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Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme.

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Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase

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N OVEL N EURAL M ODULATORS

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D-serine is an endogenous ligand for the glycine site of the N-methyl-D-aspartate receptor.

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Glia-Derived d-Serine Controls NMDA Receptor Activity and Synaptic Memory

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Serine racemase: A glial enzyme synthesizing <scp>d</scp> -serine to regulate glutamate- <i>N</i> -methyl- <scp>d</scp> -aspartate neurotransmission

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(S)NO Signals: Translocation, Regulation, and a Consensus Motif

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Nitric Oxide Acts Directly in the Presynaptic Neuron to Produce Long-Term Potentiationin Cultured Hippocampal Neurons

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Neuron-derived D-Serine Release Provides a Novel Means to Activate N-Methyl-D-aspartate Receptors

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Cofactors of serine racemase that physiologically stimulate the synthesis of the N -methyl- d -aspartate (NMDA) receptor coagonist d -serine

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Serine Racemase Modulates Intracellular D-Serine Levels through an α,β-Elimination Activity

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Receptor-regulated Dynamic S-Nitrosylation of Endothelial Nitric-oxide Synthase in Vascular Endothelial Cells

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Serine racemase: activation by glutamate neurotransmission via glutamate receptor interacting protein and mediation of neuronal migration.

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Ion homeostasis in brain cells: differences in intracellular ion responses to energy limitation between cultured neurons and glial cells

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S‐Nitrosoglutathione in Rat Cerebellum: Identification and Quantification by Liquid Chromatography‐Mass Spectrometry

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IV. Nitric oxide synthase gene knockout mice

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Retrograde messengers, long-term potentiation and memory

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Regulation of serine racemase activity by d-serine and nitric oxide in human glioblastoma cells

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Mutual regulation between serine and nitric oxide metabolism in human glioblastoma cells

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Ketamine-Induced Loss of Phenotype of Fast-Spiking Interneurons Is Mediated by NADPH-Oxidase

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Signaling by Gasotransmitters

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S-nitrosylation of histone deacetylase 2 induces chromatin remodelling in neurons

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Redox Signaling Mediated by Thioredoxin and Glutathione Systems in the Central Nervous System

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Aberrant Protein S-Nitrosylation in Neurodegenerative Diseases

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Detection of protein S-nitrosylation with the biotin-switch technique

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Redox dysregulation, neuroinflammation, and NMDA receptor hypofunction: A “central hub” in schizophrenia pathophysiology?

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Serine racemase is predominantly localized in neurons in mouse brain

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Interleukin-6 Mediates the Increase in NADPH-Oxidase in the Ketamine Model of Schizophrenia

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NMDA- and β-Amyloid1–42-Induced Neurotoxicity Is Attenuated in Serine Racemase Knock-Out Mice

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Does schizophrenia arise from oxidative dysregulation of parvalbumin-interneurons in the developing cortex?

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Serine racemase and the serine shuttle between neurons and astrocytes

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Pathogenic disruption of DISC1-serine racemase binding elicits schizophrenia-like behavior via D-serine depletion

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Regulation of N-methyl-d-aspartate receptors by astrocytic d-serine

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Drug Discovery Targeting Amino Acid Racemases

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D-Serine: Potential Therapeutic Agent and/or Biomarker in Schizophrenia and Depression?

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Metabolism of the neuromodulator d-serine

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Regulation of brain glutamate metabolism by nitric oxide and S-nitrosylation

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Contributions of the d-serine pathway to schizophrenia

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Prenatal exposure to environmental insults and enhanced risk of developing Schizophrenia and Autism Spectrum Disorder: focus on biological pathways and epigenetic mechanisms

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The involvement of the NMDA receptor d-serine/glycine site in the pathophysiology and treatment of schizophrenia

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Redox regulation of protein misfolding, mitochondrial dysfunction, synaptic damage, and cell death in neurodegenerative diseases

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Serine Racemase Deletion Protects Against Cerebral Ischemia and Excitotoxicity

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Cell-type specific mechanisms of D-serine uptake and release in the brain

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Redox Signaling in Neurotransmission and Cognition During Aging

