Liaisons dangereuses: P2X7 and the inflammasome

Innate immune recognition

Janeway, C. A., & Medzhitov, R. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.083001.084359 · Cited by 8,394 · see citing works

The Inflammasome

Martinon, F., Burns, K., & Tschopp, J. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00599-3 · Cited by 6,066 · see citing works

Gout-associated uric acid crystals activate the NALP3 inflammasome

Martinon, F., Pétrilli, V., Mayor, A., Tardivel, A., & Tschopp, J. (2006) · Nature · doi:10.1038/nature04516 · Cited by 5,326 · see citing works

The Danger Model: A Renewed Sense of Self

Matzinger, P. (2002) · Science · doi:10.1126/science.1071059 · Cited by 4,205 · see citing works

Cryopyrin activates the inflammasome in response to toxins and ATP

Mariathasan, S., Weiss, D. S., Newton, K., McBride, J., O'Rourke, K., Roose-Girma, M., Lee, W. P., Weinrauch, Y., Monack, D. M., & Dixit, V. M. (2006) · Nature · doi:10.1038/nature04515 · Cited by 3,080 · see citing works

Molecular Physiology of P2X Receptors

North, R. A. (2002) · Physiological Reviews · doi:10.1152/physrev.00015.2002 · Cited by 2,919 · see citing works

Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf

Mariathasan, S., Newton, K., Monack, D. M., Vucic, D., French, D. M., Lee, W. P., Roose-Girma, M., Erickson, S. L., & Dixit, V. M. (2004) · Nature · doi:10.1038/nature02664 · Cited by 1,822 · see citing works

The Cytolytic P _2Z Receptor for Extracellular ATP Identified as a P _2X Receptor (P2X ₇ )

Surprenant, A., Rassendren, F., Kawashima, E., North, R. A., & Buell, G. (1996) · Science · doi:10.1126/science.272.5262.735 · Cited by 1,739 · see citing works

Pannexin‐1 mediates large pore formation and interleukin‐1β release by the ATP‐gated P2X7 receptor

Pelegrı́n, P., & Surprenant, A. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601378 · Cited by 1,428 · see citing works

Intracellular pattern recognition receptors in the host response

Meylan, E., Tschopp, J., & Karin, M. (2006) · Nature · doi:10.1038/nature04946 · Cited by 1,196 · see citing works

Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3

Kanneganti, T., Özören, N., Body–Malapel, M., Amer, A. O., Park, J., Franchi, L., Whitfield, J. R., Barchet, W., Colonna, M., Vandenabeele, P., et al. (2006) · Nature · doi:10.1038/nature04517 · Cited by 1,149 · see citing works

Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1β in salmonella-infected macrophages

Franchi, L., Amer, A., Body-Malapel, M., Kanneganti, T.-D., Özören, N., Jagirdar, R., Inohara, N., Vandenabeele, P., Bertin, J., Coyle, A., et al. (2006) · Nature Immunology · doi:10.1038/ni1346 · Cited by 1,131 · see citing works

Adenosine 5′-triphosphate and adenosine as endogenous signaling molecules in immunity and inflammation

Bours, M. J. L., Swennen, E. L. R., Di Virgilio, F., Cronstein, B. N., & Dagnelie, P. C. (2006) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2005.04.013 · Cited by 1,030 · see citing works

The P2X7 Receptor: A Key Player in IL-1 Processing and Release

Ferrari, D., Pizzirani, C., Adinolfi, E., Lemoli, R. M., Curti, A., Idzko, M., Panther, E., & Di Virgilio, F. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.7.3877 · Cited by 1,025 · see citing works

Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1

Sutterwala, F. S., Ogura, Y., Szczepanik, M., Lara-Tejero, M., Lichtenberger, G. S., Grant, E. P., Bertin, J., Coyle, A. J., Galán, J. E., Askenase, P. W., et al. (2006) · Immunity · doi:10.1016/j.immuni.2006.02.004 · Cited by 980 · see citing works

Inflammatory Caspases

Martinon, F., & Tschopp, J. (2004) · Cell · doi:10.1016/j.cell.2004.05.004 · Cited by 940 · see citing works

Altered Cytokine Production in Mice Lacking P2X7Receptors

Solle, M., Labasi, J. M., Perregaux, D. G., Stam, E. J., Petrushova, N., Koller, B. H., Griffiths, R., & Gabel, C. A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m006781200 · Cited by 924 · see citing works

