The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Neuregulin 1–erbB2 signaling is required for the establishment of radial glia and their transformation into astrocytes in cerebral cortex
Open accessAbstract
Radial glial cells and astrocytes function to support the construction and maintenance, respectively, of the cerebral cortex. However, the mechanisms that determine how radial glial cells are established, maintained, and transformed into astrocytes in the cerebral cortex are not well understood. Here, we show that neuregulin-1 (NRG-1) exerts a critical role in the establishment of radial glial cells. Radial glial cell generation is significantly impaired in NRG mutants, and this defect can be rescued by exogenous NRG-1. Down-regulation of expression and activity of erbB2, a member of the NRG-1 receptor complex, leads to the transformation of radial glial cells into astrocytes. Reintroduction of erbB2 transforms astrocytes into radial glia. The activated form of the Notch1 receptor, which promotes the radial glial phenotype, activates the erbB2 promoter in radial glial cells. These results suggest that developmental changes in NRG-1–erbB2 interactions modulate the establishment of radial glia and contribute to their appropriate transformation into astrocytes.
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Cites
Mode of cell migration to the superficial layers of fetal monkey neocortex
Rakic, P. (1972) · Journal of Comparative Neurology · doi:10.1002/cne.901450105 · Cited by 2,170
Astrocytes give rise to new neurons in the adult mammalian hippocampus
Seri, B., Garcı́a-Verdugo, J. M., McEwen, B. S., & Alvarez-Buylla, A. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-18-07153.2001 · Cited by 1,495
Isolation of radial glial cells by fluorescent-activated cell sorting reveals a neuronal lineage
Malatesta, P., Hartfuss, E., & Götz, M. (2000) · Development · doi:10.1242/dev.127.24.5253 · Cited by 1,157
Cited by
The origin and development of glial cells in peripheral nerves
Jessen, K. R., & Mirsky, R. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1746 · Cited by 1,354
Neuregulin 1 in neural development, synaptic plasticity and schizophrenia
Mei, L., & Xiong, W.-C. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2392 · Cited by 1,030
Niche-Independent Symmetrical Self-Renewal of a Mammalian Tissue Stem Cell
Conti, L., Pollard, S. M., Gorba, T., Reitano, E., Toselli, M., Biella, G., Sun, Y., Sanzone, S., Ying, Q.-L., Cattaneo, E., et al. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030283 · Cited by 870
Timing Is Everything: Making Neurons versus Glia in the Developing Cortex
Miller, F. D., & Gauthier, A. S. (2007) · Neuron · doi:10.1016/j.neuron.2007.04.019 · Cited by 588
Notch signaling in the mammalian central nervous system: insights from mouse mutants
Yoon, K., & Gaiano, N. (2005) · Nature Neuroscience · doi:10.1038/nn1475 · Cited by 587
Metadata
- Authors
- Schmid, R. S., McGrath, B., Berechid, B. E., Boyles, B., Marchionni, M., Šestan, N., & Anton, E. S.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2003-03-20
- Volume
- 100
- Issue
- 7
- Pages
- 4251-4256
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1968983678
- Cited by
- 210
- References
- 3
- FWCI
- 4.21
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Neuregulin 1–erbB2 signaling is required for the establishment of radial glia and their transformation into astrocytes in cerebral cortex. https://app.cochat.ai/papers/10.1073/pnas.0630496100
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- Schmid, R. S., McGrath, B., Berechid, B. E., Boyles, B., Marchionni, M., Šestan, N., & Anton, E. S. (2003). Neuregulin 1–erbB2 signaling is required for the establishment of radial glia and their transformation into astrocytes in cerebral cortex. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0630496100
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