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Conserved P-TEFb-interacting domain of BRD4 inhibits HIV transcription
Open accessAbstract
We have identified a conserved region in the C-terminal domain of bromodomain-containing protein 4 (BRD4) that mediates its specific interaction with positive transcription elongation factor b (P-TEFb). This domain is highly conserved in testis-specific bromodomain protein (BRDT) and Drosophila fs( 1 )h. Both BRDT and fs( 1 )h specifically interact with P-TEFb in mammalian cells, and this interaction depends on their C-terminal domains. Overexpression of the BRD4 P-TEFb-interacting domain disrupts the interaction between the HIV transactivator Tat and P-TEFb and suppresses the ability of Tat to transactivate the HIV promoter. Incubation of cells with a synthetic peptide containing the C-terminal domain of BRD4 interferes with transactivation of the HIV promoter by the Tat protein.
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Siliciano, J. D., Kajdas, J., Finzi, D., Quinn, T. C., Chadwick, K., Margolick, J. B., Kovacs, C., Gange, S. J., & Siliciano, R. F. (2003) · Nature Medicine · doi:10.1038/nm880 · Cited by 1,703
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Chapuy, B., McKeown, M. R., Lin, C. Y., Monti, S., Roemer, M. G. M., Qi, J., Rahl, P. B., Sun, H. H., Yeda, K. T., Doench, J. G., et al. (2013) · Cancer Cell · doi:10.1016/j.ccr.2013.11.003 · Cited by 735
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Metadata
- Authors
- Bisgrove, D. A., Mahmoudi, T., Henklein, P., & Verdin, E.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2007-08-21
- Volume
- 104
- Issue
- 34
- Pages
- 13690-13695
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2096673680
- Cited by
- 387
- References
- 1
- FWCI
- 2.63
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Conserved P-TEFb-interacting domain of BRD4 inhibits HIV transcription. https://app.cochat.ai/papers/10.1073/pnas.0705053104
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- Bisgrove, D. A., Mahmoudi, T., Henklein, P., & Verdin, E. (2007). Conserved P-TEFb-interacting domain of BRD4 inhibits HIV transcription. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0705053104
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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