The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Selective control of cortical axonal spikes by a slowly inactivating K+current
Open accessAbstract
Neurons are flexible electrophysiological entities in which the distribution and properties of ionic channels control their behaviors. Through simultaneous somatic and axonal whole-cell recording of layer 5 pyramidal cells, we demonstrate a remarkable differential expression of slowly inactivating K+currents. Depolarizing the axon, but not the soma, rapidly activated a low-threshold, slowly inactivating, outward current that was potently blocked by low doses of 4-aminopyridine, α-dendrotoxin, and rTityustoxin-Kα. Block of this slowly inactivating current caused a large increase in spike duration in the axon but only a small increase in the soma and could result in distal axons generating repetitive discharge in response to local current injection. Importantly, this current was also responsible for slow changes in the axonal spike duration that are observed after somatic membrane potential change. These data indicate that low-threshold, slowly inactivating K+currents, containing Kv1.2 α subunits, play a key role in the flexible properties of intracortical axons and may contribute significantly to intracortical processing.
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Cites
[6] Correction for liquid junction potentials in patch clamp experiments
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Kv3 channels: voltage-gated K+ channels designed for high-frequency repetitive firing
Rudy, B., & McBain, C. J. (2001) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01892-0 · Cited by 781
Chapter 12 Potassium currents in hippocampal pyramidal cells
Storm, J. F. (1990) · Progress in Brain Research · doi:10.1016/s0079-6123(08)61248-0 · Cited by 743
Zhang, L., & McBain, C. J. (1995) · The Journal of Physiology · doi:10.1113/jphysiol.1995.sp020998 · Cited by 193
Cell‐attached measurements of the firing threshold of rat hippocampal neurones
Fricker, D., Verheugen, J. A. H., & Miles, R. (1999) · The Journal of Physiology · doi:10.1111/j.1469-7793.1999.0791s.x · Cited by 160
Cited by
The subcellular organization of neocortical excitatory connections
Petreanu, L., Mao, T., Sternson, S. M., & Svoboda, K. (2009) · Nature · doi:10.1038/nature07709 · Cited by 1,047
Distinct contributions of Nav1.6 and Nav1.2 in action potential initiation and backpropagation
Hu, W., Tian, C., Li, T., Yang, M., Hou, H., & Shu, Y. (2009) · Nature Neuroscience · doi:10.1038/nn.2359 · Cited by 706
Self-citationSignal processing in the axon initial segment
Kole, M. H. P., & Stuart, G. J. (2012) · Neuron · doi:10.1016/j.neuron.2012.01.007 · Cited by 463
Localization and Targeting of Voltage-Dependent Ion Channels in Mammalian Central Neurons
Vacher, H., Mohapatra, D. P., & Trimmer, J. S. (2008) · Physiological Reviews · doi:10.1152/physrev.00002.2008 · Cited by 488
Axon Initial Segment Kv1 Channels Control Axonal Action Potential Waveform and Synaptic Efficacy
Kole, M. H. P., Letzkus, J. J., & Stuart, G. J. (2007) · Neuron · doi:10.1016/j.neuron.2007.07.031 · Cited by 451
Metadata
- Authors
- Shu, Y., Yu, Y., Yang, J., & McCormick, D. A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2007-07-03
- Volume
- 104
- Issue
- 27
- Pages
- 11453-11458
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2137393514
- Cited by
- 212
- References
- 5
- FWCI
- 6.11
- Type
- journal article
- Language
- en
- Open access
- green
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