The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Collective migration of an epithelial monolayer in response to a model wound
Open accessAbstract
Using an original microfabrication-based technique, we experimentally study situations in which a virgin surface is presented to a confluent epithelium with no damage made to the cells. Although inspired by wound-healing experiments, the situation is markedly different from classical scratch wounding because it focuses on the influence of the free surface and uncouples it from the other possible contributions such as cell damage and/or permeabilization. Dealing with Madin–Darby canine kidney cells on various surfaces, we found that a sudden release of the available surface is sufficient to trigger collective motility. This migration is independent of the proliferation of the cells that mainly takes place on the fraction of the surface initially covered. We find that this motility is characterized by a duality between collective and individual behaviors. On the one hand, the velocity fields within the monolayer are very long range and involve many cells in a coordinated way. On the other hand, we have identified very active “leader cells” that precede a small cohort and destabilize the border by a fingering instability. The sides of the fingers reveal a pluricellular actin “belt” that may be at the origin of a mechanical signaling between the leader and the followers. Experiments performed with autocrine cells constitutively expressing hepatocyte growth factor (HGF) or in the presence of exogenous HGF show a higher average velocity of the border and no leader.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Particle Image Velocimetry: A Practical Guide
Raffel, M., Willert, C. E., Scarano, F., Kähler, C. J., Wereley, S. T., & Kompenhans, J. (2018) · doi:10.1007/978-3-319-68852-7 · Cited by 5,049
Complex networks orchestrate epithelial–mesenchymal transitions
Thiery, J. P., & Sleeman, J. P. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1835 · Cited by 3,958
Rho GTPases Control Polarity, Protrusion, and Adhesion during Cell Movement
Nobes, C. D., & Hall, A. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.144.6.1235 · Cited by 1,445
Raffel, M., Willert, C. E., & Kompenhans, J. (1998) · Springer eBooks · doi:10.1007/978-3-662-03637-2 · Cited by 1,371
Twenty years of particle image velocimetry
Adrian, R. J. (2005) · Experiments in Fluids · doi:10.1007/s00348-005-0991-7 · Cited by 1,267
Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex
Fujita, Y., Krause, G., Scheffner, M., Zechner, D., Leddy, H. E. M., Behrens, J., Sommer, T., & Birchmeier, W. (2002) · Nature Cell Biology · doi:10.1038/ncb758 · Cited by 846
The extracellular matrix guides the orientation of the cell division axis
Théry, M., Racine, V., Pépin, A., Piel, M., Chen, Y., Sibarita, J.-B., & Bornens, M. (2005) · Nature Cell Biology · doi:10.1038/ncb1307 · Cited by 780
Prespecification and plasticity: shifting mechanisms of cell migration
Friedl, P. (2004) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2003.11.001 · Cited by 667
Parallels between tissue repair and embryo morphogenesis
Martin, P., & Parkhurst, S. M. (2004) · Development · doi:10.1242/dev.01253 · Cited by 565
Wound healing recapitulates morphogenesis in Drosophila embryos
Wood, W., Jacinto, A., Grose, R., Woolner, S., Gale, J., Wilson, C., & Martin, P. (2002) · Nature Cell Biology · doi:10.1038/ncb875 · Cited by 435
Cited by
Collective cell migration in morphogenesis, regeneration and cancer
Friedl, P., & Gilmour, D. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2720 · Cited by 2,712
In vitro cell migration and invasion assays
Kramer, N., Walzl, A., Unger, C., Rosner, M., Krupitza, G., Hengstschläger, M., & Dolznig, H. (2013) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2012.08.001 · Cited by 1,170
Mechanobiology of collective cell behaviours
Ladoux, B., & Mège, R.-M. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.98 · Cited by 749
Self-citationMicropatterning as a tool to decipher cell morphogenesis and functions
Théry, M. (2010) · Journal of Cell Science · doi:10.1242/jcs.075150 · Cited by 730
Motility-Driven Glass and Jamming Transitions in Biological Tissues
Bi, D., Yang, X., Marchetti, M. C., & Manning, M. L. (2016) · Physical Review X · doi:10.1103/physrevx.6.021011 · Cited by 677
Metadata
- Authors
- Poujade, M., Grasland-Mongrain, E., Hertzog, A., Jouanneau, J., Chavrier, P., Ladoux, B., Buguin, A., & Silberzan, P.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2007-10-09
- Volume
- 104
- Issue
- 41
- Pages
- 15988-15993
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2094098398
- Cited by
- 912
- References
- 42
- FWCI
- 5.70
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Collective migration of an epithelial monolayer in response to a model wound. https://app.cochat.ai/papers/10.1073/pnas.0705062104
- The paper
- Poujade, M., Grasland-Mongrain, E., Hertzog, A., Jouanneau, J., Chavrier, P., Ladoux, B., Buguin, A., & Silberzan, P. (2007). Collective migration of an epithelial monolayer in response to a model wound. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0705062104
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