Rapid Secretion of Interleukin-1β by Microvesicle Shedding

Mackenzie, A. B., Wilson, H. L., Kiss‐Toth, E., Dower, S., North, R. A., & Surprenant, A. (2001) · Immunity · doi:10.1016/s1074-7613(01)00229-1 · Cited by 862 · see citing works

Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin

Boyden, E. D., & Dietrich, W. F. (2006) · Nature Genetics · doi:10.1038/ng1724 · Cited by 860 · see citing works

Inflammatory caspases and inflammasomes: master switches of inflammation

Martinon, F., & Tschopp, J. (2006) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4402038 · Cited by 821 · see citing works

Pannexins, a family of gap junction proteins expressed in brain

Bruzzone, R., Hormuzdi, S. G., Barbe, M. T., Herb, A., & Monyer, H. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2233464100 · Cited by 776 · see citing works

Interleukin-1 beta maturation and release in response to ATP and nigericin. Evidence that potassium depletion mediated by these agents is a necessary and common feature of their activity.

Perregaux, D. G., & Gabel, C. A. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36591-2 · Cited by 760 · see citing works

Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspases

Deveraux, Q. L., Leo, E., Stennicke, H. R., Welsh, K., Salvesen, G. S., & Reed, J. C. (1999) · The EMBO Journal · doi:10.1093/emboj/18.19.5242 · Cited by 751 · see citing works

NALPs: a novel protein family involved in inflammation

Tschopp, J., Martinon, F., & Burns, K. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1019 · Cited by 719 · see citing works

Reconstituted NALP1 Inflammasome Reveals Two-Step Mechanism of Caspase-1 Activation

Faustin, B., Lartigue, L., Bruey, J., Luciano, F., Sergienko, E. A., Bailly‐Maitre, B., Volkmann, N., Hanein, D., Rouiller, I., & Reed, J. C. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.01.032 · Cited by 709 · see citing works

P hysiological C ontrol of I mmune R esponse and I nflammatory T issue D amage by H ypoxia -I nducible F actors and A denosine A 2A R eceptors

Sitkovsky, M. V., Lukashev, D. E., Apasov, S. G., Kojima, H., Koshiba, M., Caldwell, C. C., Ohta, A., & Thiel, M. (2004) · Annual Review of Immunology · doi:10.1146/annurev.immunol.22.012703.104731 · Cited by 697 · see citing works

NLRs join TLRs as innate sensors of pathogens

Martinon, F., & Tschopp, J. (2005) · Trends in Immunology · doi:10.1016/j.it.2005.06.004 · Cited by 673 · see citing works

Extracellular ATP triggers IL-1 beta release by activating the purinergic P2Z receptor of human macrophages

Ferrari, D., Chiozzi, P., Falzoni, S., Susino, M. D., Melchiorri, L., Baricordi, O. R., & Virgilio, F. D. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.159.3.1451 · Cited by 616 · see citing works

Pathophysiology and Therapeutic Potential of Purinergic Signaling

Burnstock, G. (2006) · Pharmacological Reviews · doi:10.1124/pr.58.1.5 · Cited by 609 · see citing works

The IL-1 family and inflammatory diseases.

Dinarello, C. A. (2002) · PubMed · Cited by 600 · see citing works

A ubiquitous family of putative gap junction molecules

Panchina, Y., Kelmanson, I. V., Matz, M. V., Lukyanov, K. A., Usman, N. Y., & Lukyanov, S. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00576-5 · Cited by 559 · see citing works

The B30.2 domain of pyrin, the familial Mediterranean fever protein, interacts directly with caspase-1 to modulate IL-1β production

Chae, J. J., Wood, G., Masters, S. L., Richard, K., Park, G. S. H., Smith, B. J., & Kastner, D. L. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0602081103 · Cited by 555 · see citing works

Historical review: ATP as a neurotransmitter

Burnstock, G. (2006) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2006.01.005 · Cited by 539 · see citing works

The role of pannexin 1 hemichannels in ATP release and cell–cell communication in mouse taste buds

Huang, Y.-J., Maruyama, Y., Dvoryanchikov, G. A., Pereira, E., Chaudhari, N., & Roper, S. D. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611280104 · Cited by 533 · see citing works

The Birc1e cytosolic pattern-recognition receptor contributes to the detection and control of Legionella pneumophila infection

