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T cell activation requires mitochondrial translocation to the immunological synapse
Open accessAbstract
T helper (T h ) cell activation is required for the adaptive immune response. Formation of the immunological synapse (IS) between T h cells and antigen-presenting cells is essential for T h cell activation. IS formation induces the polarization and redistribution of many signaling molecules; however, very little is known about organelle redistribution during IS formation in T h cells. We show that formation of the IS induced cytoskeleton-dependent mitochondrial redistribution to the immediate vicinity of the IS. Using total internal reflection microscopy, we found that upon stimulation, the distance between the IS and mitochondria was decreased to values <200 nm. Consequently, mitochondria close to the IS took up more Ca 2+ than the ones farther away from the IS. The redistribution of mitochondria to the IS was necessary to maintain Ca 2+ influx across the plasma membrane and Ca 2+ -dependent T h cell activation. Our results suggest that mitochondria are part of the signaling complex at the IS and that their localization close to the IS is required for T h cell activation.
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Cites
Store-Operated Calcium Channels
Parekh, A. B., & Putney, J. W. (2005) · Physiological Reviews · doi:10.1152/physrev.00057.2003 · Cited by 2,089
Cited by
Store-Operated Calcium Channels
Prakriya, M., & Lewis, R. S. (2015) · Physiological Reviews · doi:10.1152/physrev.00020.2014 · Cited by 1,239
Mitochondria in the Regulation of Innate and Adaptive Immunity
Weinberg, S. E., Sena, L. A., & Chandel, N. S. (2015) · Immunity · doi:10.1016/j.immuni.2015.02.002 · Cited by 960
The machineries, regulation and cellular functions of mitochondrial calcium
Giorgi, C., Marchi, S., & Pinton, P. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0052-8 · Cited by 941
Pernas, L., & Scorrano, L. (2016) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021115-105011 · Cited by 817
Molecular Basis of Calcium Signaling in Lymphocytes: STIM and ORAI
Hogan, P. G., Lewis, R. S., & Rao, A. (2010) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132550 · Cited by 760
Metadata
- Authors
- Quintana, A., Schwindling, C., Wenning, A. S., Becherer, U., Rettig, J., Schwarz, E. C., & Hoth, M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2007-09-04
- Volume
- 104
- Issue
- 36
- Pages
- 14418-14423
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2000528910
- Cited by
- 345
- References
- 1
- FWCI
- 5.87
- Type
- journal article
- Language
- en
- Open access
- green
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- Quintana, A., Schwindling, C., Wenning, A. S., Becherer, U., Rettig, J., Schwarz, E. C., & Hoth, M. (2007). T cell activation requires mitochondrial translocation to the immunological synapse. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0703126104
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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