The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Suppression of androgen receptor-mediated gene expression by a sequence-specific DNA-binding polyamide
Open accessAbstract
Androgen receptor (AR) is essential for the growth and progression of prostate cancer in both hormone-sensitive and hormone-refractory disease. A DNA-binding polyamide that targets the consensus androgen response element binds the prostate-specific antigen (PSA) promoter androgen response element, inhibits androgen-induced expression of PSA and several other AR-regulated genes in cultured prostate cancer cells, and reduces AR occupancy at the PSA promoter and enhancer. Down-regulation of PSA by this polyamide was comparable to that produced by the synthetic antiandrogen bicalutamide (Casodex) at the same concentration. Genome-wide expression analysis reveals that a similar number of transcripts are affected by treatment with the polyamide and with bicalutamide. Direct inhibition of the AR-DNA interface by sequence-specific DNA binding small molecules could offer an alternative approach to antagonizing AR activity.
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Cites
Recurrent Fusion of TMPRSS2 and ETS Transcription Factor Genes in Prostate Cancer
Tomlins, S. A., Rhodes, D. R., Perner, S., Dhanasekaran, S. M., Mehra, R., Sun, X.-W., Varambally, S., Cao, X., Tchinda, J., Kuefer, R., et al. (2005) · Science · doi:10.1126/science.1117679 · Cited by 3,846
Molecular determinants of resistance to antiandrogen therapy
Chen, C. D., Welsbie, D. S., Tran, C., Baek, S. H., Chen, R., Vessella, R., Rosenfeld, M. G., & Sawyers, C. L. (2004) · Nature Medicine · doi:10.1038/nm972 · Cited by 2,278
Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA
Luisi, B. F., Xu, W. X., Otwinowski, Z., Freedman, L. P., Yamamoto, K. R., & Sigler, P. B. (1991) · Nature · doi:10.1038/352497a0 · Cited by 1,503
Transcription factors as targets for cancer therapy
Darnell, J. E. (2002) · Nature Reviews Cancer · doi:10.1038/nrc906 · Cited by 1,194
Scher, H. I., & Sawyers, C. L. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2005.03.4777 · Cited by 1,025
Structural basis of androgen receptor binding to selective androgen response elements
Shaffer, P. L., Jivan, A., Dollins, D. E., Claessens, F., & Gewirth, D. T. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401123101 · Cited by 400
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Self-citationDirect, Androgen Receptor-Mediated Regulation of the FKBP5 Gene via a Distal Enhancer Element
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Cited by
Block, K. M., Wang, H., Szabó, L. Z., Polaske, N. W., Henchey, L. K., Dubey, R., Kushal, S., László, C. F., Makhoul, J., Song, Z., et al. (2009) · Journal of the American Chemical Society · doi:10.1021/ja807601b · Cited by 79
Marshall, E., Lowrey, J., MacPherson, S., Maybin, J. A., Collins, F., Critchley, H. O. D., & Saunders, P. T. K. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-0272 · Cited by 66
DNA‐Binding Small Molecules as Inhibitors of Transcription Factors
Leung, C., Chan, D. S., Ma, V. P., & Ma, D. (2013) · Medicinal Research Reviews · doi:10.1002/med.21266 · Cited by 58
Metadata
- Authors
- Nickols, N. G., & Dervan, P. B.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2007-06-19
- Volume
- 104
- Issue
- 25
- Pages
- 10418-10423
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2037932659
- Cited by
- 189
- References
- 9
- FWCI
- 11.20
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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