Zamboni, D. S., Kobayashi, K. S., Kohlsdorf, T., Ogura, Y., Long, E. M., Vance, R. E., Kuida, K., Mariathasan, S., Dixit, V. M., Flavell, R. A., et al. (2006) · Nature Immunology · doi:10.1038/ni1305 · Cited by 515 · see citing works

Caspase-1 Activation of Lipid Metabolic Pathways in Response to Bacterial Pore-Forming Toxins Promotes Cell Survival

Gurcel, L., Abrami, L., Girardin, S. E., Tschopp, J., & van der Goot, F. G. (2006) · Cell · doi:10.1016/j.cell.2006.07.033 · Cited by 508 · see citing works

P2X7 receptor inhibition improves recovery after spinal cord injury

Wang, X., Arcuino, G., Takano, T., Lin, J. H.-C., Peng, W. G., Wan, P., Li, P., Xu, Q., Liu, Q. S., Goldman, S. A., et al. (2004) · Nature Medicine · doi:10.1038/nm1082 · Cited by 495 · see citing works

Blocking IL-1 in systemic inflammation

Dinarello, C. A. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20050640 · Cited by 494 · see citing works

The Inflammasome: First Line of the Immune Response to Cell Stress

Ogura, Y., Sutterwala, F. S., & Flavell, R. A. (2006) · Cell · doi:10.1016/j.cell.2006.08.002 · Cited by 474 · see citing works

Purinergic Modulation of Interleukin-1β Release from Microglial Cells Stimulated with Bacterial Endotoxin

Ferrari, D., Chiozzi, P., Falzoni, S., Hanau, S., & Virgilio, F. D. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.185.3.579 · Cited by 474 · see citing works

The orphan receptor GPR17 identified as a new dual uracil nucleotides/cysteinyl‐leukotrienes receptor

Ciana, P., Fumagalli, M., Trincavelli, M. L., Verderio, C., Rosa, P., Lecca, D., Ferrario, S., Parravicini, C., Capra, V., Gelosa, P., et al. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601341 · Cited by 438 · see citing works

Pannexin1 is part of the pore forming unit of the P2X7 receptor death complex

Locovei, S., Scemes, E., Qiu, F., Spray, D. C., & Dahl, G. (2007) · FEBS Letters · doi:10.1016/j.febslet.2006.12.056 · Cited by 434 · see citing works

A-740003 [N-(1-{[(Cyanoimino)(5-quinolinylamino) methyl]amino}-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide], a Novel and Selective P2X7 Receptor Antagonist, Dose-Dependently Reduces Neuropathic Pain in the Rat

Honoré, P., Donnelly‐Roberts, D. L., Namovic, M. T., Hsieh, G. C., Zhu, C., Mikusa, J. P., Hernandez, G., Zhong, C., Gauvin, D. M., Chandran, P., et al. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.111559 · Cited by 418 · see citing works

Phospholipases C and A 2 control lysosome-mediated IL-1β secretion: Implications for inflammatory processes

Andrei, C., Margiocco, P., Poggi, A. D., Lotti, L. V., Torrisi, M. R., & Rubartelli, A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308558101 · Cited by 409 · see citing works

The P2Z purinoceptor: an intriguing role in immunity, inflammation and cell death

Virgilio, F. D. (1995) · Immunology Today · doi:10.1016/0167-5699(95)80045-x · Cited by 374 · see citing works

Oxidized ATP. An irreversible inhibitor of the macrophage purinergic P2Z receptor.

Murgia, M., Hanau, S., Pizzo, P., Rippa, M., & Virgilio, F. D. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53082-9 · Cited by 367 · see citing works

ATP Release From Activated Neutrophils Occurs via Connexin 43 and Modulates Adenosine-Dependent Endothelial Cell Function

Eltzschig, H. K., Eckle, T. D. L. G., Mager, A., Küper, N., Karcher, C., Weissmüller, T., Boengler, K., Schulz, R., Robson, S. C., & Colgan, S. P. (2006) · Circulation Research · doi:10.1161/01.res.0000250174.31269.70 · Cited by 354 · see citing works

Familial autoinflammatory diseases: genetics, pathogenesis and treatment

STOJANOV, S., & Kastner, D. L. (2005) · Current Opinion in Rheumatology · doi:10.1097/bor.0000174210.78449.6b · Cited by 348 · see citing works

