Cited by 588Neurogenesis and neuroplasticity mechanismsDevelopmental Biology and Gene RegulationCongenital heart defects research

Timing Is Everything: Making Neurons versus Glia in the Developing Cortex

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Miller, Freda D., Gauthier, Andrée S.·2007·Neuron

Abstract

During development of the mammalian nervous system, neural stem cells generate neurons first and glia second, thereby allowing the initial establishment of neural circuitry, and subsequent matching of glial numbers and position to that circuitry. Here, we have reviewed work addressing the mechanisms underlying this timed cell genesis, with a particular focus on the developing cortex. These studies have defined an intriguing interplay between intrinsic epigenetic status, transcription factors, and environmental cues, all of which work together to establish this fascinating and complex biological timing mechanism.

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Crossref · 10.1016/j.neuron.2007.04.019

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Authors
Miller, F. D., & Gauthier, A. S.
Affiliations
University of Toronto (CA)
Corresponding author
Miller, Freda D.
Venue
Neuron
Publisher
Elsevier BV
Published
2007-05
Volume
54
Issue
3
Pages
357-369
ISSN
0896-6273 (ISSN-L)
OpenAlex
W2063721381
Cited by
588
References
113
Citations by year
2026: 17 · 2025: 22 · 2024: 22 · 2023: 31 · 2022: 32 · 2021: 45 · 2020: 39 · 2019: 35 · 2018: 37 · 2017: 18 · 2016: 32 · 2015: 22 · 2014: 29 · 2013: 39 · 2012: 24
FWCI
3.05
Type
journal article
Language
en
Open access
Locations
  • Neuron (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
Keywords
cortical development, neural stem cells, cell fate specification, epigenetic regulation, transcription factors, environmental cues, neural circuits
MeSH terms
Animals, Cell Differentiation, Cerebral Cortex, Models, Biological, Neuroglia, Neurons, Stem Cells, Transcription Factors, Epigenesis, Genetic

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