Cited by 939Bacterial Genetics and BiotechnologyMicrobial Natural Products and BiosynthesisIron Metabolism and Disorders

The DOI matches its Crossref record; 80 of the 83 references it cites were found in a registry or an index.

Enterobactin: an archetype for microbial iron transport.

Open access

Raymond, Kenneth N., Dertz, Emily A., Kim, Sanggoo S.·2003·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.0630018100PMC PMC152965

Open this paper in CoChat — free account

Abstract

Bacteria have aggressive acquisition processes for iron, an essential nutrient. Siderophores are small iron chelators that facilitate cellular iron transport. The siderophore enterobactin is a triscatechol derivative of a cyclic triserine lactone. Studies of the chemistry, regulation, synthesis, recognition, and transport of enterobactin make it perhaps the best understood of the siderophore-mediated iron uptake systems, displaying a lot of function packed into this small molecule. However, recent surprises include the isolation of corynebactin, a closely related trithreonine triscatechol derivative lactone first found in Gram-positive bacteria, and the crystal structure of a ferric enterobactin complex of a protein identified as an antibacterial component of the human innate immune system.

Integrity signals

Registry

Crossref · 10.1073/pnas.0630018100

Cites

80 of 80 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Siderophores: Structure and Function of Microbial Iron Transport Compounds
Neilands, J. B. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.45.26723 · Cited by 1,652
Iron Metabolism in Pathogenic Bacteria
Ratledge, C., & Dover, L. G. (2000) · Annual Review of Microbiology · doi:10.1146/annurev.micro.54.1.881 · Cited by 1,539
The Neutrophil Lipocalin NGAL Is a Bacteriostatic Agent that Interferes with Siderophore-Mediated Iron Acquisition
Goetz, D. H., Holmes, M. A., Borregaard, N., Bluhm, M. E., Raymond, K. N., & Strong, R. K. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00708-6 · Cited by 1,355
Self-citation
Isolation and primary structure of NGAL, a novel protein associated with human neutrophil gelatinase
Kjeldsen, L., Johnsen, A., Sengeløv, H., & Borregaard, N. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)82217-7 · Cited by 1,286
Chemistry and biology of eukaryotic iron metabolism
Aisen, P. (2001) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(01)00063-2 · Cited by 804
Iron and metal regulation in bacteria
Hantke, K. (2001) · Current Opinion in Microbiology · doi:10.1016/s1369-5274(00)00184-3 · Cited by 755
Iron transport in microbes, plants and animals
Danchin, A. (1988) · Biochimie · doi:10.1016/0300-9084(88)90122-8 · Cited by 607
Stoichiometric and site characteristics of the binding of iron to human transferrin
Aisen, P., Leibman, A., & Zweier, J. (1978) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)62337-9 · Cited by 601
Ferric uptake regulation protein acts as a repressor, employing iron (II) as a cofactor to bind the operator of an iron transport operon in Escherichia coli
Bagg, A., & Neilands, J. B. (1987) · Biochemistry · doi:10.1021/bi00391a039 · Cited by 593
Crystal structure of the outer membrane active transporter FepA from Escherichia coli.
Buchanan (1999) · Nature Structural Biology · doi:10.1038/4931 · Cited by 591
Iron carriers and iron proteins
Loehr, T. M. (1989) · Wiley-VCH eBooks · Cited by 434
Enterobactin, an iron transport compound from Salmonella typhimurium
Pollack, J. R., & Neilands, J. B. (1970) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(70)90819-3 · Cited by 433
Induction of NGAL synthesis in epithelial cells of human colorectal neoplasia and inflammatory bowel diseases.
