Micropatterning as a tool to decipher cell morphogenesis and functions

Geometric Control of Cell Life and Death

Chen, C. S., Mrksich, M., Huang, S., Whitesides, G. M., & Ingber, D. E. (1997) · Science · doi:10.1126/science.276.5317.1425 · Cited by 4,668 · see citing works

Cell Shape, Cytoskeletal Tension, and RhoA Regulate Stem Cell Lineage Commitment

McBeath, R., Pirone, D. M., Nelson, C. M., Bhadriraju, K., & Chen, C. S. (2004) · Developmental Cell · doi:10.1016/s1534-5807(04)00075-9 · Cited by 4,182 · see citing works

Soft Lithography in Biology and Biochemistry

Whitesides, G. M., Ostuni, E., Takayama, S., Jiang, X., & Ingber, D. E. (2001) · Annual Review of Biomedical Engineering · doi:10.1146/annurev.bioeng.3.1.335 · Cited by 2,614 · see citing works

Cells lying on a bed of microneedles: An approach to isolate mechanical force

Tan, J. L., Tien, J., Pirone, D. M., Gray, D. S., Bhadriraju, K., & Chen, C. S. (2003) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.0235407100 · Cited by 2,036 · see citing works

Geometric cues for directing the differentiation of mesenchymal stem cells

Kilian, K. A., Bugarija, B., Lahn, B. T., & Mrksich, M. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0903269107 · Cited by 1,841 · see citing works

Mechanotransduction at a distance: mechanically coupling the extracellular matrix with the nucleus

Wang, N., Tytell, J. D., & Ingber, D. E. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2594 · Cited by 1,768 · see citing works

Myotubes differentiate optimally on substrates with tissue-like stiffness

Engler, A. J., Griffin, M. A., Sen, S., Bönnemann, C. G., Sweeney, H. L., & Discher, D. E. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200405004 · Cited by 1,743 · see citing works

Engineering cell shape and function

Singhvi, R., Kumar, A., Lopez, G. P., Stephanopoulos, G. N., Wang, D. I. C., Whitesides, G. M., & Ingber, D. E. (1994) · Science · doi:10.1126/science.8171320 · Cited by 1,453 · see citing works

Three-dimensional culture models of normal and malignant breast epithelial cells

Lee, G. Y., Kenny, P. A., Lee, E. H., & Bissell, M. J. (2007) · Nature Methods · doi:10.1038/nmeth1015 · Cited by 1,336 · see citing works

Microscale culture of human liver cells for drug development

Khetani, S. R., & Bhatia, S. N. (2008) · Nature Biotechnology · doi:10.1038/nbt1361 · Cited by 1,219 · see citing works

Physical forces during collective cell migration

Trepat, X., Wasserman, M. R., Angelini, T. E., Millet, E. J., Weitz, D. A., Butler, J. P., & Fredberg, J. J. (2009) · Nature Physics · doi:10.1038/nphys1269 · Cited by 1,198 · see citing works

Activation of Integrin Function by Nanopatterned Adhesive Interfaces

Arnold, M., Cavalcanti‐Adam, E. A., Glass, R., Blümmel, J., Eck, W., Kantlehner, M., Kessler, H., & Spatz, J. P. (2004) · ChemPhysChem · doi:10.1002/cphc.200301014 · Cited by 1,165 · see citing works

Mechanical regulation of cell function with geometrically modulated elastomeric substrates

Fu, J., Wang, Y.-K., Yang, M. T., Desai, R. A., Yu, X., Liu, Z., & Chen, C. S. (2010) · Nature Methods · doi:10.1038/nmeth.1487 · Cited by 1,073 · see citing works

Collective migration of an epithelial monolayer in response to a model wound

Poujade, M., Grasland‐Mongrain, E., Hertzog, A., Jouanneau, J., Chavrier, P., Ladoux, B., Buguin, A., & Silberzan, P. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705062104 · Cited by 898 · see citing works

Adhesion-Dependent Cell Mechanosensitivity

Bershadsky, A. D., Balaban, N. Q., & Geiger, B. (2003) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.19.111301.153011 · Cited by 858 · see citing works

Emergent patterns of growth controlled by multicellular form and mechanics

Nelson, C. M., Jean, R. P., Tan, J. L., Liu, W. F., Sniadecki, N. J., Spector, A. A., & Chen, C. S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502575102 · Cited by 852 · see citing works

Tensegrity II. How structural networks influence cellular information processing networks

Ingber, D. E. (2003) · Journal of Cell Science · doi:10.1242/jcs.00360 · Cited by 839 · see citing works

The extracellular matrix guides the orientation of the cell division axis

Théry, M., Racine, V., Pépin, A., Piel, M., Chen, Y., Sibarita, J., & Bornens, M. (2005) · Nature Cell Biology · doi:10.1038/ncb1307 · Cited by 780 · see citing works

Muscular Thin Films for Building Actuators and Powering Devices

Feinberg, A. W., Feigel, A., Shevkoplyas, S. S., Sheehy, S., Whitesides, G. M., & Parker, K. K. (2007) · Science · doi:10.1126/science.1146885 · Cited by 765 · see citing works

One-dimensional topography underlies three-dimensional fibrillar cell migration

Doyle, A. D., Wang, F. W., Matsumoto, K., & Yamada, K. M. (2009) · The Journal of Cell Biology · doi:10.1083/jcb.200810041 · Cited by 736 · see citing works

Mechanical tugging force regulates the size of cell–cell junctions

Liu, Z., Tan, J. L., Cohen, D. M., Yang, M. T., Sniadecki, N. J., Ruiz, S. A., Nelson, C. M., & Chen, C. S. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0914547107 · Cited by 704 · see citing works

Focal adhesion size controls tension-dependent recruitment of α-smooth muscle actin to stress fibers

Goffin, J. M., Pittet, P., Csúcs, G., Lussi, J. W., Meister, J.-J., & Hinz, B. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200506179 · Cited by 703 · see citing works

Nuclear Actin Regulates Dynamic Subcellular Localization and Activity of the SRF Cofactor MAL

Vartiainen, M., Guettler, S., Larijani, B., & Treisman, R. (2007) · Science · doi:10.1126/science.1141084 · Cited by 672 · see citing works

Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomesPreprint

Kwon, M., Godinho, S. A., Chandhok, N. S., Ganem, N. J., Azioune, A., Théry, M., & Pellman, D. S. (2008) · Genes & Development · doi:10.1101/gad.1700908 · Cited by 654 · see citing works

