DNA‐Binding Small Molecules as Inhibitors of Transcription Factors
Abstract
Accumulating evidence implicating the role of aberrant transcription factor signaling in the pathogenesis of various human diseases such as cancer and inflammation has stimulated the development of small molecule ligands capable of targeting transcription factor activity and modulating gene expression. The use of DNA ‐binding small molecules to selectively inhibit transcription factor– DNA interactions represents one possible approach toward this goal. In this review, we summarize the development of DNA ‐binding small molecule inhibitors of transcription factors from 2004 to 2011, and their binding mode and therapeutic potential will be discussed.
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In addition to PPI inhibitors, blocking the interaction of TFs with DNA is another option, as some of these factors bind directly to DNA.
“In addition to PPI inhibitors, blocking the interaction of TFs with DNA is another option, as some of these factors bind directly to DNA.465–467”
From Recent advances in targeting the “undruggable” proteins: from drug discovery to clinical trials (2023) · cites this paper as [465]
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STATs in cancer inflammation and immunity: a leading role for STAT3
Yu, H., Pardoll, D., & Jove, R. (2009) · Nature reviews. Cancer · doi:10.1038/nrc2734 · Cited by 4,383 · see citing works
Role of Transforming Growth Factor β in Human Disease
Blobe, G. C., Schiemann, W. P., & Lodish, H. F. (2000) · New England Journal of Medicine · doi:10.1056/nejm200005043421807 · Cited by 2,430 · see citing works
The STATs of cancer — new molecular targets come of age
Yu, H., & Jove, R. (2004) · Nature Reviews Cancer · doi:10.1038/nrc1275 · Cited by 2,278 · see citing works
AP-1: a double-edged sword in tumorigenesis
Eferl, R., & Wagner, E. F. (2003) · Nature reviews. Cancer · doi:10.1038/nrc1209 · Cited by 2,218 · see citing works
Reaching for high-hanging fruit in drug discovery at protein–protein interfaces
Wells, J. A., & McClendon, C. L. (2007) · Nature · doi:10.1038/nature06526 · Cited by 1,963 · see citing works
Androgen Receptor in Prostate Cancer
Heinlein, C. A., & Chang, C. (2004) · Endocrine Reviews · doi:10.1210/er.2002-0032 · Cited by 1,780 · see citing works
Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics
Semenza, G. L. (2010) · Oncogene · doi:10.1038/onc.2009.441 · Cited by 1,712 · see citing works
Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages
Scott, E. W., Simon, M. C., Anastasi, J., & Singh, H. (1994) · Science · doi:10.1126/science.8079170 · Cited by 1,532 · see citing works
Transcription factors: structural families and principles of DNA recognition.
Pabo, C., & Sauer, R. (1992) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.61.070192.005201 · Cited by 1,445 · see citing works
Inflammation meets cancer, with NF-κB as the matchmaker
Ben‐Neriah, Y., & Karin, M. (2011) · Nature Immunology · doi:10.1038/ni.2060 · Cited by 1,379 · see citing works
A Road Map for Those Who Don't Know JAK-STAT
Aaronson, D. S., & Horvath, C. M. (2002) · Science · doi:10.1126/science.1071545 · Cited by 1,339 · see citing works
Sequence-Specific Cleavage of Double Helical DNA by Triple Helix Formation
Moser, H. E., & Dervan, P. B. (1987) · Science · doi:10.1126/science.3118463 · Cited by 1,285 · see citing works
Koch, M. A., Tucker-Heard, G., Perdue, N. R., Killebrew, J. R., Urdahl, K. B., & Campbell, D. J. (2009) · Nature Immunology · doi:10.1038/ni.1731 · Cited by 1,258 · see citing works
Electrophoretic mobility shift assay (EMSA) for detecting protein–nucleic acid interactions
Hellman, L. M., & Fried, M. G. (2007) · Nature Protocols · doi:10.1038/nprot.2007.249 · Cited by 1,214 · see citing works
Transcription factors as targets for cancer therapy
Darnell, J. E. (2002) · Nature Reviews Cancer · doi:10.1038/nrc906 · Cited by 1,194 · see citing works
Crisponi, L., Deiana, M., Loi, A., Chiappe, F., Uda, M., Amati‐Bonneau, P., Bisceglia, L., Zelante, L., Nagaraja, R., Porcu, S., et al. (2001) · Nature Genetics · doi:10.1038/84781 · Cited by 982 · see citing works
Transcription of eukaryotic protein-coding genes.
