The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Inactivation of menin, a Smad3-interacting protein, blocks transforming growth factor type β signaling
Open accessAbstract
Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder characterized by endocrine tumors of parathyroids, pancreatic islets, and anterior pituitary. The MEN1 gene encodes a nuclear protein called menin. In MEN1 carriers inactivating mutations give rise to a truncated product consistent with menin acting as a tumor suppressor gene. However, the role of menin in tumorigenesis and its physiological functions are not known. Here, we show that menin inactivation by antisense RNA antagonizes transforming growth factor type β-mediated cell growth inhibition. Menin interacts with Smad3, and antisense menin suppresses transforming growth factor type β-induced and Smad3-induced transcriptional activity by inhibiting Smad3/4-DNA binding at specific transcriptional regulatory sites. These results implicate a mechanism of tumorigenesis by menin inactivation.
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Cites
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Multiple endocrine neoplasia type 1 gene maps to chromosome 11 and is lost in insulinoma
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A mechanism of repression of TGFbeta / Smad signaling by oncogenic Ras
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Menin Interacts with the AP1 Transcription Factor JunD and Represses JunD-Activated Transcription
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Cited by
TGF-β Signaling in Tumor Suppression and Cancer Progression
Derynck, R., Akhurst, R. J., & Balmain, A. (2001) · Nature Genetics · doi:10.1038/ng1001-117 · Cited by 2,275
SPECIFICITY AND VERSATILITY IN TGF-β SIGNALING THROUGH SMADS
Feng, X.-H., & Derynck, R. (2005) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.21.022404.142018 · Cited by 1,869
The pathogenesis of pituitary tumours
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Metadata
- Authors
- Kaji, H., Canaff, L., Lebrun, J.-J., Goltzman, D., & Hendy, G. N.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2001-03-13
- Volume
- 98
- Issue
- 7
- Pages
- 3837-3842
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2074883939
- Cited by
- 300
- References
- 32
- FWCI
- 8.79
- Type
- journal article
- Language
- en
- Open access
- green
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- Kaji, H., Canaff, L., Lebrun, J.-J., Goltzman, D., & Hendy, G. N. (2001). Inactivation of menin, a Smad3-interacting protein, blocks transforming growth factor type β signaling. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.061358098
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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