Nielsen, B. S., Borregaard, N., Bundgaard, J. R., Timshel, S., Sehested, M., & Kjeldsen, L. (1996) · Gut · doi:10.1136/gut.38.3.414 · Cited by 422
Bacterial solutions to the iron-supply problem
Braun, V., & Killmann, H. (1999) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(99)01359-6 · Cited by 407
Iron transport in microbes, plants, and animals
Winkelmann, G., der Helm, D. V., & Neilands, J. B. (1987) · Cited by 380
Induction of Apoptosis by a Secreted Lipocalin That is Transcriptionally Regulated by IL-3 Deprivation
Devireddy, L. R., Teodoro, J. G., Richard, F. A., & Green, M. R. (2001) · Science · doi:10.1126/science.1061075 · Cited by 380
The dhb Operon of Bacillus subtilisEncodes the Biosynthetic Template for the Catecholic Siderophore 2,3-Dihydroxybenzoate-Glycine-Threonine Trimeric Ester Bacillibactin
May, J. J., Wendrich, T. M., & Marahiel, M. A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m009140200 · Cited by 370
The structure of enterochelin and related 2,3-dihydroxy-N-benzoyne conjugates from Eschericha Coli
O'Brien, I. G., & Gibson, F. (1970) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(70)90038-3 · Cited by 366
Role of iron in the pathogenesis of Vibrio vulnificus infections
Wright, A. C., Simpson, L. M., & Oliver, J. D. (1981) · Infection and Immunity · doi:10.1128/iai.34.2.503-507.1981 · Cited by 343
Coordination chemistry and microbial iron transport
Raymond, K. N., & Carrano, C. J. (1979) · Accounts of Chemical Research · doi:10.1021/ar50137a004 · Cited by 298
Self-citation
Bacterial iron transport: mechanisms, genetics, and regulation.
Braun, V., Hantke, K., & Köster, W. L. (1998) · PubMed · Cited by 297
Effects of iron and desferrioxamine on infections with Yersinia enterocolitica
Robins-Browne, R. M., & Prpic, J. K. (1985) · Infection and Immunity · doi:10.1128/iai.47.3.774-779.1985 · Cited by 266
Iron uptake mechanisms and their regulation in pathogenic bacteria
Braun, V. (2001) · International Journal of Medical Microbiology · doi:10.1078/1438-4221-00103 · Cited by 249
Enterobactin Biosynthesis in Escherichia coli : Isochorismate Lyase (EntB) Is a Bifunctional Enzyme That Is Phosphopantetheinylated by EntD and Then Acylated by EntE Using ATP and 2,3-Dihydroxybenzoate
Gehring, A. M., Bradley, K. A., & Walsh, C. T. (1997) · Biochemistry · doi:10.1021/bi970453p · Cited by 227
Transferrin binding of Al3+ and Fe3+.
Martin, R. B., Savory, J., Brown, S., Bertholf, R. L., & Wills, M. R. (1987) · Clinical Chemistry · doi:10.1093/clinchem/33.3.405 · Cited by 217
Molecular studies on enzymes in chorismate metabolism and the enterobactin biosynthetic pathway
Walsh, C. T., Liu, J. O., Rusnak, F. M., & Sakaitani, M. (1990) · Chemical Reviews · doi:10.1021/cr00105a003 · Cited by 213
Cloning of the repressor protein gene of iron-regulated systems in Escherichia coli K12
Hantke, K. (1984) · Molecular and General Genetics MGG · doi:10.1007/bf00330982 · Cited by 203
Ligand Preference Inferred from the Structure of Neutrophil Gelatinase Associated Lipocalin
Goetz, D. H., Willie, S. T., Armen, R. S., Bratt, T., Borregaard, N., & Strong, R. K. (2000) · Biochemistry · doi:10.1021/bi992215v · Cited by 184
Constitutive expression of the iron-enterochelin and ferrichrome uptake systems in a mutant strain of Salmonella typhimurium
Ernst, J., Bennett, R. L., & Rothfield, L. I. (1978) · Journal of Bacteriology · doi:10.1128/jb.135.3.928-934.1978 · Cited by 173
Overexpression and purification of ferric enterobactin esterase from Escherichia coli. Demonstration of enzymatic hydrolysis of enterobactin and its iron complex.
Brickman, T. J., & McIntosh, M. A. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)49846-3 · Cited by 167
Assembly line enzymology by multimodular nonribosomal peptide synthetases: the thioesterase domain of E. coli EntF catalyzes both elongation and cyclolactonization