Lee, T., & Young, R. (2000) · Annual Review of Genetics · doi:10.1146/annurev.genet.34.1.77 · Cited by 967 · see citing works
Hypoxia-Inducible Factor 1 (HIF-1) Pathway
Semenza, G. L. (2007) · Science s STKE · doi:10.1126/stke.4072007cm8 · Cited by 942 · see citing works
Molecular recognition of DNA by small molecules
Dervan, P. B. (2001) · Bioorganic & Medicinal Chemistry · doi:10.1016/s0968-0896(01)00262-0 · Cited by 905 · see citing works
Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor
Meydan, N., Grunberger, T., Dadi, H., Shahar, M., Arpaia, E., Lapidot, Z., Leeder, J. S., Freedman, M. H., Cohen, A., Gazit, A., et al. (1996) · Nature · doi:10.1038/379645a0 · Cited by 896 · see citing works
Structure and evolution of transcriptional regulatory networks
Babu, M. M., Luscombe, N. M., Aravind, L., Gerstein, M., & Teichmann, S. A. (2004) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2004.05.004 · Cited by 764 · see citing works
Recognition of the DNA minor groove by pyrrole-imidazole polyamides
Dervan, P. B., & Edelson, B. S. (2003) · Current Opinion in Structural Biology · doi:10.1016/s0959-440x(03)00081-2 · Cited by 633 · see citing works
Sequence‐Specific Recognition and Modification of Double‐Helical DNA by Oligonucleotides
Thuong, N. T., & Hélène, C. (1993) · Angewandte Chemie International Edition in English · doi:10.1002/anie.199306661 · Cited by 624 · see citing works
Mediator and the mechanism of transcriptional activation
Kornberg, R. D. (2005) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2005.03.011 · Cited by 595 · see citing works
Chang, H.-C., Sehra, S., Goswami, R., Yao, W., Yu, Q., Stritesky, G. L., Jabeen, R., McKinley, C., Ahyi, A.-N., Han, L., et al. (2010) · Nature Immunology · doi:10.1038/ni.1867 · Cited by 577 · see citing works
Eastman, A. R. (1987) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(87)90009-x · Cited by 542 · see citing works
Echinomycin, a small-molecule inhibitor of hypoxia-inducible factor-1 DNA-binding activity.
Kong, D., Park, E. J., Stephen, A. G., Calvani, M., Cardellina, J. H., Monks, A., Fisher, R. J., Shoemaker, R. H., & Melillo, G. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-1235 · Cited by 508 · see citing works
DNA minor-groove recognition by small molecules (up to 2000)
Neidle, S. (2001) · Natural Product Reports · doi:10.1039/a705982e · Cited by 494 · see citing works
Criteria for the mode of binding of DNA binding agents
Suh, D., & Chaires, J. B. (1995) · Bioorganic & Medicinal Chemistry · doi:10.1016/0968-0896(95)00053-j · Cited by 469 · see citing works
Regulation of cancer cell metabolism by hypoxia-inducible factor 1
Semenza, G. L. (2009) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2008.11.009 · Cited by 469 · see citing works
ETS transcription factors and their emerging roles in human cancer
Seth, A. K., & Watson, D. K. (2005) · European Journal of Cancer · doi:10.1016/j.ejca.2005.08.013 · Cited by 462 · see citing works
Strategies for Targeting Protein–Protein Interactions With Synthetic Agents
Yin, H. H., & Hamilton, A. D. (2005) · Angewandte Chemie International Edition · doi:10.1002/anie.200461786 · Cited by 453 · see citing works
Di Agostino, S., Strano, S., Emiliozzi, V., Zerbini, V., Mottolese, M., Sacchi, A., Blandino, G., & Piaggio, G. (2006) · Cancer Cell · doi:10.1016/j.ccr.2006.08.013 · Cited by 418 · see citing works
The molecular basis of eukaryotic transcription
Kornberg, R. (2007) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.0704138104 · Cited by 401 · see citing works
Recognition of DNA by designed ligands at subnanomolar concentrations
Trauger, J. W., Baird, E. E., & Dervan, P. B. (1996) · Nature · doi:10.1038/382559a0 · Cited by 397 · see citing works
Structural characterization of a 2:1 distamycin A.d(CGCAAATTGGC) complex by two-dimensional NMR.