Tissue Geometry Determines Sites of Mammary Branching Morphogenesis in Organotypic Cultures

Nelson, C. M., VanDuijn, M. M., Inman, J. L., Fletcher, D. A., & Bissell, M. J. (2006) · Science · doi:10.1126/science.1131000 · Cited by 610 · see citing works

A perinuclear actin cap regulates nuclear shape

Khatau, S. B., Hale, C. M., Stewart-Hutchinson, P. J., Patel, M. S., Stewart, C. L., Searson, P. C., Hodzic, D. M., & Wirtz, D. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0908686106 · Cited by 607 · see citing works

Microengineering of Cellular Interactions

Folch, A., & Toner, M. (2000) · Annual Review of Biomedical Engineering · doi:10.1146/annurev.bioeng.2.1.227 · Cited by 602 · see citing works

Building epithelial architecture: insights from three-dimensional culture models

O'Brien, L. E., Zegers, M. M. P., & Mostov, K. E. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm859 · Cited by 596 · see citing works

Anisotropy of cell adhesive microenvironment governs cell internal organization and orientation of polarity

Théry, M., Racine, V., Piel, M., Pépin, A., Dimitrov, A., Chen, Y., Sibarita, J., & Bornens, M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609267103 · Cited by 593 · see citing works

A distinctive role for focal adhesion proteins in three-dimensional cell motility

Fraley, S. I., Feng, Y., Krishnamurthy, R., Kim, D. H., Celedon, A., Longmore, G. D., & Wirtz, D. (2010) · Nature Cell Biology · doi:10.1038/ncb2062 · Cited by 587 · see citing works

Microcontact printing: A tool to pattern

Ruiz, S. A., & Chen, C. S. (2006) · Soft Matter · doi:10.1039/b613349e · Cited by 534 · see citing works

Control of Cyclin D1, p27Kip1, and Cell Cycle Progression in Human Capillary Endothelial Cells by Cell Shape and Cytoskeletal Tension

Huang, S., Chen, C. S., & Ingber, D. E. (1998) · Molecular Biology of the Cell · doi:10.1091/mbc.9.11.3179 · Cited by 487 · see citing works

Fabrication of 3D hepatic tissues by additive photopatterning of cellular hydrogels

Tsang, V. L., Chen, A. A., Cho, L. M., Jadin, K. D., Sah, R. L., DeLong, S., West, J. L., & Bhatia, S. N. (2007) · The FASEB Journal · doi:10.1096/fj.06-7117com · Cited by 462 · see citing works

Directional control of lamellipodia extension by constraining cell shape and orienting cell tractional forces

Parker, K. K., Brock, A., Brangwynne, C., Mannix, R. J., Wang, N., Ostuni, E., Geisse, N. A., Adams, J. C., Whitesides, G. M., & Ingber, D. E. (2002) · The FASEB Journal · doi:10.1096/fj.02-0038com · Cited by 460 · see citing works

Cell distribution of stress fibres in response to the geometry of the adhesive environment

Théry, M., Pépin, A., Dressaire, E., Chen, Y., & Bornens, M. (2006) · Cell Motility and the Cytoskeleton · doi:10.1002/cm.20126 · Cited by 452 · see citing works

Directing cell migration with asymmetric micropatterns

Jiang, X., Bruzewicz, D. A., Wong, A. P., Piel, M., & Whitesides, G. M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408954102 · Cited by 448 · see citing works

Control of Human Embryonic Stem Cell Colony and Aggregate Size Heterogeneity Influences Differentiation Trajectories

Bauwens, C. L., Peerani, R., Niebruegge, S., Woodhouse, K. A., Kumacheva, E., Husain, M., & Zandstra, P. W. (2008) · Stem Cells · doi:10.1634/stemcells.2008-0183 · Cited by 442 · see citing works

Actin and serum response factor transduce physical cues from the microenvironment to regulate epidermal stem cell fate decisions

Connelly, J. T., Gautrot, J. E., Trappmann, B., Tan, D. W., Donati, G., Huck, W. T. S., & Watt, F. M. (2010) · Nature Cell Biology · doi:10.1038/ncb2074 · Cited by 442 · see citing works

Geometric control of switching between growth, apoptosis, and differentiation during angiogenesis using micropatterned substrates

Dike, L. E., Chen, C. S., Mrksich, M., Tien, J., Whitesides, G. M., & Ingber, D. E. (1999) · In Vitro Cellular & Developmental Biology - Animal · doi:10.1007/s11626-999-0050-4 · Cited by 441 · see citing works

Emergence of Patterned Stem Cell Differentiation Within Multicellular Structures

Ruiz, S. A., & Chen, C. S. (2008) · Stem Cells · doi:10.1634/stemcells.2008-0432 · Cited by 415 · see citing works

Three-dimensional micropatterning of bioactive hydrogels via two-photon laser scanning photolithography for guided 3D cell migration

Lee, S.-H., Moon, J. J., & West, J. L. (2008) · Biomaterials · doi:10.1016/j.biomaterials.2008.04.004 · Cited by 413 · see citing works

Cell shape controls terminal differentiation of human epidermal keratinocytes.

Watt, F. M., Jordan, P. W., & O'Neill, C. H. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.15.5576 · Cited by 411 · see citing works

Three‐Dimensional Biochemical and Biomechanical Patterning of Hydrogels for Guiding Cell Behavior

Hahn, M. S., Miller, J. S., & West, J. L. (2006) · Advanced Materials · doi:10.1002/adma.200600647 · Cited by 407 · see citing works

Experimental and theoretical study of mitotic spindle orientation

Théry, M., Jiménez-Dalmaroni, A., Racine, V., Bornens, M., & Jülicher, F. (2007) · Nature · doi:10.1038/nature05786 · Cited by 406 · see citing works

Cell behaviour on micropatterned substrata: limits of extracellular matrix geometry for spreading and adhesion

Lehnert, D., Wehrle‐Haller, B., Dávid, C., Weiland, U., Ballestrem, C., Imhof, B. A., & Bastmeyer, M. (2003) · Journal of Cell Science · doi:10.1242/jcs.00836 · Cited by 395 · see citing works

Anisotropic mechanosensing by mesenchymal stem cells

Kurpinski, K. T., Chu, J. S. F., Hashi, C. K., & Li, S. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604182103 · Cited by 393 · see citing works

