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Src phosphorylation of cortactin enhances actin assembly
Open accessAbstract
Src kinase mediates growth factor signaling and causes oncogenic transformation, which includes dramatic changes in the actin cytoskeleton, cell shape, and motility. Cortactin was discovered as a substrate for Src. How phosphorylation of cortactin can enhance actin assembly is unknown. Here, using an actin assembly system reconstituted from purified components, we demonstrate for the first time a biochemical mechanism by which Src phosphorylation of cortactin affects actin assembly. The adaptor Nck is an important component of the system, linking phosphorylated cortactin with neuronal WASp (N-WASp) and WASp-interacting protein (WIP) to activate Arp2/3 complex.
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Cited by
Regulation of Actin Assembly Associated With Protrusion and Adhesion in Cell Migration
Le Clainche, C., & Carlier, M.-F. (2008) · Physiological Reviews · doi:10.1152/physrev.00021.2007 · Cited by 849
The actin cytoskeleton in cancer cell motility
Olson, M. F., & Sahai, E. (2009) · Clinical & Experimental Metastasis · doi:10.1007/s10585-008-9174-2 · Cited by 572
Mader, C. C., Oser, M., Magalhaes, M. A. O., Bravo-Cordero, J. J., Condeelis, J., Koleske, A. J., & Gil-Henn, H. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-1432 · Cited by 294
Src Family Kinases as Therapeutic Targets in Advanced Solid Tumors: What We Have Learned So Far
Martellucci, S., Clementi, L., Sabetta, S., Mattei, V., Botta, L., & Angelucci, A. (2020) · Cancers · doi:10.3390/cancers12061448 · Cited by 139
Nallar, S. C., Kalakonda, S., Lindner, D. J., Lorenz, R. R., Lamarre, E., Weihua, X., & Kalvakolanu, D. V. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.440610 · Cited by 29
Metadata
- Authors
- Tehrani, S., Tomasevic, N., Weed, S., Sakowicz, R., & Cooper, J. A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2007-07-17
- Volume
- 104
- Issue
- 29
- Pages
- 11933-11938
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2138815602
- Cited by
- 239
- References
- 0
- FWCI
- 7.18
- Type
- journal article
- Language
- en
- Open access
- green
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- Tehrani, S., Tomasevic, N., Weed, S., Sakowicz, R., & Cooper, J. A. (2007). Src phosphorylation of cortactin enhances actin assembly. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0701077104
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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