Pelton, J. G., & Wemmer, D. E. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.15.5723 · Cited by 394 · see citing works
NF-κB controls energy homeostasis and metabolic adaptation by upregulating mitochondrial respiration
Mauro, C., Leow, S. C., Ansó, E., Rocha, S., Thotakura, A. K., Tornatore, L., Moretti, M., Smaele, E. D., Beg, A. A., Tergaonkar, V., et al. (2011) · Nature Cell Biology · doi:10.1038/ncb2324 · Cited by 393 · see citing works
DNA minor groove binders as potential antitumor and antimicrobial agents
Baraldi, P. G., Bovero, A., Fruttarolo, F., Preti, D., Tabrizi, M. A., Pavani, M. G., & Romagnoli, R. (2004) · Medicinal Research Reviews · doi:10.1002/med.20000 · Cited by 377 · see citing works
Chen, M., Masaki, Τ., & Sawamura, T. (2002) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(02)00236-x · Cited by 376 · see citing works
Evolution of transcription factors and the gene regulatory network in Escherichia coli
Babu, M. M. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkg210 · Cited by 354 · see citing works
A 1H NMR Study of the DNA Binding of Ruthenium(II) Polypyridyl Complexes
Collins, J. G., Sleeman, A. D., Aldrich-Wright, J. R., Greguric, I. D., & Hambley, T. W. (1998) · Inorganic Chemistry · doi:10.1021/ic971194v · Cited by 326 · see citing works
Chaires, J. B. (1998) · Current Opinion in Structural Biology · doi:10.1016/s0959-440x(98)80064-x · Cited by 303 · see citing works
Bourbon, H., Aguilera, A., Ansari, A., Asturias, F., Berk, A., Björklund, S., Blackwell, T., Borggrefe, T., Carey, M. F., Carlson, M., et al. (2004) · Molecules and Cells · doi:10.1016/j.molcel.2004.05.011 · Cited by 293 · see citing works
Transcription factors control invasion: AP-1 the first among equals
Ozanne, B. W., Spence, H. J., McGarry, L., & Hennigan, R. F. (2006) · Oncogene · doi:10.1038/sj.onc.1209759 · Cited by 287 · see citing works
Sakamoto, K. M., & Frank, D. A. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-1137 · Cited by 278 · see citing works
New androgen receptor genomic targets show an interaction with the ETS1 transcription factor
Massie, C. E., Adryan, B., Barbosa‐Morais, N. L., Lynch, A. G., Tran, M. G., Neal, D. E., & Mills, I. G. (2007) · The EMBO Reports · doi:10.1038/sj.embor.7401046 · Cited by 259 · see citing works
Specific inhibition of transcription by triple helix-forming oligonucleotides.
Duval-Valentin, G., Thuong, N. T., & Hélène, C. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.2.504 · Cited by 243 · see citing works
Nucleic acids in chemistry and biology
(2007) · Choice Reviews Online · doi:10.5860/choice.44-6246 · Cited by 232 · see citing works
Chemical Properties and Toxicity of Chromium(III) Nutritional Supplements
Levina, A., & Lay, P. A. (2008) · Chemical Research in Toxicology · doi:10.1021/tx700385t · Cited by 221 · see citing works
Wade, W. S., Mrksich, M., & Dervan, P. B. (1992) · Journal of the American Chemical Society · doi:10.1021/ja00049a006 · Cited by 220 · see citing works
Olenyuk, B. Z., Zhang, G.-J., Klco, J. M., Nickols, N. G., Kaelin, W. G., & Dervan, P. B. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407617101 · Cited by 219 · see citing works
Echinomycin Binding Sites on DNA
Van Dyke, M. M., & Dervan, P. B. (1984) · Science · doi:10.1126/science.6089341 · Cited by 218 · see citing works
A complex task? Direct modulation of transcription factors with small molecules
Koehler, A. N. (2010) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2010.03.022 · Cited by 189 · see citing works
Nickols, N. G., & Dervan, P. B. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0704217104 · Cited by 189 · see citing works
Mrksich, M., Wade, W. S., Dwyer, T. J., Geierstanger, B. H., Wemmer, D. E., & Dervan, P. B. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.16.7586 · Cited by 184 · see citing works
Triplex forming oligonucleotides: sequence-specific tools for gene targeting
Knauert, M. P. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.20.2243 · Cited by 181 · see citing works
Targeting the minor groove of DNA