Micromechanical control of cell–cell interactions

Hui, E. E., & Bhatia, S. N. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0608660104 · Cited by 392 · see citing works

Niche‐mediated control of human embryonic stem cell self‐renewal and differentiation

Peerani, R., Rao, B. M., Bauwens, C. L., Yin, T., Wood, G. A., Nagy, A., Kumacheva, E., & Zandstra, P. W. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601896 · Cited by 390 · see citing works

Differential adhesion in morphogenesis: a modern view

Steinberg, M. S. (2007) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2007.05.002 · Cited by 382 · see citing works

Rigidity-driven growth and migration of epithelial cells on microstructured anisotropic substrates

Saez, A., Ghibaudo, M., Buguin, A., Silberzan, P., & Ladoux, B. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0702259104 · Cited by 381 · see citing works

Stem Cell Shape Regulates a Chondrogenic Versus Myogenic Fate Through Rac1 and N-Cadherin

Gao, L., McBeath, R., & Chen, C. S. (2010) · Stem Cells · doi:10.1002/stem.308 · Cited by 369 · see citing works

Mechanical control of tissue morphogenesis during embryological development

Ingber, D. E. (2006) · The International Journal of Developmental Biology · doi:10.1387/ijdb.052044di · Cited by 352 · see citing works

Using electroactive substrates to pattern the attachment of two different cell populations

Yousaf, M. N., Houseman, B. T., & Mrksich, M. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.101112898 · Cited by 351 · see citing works

Velocity Fields in a Collectively Migrating Epithelium

Petitjean, L., Reffay, M., Grasland‐Mongrain, E., Poujade, M., Ladoux, B., Buguin, A., & Silberzan, P. (2010) · Biophysical Journal · doi:10.1016/j.bpj.2010.01.030 · Cited by 342 · see citing works

Directing cell motions on micropatterned ratchets

Mahmud, G., Campbell, C. J., Bishop, K. J. M., Komarova, Y. A., Chaga, O. Y., Soh, S., Huda, S., Kandere‐Grzybowska, K., & Grzybowski, B. A. (2009) · Nature Physics · doi:10.1038/nphys1306 · Cited by 328 · see citing works

Microfabrication of Hepatocyte/Fibroblast Co-cultures: Role of Homotypic Cell Interactions

Bhatia, S. N., Balis, U. J., Yarmush, M. L., & Toner, M. (1998) · Biotechnology Progress · doi:10.1021/bp980036j · Cited by 304 · see citing works

Cell shape and cell division

Théry, M., & Bornens, M. (2006) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2006.10.001 · Cited by 296 · see citing works

Micropatterning tractional forces in living cells

Wang, N., Ostuni, E., Whitesides, G. M., & Ingber, D. E. (2002) · Cell Motility and the Cytoskeleton · doi:10.1002/cm.10037 · Cited by 289 · see citing works

Behavior of cultured cells on substrata of variable adhesiveness

Harris, A. K. (1973) · Experimental Cell Research · doi:10.1016/0014-4827(73)90579-x · Cited by 283 · see citing works

Simple and rapid process for single cell micro-patterning

Azioune, A., Storch, M., Bornens, M., Théry, M., & Piel, M. (2009) · Lab on a Chip · doi:10.1039/b821581m · Cited by 270 · see citing works

Responses of fibroblasts to anchorage of dorsal extracellular matrix receptors

Beningo, K. A., Dembo, M., & Wang, Y.-L. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0405747102 · Cited by 269 · see citing works

Cell‐cell signaling by direct contact increases cell proliferation via a PI3K‐dependent signal

Nelson, C. M., & Chen, C. S. (2002) · FEBS Letters · doi:10.1016/s0014-5793(02)02370-0 · Cited by 264 · see citing works

Dynamic Interfaces between Cells and Surfaces: Electroactive Substrates that Sequentially Release and Attach Cells

Yeo, W., Yousaf, M. N., & Mrksich, M. (2003) · Journal of the American Chemical Society · doi:10.1021/ja038265b · Cited by 254 · see citing works

Geometric Determinants of Directional Cell Motility Revealed Using Microcontact Printing

Brock, A., Chang, E. I., Ho, C., LeDuc, P. R., Jiang, X., Whitesides, G. M., & Ingber, D. E. (2003) · Langmuir · doi:10.1021/la026394k · Cited by 252 · see citing works

Local and Long-Range Reciprocal Regulation of cAMP and cGMP in Axon/Dendrite Formation

Shelly, M., Lim, B. K., Cancedda, L., Heilshorn, S. C., Gao, H., & Poo, M. (2010) · Science · doi:10.1126/science.1179735 · Cited by 251 · see citing works

Strength Dependence of Cadherin-Mediated Adhesions

Ladoux, B., Anon, E., Lambert, M., Rabodzey, A., Hersen, P., Buguin, A., Silberzan, P., & Mège, R. (2010) · Biophysical Journal · doi:10.1016/j.bpj.2009.10.044 · Cited by 243 · see citing works

Cell polarity triggered by cell-cell adhesion via E-cadherin

Desai, R. A., Gao, L., Raghavan, S., Liu, W. F., & Chen, C. S. (2009) · Journal of Cell Science · doi:10.1242/jcs.028183 · Cited by 242 · see citing works

Tissue phenotype depends on reciprocal interactions between the extracellular matrix and the structural organization of the nucleus

Lelièvre, S. A., Weaver, V. M., Nickerson, J. A., Larabell, C. A., Bhaumik, A., PETERSEN, O. W., & Bissell, M. J. (1998) · eScholarship (California Digital Library) · Cited by 236 · see citing works

Sarcomere alignment is regulated by myocyte shape

Bray, M., Sheehy, S. P., & Parker, K. K. (2008) · Cell Motility · doi:10.1002/cm.20290 · Cited by 228 · see citing works

Cell-Shape Regulation of Smooth Muscle Cell Proliferation

Thakar, R. G., Cheng, Q., Patel, S. A., Chu, J. S. F., Nasir, M., Liepmann, D., Komvopoulos, K., & Li, S. (2009) · Biophysical Journal · doi:10.1016/j.bpj.2008.11.074 · Cited by 214 · see citing works

Tissue geometry patterns epithelial–mesenchymal transition via intercellular mechanotransduction

Gomez, E. W., Chen, Q. K., Gjorevski, N., & Nelson, C. M. (2010) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22545 · Cited by 214 · see citing works

