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Cited by 437

The DOI matches its Crossref record; 71 of the 71 references it cites were found in a registry or an index.

Stimulation of subterritories of the subthalamic nucleus reveals its role in the integration of the emotional and motor aspects of behavior

Open access
Mallet, Luc, Schüpbach, Michael, N'Diaye, Karim, Remy, Philippe, Bardinet, Eric, Czernecki, Virginie, Welter, Marie-Laure, Pelissolo, Antoine, Ruberg, Merle, Agid, Yves, Yelnik, Jérôme·2007·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.0610849104
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Abstract

Two parkinsonian patients who experienced transient hypomanic states when the subthalamic nucleus (STN) was stimulated during postoperative adjustment of the electrical parameters for antiparkinsonian therapy agreed to have the mood disorder reproduced, in conjunction with motor, cognitive, and behavioral evaluations and concomitant functional neuroimaging. During the experiment, STN stimulation again induced a hypomanic state concomitant with activation of cortical and thalamic regions known to process limbic and associative information. This observation suggests that the STN plays a role in the control of a complex behavior that includes emotional as well as cognitive and motor components. The localization of the four contacts of the quadripolar electrode was determined precisely with an interactive brain atlas. The results showed that (i) the hypomanic state was caused only by stimulation through one contact localized in the anteromedial STN; (ii) both this contact and the contact immediately dorsal to it improved the parkinsonian motor state; (iii) the most dorsal and ventral contacts, located at the boundaries of the STN, neither induced the behavioral disorder nor improved motor performance. Detailed analysis of these data led us to consider a model in which the three functional modalities, emotional, cognitive, and motor, are not processed in a segregated manner but can be subtly combined in the small volume of the STN. This nucleus would thus serve as a nexus that integrates the motor, cognitive, and emotional components of behavior and might consequently be an effective target for the treatment of behavioral disorders that combine emotional, cognitive, and motor impairment.

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Metadata

Authors
Mallet, L., Schüpbach, M., N'Diaye, K., Remy, P., Bardinet, E., Czernecki, V., Welter, M.-L., Pelissolo, A., Ruberg, M., Agid, Y., & Yelnik, J.
Venue
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Published
2007-06-19
Volume
104
Issue
25
Pages
10661-10666
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.0610849104
OpenAlex
W2059631807
Cited by
437
References
71
FWCI
15.56
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Stimulation of subterritories of the subthalamic nucleus reveals its role in the integration of the emotional and motor aspects of behavior. https://app.cochat.ai/papers/10.1073/pnas.0610849104
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Mallet, L., Schüpbach, M., N'Diaye, K., Remy, P., Bardinet, E., Czernecki, V., Welter, M.-L., Pelissolo, A., Ruberg, M., Agid, Y., & Yelnik, J. (2007). Stimulation of subterritories of the subthalamic nucleus reveals its role in the integration of the emotional and motor aspects of behavior. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0610849104

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.