Wemmer, D. E., & Dervan, P. B. (1997) · Current Opinion in Structural Biology · doi:10.1016/s0959-440x(97)80051-6 · Cited by 180 · see citing works
Allosteric modulation of DNA by small molecules
Chenoweth, D. M., & Dervan, P. B. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0906532106 · Cited by 153 · see citing works
Solution structure of the mithramycin dimer-DNA complex
Sastry, M., & Patel, D. J. (1993) · Biochemistry · doi:10.1021/bi00077a012 · Cited by 142 · see citing works
CREB: the unindicted cancer co-conspirator
Conkright, M. D., & Montminy, M. (2005) · Trends in Cell Biology · doi:10.1016/j.tcb.2005.07.007 · Cited by 139 · see citing works
Transcription-Factor Mutations and Disease
Latchman, D. S. (1996) · New England Journal of Medicine · doi:10.1056/nejm199601043340108 · Cited by 133 · see citing works
Modulating Hypoxia-Inducible Transcription by Disrupting the HIF-1–DNA Interface
Nickols, N. G., Jacobs, C. S., Farkas, M. E., & Dervan, P. B. (2007) · ACS Chemical Biology · doi:10.1021/cb700110z · Cited by 127 · see citing works
Kozlowski, K. (2000) · Human Molecular Genetics · doi:10.1093/hmg/9.14.2131 · Cited by 121 · see citing works
Hypoxia inducible factor-1: a novel target for cancer therapy
Belozerov, V. E., & Meir, E. G. V. (2005) · Anti-Cancer Drugs · doi:10.1097/01.cad.0000180116.85912.69 · Cited by 117 · see citing works
Inhibition of transcription factors with small organic molecules
Berg, T. (2008) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2008.07.023 · Cited by 115 · see citing works
Drug Insight: VEGF as a therapeutic target for breast cancer
Schneider, B. P., & Sledge, G. W. (2007) · Nature Clinical Practice Oncology · doi:10.1038/ncponc0740 · Cited by 113 · see citing works
Evi-1, a murine zinc finger proto-oncogene, encodes a sequence-specific DNA-binding protein.
Perkins, A. S., Fishel, R. A., Jenkins, N. A., & Copeland, N. G. (1991) · Molecular and Cellular Biology · doi:10.1128/mcb.11.5.2665 · Cited by 111 · see citing works
Matsuda, H., Fukuda, N., Ueno, T., Tahira, Y., Ayame, H., Zhang, W., Bando, T., Sugiyama, H., Saitô, S., Matsumoto, K., et al. (2005) · Journal of the American Society of Nephrology · doi:10.1681/asn.2005060650 · Cited by 108 · see citing works
The molecular basis for developmental disorders of the pituitary gland in man
Dattani, M., & Robinson, I. C. A. F. (2000) · Clinical Genetics · doi:10.1034/j.1399-0004.2000.570503.x · Cited by 107 · see citing works
Flavopiridol binds to duplex DNA.
Bible, K. C., Bible, R. H., Kottke, T. J., Svingen, P. A., Xu, K., Pang, Y., Hajdu, E., & Kaufmann, S. H. (2000) · PubMed · Cited by 102 · see citing works
Metastatic bone disease: Role of transcription factors and future targets
Pratap, J., Lian, J. B., & Stein, G. S. (2010) · Bone · doi:10.1016/j.bone.2010.05.035 · Cited by 99 · see citing works
Physical Studies of Protein-DNA Complexes by Footprinting
Tullius, T. D. (1989) · Annual Review of Biophysics and Biophysical Chemistry · doi:10.1146/annurev.bb.18.060189.001241 · Cited by 99 · see citing works
Improved nuclear localization of DNA-binding polyamides
Nickols, N. G., Jacobs, C. S., Farkas, M. E., & Dervan, P. B. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl1042 · Cited by 96 · see citing works
Wells, G., Martin, C. R. H., Howard, P. W., Sands, Z. A., Laughton, C. A., Tiberghien, A. C., Woo, C. K., Masterson, L. A., Stephenson, M., Hartley, J. A., et al. (2006) · Journal of Medicinal Chemistry · doi:10.1021/jm051199z · Cited by 81 · see citing works
Targeting DNA with triplex-forming oligonucleotides to modify gene sequence
Simon, P., Cannata, F., Concordet, J., & Giovannangeli, C. (2008) · Biochimie · doi:10.1016/j.biochi.2008.04.004 · Cited by 80 · see citing works
Novel DNA Bis-intercalation by MLN944, a Potent Clinical Bisphenazine Anticancer Drug
Dai, J., Punchihewa, C., Mistry, P., Ooi, A. T., & Yang, D. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m404053200 · Cited by 78 · see citing works
POU domain transcription factors: BRN2 as a regulator of melanocytic growth and tumourigenesis
Cook, A. L., & Sturm, R. A. (2008) · Pigment Cell & Melanoma Research · doi:10.1111/j.1755-148x.2008.00510.x · Cited by 77 · see citing works