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d-Serine as the gatekeeper of NMDA receptor activity: implications for the pharmacologic management of anxiety disorders

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d-Amino acid metabolism in mammals: Biosynthesis, degradation and analytical aspects of the metabolic study

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Reduced serine racemase expression contributes to age-related deficits in hippocampal cognitive function

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Reversal of age‐related oxidative stress prevents hippocampal synaptic plasticity deficits by protecting <scp>d</scp>‐serine‐dependent NMDA receptor activation

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Encoding of the cough reflex in anesthetized guinea pigs

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The serine shuttle between glia and neurons: implications for neurotransmission and neurodegeneration

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Central regulation of the cough reflex: Therapeutic implications

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Nitric Oxide Signaling and Nitrosative Stress in Neurons: Role for S -Nitrosylation

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Feedback inactivation of D-serine synthesis by NMDA receptor-elicited translocation of serine racemase to the membrane

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Serine racemase: an unconventional enzyme for an unconventional transmitter

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The Neurobiology of d -Serine Signaling

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Glutamatergic regulation of serine racemase via reversal of PIP2 inhibition

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SNO-ing at the Nociceptive Synapse?

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Protein modifications involved in neurotransmitter and gasotransmitter signaling

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Inhibition of Human Serine Racemase, an Emerging Target for Medicinal Chemistry

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In Vivo d -Serine Hetero-Exchange through Alanine-Serine-Cysteine (ASC) Transporters Detected by Microelectrode Biosensors

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d ‐Amino acids in the brain: the biochemistry of brain serine racemase

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Nitric oxide-mediated modulation of calcium/calmodulin-dependent protein kinase II

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D-Serine Signaling and NMDAR-Mediated Synaptic Plasticity Are Regulated by System A-Type of Glutamine/D-Serine Dual Transporters

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Working memory deficits in neuronal nitric oxide synthase knockout mice: Potential impairments in prefrontal cortex mediated cognitive function

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Glycolytic flux controls d -serine synthesis through glyceraldehyde-3-phosphate dehydrogenase in astrocytes

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How Nox2-Containing NADPH Oxidase Affects Cortical Circuits in the NMDA Receptor Antagonist Model of Schizophrenia

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Cerebrospinal fluid biomarker candidates of schizophrenia: where do we stand?

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Serine Racemase Regulated by Binding to Stargazin and PSD-95

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D‐serine signalling as a prominent determinant of neuronal‐glial dialogue in the healthy and diseased brain

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d-serine in physiological and pathological brain aging

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d-Serine in the aging hippocampus

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Global analysis of S-nitrosylation sites in the wild type (APP) transgenic mouse brain: Clues for synaptic pathology

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Antidyskinetic Effect of 7-Nitroindazole and Sodium Nitroprusside Associated with Amantadine in a Rat Model of Parkinson’s Disease

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d-Serine: The right or wrong isoform?

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The Energy Landscape of Human Serine Racemase

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Protein kinase C activity regulates d-serine availability in the brain

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The plastic d-serine signaling pathway: Sliding from neurons to glia and vice-versa

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Serine racemase as a prime target for age‐related memory deficits

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Activity-Dependent Sulfhydration Signal Controls N-Methyl-D-Aspartate Subtype Glutamate Receptor-Dependent Synaptic Plasticity via Increasing d -Serine Availability

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Interference with cellular differentiation by D ‐serine through antagonism at N‐methyl‐ D ‐aspartate receptors composed of NR1 and NR3A subunits in chondrocytes

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Serine Racemase Knockout Mice

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ATP binding to human serine racemase is cooperative and modulated by glycine

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Glycine site agonists of the N‐methyl‐ d ‐aspartate receptor and Parkinson's disease: A hypothesis

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d -serine and schizophrenia: an update

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Modulation of Ionotropic Glutamate Receptors and Acid-Sensing Ion Channels by Nitric Oxide

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Methods for detection and characterization of protein S-nitrosylation

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Serine racemase: a key player in apoptosis and necrosis

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Serine racemase deficiency attenuates choroidal neovascularization and reduces nitric oxide and VEGF levels by retinal pigment epithelial cells