Shaw-Reid, C. A., Kelleher, N. L., Losey, H. C., Gehring, A. M., Berg, C., & Walsh, C. T. (1999) · Chemistry & Biology · doi:10.1016/s1074-5521(99)80050-7 · Cited by 163
Increased Incidence of Gram-Negative Neonatal Sepsis With Intramuscular Iron Administration
Barry, D. M., & Reeve, A. W. (1977) · PEDIATRICS · doi:10.1542/peds.60.6.908 · Cited by 157
Molecular and Cellular Iron Transport
(2002) · CRC Press eBooks · doi:10.1201/9780824744175.fmatt1 · Cited by 150
Biosynthesis of the Escherichia coli siderophore enterobactin: sequence of the entF gene, expression and purification of EntF, and analysis of covalent phosphopantetheine
Rusnak, F. M., Sakaitani, M., Drueckhammer, D. G., Reichert, J. M., & Walsh, C. T. (1991) · Biochemistry · doi:10.1021/bi00225a027 · Cited by 147
Mechanisms of iron acquisition and bacterial virulence
MartÃnez, J. L., Delgado‐Iribarren, A., & Baquero, F. (1990) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.1990.tb04085.x · Cited by 146
Increased incidence of gram-negative neonatal sepsis with intramuscula iron administration.
Barry, D. M., & Reeve, A. W. (1977) · PubMed · Cited by 143
Iron, DtxR, and the regulation of diphtheria toxin expression
Tao, X., Schiering, N., Zeng, H., Ringe, D., & Murphy, J. R. (1994) · Molecular Microbiology · doi:10.1111/j.1365-2958.1994.tb01280.x · Cited by 143
Nucleotide sequence of Escherichia coli isochorismate synthetase gene entC and evolutionary relationship of isochorismate synthetase and other chorismate-utilizing enzymes
Ozenberger, B. A., Brickman, T. J., & McIntosh, M. A. (1989) · Journal of Bacteriology · doi:10.1128/jb.171.2.775-783.1989 · Cited by 118
Rational reduction of the conformational space of a siderophore analog through nonbonded interactions: the role of entropy in enterobactin
Stack, T. D. P., Hou, Z., & Raymond, K. N. (1993) · Journal of the American Chemical Society · doi:10.1021/ja00067a094 · Cited by 111
Self-citation
Effect of serum albumin on siderophore-mediated utilization of transferrin iron
Konopka, K., & Neilands, J. B. (1984) · Biochemistry · doi:10.1021/bi00305a003 · Cited by 108
Coordination chemistry of microbial iron transport. 49. The vanadium(IV) enterobactin complex: structural, spectroscopic, and electrochemical characterization
Karpishin, T. B., Dewey, T. M., & Raymond, K. N. (1993) · Journal of the American Chemical Society · doi:10.1021/ja00058a032 · Cited by 108
Self-citation
The effect of iron compounds on the virulence of Escherichia coli for guinea-pigs.
Bullen, J. J., Leigh, L. C., & Rogers, H. J. (1968) · PubMed · Cited by 108
Iron and its sensitive balance in the cell
Freitas, J. M. D., & Meneghini, R. (2001) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(01)00066-5 · Cited by 101
Enterobactin: the characteristic catecholate siderophore of Enterobacteriaceae is produced byStreptomycesspecies
Fiedler, H., Krastel, P., MÃ¼ller, J., Gebhardt, K., & Zeeck, A. (2001) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2001.tb10556.x · Cited by 91
Effect of loop deletions on the binding and transport of ferric enterobactin by FepA
Newton, S. M. C., Igo, J. D., Scott, D. C., & Klebba, P. E. (1999) · Molecular Microbiology · doi:10.1046/j.1365-2958.1999.01424.x · Cited by 91
Iron and bacterial virulence–a brief overview.
Griffiths, E. (1991) · Biology of Metals · doi:10.1007/bf01135551 · Cited by 86
Recognition and transport of ferric enterobactin in Escherichia coli
Ecker, D. J., Matzanke, B. F., & Raymond, K. N. (1986) · Journal of Bacteriology · doi:10.1128/jb.167.2.666-673.1986 · Cited by 86
Self-citation
Synthesis of iron chelators. Enterobactin, enantioenterobactin, and a chiral analog
