The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
An EGFR–Src–Arg–Cortactin Pathway Mediates Functional Maturation of Invadopodia and Breast Cancer Cell Invasion
Open accessAbstract
Invasive carcinoma cells use specialized actin polymerization–driven protrusions called invadopodia to degrade and possibly invade through the extracellular matrix (ECM) during metastasis. Phosphorylation of the invadopodium protein cortactin is a master switch that activates invadopodium maturation and function. Cortactin was originally identified as a hyperphosphorylated protein in v-Src–transformed cells, but the kinase or kinases that are directly responsible for cortactin phosphorylation in invadopodia remain unknown. In this study, we provide evidence that the Abl-related nonreceptor tyrosine kinase Arg mediates epidermal growth factor (EGF)–induced cortactin phosphorylation, triggering actin polymerization in invadopodia, ECM degradation, and matrix proteolysis–dependent tumor cell invasion. Both Src and Arg localize to invadopodia and are required for EGF-induced actin polymerization. Notably, Arg overexpression in Src knockdown cells can partially rescue actin polymerization in invadopodia while Src overexpression cannot compensate for loss of Arg, arguing that Src indirectly regulates invadopodium maturation through Arg activation. Our findings suggest a novel mechanism by which an EGFR–Src–Arg–cortactin pathway mediates functional maturation of invadopodia and breast cancer cell invasion. Furthermore, they identify Arg as a novel mediator of invadopodia function and a candidate therapeutic target to inhibit tumor invasion in vivo. Cancer Res; 71(5); 1730–41. ©2011 AACR.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Tumour-cell invasion and migration: diversity and escape mechanisms
Friedl, P., & Wolf, K. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1075 · Cited by 3,222
Wyckoff, J., Wang, W., Lin, E. Y., Wang, Y., Pixley, F., Stanley, E. R., Graf, T., Pollard, J. W., Segall, J., & Condeelis, J. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-1449 · Cited by 1,188
Self-citationYamaguchi, H., Wyckoff, J., & Condeelis, J. (2005) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2005.08.002 · Cited by 761
Self-citationMolecular mechanisms of invadopodium formation
Yamaguchi, H., Lorenz, M., Kempiak, S., Sarmiento, C., Coniglio, S., Symons, M., Segall, J., Eddy, R., Miki, H., Takenawa, T., et al. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200407076 · Cited by 669
Self-citationSabeh, F., Shimizu-Hirota, R., & Weiss, S. J. (2009) · Journal of Cell Biology · doi:10.1083/jcb.200807195 · Cited by 658
Artym, V. V., Zhang, Y., Seillier-Moiseiwitsch, F., Yamada, K. M., & Mueller, S. C. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-2177 · Cited by 617
Sabeh, F., Ota, I., Holmbeck, K., Birkedal-Hansen, H., Soloway, P., Balbin, M., Lopez-Otin, C., Shapiro, S., Inada, M., Krane, S., et al. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200408028 · Cited by 586
Wu, H., & Parsons, J. T. (1993) · The Journal of cell biology · doi:10.1083/jcb.120.6.1417 · Cited by 511
Matrix invasion by tumour cells: a focus on MT1-MMP trafficking to invadopodia
Poincloux, R., Lizárraga, F., & Chavrier, P. (2009) · Journal of Cell Science · doi:10.1242/jcs.034561 · Cited by 504
Loss of basement membrane components by invasive tumors but not by their benign counterparts.
Barsky, S. H., Siegal, G. P., Jannotta, F. S., & Liotta, L. A. (1983) · PubMed · Cited by 494
Cited by
Matrix Metalloproteinases Shape the Tumor Microenvironment in Cancer Progression
Niland, S., Riscanevo, A. X., & Eble, J. A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms23010146 · Cited by 503
Directed cell invasion and migration during metastasis
Bravo-Cordero, J. J., Hodgson, L., & Condeelis, J. (2012) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2011.12.004 · Cited by 462
Self-citationFunctions of cofilin in cell locomotion and invasion
Bravo-Cordero, J. J., Magalhaes, M. A. O., Eddy, R. J., Hodgson, L., & Condeelis, J. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3609 · Cited by 461
Self-citationRole of ABL family kinases in cancer: from leukaemia to solid tumours
Greuber, E. K., Smith-Pearson, P., Wang, J., & Pendergast, A. M. (2013) · Nature Reviews Cancer · doi:10.1038/nrc3563 · Cited by 432
Invadopodia Are Required for Cancer Cell Extravasation and Are a Therapeutic Target for Metastasis
Leong, H. S., Robertson, A. E., Stoletov, K., Leith, S. J., Chin, C. A., Chien, A. E., Hague, M. N., Ablack, A., Carmine-Simmen, K., McPherson, V. A., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.07.050 · Cited by 400
Metadata
- Authors
- Mader, C. C., Oser, M., Magalhaes, M. A. O., Bravo-Cordero, J. J., Condeelis, J., Koleske, A. J., & Gil-Henn, H.
- Venue
- Cancer Research
- Published
- 2011-03-01
- Volume
- 71
- Issue
- 5
- Pages
- 1730-1741
- ISSN
- 0008-5472 (ISSN-L)
- 1538-7445
- OpenAlex
- W2154561072
- Cited by
- 294
- References
- 45
- FWCI
- 11.85
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: An EGFR–Src–Arg–Cortactin Pathway Mediates Functional Maturation of Invadopodia and Breast Cancer Cell Invasion. https://app.cochat.ai/papers/10.1158/0008-5472.can-10-1432
- The paper
- Mader, C. C., Oser, M., Magalhaes, M. A. O., Bravo-Cordero, J. J., Condeelis, J., Koleske, A. J., & Gil-Henn, H. (2011). An EGFR–Src–Arg–Cortactin Pathway Mediates Functional Maturation of Invadopodia and Breast Cancer Cell Invasion. Cancer Research. https://doi.org/10.1158/0008-5472.can-10-1432
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