Triplex-forming molecules: from concepts to applications
Faria, M., & Giovannangeli, C. (2001) · The Journal of Gene Medicine · doi:10.1002/jgm.192 · Cited by 77 · see citing works
Matsuda, H., Fukuda, N., Ueno, T., Katakawa, M., Wang, X., Watanabe, T., Matsui, S., Aoyama, T., Saito, K., Bando, T., et al. (2010) · Kidney International · doi:10.1038/ki.2010.330 · Cited by 75 · see citing works
Determination of the drug–DNA binding modes using fluorescence-based assays
Williams, A. K., Dasilva, S. C., Bhatta, A., Rawal, B., Liu, M., & Korobkova, E. A. (2012) · Analytical Biochemistry · doi:10.1016/j.ab.2011.12.041 · Cited by 74 · see citing works
Lee, T.-J., Jung, E. M., Lee, J. T., Kim, S., Park, J. W., Choi, K. S., & Kwon, T. K. (2006) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-06-0426 · Cited by 73 · see citing works
Nuclear Receptors and Inflammatory Diseases
Wang, K., & Wan, Y. Y. (2008) · Experimental Biology and Medicine · doi:10.3181/0708-mr-231 · Cited by 72 · see citing works
Swalley, S. E., Baird, E. E., & Dervan, P. B. (1999) · Journal of the American Chemical Society · doi:10.1021/ja9830905 · Cited by 72 · see citing works
Allosteric Inhibition of Protein−DNA Complexes by Polyamide−Intercalator Conjugates
Fechter, E. J., & Dervan, P. B. (2003) · Journal of the American Chemical Society · doi:10.1021/ja030125e · Cited by 70 · see citing works
Small Molecule Modulators of Transcription
Arndt, H. (2006) · Angewandte Chemie International Edition · doi:10.1002/anie.200600285 · Cited by 68 · see citing works
Completion of a programmable DNA-binding small molecule library
Hsu, C. F., Phillips, J. W., Trauger, J. W., Farkas, M. E., Belitsky, J. M., Heckel, A., Olenyuk, B. Z., Puckett, J. W., Wang, C. C. C., & Dervan, P. B. (2007) · Tetrahedron · doi:10.1016/j.tet.2007.03.041 · Cited by 66 · see citing works
Nunn, C. M., & Neidle, S. (1995) · Journal of Medicinal Chemistry · doi:10.1021/jm00013a008 · Cited by 62 · see citing works
Gamage, S. A., Spicer, J. A., Finlay, G. J., Stewart, A. J., Charlton, P., Baguley, B. C., & Denny, W. A. (2001) · Journal of Medicinal Chemistry · doi:10.1021/jm0003283 · Cited by 60 · see citing works
Lee, Y. K., Isham, C. R., Kaufmann, S. H., & Bible, K. C. (2006) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-05-0235 · Cited by 60 · see citing works
Kotecha, M., Kluza, J., Wells, G., O’Hare, C. C., Forni, C., Mantovani, R., Howard, P. W., Morris, P., Thurston, D. E., Hartley, J. A., et al. (2008) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-07-0475 · Cited by 60 · see citing works
Specific Blocking of CREB/DNA Binding by Cyclometalated Platinum(II) Complexes
Wang, P., Leung, C., Ma, D., Sun, R. W., Yan, S., Chen, Q., & Che, C. (2011) · Angewandte Chemie International Edition · doi:10.1002/anie.201006887 · Cited by 56 · see citing works
Self-citationChemical approaches to transcriptional regulation
Majmudar, C. Y., & Mapp, A. K. (2005) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2005.08.012 · Cited by 55 · see citing works
Gil, C., Seoane, S., Blanco, M. M. V., Macia, M., García‐Caballero, T., Segura, C., & Pérez-Fernández, R. (2005) · European Journal of Endocrinology · doi:10.1530/eje.1.01962 · Cited by 54 · see citing works
Antitumor activity of XR5944, a novel and potent topoisomerase poison
Stewart, A. J., Mistry, P., Dangerfield, W., Bootle, D., Baker, M., Kofler, B., Okiji, S., Baguley, B. C., Denny, W. A., & Charlton, P. (2001) · Anti-Cancer Drugs · doi:10.1097/00001813-200104000-00009 · Cited by 54 · see citing works
Transcription Factors As Targets for DNA-Interacting Drugs
Gniazdowski, M., Denny, W., Nelson, S., & Czyz, M. (2003) · Current Medicinal Chemistry · doi:10.2174/0929867033457683 · Cited by 52 · see citing works
Peixoto, P., Liu, Y., Depauw, S., Hildebrand, M., Boykin, D. W., Bailly, C., Wilson, W. D., & David‐Cordonnier, M. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkn208 · Cited by 52 · see citing works
Gradishar, W. J., Vogelzang, N. J., Kilton, L. J., Leibach, S. J., Rademaker, A. W., French, S., & Benson, A. B. (1995) · Investigational New Drugs · doi:10.1007/bf00872868 · Cited by 49 · see citing works