Rastetter, W. H., Erickson, T. J., & Venuti, M. C. (1981) · The Journal of Organic Chemistry · doi:10.1021/jo00331a001 · Cited by 86
Organization of genes encoding membrane proteins of the Escherichia coli ferrienterobactin permease
Chenault, S. S., & Earhart, C. F. (1991) · Molecular Microbiology · doi:10.1111/j.1365-2958.1991.tb00787.x · Cited by 83
Binding of Ferric Enterobactin by theEscherichia coliPeriplasmic Protein FepB
Sprencel, C., Cao, Z., Qi, Z., Scott, D. C., Montague, M. A., Ivanoff, N., Xu, J., Raymond, K., Newton, S. M. C., & Klebba, P. E. (2000) · Journal of Bacteriology · doi:10.1128/jb.182.19.5359-5364.2000 · Cited by 82
Self-citation
Iron and Infection: Molecular, physiological and clinical aspects
WILLIAMS, P. H. (1988) · Biochemical Society Transactions · doi:10.1042/bst0160078a · Cited by 78
Stereospecificity of the ferric enterobactin receptor of Escherichia coli K-12.
Neilands, J. B., Erickson, T. J., & Rastetter, W. H. (1981) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)69531-1 · Cited by 77
Selectivity of Ferric Enterobactin Binding and Cooperativity of Transport in Gram-Negative Bacteria
Thulasiraman, P., Newton, S. M. C., Xu, J., Raymond, K. N., Mai, C., Hall, A., Montague, M. A., & Klebba, P. E. (1998) · Journal of Bacteriology · doi:10.1128/jb.180.24.6689-6696.1998 · Cited by 74
Self-citation
A Multifunctional ATP-Binding Cassette Transporter System from Vibrio cholerae Transports Vibriobactin and Enterobactin
Wyckoff, E. E., Valle, A.-M., Smith, S. L., & Payne, S. M. (1999) · Journal of Bacteriology · doi:10.1128/jb.181.24.7588-7596.1999 · Cited by 74
Metal Ions in Biological Systems. Vol. 35: Iron Transport and Storage in Microorganisms, Plants and Animals
Bidlack, W. R. (1999) · Journal of the American College of Nutrition · doi:10.1080/07315724.1999.10718833 · Cited by 73
High-Yield Synthesis of the Enterobactin Trilactone and Evaluation of Derivative Siderophore Analogs1
Meyer, M., Telford, J. R., Cohen, S. M., White, D. J., Xu, J., & Raymond, K. N. (1997) · Journal of the American Chemical Society · doi:10.1021/ja970718n · Cited by 72
Self-citation
The First Structural Characterization of a Metal–Enterobactin Complex: [V(enterobactin)]2−
Karpishin, T. B., & Raymond, K. N. (1992) · Angewandte Chemie International Edition in English · doi:10.1002/anie.199204661 · Cited by 71
Self-citation
Structural and spectroscopic characterization of chiral ferric tris-catecholamides: unraveling the design of enterobactin
Stack, T. D. P., Karpishin, T. B., & Raymond, K. N. (1992) · Journal of the American Chemical Society · doi:10.1021/ja00030a075 · Cited by 71
Self-citation
The critical role of iron in some clinical infections
Bullen, J. J., Ward, C., & Rogers, H. J. (1991) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/bf01975810 · Cited by 71
Iron(III) coordination chemistry of linear dihydroxyserine compounds derived from enterobactin
Scarrow, R. C., Ecker, D. J., Ng, C. Y., Liu, S., & Raymond, K. N. (1991) · Inorganic Chemistry · doi:10.1021/ic00005a007 · Cited by 68
Self-citation
The plug domain of FepA, a TonB-dependent transport protein from Escherichia coli , binds its siderophore in the absence of the transmembrane barrel domain
Usher, K. C., Özkan, E., Gardner, K. H., & Deisenhofer, J. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.181353398 · Cited by 67
Enhanced iron(III) chelation through ligand predisposition: syntheses, structures and stability of tris-catecholate enterobactin analogs
Hou, Z., Stack, T. D. P., Sunderland, C. J., & Raymond, K. N. (1997) · Inorganica Chimica Acta · doi:10.1016/s0020-1693(97)05664-8 · Cited by 64
Self-citation
Total synthesis of enterobactin, a macrocyclic iron transporting agent of bacteria
Corey, E. J., & Bhattacharyya, S. (1977) · Tetrahedron Letters · doi:10.1016/s0040-4039(01)83390-6 · Cited by 62
