · see citing works

Activation of the mTORC1/PGC-1 axis promotes mitochondrial biogenesis and induces cellular senescence in the lung epithelium

Summer, R. S., Shaghaghi, H., Schriner, D., Roque, W., Sales, D., Cuevas-Mora, K., Desai, V. S., Bhushan, A., Ramirez, M. I., & Romero, F. (2019) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00244.2018 · Cited by 145 · see citing works

Long-term clearance from small airways decreases with age

Svartengren, M., Falk, R., & Philipson, K. (2005) · European Respiratory Journal · doi:10.1183/09031936.05.00002105 · Cited by 144 · see citing works

The generation of memory B cells is maintained, but the antibody response is not, in the elderly after repeated influenza immunizations

Frasca, D., Diaz, A., Romero, M., & Blomberg, B. B. (2016) · Vaccine · doi:10.1016/j.vaccine.2016.04.023 · Cited by 144 · see citing works

Age‐Associated Inflammation and Toll‐Like Receptor Dysfunction Prime the Lungs for Pneumococcal Pneumonia

Hinojosa, E., Boyd, A. R., & Orihuela, C. J. (2009) · The Journal of Infectious Diseases · doi:10.1086/600870 · Cited by 143 · see citing works

Influenza Virus Vaccination Elicits Poorly Adapted B Cell Responses in Elderly Individuals

Henry, C., Zheng, N., Huang, M., Cabanov, A., Rojas, K. T., Kaur, K., Andrews, S. F., Palm, A.-K. E., Chen, Y.-Q., Li, Y., et al. (2019) · Cell Host & Microbe · doi:10.1016/j.chom.2019.01.002 · Cited by 142 · see citing works

Defective TFH Cell Function and Increased TFR Cells Contribute to Defective Antibody Production in Aging

Sage, P. T., Tan, C. L., Freeman, G. J., Haigis, M. C., & Sharpe, A. H. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.06.015 · Cited by 141 · see citing works

Partial restoration of T‐cell function in aged mice by in vitro blockade of the PD‐1/ PD‐L1 pathway

Lages, C. S., Lewkowich, I. P., Sproles, A. A., Wills-Karp, M. A., & Chougnet, C. A. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2010.00611.x · Cited by 140 · see citing works

Immune function parameters as markers of biological age and predictors of longevity

de Toda, I. M., Maté, I., Vida, C., Cruces, J., & la Fuente, M. D. (2016) · Aging · doi:10.18632/aging.101116 · Cited by 140 · see citing works

Genome-wide association analysis identifies six new loci associated with forced vital capacity

Loth, D. W., Artigas, M. S., Gharib, S. A., Wain, L. V., Franceschini, N., Koch, B., Pottinger, T. D., Smith, A. V., Duan, Q., Oldmeadow, C. J., et al. (2014) · Nature Genetics · doi:10.1038/ng.3011 · Cited by 138 · see citing works

Expression of CD39 on activated T cells impairs their survival in older individuals

Fang, F., Yu, M., Cavanagh, M. M., Hutter Saunders, J., Qi, Q., Ye, Z., Le Saux, S., Sultan, W., Turgano, E., Dekker, C. L., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.01.002 · Cited by 138 · see citing works

Submucosal Gland Myoepithelial Cells Are Reserve Stem Cells That Can Regenerate Mouse Tracheal Epithelium

Lynch, T. J., Anderson, P. J., Rotti, P. G., Tyler, S. R., Crooke, A. K., Choi, S. H., Montoro, D. T., Silverman, C. L., Shahin, W. S., Zhao, R., et al. (2018) · Cell stem cell · doi:10.1016/j.stem.2018.03.017 · Cited by 136 · see citing works

Improving Vaccine-Induced Immunity: Can Baseline Predict Outcome?

Tsang, J. S., Dobaño, C., Damme, P. V., Moncunill, G., Marchant, A., Othman, R. B., Sadarangani, M., Koff, W. C., & Kollmann, T. R. (2020) · Trends in Immunology · doi:10.1016/j.it.2020.04.001 · Cited by 136 · see citing works

Idiopathic Pulmonary Fibrosis

Orbach, H., Karlinskaya, M., & Fruchter, O. (2018) · New England Journal of Medicine · doi:10.1056/nejmc1807508 · Cited by 133 · see citing works

Vascular aging in the longest-living rodent, the naked mole rat

Csiszár, A., Labinskyy, N., Orosz, Z. Z., Xiangmin, Z., Buffenstein, R., & Ungvari, Z. I. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01287.2006 · Cited by 129 · see citing works

Spirometric reference equations for European females and males aged 65–85 yrs

García-Río, F., Pino, J. M., Dorgham, A., Alonso, A., & Villamor, J. (2004) · European Respiratory Journal · doi:10.1183/09031936.04.00088403 · Cited by 128 · see citing works

Excessive neutrophil levels in the lung underlie the age-associated increase in influenza mortality