Extracellular matrix controls myosin light chain phosphorylation and cell contractility through modulation of cell shape and cytoskeletal prestress

Polte, T. R., Eichler, G. S., Wang, N., & Ingber, D. E. (2004) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00280.2003 · Cited by 214 · see citing works

Cell shape and contractility regulate ciliogenesis in cell cycle–arrested cells

Pitaval, A., Tseng, Q., Bornens, M., & Théry, M. (2010) · The Journal of Cell Biology · doi:10.1083/jcb.201004003 · Cited by 213 · see citing works

Regulation of cell motile behavior by crosstalk between cadherin- and integrin-mediated adhesions

Borghi, N., Lowndes, M., Maruthamuthu, V., Gardel, M. L., & Nelson, W. J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002662107 · Cited by 212 · see citing works

Role of RhoA, mDia, and ROCK in Cell Shape-dependent Control of the Skp2-p27 Pathway and the G1/S Transition

Mammoto, A., Huang, S., Moore, K. A., Oh, P., & Ingber, D. E. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402725200 · Cited by 210 · see citing works

Micropatterning of Single Endothelial Cell Shape Reveals a Tight Coupling between Nuclear Volume in G1 and Proliferation

Roca‐Cusachs, P., Alcaraz, J., Sunyer, R., Samitier, J., Farré, R., & Navajas, D. (2008) · Biophysical Journal · doi:10.1529/biophysj.107.116863 · Cited by 203 · see citing works

A Photochemical Method for Patterning the Immobilization of Ligands and Cells to Self-Assembled Monolayers

Dillmore, W. S., Yousaf, M. N., & Mrksich, M. (2004) · Langmuir · doi:10.1021/la049826v · Cited by 194 · see citing works

Micropatterning of Poly(Ethylene Glycol) Diacrylate Hydrogels with Biomolecules to Regulate and Guide Endothelial Morphogenesis

Moon, J. J., Hahn, M. S., Kim, I., Nsiah, B. A., & West, J. L. (2008) · Tissue Engineering Part A · doi:10.1089/ten.tea.2008.0196 · Cited by 193 · see citing works

Organelle positioning and cell polarity

Bornens, M. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2524 · Cited by 191 · see citing works

Controlled Switchable Surface

Liu, Y., Li, M., Liu, B., & Kong, J. (2005) · Chemistry - A European Journal · doi:10.1002/chem.200400931 · Cited by 190 · see citing works

Determination of hierarchical relationship of Src and Rac at subcellular locations with FRET biosensors

Ouyang, M., Sun, J., Chien, S., & Wang, Y. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0807537105 · Cited by 189 · see citing works

Classical cadherins control nucleus and centrosome position and cell polarity

Dupin, I., Camand, E., & Etienne‐Manneville, S. (2009) · The Journal of Cell Biology · doi:10.1083/jcb.200812034 · Cited by 187 · see citing works

Regulation of vascular smooth muscle cells by micropatterning

Thakar, R. G., Ho, F., Huang, N. F., Liepmann, D., & Li, S. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)01285-3 · Cited by 183 · see citing works

Comparative study and improvement of current cell micro-patterning techniques

Fink, J., Théry, M., Azioune, A., Dupont, R., Chatelain, F., Bornens, M., & Piel, M. (2007) · Lab on a Chip · doi:10.1039/b618545b · Cited by 177 · see citing works

Flexible polyacrylamide substrata for the analysis of mechanical interactions at cell-substratum adhesions

Beningo, K. A., Lo, C., & Wang, Y.-L. (2002) · Methods in cell biology · doi:10.1016/s0091-679x(02)69021-1 · Cited by 174 · see citing works

Axonal outgrowth of hippocampal neurons on micro-scale networks of polylysine-conjugated laminin

Kam, L. C. (2001) · Biomaterials · doi:10.1016/s0142-9612(00)00352-5 · Cited by 171 · see citing works

Cell shape regulates global histone acetylation in human mammary epithelial cells

Beyec, J. L., Xu, R., Lee, S., Nelson, C. M., Rizki, A., Alcaraz, J., & Bissell, M. J. (2007) · Experimental Cell Research · doi:10.1016/j.yexcr.2007.04.022 · Cited by 170 · see citing works

In migrating cells, the Golgi complex and the position of the centrosome depend on geometrical constraints of the substratum

Pouthas, F., Girard, P. P., Lecaudey, V., Ly, T. B. N., Gilmour, D. T., Boulin, C., Pepperkok, R., & Reynaud, E. G. (2008) · Journal of Cell Science · doi:10.1242/jcs.026849 · Cited by 167 · see citing works

Microcontact Printing for Precise Control of Nerve Cell Growth in Culture

Wheeler, B. C., Corey, J. M., Brewer, G. J., & Branch, D. W. (1999) · Journal of Biomechanical Engineering · doi:10.1115/1.2798045 · Cited by 165 · see citing works

Micropatterned matrix directs differentiation of human mesenchymal stem cells towards myocardial lineage

Tay, C. Y., Yu, H., Pal, M., Leong, W. S., Tan, N. S., Ng, K. W., Leong, D. T., & Tan, L. P. (2010) · Experimental Cell Research · doi:10.1016/j.yexcr.2010.02.010 · Cited by 165 · see citing works

Directional control of cell motility through focal adhesion positioning and spatial control of Rac activation

Xia, N., Thodeti, C. K., Hunt, T. P., Xu, Q., Ho, M., Whitesides, G. M., Westervelt, R. M., & Ingber, D. E. (2008) · The FASEB Journal · doi:10.1096/fj.07-090571 · Cited by 162 · see citing works

Geometrically Controlled Endothelial Tubulogenesis in Micropatterned Gels

Raghavan, S., Nelson, C. M., Baranski, J. D., Lim, E. A., & Chen, C. S. (2010) · Tissue Engineering Part A · doi:10.1089/ten.tea.2009.0584 · Cited by 160 · see citing works

Microlithographic determination of axonal/dendritic polarity in cultured hippocampal neurons

Stenger, D. A., Hickman, J. J., Bateman, K. E., Ravenscroft, M. S., Ma, W., Pancrazio, J. J., Shaffer, K. M., Schaffner, A. E., Cribbs, D. H., & Cotman, C. W. (1998) · Journal of Neuroscience Methods · doi:10.1016/s0165-0270(98)00047-8 · Cited by 155 · see citing works