CATERPILLERs, pyrin and hereditary immunological disorders

Ting, J. P. ‐., Kastner, D. L., & Hoffman, H. M. (2006) · Nature reviews. Immunology · doi:10.1038/nri1788 · Cited by 342 · see citing works

CD39 is the dominant Langerhans cell–associated ecto-NTPDase: Modulatory roles in inflammation and immune responsiveness

Mizumoto, N., Kumamoto, T., Robson, S. C., Sévigny, J., Matsue, H., Enjyoji, K., & Takashima, A. (2002) · Nature Medicine · doi:10.1038/nm0402-358 · Cited by 327 · see citing works

Pannexin-1 Couples to Maitotoxin- and Nigericin-induced Interleukin-1β Release through a Dye Uptake-independent Pathway

Pelegrı́n, P., & Surprenant, A. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m610351200 · Cited by 301 · see citing works

Pharmacology of P2X channels

Gever, J. R., Cockayne, D. A., Dillon, M. P., Burnstock, G., & Ford, A. P. D. W. (2006) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-006-0070-9 · Cited by 298 · see citing works

Stimulation of P2 receptors causes release of IL-1β–loaded microvesicles from human dendritic cells

Pizzirani, C., Ferrari, D., Chiozzi, P., Adinolfi, E., Sandonà, D., Savaglio, E., & Virgilio, F. D. (2006) · Blood · doi:10.1182/blood-2005-06-031377 · Cited by 280 · see citing works

Kinetics and Mechanism of ATP-Dependent IL-1β Release from Microglial Cells

Sanz, J. M., & Virgilio, F. D. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.9.4893 · Cited by 274 · see citing works

The ‘danger’ sensors that STOP the immune response: the A2 adenosine receptors?

Sitkovsky, M. V., & Ohta, A. (2005) · Trends in Immunology · doi:10.1016/j.it.2005.04.004 · Cited by 265 · see citing works

Extracellular ATP Induces a Distorted Maturation of Dendritic Cells and Inhibits Their Capacity to Initiate Th1 Responses

la Sala, A., Ferrari, D., Corinti, S., Cavani, A., Virgilio, F. D., & Girolomoni, G. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.3.1611 · Cited by 226 · see citing works

Alerting and tuning the immune response by extracellular nucleotides

la Sala, A., Ferrari, D., Virgilio, F. D., Idzko, M., Norgauer, J., & Girolomoni, G. (2003) · Journal of Leukocyte Biology · doi:10.1189/jlb.0802418 · Cited by 211 · see citing works

Physiological Concentrations of K+ Inhibit Cytochrome c-dependent Formation of the Apoptosome

Cain, K., Langlais, C., Sun, X.-M., Brown, D. G., & Cohen, G. M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m107419200 · Cited by 197 · see citing works

Evidence that the gap junction protein connexin-43 is the ATP-induced pore of mouse macrophages

Beyer, E. C., & Steinberg, T. H. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)92924-8 · Cited by 196 · see citing works

ATP Treatment of Human Monocytes Promotes Caspase-1 Maturation and Externalization

Laliberte, R. E., Eggler, J. F., & Gabel, C. A. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.52.36944 · Cited by 138 · see citing works

Characterization of a selective and potent antagonist of human P2X7receptors, AZ11645373

Stokes, L., Jiang, L., Alcaraz, L., Bent, J., Bowers, K., Fagura, M., Furber, M., Mortimore, M., Lawson, M., Theaker, J., et al. (2006) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706933 · Cited by 134 · see citing works

Hit-to-Lead studies: The discovery of potent adamantane amide P2X7 receptor antagonists

Baxter, A., Bent, J., Bowers, K. C., Braddock, M., Brough, S., Fagura, M., Lawson, M., McInally, T., Mortimore, M., Robertson, M. J., et al. (2003) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2003.08.034 · Cited by 122 · see citing works

P2Z purinoceptor-associated pores induced by extracellular ATP in macrophages and J774 cells

Coutinho‐Silva, R., & Persechini, P. M. (1997) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1997.273.6.c1793 · Cited by 119 · see citing works

Calcium signalling during cell interactions with bacterial pathogens

Nhieu, G. T. V., Clair, C., Grompone, G., et al. (2004) · Biology of the Cell · doi:10.1016/j.biolcel.2003.10.006 · Cited by 110 · see citing works