Kulkarni, U., Zemans, R. L., Smith, C. A., Wood, S. C., Deng, J. C., & Goldstein, D. R. (2019) · Mucosal Immunology · doi:10.1038/s41385-018-0115-3 · Cited by 125 · see citing works

Cancer—Incidence, prevalence and mortality in the oldest-old. A comprehensive review

Nolen, S. C., Evans, M. A., Fischer, A., Corrada, M. M., Kawas, C. H., & Bota, D. A. (2017) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2017.05.002 · Cited by 122 · see citing works

Persistent degenerative changes in thymic organ function revealed by an inducible model of organ regrowth

Griffith, A. V., Fallahi, M., Venables, T., & Petrie, H. T. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2011.00773.x · Cited by 120 · see citing works

Detection of Age-Dependent Changes in Healthy Adult Lungs With Diffusion-Weighted 3He MRI

Fain, S. B., Altes, T. A., Panth, S. R., et al. (2005) · Academic Radiology · doi:10.1016/j.acra.2005.08.005 · Cited by 120 · see citing works

Inflammation and aging: signaling pathways and intervention therapies

Li, X., Li, C., Zhang, W., Wang, Y., Qian, P., & Huang, H. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01502-8 · Cited by 1,443 · see citing works

Telomere dysfunction in ageing and age-related diseases

Rossiello, F., Jurk, D., Passos, J. F., & d’Adda di Fagagna, F. (2022) · Nature Cell Biology · doi:10.1038/s41556-022-00842-x · Cited by 754 · see citing works

COVID-19 and cellular senescence

Schmitt, C. A., Tchkonia, T., Niedernhofer, L. J., Robbins, P. D., Kirkland, J. L., & Lee, S. (2023) · Nature Reviews Immunology · doi:10.1038/s41577-022-00785-2 · Cited by 153 · see citing works

Pulmonary infection by SARS-CoV-2 induces senescence accompanied by an inflammatory phenotype in severe COVID-19: possible implications for viral mutagenesis

Evangelou, K., Veroutis, D., Paschalaki, K., Foukas, P. G., Lagopati, N., Dimitriou, M., Papaspyropoulos, A., Konda, B., Hazapis, O., Polyzou, A., et al. (2022) · European Respiratory Journal · doi:10.1183/13993003.02951-2021 · Cited by 98 · see citing works

The YAP-TEAD complex promotes senescent cell survival by lowering endoplasmic reticulum stress

Anerillas, C., Mazan-Mamczarz, K., Herman, A. B., Munk, R., Lam, K.-W. G., Calvo-Rubio, M., Garrido, A., Tsitsipatis, D., Martindale, J. L., Altés, G., et al. (2023) · Nature Aging · doi:10.1038/s43587-023-00480-4 · Cited by 76 · see citing works

Nuclear envelope disruption triggers hallmarks of aging in lung alveolar macrophages

De Silva, N. S., Siewiera, J., Alkhoury, C., Nader, G. P. F., Nadalin, F., de Azevedo, K., Couty, M., Izquierdo, H. M., Bhargava, A., Conrad, C., et al. (2023) · Nature Aging · doi:10.1038/s43587-023-00488-w · Cited by 34 · see citing works

Erythromycin attenuates oxidative stress-induced cellular senescence via the PI3K-mTOR signaling pathway in chronic obstructive pulmonary disease

Xiaofei, Y., Tingting, L., Xuan, W., & Zhiyi, H. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1043474 · Cited by 31 · see citing works

SenCat: Cataloging human cell senescence through multi-omic profiling of multiple senescent primary cell types

Anerillas, C., Altés, G., Gresova, K., Tsitsipatis, D., Mazan-Mamczarz, K., Banarjee, R., Cunningham, A. S. G., Salamini-Montemurri, M., Yang, J.-H., Munk, R., et al. (2026) · Molecular Cell · doi:10.1016/j.molcel.2026.05.017 · Cited by 11 · see citing works

The Innate Immune System

Heeg, K. M. (2007) · Neuroimmune biology · doi:10.1016/s1567-7443(07)00205-0

Aspects of the innate and adaptive immune responses to acute infections with BVDV

Brackenbury, L. S., Carr, B. V., & Charleston, B. (2003) · Veterinary Microbiology · doi:10.1016/j.vetmic.2003.09.004 · Cited by 58 · see citing works

Do adaptive immune cells suppress or activate innate immunity?

Zhao, J., Yang, X., Auh, S. L., Kim, K. D., Tang, H., & Fu, Y. (2008) · Trends in Immunology · doi:10.1016/j.it.2008.10.003 · Cited by 40 · see citing works

Earthworm and innate immunity

Liu, Z., & Niu, B. (2008) · Int J Immunol · doi:10.3760/cma.j.issn.1673-4394.2008.04.005

Innate and adaptive immunity

Noakes, P. S., & Michaelis, L. J. (2013) · Elsevier eBooks · doi:10.1533/9780857095749.1.3 · Cited by 12 · see citing works