Bulk and Micropatterned Conjugation of Extracellular Matrix Proteins to Characterized Polyacrylamide Substrates for Cell Mechanotransduction Assays

Damljanovic, V., Lagerholm, B. C., & Jacobson, K. (2005) · BioTechniques · doi:10.2144/000112026 · Cited by 153 · see citing works

An inverted microcontact printing method on topographically structured polystyrene chips for arrayed micro-3-D culturing of single cells

Dusseiller, M. R., Schlaepfer, D., Koch, M. C., Kroschewski, R., & Textor, M. (2005) · Biomaterials · doi:10.1016/j.biomaterials.2005.02.032 · Cited by 153 · see citing works

Adhesive Micropatterns for Cells: A Microcontact Printing ProtocolPreprint

Théry, M., & Piel, M. (2009) · Cold Spring Harbor Protocols · doi:10.1101/pdb.prot5255 · Cited by 149 · see citing works

Using self-assembled monolayers to model the extracellular matrix

Mrksich, M. (2009) · Acta Biomaterialia · doi:10.1016/j.actbio.2009.01.016 · Cited by 145 · see citing works

Patterning Axonal Guidance Molecules Using a Novel Strategy for Microcontact Printing

Oliva, A. A., James, C. D., Kingman, C. E., Craighead, H. G., & Banker, G. A. (2003) · Neurochemical Research · doi:10.1023/a:1026052820129 · Cited by 137 · see citing works

Change in cell shape is required for matrix metalloproteinase‐induced epithelial‐mesenchymal transition of mammary epithelial cells

Nelson, C. M., Khauv, D., Bissell, M. J., & Radisky, D. C. (2008) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21821 · Cited by 136 · see citing works

Protein Micropatterns

Azioune, A., Carpi, N., Tseng, Q., Théry, M., & Piel, M. (2010) · Methods in cell biology · doi:10.1016/s0091-679x(10)97008-8 · Cited by 135 · see citing works

Electroactive Self-Assembled Monolayers that Permit Orthogonal Control over the Adhesion of Cells to Patterned Substrates

Yeo, W., & Mrksich, M. (2006) · Langmuir · doi:10.1021/la061212y · Cited by 122 · see citing works

Recent Advances in Cell Micropatterning Techniques for Bioanalytical and Biomedical Sciences

Nakanishi, J., Takarada, T., Yamaguchi, K., & Maeda, M. (2008) · Analytical Sciences · doi:10.2116/analsci.24.67 · Cited by 116 · see citing works

Force generated by actomyosin contraction builds bridges between adhesive contacts

Rossier, O., Gauthier, N. C., Biais, N., Vonnegut, W., Fardin, M.-A., Avigan, P., Heller, E., Mathur, A., Ghassemi, S., Koeckert, M. S., et al. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.2 · Cited by 115 · see citing works

Subcellular curvature at the perimeter of micropatterned cells influences lamellipodial distribution and cell polarity

James, J., Goluch, E. D., Hu, H., Liu, C., & Mrksich, M. (2008) · Cell Motility and the Cytoskeleton · doi:10.1002/cm.20305 · Cited by 113 · see citing works

Haptotactic islands

CARTER, S. B. (1967) · Experimental Cell Research · doi:10.1016/0014-4827(67)90298-4 · Cited by 107 · see citing works

Symmetry‐breaking in mammalian cell cohort migration during tissue pattern formation: Role of random‐walk persistence

Huang, S., Brangwynne, C. P., Parker, K. K., & Ingber, D. E. (2005) · Cell Motility and the Cytoskeleton · doi:10.1002/cm.20077 · Cited by 105 · see citing works

Probabilistic density maps to study global endomembrane organization

Schauer, K., Duong, T., Bleakley, K., Bardin, S., Bornens, M., & Goud, B. (2010) · Nature Methods · doi:10.1038/nmeth.1462 · Cited by 105 · see citing works

Finding the Cell Center by a Balance of Dynein and Myosin Pulling and Microtubule Pushing: A Computational Study

Zhu, J., Burakov, A. V., Rodionov, V., & Mogilner, A. (2010) · Molecular Biology of the Cell · doi:10.1091/mbc.e10-07-0627 · Cited by 104 · see citing works

Directional shear flow and Rho activation prevent the endothelial cell apoptosis induced by micropatterned anisotropic geometry

Wu, C., Li, Y.-S. J., Haga, J., Kaunas, R. R., Chiu, J., Su, F., Usami, S., & Chien, S. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609806104 · Cited by 99 · see citing works

3D femtosecond laser patterning of collagen for directed cell attachment

Liu, Y., Sun, S., Singha, S., Cho, M., & Gordon, R. J. (2005) · Biomaterials · doi:10.1016/j.biomaterials.2004.11.033 · Cited by 97 · see citing works

Dimensionality Controls Cytoskeleton Assembly and Metabolism of Fibroblast Cells in Response to Rigidity and Shape

Ochsner, M., Textor, M., Viola Vogel, B., & Smith, M. L. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009445 · Cited by 92 · see citing works

UV-Based Patterning of Polymeric Substrates for Cell Culture Applications

Welle, A., & Gottwald, E. (2002) · Biomedical Microdevices · doi:10.1023/a:1014267712144 · Cited by 89 · see citing works

Retrograde Fluxes of Focal Adhesion Proteins in Response to Cell Migration and Mechanical Signals

Guo, W.-H., & Wang, Y. (2007) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-06-0582 · Cited by 88 · see citing works

Demystifying the Effects of a Three‐Dimensional Microenvironment in Tissue Morphogenesis

Levental, K. R., Leight, J. L., & Weaver, V. M. (2007) · Methods in cell biology · doi:10.1016/s0091-679x(07)83023-8 · Cited by 87 · see citing works

Photochemical Patterning of Biological Molecules Inside a Glass Capillary

Balakirev, M. Y., Porte, S., Vernaz-Gris, M., Berger, M., Arié, J., Fouqué, B., & Chatelain, F. (2005) · Analytical Chemistry · doi:10.1021/ac0504619 · Cited by 84 · see citing works

Control of myocyte remodeling in vitro with engineered substrates

Geisse, N. A., Sheehy, S. P., & Parker, K. K. (2009) · In Vitro Cellular & Developmental Biology - Animal · doi:10.1007/s11626-009-9182-9 · Cited by 82 · see citing works

Addressable Micropatterning of Multiple Proteins and Cells by Microscope Projection Photolithography Based on a Protein Friendly Photoresist

