Timing Is Everything: Making Neurons versus Glia in the Developing Cortex
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During development of the mammalian nervous system, neural stem cells generate neurons first and glia second, thereby allowing the initial establishment of neural circuitry, and subsequent matching of glial numbers and position to that circuitry. Here, we have reviewed work addressing the mechanisms underlying this timed cell genesis, with a particular focus on the developing cortex. These studies have defined an intriguing interplay between intrinsic epigenetic status, transcription factors, and environmental cues, all of which work together to establish this fascinating and complex biological timing mechanism.
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During human brain development, precursors differentiate into neurons first and glial cells later.
“During human brain development, precursors differentiate into neurons first and glial cells later [91].”
From The ASD Living Biology: from cell proliferation to clinical phenotype (2019) · cites this paper as [91]
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Neurogenin3 participates in gliogenesis in the developing vertebrate spinal cord.
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Radial glial cells defined and major intermediates between embryonic stem cells and CNS neurons.
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Further Studies of the Distribution of CDF/LIF mRNA
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The essential haematopoietic transcription factor Scl is also critical for neuronal development
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Cell Lineage and Patterns of Migration in the Developing Cortex
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- Authors
- Miller, F. D., & Gauthier, A. S.
- Affiliations
- University of Toronto (CA)
- Corresponding author
- Miller, Freda D.
- ORCID
- Miller, Freda D.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2007-05
- Volume
- 54
- Issue
- 3
- Pages
- 357-369
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2063721381
- Cited by
- 588
- References
- 113
- Citations by year
- 2026: 17 · 2025: 22 · 2024: 22 · 2023: 31 · 2022: 32 · 2021: 45 · 2020: 39 · 2019: 35 · 2018: 37 · 2017: 18 · 2016: 32 · 2015: 22 · 2014: 29 · 2013: 39 · 2012: 24
- FWCI
- 3.05
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 2269 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Keywords
- cortical development, neural stem cells, cell fate specification, epigenetic regulation, transcription factors, environmental cues, neural circuits
- MeSH terms
- Animals, Cell Differentiation, Cerebral Cortex, Models, Biological, Neuroglia, Neurons, Stem Cells, Transcription Factors, Epigenesis, Genetic
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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