Cluster of genes controlling synthesis and activation of 2,3-dihydroxybenzoic acid in production of enterobactin in Escherichia coli
Nahlik, M. S., Fleming, T. P., & McIntosh, M. A. (1987) · Journal of Bacteriology · doi:10.1128/jb.169.9.4163-4170.1987 · Cited by 61
Hemoglobin and Escherichia coli , a Lethal Intraperitoneal Combination
Bornside, G. H., Bouis, P. J., & Cohn, I. (1968) · Journal of Bacteriology · doi:10.1128/jb.95.5.1567-1571.1968 · Cited by 57
Iron and virulence in Shigella
Payne, S. M. (1989) · Molecular Microbiology · doi:10.1111/j.1365-2958.1989.tb00281.x · Cited by 57
The bacteriostatic effect of serum on Pasteurella septica and its abolition by iron compounds.
Bullen, J. J., Rogers, H. J., & Lewin, J. E. (1971) · PubMed · Cited by 53
Effect of iron compounds on antibacterial function of human polymorphs and plasma
Ward, C., Hammond, J. S., & Bullen, J. J. (1986) · Infection and Immunity · doi:10.1128/iai.51.3.723-730.1986 · Cited by 52
The Triolide of (R)‐3‐Hydroxybutyric acid—Direct Preparation from Polyhydroxybutyrate and Formation of a Crown Estercarbonyl Complex with Na Ions
Seebàch, D., Müller, H., Bürger, H. M., & Plattner, D. A. (1992) · Angewandte Chemie International Edition in English · doi:10.1002/anie.199204341 · Cited by 51
The spectroelectrochemical determination of the reduction potential of differic serum transferrin
Kretchmar, S. A., Reyes, Z. E., & Raymond, K. N. (1988) · Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology · doi:10.1016/0167-4838(88)90301-9 · Cited by 45
Self-citation
Corynebactin and Enterobactin: Related Siderophores of Opposite Chirality
Bluhm, M. E., Kim, S. S., Dertz, E. A., & Raymond, K. N. (2002) · Journal of the American Chemical Society · doi:10.1021/ja016651s · Cited by 45
Self-citation
Aromatic components of two ferric enterobactin binding sites in Escherichia coli FepA
Cao, Z., Qi, Z., Sprencel, C., Newton, S. M. C., & Klebba, P. E. (2000) · Molecular Microbiology · doi:10.1046/j.1365-2958.2000.02093.x · Cited by 45
Characterization of EntF as a serine‐activating enzyme
Reichert, J. M., Sakaitani, M., & Walsh, C. T. (1992) · Protein Science · doi:10.1002/pro.5560010410 · Cited by 44
Enzymatic hydrolysis of enterochelin and its iron complex in Escherichia coli K-12. Properties of enterochelin esterase
Greenwood, K. T., & Luke, R. K. J. (1978) · Biochimica et Biophysica Acta (BBA) - Enzymology · doi:10.1016/0005-2744(78)90216-4 · Cited by 44
Total synthesis of enterobactin via an organotin template
Shanzer, A., & Libman, J. (1983) · Journal of the Chemical Society Chemical Communications · doi:10.1039/c39830000846 · Cited by 44
Corynebactin, a Cyclic Catecholate Siderophore from
Budzikiewicz, H., Bössenkamp, A., Taraz, K., Pandey, A., & Meyer, J. (1997) · Zeitschrift für Naturforschung C · doi:10.1515/znc-1997-7-820 · Cited by 42
Conformationally Rigid Tricyclic Tripods: Synthesis and Application to Preparation of Enterobactin Analogs
Tse, B., & Kishi, Y. (1994) · The Journal of Organic Chemistry · doi:10.1021/jo00104a043 · Cited by 35
A much improved synthesis of the siderophore enterobactin
Ramirez, R. J. A., Karamanukyan, L., Ortiz, S., & Gutierrez, C. G. (1997) · Tetrahedron Letters · doi:10.1016/s0040-4039(96)02452-5 · Cited by 35
Corynebactin and a Serine Trilactone Based Analogue: Chirality and Molecular Modeling of Ferric Complexes
Bluhm, M. E., Hay, B. P., Kim, S. S., Dertz, E. A., & Raymond, K. N. (2002) · Inorganic Chemistry · doi:10.1021/ic025531y · Cited by 29
Self-citation
The availability of iron and the growth ofVibrio vulnificusin sera from patients with haemochromatosis
Chart, H., & Griffiths, E. (1985) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.1985.tb01596.x · Cited by 23