Kim, M., Choi, J., Jung, H.-R., Katz, J. S., Kim, M., & Doh, J. (2010) · Langmuir · doi:10.1021/la1014253 · Cited by 79 · see citing works

Lamellipodia nucleation by filopodia depends on integrin occupancy and downstream Rac1 signaling

Guillou, H., Depraz-Depland, A., Planus, E., Vianay, B., Chaussy, J., Grichine, A., Albigès‐Rizo, C., & Block, M. R. (2007) · Experimental Cell Research · doi:10.1016/j.yexcr.2007.10.026 · Cited by 77 · see citing works

Spatiotemporal control of cell adhesion on a self-assembled monolayer having a photocleavable protecting group

Nakanishi, J., Kikuchi, Y., Takarada, T., Nakayama, H., Yamaguchi, K., & Maeda, M. (2006) · Analytica Chimica Acta · doi:10.1016/j.aca.2006.04.059 · Cited by 76 · see citing works

Tunable interplay between epidermal growth factor and cell–cell contact governs the spatial dynamics of epithelial growth

Kim, J., Kushiro, K., Graham, N. A., & Asthagiri, A. R. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0812651106 · Cited by 73 · see citing works

Micropatterned Dynamically Adhesive Substrates for Cell Migration

Raghavan, S., Desai, R. A., Kwon, Y., Mrksich, M., & Chen, C. S. (2010) · Langmuir · doi:10.1021/la102955m · Cited by 68 · see citing works

Photo-chemically patterned polymer surfaces for controlled PC-12 adhesion and neurite guidance

Welle, A., Horn, S., Schimmelpfeng, J., & Kalka, D. (2004) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2004.08.011 · Cited by 64 · see citing works

Rigidity-Dependent Cross Talk between Integrin and Cadherin Signaling

Tsai, J., & Kam, L. C. (2009) · Biophysical Journal · doi:10.1016/j.bpj.2009.01.005 · Cited by 63 · see citing works

Engineering amount of cell–cell contact demonstrates biphasic proliferative regulation through RhoA and the actin cytoskeleton

Gray, D. S., Liu, W. F., Shen, C. J., Bhadriraju, K., Nelson, C. M., & Chen, C. S. (2008) · Experimental Cell Research · doi:10.1016/j.yexcr.2008.06.023 · Cited by 63 · see citing works

Impact of micropatterned surfaces on neuronal polarity

Vogt, A. K., Stefani, F. D., Best, A., Nelles, G., Yasuda, A., Knoll, W., & Offenhäusser, A. (2004) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2003.11.004 · Cited by 62 · see citing works

Spatial patterning of cell proliferation and differentiation depends on mechanical stress magnitude

Li, B., Li, F., Puskar, K. M., & Wang, J. H. (2009) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2009.04.033 · Cited by 62 · see citing works

Cadherin-Mediated Cell–Cell Contact Regulates Keratinocyte Differentiation

Charest, J. L., Jennings, J. M., King, W. P., Kowalczyk, A. P., & Garcı́a, A. J. (2008) · Journal of Investigative Dermatology · doi:10.1038/jid.2008.265 · Cited by 62 · see citing works

Local presentation of L1 and N‐cadherin in multicomponent, microscale patterns differentially direct neuron function in vitro

Shi, P., Shen, K., & Kam, L. C. (2007) · Developmental Neurobiology · doi:10.1002/dneu.20553 · Cited by 60 · see citing works

Patterning, Prestress, and Peeling Dynamics of Myocytes

Griffin, M. A., Engler, A. J., Barber, T. A., Healy, K. E., Sweeney, H. L., & Discher, D. E. (2004) · Biophysical Journal · doi:10.1016/s0006-3495(04)74195-8 · Cited by 53 · see citing works

Arraying Heterotypic Single Cells on Photoactivatable Cell-Culturing Substrates

Kikuchi, Y., Nakanishi, J., Shimizu, T., Nakayama, H., Inoue, S., Yamaguchi, K., Iwaï, H., Yoshida, Y., Horiike, Y., Takarada, T., et al. (2008) · Langmuir · doi:10.1021/la8024414 · Cited by 52 · see citing works

Cytoskeletal structure regulates endothelial cell immunogenicity independent of fluid shear stress

Vartanian, K. B., Berny‐Lang, M. A., McCarty, O. J. T., Hanson, S. R., & Hinds, M. T. (2009) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00340.2009 · Cited by 51 · see citing works

Rapid multicomponent optical protein patterning

Bélisle, J. M., Kunik, D., & Costantino, S. (2009) · Lab on a Chip · doi:10.1039/b911967a · Cited by 49 · see citing works

Cytoskeletal control of fibroblast length: experiments with linear strips of substrate

Levina, E. M., Kharitonova, M. A., Rovensky, Y. A., & Vasiliev, J. M. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.23.4335 · Cited by 48 · see citing works

Exercising Spatiotemporal Control of Cell Attachment with Optically Transparent Microelectrodes

Shah, S. S., Lee, J. Y., Verkhoturov, S. V., Tuleuova, N., Schweikert, E. A., Ramanculov, E. M., & Revzin, A. (2008) · Langmuir · doi:10.1021/la800231e · Cited by 40 · see citing works

The microenvironmental determinants for kidney epithelial cyst morphogenesis

Guo, Q., Xia, B., Moshiach, S., Xu, C., Jiang, Y., Chen, Y., Sun, Y., Lahti, J. M., & Zhang, X. A. (2008) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2007.11.004 · Cited by 39 · see citing works

Grafting Poly(ethylene glycol) to a Glass Surface via a Photocleavable Linker for Light-induced Cell Micropatterning and Cell Proliferation Control

Kikuchi, Y., Nakanishi, J., Nakayama, H., Shimizu, T., Yoshino, Y., Yamaguchi, K., Yoshida, Y., & Horiike, Y. (2008) · Chemistry Letters · doi:10.1246/cl.2008.1062 · Cited by 36 · see citing works

Coordination between Extrinsic Extracellular Matrix Cues and Intrinsic Responses to Orient the Centrosome in Polarizing Cerebellar Granule Neurons

GUPTA, S. K., Meiri, K. F., Mahfooz, K., Bharti, U., & Mani, S. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.4218-09.2010 · Cited by 32 · see citing works