Bailly, C., Tardy, C., Wang, L., Armitage, B. A., Hopkins, K. T., Kumar, A., Schuster, G. B., Boykin, D. W., & Wilson, W. D. (2001) · Biochemistry · doi:10.1021/bi0108453 · Cited by 48 · see citing works
Wang, C. C. C., Ellervik, U., & Dervan, P. B. (2001) · Bioorganic & Medicinal Chemistry · doi:10.1016/s0968-0896(00)00282-0 · Cited by 47 · see citing works
Sequence-Specific Gene Silencing in Mammalian Cells by Alkylating Pyrrole−Imidazole Polyamides
Shinohara, K., Narita, A., Oyoshi, T., Bando, T., Teraoka, H., & Sugiyama, H. (2004) · Journal of the American Chemical Society · doi:10.1021/ja031673v · Cited by 45 · see citing works
Phase II trial of echinomycin in patients with advanced or recurrent colorectal cancer
Wadler, S., Tenteromano, L., Cazenave, L., Sparano, J. A., Greenwald, E. S., Rozenblit, A., Kaleya, R., & Wiernik, P. H. (1994) · Cancer Chemotherapy and Pharmacology · doi:10.1007/bf00685088 · Cited by 43 · see citing works
Chromium(III) complexes inhibit transcription factors binding to DNA and associated gene expression
Sella, R. N., & Nair, B. U. (2008) · Toxicology · doi:10.1016/j.tox.2008.07.052 · Cited by 41 · see citing works
Effects of anticancer drugs on transcription factor–DNA interactions
Gniazdowski, M., Denny, W. A., Nelson, S. M., & Czyz, M. (2005) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.9.3.471 · Cited by 41 · see citing works
Site-Specific Inhibition of Transcription Factor Binding to DNA by a Metallointercalator
Odom, D. T., Parker, C. S., & Barton, J. K. (1999) · Biochemistry · doi:10.1021/bi9827969 · Cited by 40 · see citing works
The Genome as a Drug Target Sequence Specific Minor Groove Binding Ligands
Turner, P., & Denny, W. A. (2000) · Current Drug Targets · doi:10.2174/1389450003349407 · Cited by 36 · see citing works
Targeting a DNA Binding Motif of the EVI1 Protein by a Pyrrole–Imidazole Polyamide
Zhang, Y., Sicot, G., Cui, X., Vogel, M. J., Wuertzer, C. A., Lezon-Geyda, K., Wheeler, J., Harki, D. A., Muzikar, K. A., Stolper, D. A., et al. (2011) · Biochemistry · doi:10.1021/bi200962u · Cited by 35 · see citing works
Quantitating the concentration of Py-Im polyamide–fluorescein conjugates in live cells
Hsu, C. F., & Dervan, P. B. (2008) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2008.05.063 · Cited by 35 · see citing works
Drug Effects Viewed from a Signal Transduction Network Perspective
Fliri, A. F. J., Loging, W., & Volkmann, R. A. (2009) · Journal of Medicinal Chemistry · doi:10.1021/jm901001p · Cited by 34 · see citing works
In vitro DNA-binding profile of transcription factors: methods and new insights
Wang, J., Lu, J., Gu, G., & Liu, Y. (2011) · Journal of Endocrinology · doi:10.1530/joe-11-0010 · Cited by 34 · see citing works
Yao, E., Fukuda, N., Ueno, T., Matsuda, H., Matsumoto, K., Nagase, H., Matsumoto, Y., Takasaka, A., Serie, K., Sugiyama, H., et al. (2008) · Hypertension · doi:10.1161/hypertensionaha.108.112797 · Cited by 31 · see citing works
Viger, A., & Dervan, P. B. (2006) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2006.08.028 · Cited by 28 · see citing works
Kageyama, Y., Sugiyama, H., Ayame, H., Iwai, A., Fujii, Y., Huang, E. L., Kizaka‐Kondoh, S., Hiraoka, M., & Kihara, K. (2006) · Acta Oncologica · doi:10.1080/02841860500486648 · Cited by 28 · see citing works
Modulation of topoisomerase IIα expression by a DNA sequence-specific polyamide
Hochhauser, D., Kotecha, M., O’Hare, C. C., Morris, P. J., Hartley, J. M., Taherbhai, Z., Harris, D., Forni, C., Mantovani, R., Lee, M., et al. (2007) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-06-0503 · Cited by 24 · see citing works
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Singhal, G., Akhter, M. Z., Stern, D. F., Gupta, S. D., Ahuja, A., Sharma, U., Jagannathan, N. R., & Rajeswari, M. R. (2011) · Cancer Gene Therapy · doi:10.1038/cgt.2011.21 · Cited by 22 · see citing works
The Interactions of Small Molecules with DNA and RNA
Xie, Y., Tam, V. K., & Tor, Y. (2010) · doi:10.1002/9780470664001.ch6 · Cited by 20 · see citing works