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Changes in Serine Racemase-Dependent Modulation of NMDA Receptor: Impact on Physiological and Pathological Brain Aging

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S‐nitrosation and neuronal plasticity

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Serine racemase suppresses chondrogenic differentiation in cartilage in a Sox9‐dependent manner

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Role of nitric oxide on defensive behavior and long-term aversive learning induced by chemical stimulation of the dorsolateral periaqueductal gray matter

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Nuclear Compartmentalization of Serine Racemase Regulates d-Serine Production

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D‐Serine metabolism in C6 glioma cells: Involvement of alanine‐serine‐cysteine transporter (ASCT2) and serine racemase (SRR) but not D‐amino acid oxidase (DAO)

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Retinal NMDA receptor function and expression are altered in a mouse lacking d -amino acid oxidase

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Regulation of human serine racemase activity and dynamics by halides, ATP and malonate

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Metal ion dependency of serine racemase from Dictyostelium discoideum

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Differential role of nitric oxide in the psychedelic symptoms induced by racemic ketamine and esketamine in human volunteers

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Exploiting racemases

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Osteoclastogenesis is negatively regulated by D ‐serine produced by osteoblasts

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FBXO22 Protein Is Required for Optimal Synthesis of the N-Methyl-d-Aspartate (NMDA) Receptor Coagonist d-Serine

Dikopoltsev, E., Foltyn, V. N., Zehl, M., Jensen, O. N., Mori, H., Radzishevsky, I. S., & Wolosker, H. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.618405 · Cited by 17 · see citing works

The inverse link between genetic risk for schizophrenia and migraine through NMDA (N-methyl-D-aspartate) receptor activation via D-serine

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Increased Sensitivity to Inflammatory Pain Induced by Subcutaneous Formalin Injection in Serine Racemase Knock-Out Mice

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Serine Racemase Expression Differentiates Aging from Alzheimer’s Brain

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Cross‐linking of serine racemase dimer by reactive oxygen species and reactive nitrogen species

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Roles of quaternary structure and cysteine residues in the activity of human serine racemase

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Arginine vasopressin regulated ASCT1 expression in astrocytes from stroke-prone spontaneously hypertensive rats and congenic SHRpch1_18 rats

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Reduced serine racemase expression in aging rat cerebellum is associated with oxidative DNA stress and hypermethylation in the promoter

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TGFβ1-Smad3 signaling mediates the formation of a stable serine racemase dimer in microglia.

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The allosteric interplay between S‐nitrosylation and glycine binding controls the activity of human serine racemase

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D-Serine Production, Degradation, and Transport in ALS: Critical Role of Methodology

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Human serine racemase is nitrosylated at multiple sites

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Paradox of schizophrenia genetics: is a paradigm shift occurring?

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Astrocytic dopamine D1 receptor modulates glutamatergic transmission and synaptic plasticity in the prefrontal cortex through d-serine

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Tyrosine 121 moves revealing a ligandable pocket that couples catalysis to ATP-binding in serine racemase

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The Role of Astrocytes in the Pathophysiology of Schizophrenia.

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Human serine racemase is nitrosylated at multiple sites

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The allosteric interplay between S‐nitrosylation and glycine binding controls the activity of human serine racemase

Marchesani, F., Gianquinto, E., Autiero, I., Michielon, A., Campanini, B., Faggiano, S., Bettati, S., Mozzarelli, A., Spyrakis, F., & Bruno, S. (2020) · FEBS Journal · doi:10.1111/febs.15645 · Cited by 12 · see citing works

A new strategy to decrease N -methyl- d -aspartate (NMDA) receptor coactivation: Inhibition of d -serine synthesis by converting serine racemase into an eliminase

Panizzutti, R., Miranda, J. D., Ribeiro, C. S., Engelender, S., & Wolosker, H. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.091002298 · Cited by 83 · see citing works

Feedback inactivation of D-serine synthesis by NMDA receptor-elicited translocation of serine racemase to the membrane

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Human serine racemase is allosterically modulated by NADH and reduced nicotinamide derivatives

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