Electrically Programmable Surfaces for Configurable Patterning of Cells

Fan, C., Tung, Y., Takayama, S., Meyhöfer, E., & Kurabayashi, K. (2008) · Advanced Materials · doi:10.1002/adma.200702191 · Cited by 29 · see citing works

Auto‐reverse nuclear migration in bipolar mammalian cells on micropatterned surfaces

Szabó, B., Környei, Z., Tárnoki-Zách, J., Selmeczi, D., Csúcs, G., Czirók, A., & Vicsek, T. (2004) · Cell Motility and the Cytoskeleton · doi:10.1002/cm.20022 · Cited by 20 · see citing works

Electrically controlling cell adhesion, growth and migration

Gabi, M., Larmagnac, A., Schulte, P., & Vörös, J. (2010) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2010.04.019 · Cited by 18 · see citing works

Encouraging Effect of Cadherin-Mediated Cell−Cell Junctions on Transfer Printing of Micropatterned Vascular Endothelial Cells

Okochi, N., Okazaki, T., & Hattori, H. (2009) · Langmuir · doi:10.1021/la9006668 · Cited by 17 · see citing works

Geometric confinement influences cellular mechanical properties II -- intracellular variances in polarized cells.

Su, J., Brau, R. R., Jiang, X., Whitesides, G. M., Lang, M. J., & So, P. T. C. (2007) · PubMed · Cited by 14 · see citing works

Modeling physiological events in 2D vs. 3D cell culture

Duval, K., Grover, H., Han, L.-H., Mou, Y., Pegoraro, A. F., Fredberg, J., & Chen, Z. (2017) · Physiology · doi:10.1152/physiol.00036.2016 · Cited by 1,849 · see citing works

Deconstructing the third dimension – how 3D culture microenvironments alter cellular cues

Baker, B. M., & Chen, C. S. (2012) · Journal of Cell Science · doi:10.1242/jcs.079509 · Cited by 1,760 · see citing works

Current hydrogel advances in physicochemical and biological response-driven biomedical application diversity

Cao, H., Duan, L., Zhang, Y., Cao, J., & Zhang, K. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00830-x · Cited by 1,318 · see citing works

A Review of Cell Adhesion Studies for Biomedical and Biological Applications

Khalili, A. A., & Ahmad, M. R. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms160818149 · Cited by 950 · see citing works

Three-dimensional culture systems in cancer research: Focus on tumor spheroid model

Nath, S., & Devi, G. R. (2016) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2016.03.013 · Cited by 919 · see citing works

Functional and Biomimetic Materials for Engineering of the Three-Dimensional Cell Microenvironment

Huang, G., Li, F., Zhao, X., Ma, Y., Li, Y., Lin, M., Jin, G., Lu, T. J., Genin, G. M., & Xu, F. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00094 · Cited by 825 · see citing works

Surface-Initiated Polymer Brushes in the Biomedical Field: Applications in Membrane Science, Biosensing, Cell Culture, Regenerative Medicine and Antibacterial Coatings

Krishnamoorthy, M., Hakobyan, S., Ramstedt, M., & Gautrot, J. E. (2014) · Chemical Reviews · doi:10.1021/cr500252u · Cited by 606 · see citing works

Spatial organization of the extracellular matrix regulates cell–cell junction positioning

Tseng, Q., Duchemin-Pelletier, E., Deshière, A., Balland, M., Guillou, H., Filhol, O., & Théry, M. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1106377109 · Cited by 596 · see citing works

Mechanisms generating cancer genome complexity from a single cell division error

Umbreit, N. T., Zhang, C.-Z., Lynch, L. D., Blaine, L. J., Cheng, A. M., Tourdot, R., Sun, L., Almubarak, H. F., Judge, K., Mitchell, T. J., et al. (2020) · Science · doi:10.1126/science.aba0712 · Cited by 439 · see citing works

β1- and αv-class integrins cooperate to regulate myosin II during rigidity sensing of fibronectin-based microenvironments

Schiller, H. B., Hermann, M.-R., Polleux, J., Vignaud, T., Zanivan, S. R., Friedel, C. C., Sun, Z., Raducanu, A., Gottschalk, K., Théry, M., et al. (2013) · Nature Cell Biology · doi:10.1038/ncb2747 · Cited by 430 · see citing works

Controlling cell–cell interactions using surface acoustic waves

Guo, F., Li, P., French, J. B., Mao, Z., Zhao, H., Li, S., Nama, N., Fick, J. R., Benkovic, S. J., & Huang, T. J. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1422068112 · Cited by 408 · see citing works

Phenotypic drug discovery: recent successes, lessons learned and new directions

Vincent, F., Nueda, A., Lee, J. L. C., Schenone, M., Prunotto, M., & Mercola, M. A. (2022) · Nature Reviews Drug Discovery · doi:10.1038/s41573-022-00472-w · Cited by 372 · see citing works

Advances in Bioactive Hydrogels to Probe and Direct Cell Fate

DeForest, C. A., & Anseth, K. S. (2012) · Annual Review of Chemical and Biomolecular Engineering · doi:10.1146/annurev-chembioeng-062011-080945 · Cited by 323 · see citing works

Effect of cell anisotropy on differentiation of stem cells on micropatterned surfaces through the controlled single cell adhesion

Peng, R., Yao, X., & Ding, J. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.07.035 · Cited by 296 · see citing works

YAP/TAZ link cell mechanics to Notch signalling to control epidermal stem cell fate

Totaro, A., Castellan, M., Battilana, G., Zanconato, F., Azzolin, L., Giulitti, S., Cordenonsi, M., & Piccolo, S. (2017) · Nature Communications · doi:10.1038/ncomms15206 · Cited by 295 · see citing works

Materials from Mussel-Inspired Chemistry for Cell and Tissue Engineering Applications.

