Cited by 60DNA and Nucleic Acid ChemistryMetal complexes synthesis and propertiesSynthesis and biological activity

DNA‐Binding Small Molecules as Inhibitors of Transcription Factors

Leung, Chung‐Hang, Chan, Daniel Shiu‐Hin, Ma, Victor Pui‐Yan, Ma, Dik‐Lung·2013·Medicinal Research Reviews

Abstract

Accumulating evidence implicating the role of aberrant transcription factor signaling in the pathogenesis of various human diseases such as cancer and inflammation has stimulated the development of small molecule ligands capable of targeting transcription factor activity and modulating gene expression. The use of DNA ‐binding small molecules to selectively inhibit transcription factor– DNA interactions represents one possible approach toward this goal. In this review, we summarize the development of DNA ‐binding small molecule inhibitors of transcription factors from 2004 to 2011, and their binding mode and therapeutic potential will be discussed.

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Crossref · 10.1002/med.21266

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121 of 121 references verified0 citation errors · 0 not checkable

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Authors
Leung, C., Chan, D. S., Ma, V. P., & Ma, D.
Affiliations
  • University of Macau (MO)
  • Hong Kong Baptist University (HK)
Corresponding author
Leung, Chung‐Hang
Venue
Medicinal Research Reviews
Publisher
Wiley
Published
2012-04-30
Volume
33
Issue
4
Pages
823-846
ISSN
  • 0198-6325 (ISSN-L)
  • 1098-1128
OpenAlex
W1514300426
Cited by
58
References
121
Citations by year
2026: 1 · 2025: 1 · 2024: 3 · 2023: 6 · 2022: 4 · 2021: 4 · 2020: 7 · 2019: 8 · 2018: 3 · 2017: 6 · 2016: 5 · 2015: 4 · 2014: 3 · 2013: 2 · 2012: 1
FWCI
0.29
Type
journal article
Language
en
Open access
closed
Locations
  • Medicinal Research Reviews (publishedVersion)
  • PubMed (publishedVersion)
  • HKBU Institutional Repository (Hong Kong Baptist University) (submittedVersion)
  • The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
  • Health Sciences › Medicine › Oncology › Metal complexes synthesis and properties
  • Physical Sciences › Chemistry › Organic Chemistry › Synthesis and biological activity
Keywords
transcription factor inhibitors, transcription factor-DNA interaction, small-molecule ligands, gene expression modulation, cancer, inflammation, binding mode, therapeutic potential
MeSH terms
Animals, DNA, Eukaryotic Cells, Humans, Protein Binding, Transcription Factors, Small Molecule Libraries, Transcription Initiation, Genetic

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