Cylindrical cell membranes in uniform applied electric fields: Validation of a transport lattice method
Abstract
The frequency and time domain transmembrane voltage responses of a cylindrical cell in an external electric field are calculated using a transport lattice, which allows solution of a variety of biologically relevant transport problems with complex cell geometry and field interactions. Here we demonstrate the method for a cylindrical membrane geometry and compare results with known analytical solutions. Results of transport lattice simulations on a Cartesian lattice are found to have discrepancies with the analytical solutions due to the limited volume of the system model and approximations for the local membrane model on the Cartesian lattice. Better agreement is attained when using a triangular mesh to represent the geometry rather than a Cartesian lattice. The transport lattice method can be readily extended to more sophisticated cell, organelle, and tissue configurations. Local membrane models within a system lattice can also include nonlinear responses such as electroporation and ion-channel gating.
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As the frequency of the field increases, the high membrane field gain diminishes, allowing for higher field intensities to penetrate into the cell.
“as the frequency of the field increases, the high membrane field gain diminishes, allowing for higher field intensities to penetrate into the cell.”
From An Overview of Sub-Cellular Mechanisms Involved in the Action of TTFields (2016) · cites this paper as [33]
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Background
- Authors
- Stewart Jr., D. A., Gowrishankar, T. R., Smith, K. C., & Weaver, J. C.
- Affiliations
- Harvard–MIT Division of Health Sciences and Technology (US)
- Venue
- IEEE Transactions on Biomedical Engineering
- Published
- 2005-10
- Volume
- 52
- Issue
- 10
- Pages
- 1643-1653
- ISSN
- 0018-9294 (ISSN-L)
- OpenAlex
- W2148171986
- Cited by
- 52
- References
- 34
- Citations by year
- 2025: 1 · 2023: 1 · 2022: 1 · 2020: 1 · 2019: 4 · 2018: 2 · 2017: 3 · 2016: 4 · 2015: 3 · 2014: 2 · 2013: 2 · 2012: 3
- FWCI
- 2.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- IEEE Transactions on Biomedical Engineering (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of General Medical Sciences (R01GM063857, R01-GM63857)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Electromagnetic Fields and Biological Effects
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Electromagnetic Simulation and Numerical Methods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Microbial Inactivation Methods
- Keywords
- transmembrane voltage, external electric field, membrane transport, triangular meshes, electroporation, channel gating, cell shape
- MeSH terms
- Animals, Cell Membrane, Dose-Response Relationship, Radiation, Electric Conductivity, Electromagnetic Fields, Humans, Membrane Potentials, Radiation Dosage, Radiometry
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