Research works printed but not linked: 5

J J Bullen, L C Leigh, H J Rogers Immunology 15, 581–588 (1968).
10.1016/0378-1097(90)90522-R · DOI
J J Bullen, H J Rogers, J E Lewin Immunology 20, 391–406 (1971).
A Trousseau Lect Clin Med 5, 95–117 (1872).
V Braun, K Hantke CRC Handbook of Microbial Iron Chelators, ed G Winkelmann (CRC, Boca Raton, FL), pp. 107–138 (1991).

Sorted by citations

Siderophore-Based Iron Acquisition and Pathogen Control
Miethke, M., & Marahiel, M. A. (2007) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00012-07 · Cited by 1,774
Chemistry and biology of siderophores
Hider, R. C., & Kong, X. (2010) · Natural Product Reports · doi:10.1039/b906679a · Cited by 1,722
Bioinspired catecholic chemistry for surface modification
Ye, Q., Zhou, F., & Liu, W. (2011) · Chemical Society Reviews · doi:10.1039/c1cs15026j · Cited by 1,177
Bacterial Iron Sources: From Siderophores to Hemophores
Wandersman, C., & Delepelaire, P. (2004) · Annual Review of Microbiology · doi:10.1146/annurev.micro.58.030603.123811 · Cited by 1,095
Nonribosomal Peptide Synthesis—Principles and Prospects
Süßmuth, R. D., & Mainz, A. (2017) · Angewandte Chemie International Edition · doi:10.1002/anie.201609079 · Cited by 986

See all 939

Authors: Raymond, K. N., Dertz, E. A., & Kim, S. S.
Affiliations: University of California, Berkeley (US)
ORCID: Raymond, Kenneth N.
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2003-03-24
Volume: 100
Issue: 7
Pages: 3584-3588
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.0630018100
PMC: PMC152965
OpenAlex: W1972422447
Cited by: 933
References: 83
Citations by year: 2026: 42 · 2025: 57 · 2024: 55 · 2023: 47 · 2022: 67 · 2021: 46 · 2020: 49 · 2019: 59 · 2018: 50 · 2017: 47 · 2016: 38 · 2015: 38 · 2014: 47 · 2013: 27 · 2012: 45
FWCI: 1.91
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute of Allergy and Infectious Diseases (R01AI011744, AI-11744)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Microbial Natural Products and Biosynthesis
Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Keywords: enterobactin, siderophores, bacterial iron acquisition, iron transport, siderophore biosynthesis, innate immunity, Gram-positive bacteria
MeSH terms: Bacteria, Binding Sites, Carrier Proteins, Enterobactin, Iron, Models, Molecular, Protein Conformation, Protein Structure, Secondary

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Enterobactin: an archetype for microbial iron transport.

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks