The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Regulation of Actin Assembly Associated With Protrusion and Adhesion in Cell Migration
Abstract
To migrate, a cell first extends protrusions such as lamellipodia and filopodia, forms adhesions, and finally retracts its tail. The actin cytoskeleton plays a major role in this process. The first part of this review (sect. ii) describes the formation of the lamellipodial and filopodial actin networks. In lamellipodia, the WASP-Arp2/3 pathways generate a branched filament array. This polarized dendritic actin array is maintained in rapid treadmilling by the concerted action of ADF, profilin, and capping proteins. In filopodia, formins catalyze the processive assembly of nonbranched actin filaments. Cell matrix adhesions mechanically couple actin filaments to the substrate to convert the treadmilling into protrusion and the actomyosin contraction into traction of the cell body and retraction of the tail. The second part of this review (sect. iii) focuses on the function and the regulation of major proteins (vinculin, talin, tensin, and α-actinin) that control the nucleation, the binding, and the barbed-end growth of actin filaments in adhesions.
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Citations
Cites
Immune cell migration in inflammation: present and future therapeutic targets
Luster, A. D., Alon, R., & von Andrian, U. H. (2005) · Nature Immunology · doi:10.1038/ni1275 · Cited by 1,313
Formation of actin stress fibers and focal adhesions enhanced by Rho-kinase
Amano, M., Chihara, K., Kimura, K., Fukata, Y., Nakamura, N., Matsuura, Y., & Kaibuchi, K. (1997) · Science · doi:10.1126/science.275.5304.1308 · Cited by 1,077
Forscher, P., & Smith, S. J. (1988) · The Journal of cell biology · doi:10.1083/jcb.107.4.1505 · Cited by 854
Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck
Eden, S., Rohatgi, R., Podtelejnikov, A. V., Mann, M., & Kirschner, M. W. (2002) · Nature · doi:10.1038/nature00859 · Cited by 835
Blanchoin, L., Amann, K. J., Higgs, H. N., Marchand, J.-B., Kaiser, D. A., & Pollard, T. D. (2000) · Nature · doi:10.1038/35010008 · Cited by 586
Activation of Arp2/3 complex-mediated actin polymerization by cortactin
Uruno, T., Liu, J., Zhang, P., Fan, Y.-X., Egile, C., Li, R., Mueller, S. C., & Zhan, X. (2001) · Nature Cell Biology · doi:10.1038/35060051 · Cited by 568 · cited 1×
“The acidic domain and the tandem repeats are sufficient to stimulate the Arp2/3 complex (230, 243).”
BackgroundControl of actin dynamics in cell motility
Carlier, M.-F., & Pantaloni, D. (1997) · Journal of Molecular Biology · doi:10.1006/jmbi.1997.1062 · Cited by 351
Self-citationSun, Y., Martin, A. C., & Drubin, D. G. (2006) · Developmental Cell · doi:10.1016/j.devcel.2006.05.008 · Cited by 255
Cited by
Linking actin dynamics and gene transcription to drive cellular motile functions
Olson, E. N., & Nordheim, A. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2890 · Cited by 958
Actin in dendritic spines: connecting dynamics to function
Hotulainen, P., & Hoogenraad, C. C. (2010) · Journal of Cell Biology · doi:10.1083/jcb.201003008 · Cited by 815
Traction stress in focal adhesions correlates biphasically with actin retrograde flow speed
Gardel, M. L., Sabass, B., Ji, L., Danuser, G., Schwarz, U. S., & Waterman, C. M. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200810060 · Cited by 490
Turinetto, V., Vitale, E., & Giachino, C. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17071164 · Cited by 486
Role of Ion Channels and Transporters in Cell Migration
Schwab, A., Fabian, A., Hanley, P. J., & Stock, C. (2012) · Physiological Reviews · doi:10.1152/physrev.00018.2011 · Cited by 420
Metadata
- Authors
- Le Clainche, C., & Carlier, M.-F.
- Venue
- Physiological Reviews
- Publisher
- American Physiological Society
- Published
- 2008-04
- Volume
- 88
- Issue
- 2
- Pages
- 489-513
- ISSN
- 0031-9333 (ISSN-L)
- 1522-1210
- OpenAlex
- W2105809801
- Cited by
- 849
- References
- 8
- FWCI
- 3.65
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
