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The role of pannexin 1 hemichannels in ATP release and cell–cell communication in mouse taste buds
Open accessAbstract
ATP has been shown to be a taste bud afferent transmitter, but the cells responsible for, and the mechanism of, its release have not been identified. Using CHO cells expressing high-affinity neurotransmitter receptors as biosensors, we show that gustatory stimuli cause receptor cells to secrete ATP through pannexin 1 hemichannels in mouse taste buds. ATP further stimulates other taste cells to release a second transmitter, serotonin. These results provide a mechanism to link intracellular Ca 2+ release during taste transduction to secretion of afferent transmitter, ATP, from receptor cells. They also indicate a route for cell–cell communication and signal processing within the taste bud.
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Citations
Cited by
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Yarmolinsky, D. A., Zuker, C. S., & Ryba, N. J. P. (2009) · Cell · doi:10.1016/j.cell.2009.10.001 · Cited by 856
Eyo, U. B., Peng, J., Swiatkowski, P., Mukherjee, A., Bispo, A., & Wu, L.-J. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.0416-14.2014 · Cited by 509
Liman, E. R., Zhang, Y. V., & Montell, C. (2014) · Neuron · doi:10.1016/j.neuron.2014.02.022 · Cited by 473
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Di Virgilio, F. (2007) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2007.07.002 · Cited by 493
Pannexin 1: The Molecular Substrate of Astrocyte “Hemichannels”
Iglesias, R., Dahl, G., Qiu, F., Spray, D. C., & Scemes, E. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.6062-08.2009 · Cited by 353
Metadata
- Authors
- Huang, Y.-J., Maruyama, Y., Dvoryanchikov, G., Pereira, E., Chaudhari, N., & Roper, S. D.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2007-04-10
- Volume
- 104
- Issue
- 15
- Pages
- 6436-6441
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2014669864
- Cited by
- 532
- References
- 0
- FWCI
- 28.67
- Type
- journal article
- Language
- en
- Open access
- green
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- Huang, Y.-J., Maruyama, Y., Dvoryanchikov, G., Pereira, E., Chaudhari, N., & Roper, S. D. (2007). The role of pannexin 1 hemichannels in ATP release and cell–cell communication in mouse taste buds. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0611280104
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