The androgen receptor in hormone-refractory prostate cancer
Mao, H., Zhu, Z., & Chen, C. D. (2008) · Asian Journal of Andrology · doi:10.1038/aja.2008.14 · Cited by 18 · see citing works
Talib, J., Beck, J. L., Urathamakul, T., Nguyen, C. D., Aldrich-Wright, J. R., Mackay, J. P., & Ralph, S. F. (2009) · Chemical Communications · doi:10.1039/b904751d · Cited by 15 · see citing works
Evaluation of the DNA‐Binding Properties of Cationic Dyes by Absorption and Emission Spectroscopy
Ihmels, H., Faulhaber, K., Viola, G., & Schmuck, C. (2004) · doi:10.1002/3527603727.ch2e · Cited by 12 · see citing works
Principles of Small Molecule-DNA Recognition
Neidle, S. (2008) · Elsevier eBooks · doi:10.1016/b978-012369507-9.50006-6 · Cited by 10 · see citing works
The Ups and Downs of Transcription Factors in Melanoma
Santiago-Walker, A., & Herlyn, M. (2010) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djq267 · Cited by 6 · see citing works
Swami, M. (2010) · Nature reviews. Cancer · doi:10.1038/nrc2970 · Cited by 4 · see citing works
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Targeting transcription factors in cancer — from undruggable to reality
Bushweller, J. H. (2019) · Nature Reviews Cancer · doi:10.1038/s41568-019-0196-7 · Cited by 919 · see citing works
Recent advances in targeting the “undruggable” proteins: from drug discovery to clinical trials
Xie, X., Yu, T., Li, X., Zhang, N., Foster, L. J., Peng, C., Huang, W., & He, G. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01589-z · Cited by 396 · see citing works
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Leung, C., Zhong, H., Chan, D. S., & Ma, D. (2013) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2013.01.034 · Cited by 303 · see citing works
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Heffern, M. C., Yamamoto, N., Holbrook, R. J., Eckermann, A. L., & Meade, T. J. (2012) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2012.11.019 · Cited by 204 · see citing works
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Wang, H., Man, Q., Huo, F., Gao, X., Lin, H., Li, S.-R., Wang, J., Su, F., Cai, L., Shi, Y., et al. (2022) · MedComm · doi:10.1002/mco2.124 · Cited by 172 · see citing works
Jia, J., Liu, Z., Xiao, X., Liu, B., & Chou, K. (2016) · Molecules · doi:10.3390/molecules21010095 · Cited by 159 · see citing works
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Rahman, M. S., Shatabda, S., Saha, S., Kaykobad, M., & Rahman, M. S. (2018) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2018.05.006 · Cited by 152 · see citing works
Huang, W., Dong, Z., Wang, F., Peng, H., Liu, J., & Zhang, J. (2014) · ACS Chemical Biology · doi:10.1021/cb500071v · Cited by 123 · see citing works
Huang, W., Dong, Z., Chen, Y., Wang, F., Wang, C. J., Peng, H., He, Y., Hangoc, G., Pollok, K. E., Sandusky, G. E., et al. (2015) · Oncogene · doi:10.1038/onc.2015.215 · Cited by 110 · see citing works
Nafie, M. S., Arafa, K. K., Sedky, N. K., Alakhdar, A. A., & Arafa, R. K. (2020) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2020.109087 · Cited by 104 · see citing works
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Campbell, I. B., Macdonald, S. J. F., & Procopiou, P. A. (2017) · Drug Discovery Today · doi:10.1016/j.drudis.2017.10.007 · Cited by 103 · see citing works
Du, X., Diao, Y., Liu, H., & Li, S. (2019) · Journal of Proteome Research · doi:10.1021/acs.jproteome.9b00226 · Cited by 88 · see citing works
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Depauw, S., Lambert, M., Jambon, S., Paul, A., Peixoto, P., Nhili, R., Marongiu, L., Figeac, M., Dassi, C., Paul-Constant, C., et al. (2019) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.8b01448 · Cited by 44 · see citing works
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Chen, W., Wu, G., Zhu, Y., Zhang, W., Zhang, H., Zhou, Y., & Sun, P. (2019) · Cancer Management and Research · doi:10.2147/cmar.s201342 · Cited by 35 · see citing works
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Newman, D. J., & Cragg, G. M. L. (2014) · Royal Society of Chemistry eBooks · doi:10.1039/9781782623113-00001 · Cited by 19 · see citing works
