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Cited by 57Escherichia coli research studiesBacterial Genetics and BiotechnologySalmonella and Campylobacter epidemiology

Iron and virulence in Shigella

Open access
Payne, S. M.·1989·Molecular Microbiology
DOI 10.1111/j.1365-2958.1989.tb00281.x
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Abstract

Summary: Iron limitation, a condition encountered within mammalian hosts, induces the synthesis of a number of proteins in pathogenic Shigella species. These include several outer membrane proteins, Shiga toxin, and proteins involved in the biosynthesis and transport of high‐affinity iron‐binding compounds or siderophores. Although siderophores have been shown to play a major role in the virulence of some bacterial pathogens, these compounds do not appear to be essential for the virulence of Shigella species. Unlike those pathogens which are restricted to the extracellular compartments of the host, the Shigella species invade and multiply within host cells. Alternative iron‐acquisition systems, such as the ability to utilize haem‐iron, permit growth of the intracellular bacteria. Virulent shigellae also possess a cell‐surface haem‐binding protein, and synthesis of this protein correlates with infectivity and virulence. This protein does not appear to be involved in iron acquisition. Rather, it may allow the bacteria to coat themselves with haem compounds, thus enhancing their ability to interact with target host cells.

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  • Shigella has a number of different Fe transport systems that contribute to its ability to grow in diverse environments.

    “Shigella has a number of different Fe transport systems that contribute to the bacterium's ability to grow in these diverse environments [50].”

    From Strategies of intracellular pathogens for obtaining iron from the environment (2015) · cites this paper as [50]

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Research works printed but not linked: 2

  1. Lawior, K.M. (1987) Ph.D. Dissertation, University of Texas at Austin, USA.
  2. Winkelmann, G. etal. (eds). Weinheim: VCH Verlags- gesellschaft, pp. 99-110.

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Authors
Payne, S. M.
Affiliations
The University of Texas at Austin (US)
Corresponding author
Payne, S. M.
ORCID
Payne, S. M.
Venue
Molecular Microbiology
Publisher
Wiley
Published
1989-09
Volume
3
Issue
9
Pages
1301-1306
ISSN
  • 0950-382X (ISSN-L)
  • 1365-2958
DOI
10.1111/j.1365-2958.1989.tb00281.x
OpenAlex
W2166243297
Cited by
57
References
30
Citations by year
2022: 1 · 2021: 1 · 2017: 1 · 2015: 2 · 2014: 1 · 2012: 3
FWCI
1.06
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 6265 d)
Locations
  • Molecular Microbiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Escherichia coli research studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Salmonella and Campylobacter epidemiology
Keywords
Shigella, iron limitation, virulence, siderophores, Shiga toxin, outer membrane proteins, iron acquisition, intracellular bacterial growth, host cell invasion
MeSH terms
Biological Transport, Iron, Mutation, Shigella, Virulence

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