Purinergic mechanism in the immune system: A signal of danger for dendritic cells

Virgilio, F. D. (2005) · Purinergic Signalling · doi:10.1007/s11302-005-6312-z · Cited by 96 · see citing works

Increased Mature Interleukin-1β (IL-1β) Secretion from THP-1 Cells Induced by Nigericin Is a Result of Activation of p45 IL-1β-converting Enzyme Processing

Cheneval, D., Ramage, P., Kastelic, T., Szelestenyi, T., Niggli, H., Hemmig, R., Bachmann, M. F., & MacKenzie, A. R. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.28.17846 · Cited by 78 · see citing works

Immunostimulatory combinations: designing the next generation of vaccine adjuvants

Kornbluth, R. S., & Stone, G. W. (2006) · Journal of Leukocyte Biology · doi:10.1189/jlb.0306147 · Cited by 77 · see citing works

Synthesis and Biological Activity of N-Arylpiperazine-Modified Analogues of KN-62, a Potent Antagonist of the Purinergic P2X7 Receptor

Baraldi, P. G., Núñez, M. D. C., Morelli, A., et al. (2003) · Journal of Medicinal Chemistry · doi:10.1021/jm021049d · Cited by 68 · see citing works

Synthesis and SAR of novel 4,5-diarylimidazolines as potent P2X7 receptor antagonists

Merriman, G. H., Ma, L., Shum, P. W., et al. (2004) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2004.10.052 · Cited by 56 · see citing works

Unraveling the NALP-3/IL-1β Inflammasome

Dinarello, C. A. (2004) · Immunity · doi:10.1016/s1074-7613(04)00055-x · Cited by 56 · see citing works

Modulation of Inflammation by Extracellular Nucleotides

Boeynaems, J., & Communi, D. (2006) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700233 · Cited by 51 · see citing works

Two pathways for ATP release from host cells in enteropathogenicEscherichia coliinfection

Crane, J. K., Naeher, T. M., Choudhari, S. S., & Giroux, E. M. (2005) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00137.2005 · Cited by 31 · see citing works

Untitled work

Kalina (2002) · doi:10.1002/1521-4141(200209)32:9

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).

Klionsky, D. J., Abdelmohsen, K., Abe, A., Abedin, M. J., Abeliovich, H., Acevedo Arozena, A., Adachi, H., Adams, C. M., Adams, P. D., Adeli, K., et al. (2016) · Autophagy · doi:10.1080/15548627.2015.1100356 · Cited by 5,894 · see citing works

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) ¹

Klionsky, D. J., Abdel-Aziz, A. K., Abdelfatah, S., Abdellatif, M., Abdoli, A., Abel, S., Abeliovich, H., Abildgaard, M. H., Abudu, Y. P., Acevedo-Arozena, A., et al. (2021) · Autophagy · doi:10.1080/15548627.2020.1797280 · Cited by 2,622 · see citing works

Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β–dependent adaptive immunity against tumors

Ghiringhelli, F., Apetoh, L., Tesniere, A., Aymeric, L., Ma, Y., Ortiz, C., Vermaelen, K., Panaretakis, T., Mignot, G., Ullrich, E., et al. (2009) · Nature Medicine · doi:10.1038/nm.2028 · Cited by 1,898 · see citing works

Immunogenic and tolerogenic cell death

Green, D. R., Ferguson, T., Zitvogel, L., & Kroemer, G. (2009) · Nature Reviews Immunology · doi:10.1038/nri2545 · Cited by 1,176 · see citing works

Consensus guidelines for the detection of immunogenic cell death

Kepp, O., Senovilla, L., Vitale, I., Vacchelli, E., Adjemian, S., Agostinis, P., Apetoh, L., Aranda, F., Barnaba, V., Bloy, N., et al. (2014) · OncoImmunology · doi:10.4161/21624011.2014.955691 · Cited by 832 · see citing works

Increased Level of Extracellular ATP at Tumor Sites: In Vivo Imaging with Plasma Membrane Luciferase

Pellegatti, P., Raffaghello, L., Bianchi, G., Piccardi, F., Pistoia, V., & Di Virgilio, F. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002599 · Cited by 668 · see citing works

Sterile inflammation in the liver

Kubes, P., & Mehal, W. Z. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.09.008 · Cited by 666 · see citing works

Beginnings of a Good Apoptotic Meal: The Find-Me and Eat-Me Signaling Pathways

Ravichandran, K. S. (2011) · Immunity · doi:10.1016/j.immuni.2011.09.004 · Cited by 559 · see citing works

Neutrophil P2X7 receptors mediate NLRP3 inflammasome-dependent IL-1β secretion in response to ATP

Karmakar, M., Katsnelson, M. A., Dubyak, G. R., & Pearlman, E. (2016) · Nature Communications · doi:10.1038/ncomms10555 · Cited by 450 · see citing works

Extracellular ATP Is a Danger Signal Activating P2X7 Receptor in Lung Inflammation and Fibrosis

Riteau, N., Gasse, P., Fauconnier, L., Gombault, A., Couegnat, M., Fick, L., Kanellopoulos, J., Quesniaux, V. F. J., Marchand-Adam, S., Crestani, B., et al. (2010) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201003-0359oc · Cited by 397 · see citing works

Dealing with danger in the CNS: the response of the immune system to injury

Gadani, S. P., Walsh, J. T., Lukens, J. R., & Kipnis, J. (2015) · Neuron · doi:10.1016/j.neuron.2015.05.019 · Cited by 342 · see citing works

P2X7-Dependent Release of Interleukin-1β and Nociception in the Spinal Cord following Lipopolysaccharide

Clark, A. K., Staniland, A. A., Marchand, F., Kaan, T. K. Y., McMahon, S. B., & Malcangio, M. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.3295-09.2010 · Cited by 291 · see citing works

The role of the innate immune system in psychiatric disorders

Jones, K. A., & Thomsen, C. (2013) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2012.10.002 · Cited by 274 · see citing works

The microglial ATP‐gated ion channel P2X7 as a CNS drug target

Bhattacharya, A., & Biber, K. (2016) · Glia · doi:10.1002/glia.23001 · Cited by 221 · see citing works

P2X Receptors in Health and Disease

Burnstock, G., & Kennedy, C. (2011) · Advances in Pharmacology · doi:10.1016/b978-0-12-385526-8.00011-4 · Cited by 213 · see citing works

P2X4 receptor controls microglia activation and favors remyelination in autoimmune encephalitis

Zabala, A., Vazquez‐Villoldo, N., Rissiek, B., Gejo, J., Martin, A., Palomino, A., Perez‐Samartín, A., Pulagam, K. R., Lukowiak, M., Capetillo‐Zarate, E., et al. (2018) · EMBO Molecular Medicine · doi:10.15252/emmm.201708743 · Cited by 192 · see citing works

P2X7‐dependent, but differentially regulated release of IL‐6, CCL2, and TNF‐α in cultured mouse microglia

Shieh, C., Heinrich, A., Serchov, T., van Calker, D., & Biber, K. (2014) · Glia · doi:10.1002/glia.22628 · Cited by 179 · see citing works

Neuronal P2X7 Receptors Revisited: Do They Really Exist?

Illes, P., Khan, T. M., & Rubini, P. (2017) · The Journal of Neuroscience · doi:10.1523/jneurosci.3103-16.2017 · Cited by 179 · see citing works

Significance of P2X7 Receptor Variants to Human Health and Disease

Sluyter, R., & Stokes, L. (2011) · Recent Patents on DNA & Gene Sequences · doi:10.2174/187221511794839219 · Cited by 147 · see citing works

Immunoregulation through extracellular nucleotides

Vitiello, L., Gorini, S., Rosano, G., & la Sala, A. (2012) · Blood · doi:10.1182/blood-2012-01-406496 · Cited by 135 · see citing works

Tissue damaging toxins in snake venoms: mechanisms of action, pathophysiology and treatment strategies

Bittenbinder, M. A., van Thiel, J., Cardoso, F. C., Casewell, N. R., Gutiérrez, J.-M., Kool, J., & Vonk, F. J. (2024) · Communications Biology · doi:10.1038/s42003-024-06019-6 · Cited by 132 · see citing works

Dynamic changes in the Streptococcus pneumoniae transcriptome during transition from biofilm formation to invasive disease upon influenza A virus infection

Pettigrew, M. M., Marks, L. R., Kong, Y., Gent, J. F., Roche-Hakansson, H., & Hakansson, A. P. (2014) · Infection and Immunity · doi:10.1128/iai.02225-14 · Cited by 110 · see citing works

Overexpression of ATP-activated P2X7 Receptors in the Intestinal Mucosa Is Implicated in the Pathogenesis of Crohnʼs Disease

Neves, A. R., Castelo-Branco, M. T. L., Figliuolo, V. R., Bernardazzi, C., Buongusto, F., Yoshimoto, A., Nanini, H. F., Coutinho, C. M. L. M., Carneiro, A. J. V., Coutinho-Silva, R., et al. (2014) · Inflammatory Bowel Diseases · doi:10.1097/01.mib.0000441201.10454.06 · Cited by 107 · see citing works

Activation of P2X7 Receptor by ATP Plays an Important Role in Regulating Inflammatory Responses during Acute Viral Infection

Lee, B. H., Hwang, D. M., Palaniyar, N., Grinstein, S., Philpott, D. J., & Hu, J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0035812 · Cited by 102 · see citing works

Electro-Acupuncture Alleviates Chronic Unpredictable Stress-Induced Depressive- and Anxiety-Like Behavior and Hippocampal Neuroinflammation in Rat Model of Depression

Yue, N., Li, B., Yang, L., Han, Q.-Q., Huang, H.-J., Wang, Y.-L., Wang, J., Yu, R., Wu, G.-C., Liu, Q., et al. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00149 · Cited by 100 · see citing works

P2X7 Receptor Modulates Inflammatory and Functional Pulmonary Changes Induced by Silica

Monção-Ribeiro, L. C., Faffe, D. S., Santana, P. T., Vieira, F. S., da Graça, C. L. A. L., Marques-da-Silva, C., Machado, M. N., Caruso-Neves, C., Zin, W. A., Borojevic, R., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0110185 · Cited by 71 · see citing works

Blockage of P2X7 attenuates acute lung injury in mice by inhibiting NLRP3 inflammasome

Wang, S., Zhao, J., Wang, H., Liang, Y., Yang, N., & Huang, Y. (2015) · International Immunopharmacology · doi:10.1016/j.intimp.2015.04.035 · Cited by 68 · see citing works

Pleiotropic Roles of P2X7 in the Central Nervous System

Kanellopoulos, J. M., & Delarasse, C. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00401 · Cited by 48 · see citing works

ATP-Gated P2X7 Receptors Require Chloride Channels To Promote Inflammation in Human Macrophages

Janks, L., Sprague, R. S., & Egan, T. M. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1801101 · Cited by 45 · see citing works

Reactive astrocytes and perivascular macrophages express <scp>NLRP</scp>3 inflammasome in active demyelinating lesions of multiple sclerosis and necrotic lesions of neuromyelitis optica and cerebral infarction

Kawana, N., Yamamoto, Y., Ishida, T., Saito, Y., Konno, H., Arima, K., & Satoh, J. (2013) · Clinical and Experimental Neuroimmunology · doi:10.1111/cen3.12068 · Cited by 34 · see citing works

Potentiation of the glutamatergic synaptic input to rat locus coeruleus neurons by P2X7 receptors

Khakpay, R., Polster, D., Köles, L., Skorinkin, A., Szabo, B., Wirkner, K., & Illes, P. (2010) · Purinergic Signalling · doi:10.1007/s11302-010-9198-3 · Cited by 24 · see citing works

Lipopolysaccharide induces and activates the Nalp3 inflammasome in the liver

Michał, Ganz, Timea, Csak, Bharath, Nath, Gyongyi, & Szabó (2011) · Acta Scientiarum Naturalium Universitatis Sunyatseni · Cited by 1 · see citing works

Gout-associated uric acid crystals activate the NALP3 inflammasome

Martinon, F., Pétrilli, V., Mayor, A., Tardivel, A., & Tschopp, J. (2006) · Nature · doi:10.1038/nature04516 · Cited by 5,326 · see citing works

IL-1-3 IL-1 and the inflammasome

Hoffman, H. M. (2010) · Cytokine · doi:10.1016/j.cyto.2010.07.041

The inflammasome, autoinflammatory diseases, and gout

Pétrilli, V., & Martinon, F. (2007) · Joint Bone Spine · doi:10.1016/j.jbspin.2007.04.004 · Cited by 101 · see citing works

Inflammasomes and related diseases

Saito, M. K. (2011) · Japanese Journal of Clinical Immunology · doi:10.2177/jsci.34.20 · Cited by 1 · see citing works