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Kołat, D., Zhao, L.-Y., Kciuk, M., Płuciennik, E., & Kałuzińska‐Kołat, Ż. (2022) · Cells · doi:10.3390/cells11244124 · Cited by 7 · see citing works
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Vardevanyan, P. O., Parsadanyan, M. A., Antonyan, A. P., & Shahinyan, M. A. (2020) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2020.1823883 · Cited by 6 · see citing works
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Veillard, N., Cascio, F., Jackson, P. J., & Thurston, D. E. (2019) · Royal Society of Chemistry eBooks · doi:10.1039/9781788012898-00349 · Cited by 4 · see citing works
Arutyunyan, A. F., Kostyukov, A. A., Korolev, S. P., Gottikh, M., Kaluzhny, D. N., Susova, O. Y., & Zhuze, A. L. (2023) · Molecular Biology · doi:10.1134/s0026893323030020 · Cited by 3 · see citing works
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Li, M., Lu, D., Cheng, Y., Wu, C., Zhang, J., Shi, W., Ding, Z., Li, Y., Cheng, B., Lin, X., et al. (2021) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2021.07.077 · Cited by 2 · see citing works
Sakurabayashi, S., Yamada, T., & Nakatani, K. (2024) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2024.129985 · Cited by 2 · see citing works
Arshad, K., Arif, M., & Yu, D. (2026) · Chemometrics and Intelligent Laboratory Systems · doi:10.1016/j.chemolab.2026.105875 · Cited by 1 · see citing works
Supramolecular Assemblies in Chemical Biology
Saraogi, I., Bhoge, B. A., & Gangarde, Y. M. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-409547-2.12544-2 · Cited by 1 · see citing works
Arutyunyan, A. F., Kostyukov, A. A., Korolev, S. P., Gottikh, M., Susova, O. Y., Kaluzhny, D. N., & Zhuze, A. L. (2023) · Molecular Biology · doi:10.31857/s0026898423030023 · Cited by 1 · see citing works
IlvY is an important regulator of Shigella infection in vitro and in vivoPreprint
Holly, M. K., Anderson, M. C., Rabago, L. M., Saffarian, A., Marteyn, B., & Arnold, S. L. M. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.07.28.220327 · Cited by 1 · see citing works
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Procopiou, G., & Procopiou, P. A. (2018) · Royal Society of Chemistry eBooks · doi:10.1039/9781782624011-00001
Synthetic DNA Binding Assembly: Architecture, Application and Perspectives
Yu, Z. (2020) · Springer theses · doi:10.1007/978-981-15-4423-1_1
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Parsadanyan, M. A. (2021) · Proceedings of the YSU B Chemical and Biological Sciences · doi:10.46991/pysu:b/2021.55.1.039
BindingDB Entry 7901: Small-Molecule Inhibitors of the SOX18 Transcription Factor.
BindingDB (2017) · UC San Diego · doi:10.7270/q2mp5252
- Authors
- Leung, C., Chan, D. S., Ma, V. P., & Ma, D.
- Affiliations
- University of Macau (MO)
- Hong Kong Baptist University (HK)
- Corresponding author
- Leung, Chung‐Hang
- Venue
- Medicinal Research Reviews
- Publisher
- Wiley
- Published
- 2012-04-30
- Volume
- 33
- Issue
- 4
- Pages
- 823-846
- ISSN
- 0198-6325 (ISSN-L)
- 1098-1128
- OpenAlex
- W1514300426
- Cited by
- 58
- References
- 121
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2023: 6 · 2022: 4 · 2021: 4 · 2020: 7 · 2019: 8 · 2018: 3 · 2017: 6 · 2016: 5 · 2015: 4 · 2014: 3 · 2013: 2 · 2012: 1
- FWCI
- 0.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Medicinal Research Reviews (publishedVersion)
- PubMed (publishedVersion)
- HKBU Institutional Repository (Hong Kong Baptist University) (submittedVersion)
- The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
- Health Sciences › Medicine › Oncology › Metal complexes synthesis and properties
- Physical Sciences › Chemistry › Organic Chemistry › Synthesis and biological activity
- Keywords
- transcription factor inhibitors, transcription factor-DNA interaction, small-molecule ligands, gene expression modulation, cancer, inflammation, binding mode, therapeutic potential
- MeSH terms
- Animals, DNA, Eukaryotic Cells, Humans, Protein Binding, Transcription Factors, Small Molecule Libraries, Transcription Initiation, Genetic
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