Perikamana, S. K. M., Lee, J., Lee, Y., Shin, Y., Lee, E. J., Mikos, A., & Shin, H. (2015) · Biomacromolecules · doi:10.1021/acs.biomac.5b00852 · Cited by 272 · see citing works

Neural stem cell differentiation by electrical stimulation using a cross-linked PEDOT substrate: Expanding the use of biocompatible conjugated conductive polymers for neural tissue engineering

Pires, F., Ferreira, Q., Rodrigues, C. A. V., Morgado, J., & Ferreira, F. C. (2015) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2015.01.020 · Cited by 276 · see citing works

Development of a microphysiological model of human kidney proximal tubule function

Weber, E. J., Chapron, A., Chapron, B. D., Voellinger, J. L., Lidberg, K. A., Yeung, C. K., Wang, Z., Yamaura, Y., Hailey, D. W., Neumann, T., et al. (2016) · Kidney International · doi:10.1016/j.kint.2016.06.011 · Cited by 275 · see citing works

Cell-like pressure sensors reveal increase of mechanical stress towards the core of multicellular spheroids under compression

Dolega, M. E., Delarue, M., Ingremeau, F., Prost, J., Delon, A., & Cappello, G. (2017) · Nature Communications · doi:10.1038/ncomms14056 · Cited by 274 · see citing works

Biomaterials and engineered microenvironments to control YAP/TAZ-dependent cell behaviour

Brusatin, G., Panciera, T., Gandin, A., Citron, A., & Piccolo, S. (2018) · Nature Materials · doi:10.1038/s41563-018-0180-8 · Cited by 271 · see citing works

Actin remodeling confers BRAF inhibitor resistance to melanoma cells through YAP/TAZ activation

Kim, M. H., Kim, J., Hong, H., Lee, J. J.-K., Lee, J., Jung, E., & Kim, J. (2015) · The EMBO Journal · doi:10.15252/embj.201592081 · Cited by 259 · see citing works

Bioorthogonal Click Chemistry: An Indispensable Tool to Create Multifaceted Cell Culture Scaffolds

Azagarsamy, M. A., & Anseth, K. S. (2012) · ACS Macro Letters · doi:10.1021/mz300585q · Cited by 253 · see citing works

A review of microfabrication and hydrogel engineering for micro-organs on chips

Verhulsel, M., Vignes, M., Descroix, S., Malaquin, L., Vignjevic, D. M., & Viovy, J. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.11.021 · Cited by 231 · see citing works

Smart Dressings Based on Nanostructured Fibers Containing Natural Origin Antimicrobial, Anti-Inflammatory, and Regenerative Compounds

Andreu, V., Mendoza, G., Arruebo, M., & Irusta, S. (2015) · Materials · doi:10.3390/ma8085154 · Cited by 215 · see citing works

Myosin-II mediated traction forces evoke localized Piezo1-dependent Ca2+ flickers

Ellefsen, K. L., Holt, J. R., Chang, A. C., Nourse, J. L., Arulmoli, J., Mekhdjian, A. H., Abuwarda, H., Tombola, F., Flanagan, L. A., Dunn, A. R., et al. (2019) · Communications Biology · doi:10.1038/s42003-019-0514-3 · Cited by 208 · see citing works

Extracellular matrix elasticity and topography: Material‐based cues that affect cell function via conserved mechanisms

Janson, I. A., & Putnam, A. J. (2014) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.35254 · Cited by 203 · see citing works

Physical, Spatial, and Molecular Aspects of Extracellular Matrix of In Vivo Niches and Artificial Scaffolds Relevant to Stem Cells Research

Akhmanova, M., Osidak, E. O., Domogatsky, S. P., Rodin, S., & Domogatskaya, A. (2015) · Stem Cells International · doi:10.1155/2015/167025 · Cited by 200 · see citing works

Miro clusters regulate ER-mitochondria contact sites and link cristae organization to the mitochondrial transport machinery

Modi, S., López‐Doménech, G., Halff, E. F., Covill‐Cooke, C., Ivankovic, D., Melandri, D., Arancibia‐Cárcamo, I. L., Burden, J. J., Lowe, A. R., & Kittler, J. T. (2019) · Nature Communications · doi:10.1038/s41467-019-12382-4 · Cited by 181 · see citing works

Bridging the Gap: From 2D Cell Culture to 3D Microengineered Extracellular Matrices

Li, Y., & Kilian, K. A. (2015) · Advanced Healthcare Materials · doi:10.1002/adhm.201500427 · Cited by 180 · see citing works

Self-assembly of amorphous calcium carbonate microlens arrays

Lee, K., Wagermaier, W., Mašić, A., Kommareddy, K. P., Bennet, M. A., Manjubala, I., Lee, S., Park, S. B., Cölfen, H., & Fratzl, P. (2012) · Nature Communications · doi:10.1038/ncomms1720 · Cited by 171 · see citing works

Regulating the stemness of mesenchymal stem cells by tuning micropattern features

Wang, X., Nakamoto, T., Dulińska‐Molak, I., Kawazoe, N., & Chen, G. (2015) · Journal of Materials Chemistry B · doi:10.1039/c5tb02215k · Cited by 168 · see citing works

Collective Cell Migration: A Mechanistic Perspective

Vedula, S. R. K., Ravasio, A., Lim, C. T., & Ladoux, B. (2013) · Physiology · doi:10.1152/physiol.00033.2013 · Cited by 166 · see citing works

Compressive force induces reversible chromatin condensation and cell geometry–dependent transcriptional response

Damodaran, K., Venkatachalapathy, S., Alisafaei, F., Radhakrishnan, A., Jokhun, D. S., Shenoy, V. B., & Shivashankar, G. V. (2018) · Molecular Biology of the Cell · doi:10.1091/mbc.e18-04-0256 · Cited by 164 · see citing works

Curvature in Biological Systems: Its Quantification, Emergence, and Implications across the Scales

Schamberger, B., Ziege, R., Anselme, K., Amar, M. B., Bykowski, M., Castro, A. P. G., Cipitria, A., Coles, R., Dimova, R., Eder, M., et al. (2022) · Advanced Materials · doi:10.1002/adma.202206110 · Cited by 165 · see citing works

Multiprotein Printing by Light‐Induced Molecular Adsorption

Strale, P., Azioune, A., Bugnicourt, G., Lecomte, Y., Chahid, M., & Studer, V. (2015) · Advanced Materials · doi:10.1002/adma.201504154 · Cited by 162 · see citing works

High‐Resolution Projection Microstereolithography for Patterning of Neovasculature

Raman, R., Bhaduri, B., Mir, M., Shkumatov, A. A., Lee, M. K., Popescu, G., Kong, H., & Bashir, R. (2015) · Advanced Healthcare Materials · doi:10.1002/adhm.201500721 · Cited by 159 · see citing works

The Human Epidermal Basement Membrane: A Shaped and Cell Instructive Platform That Aging Slowly Alters

Roig-Rosello, E., & Rousselle, P. (2020) · Biomolecules · doi:10.3390/biom10121607 · Cited by 142 · see citing works

Integrated Micro/Nanoengineered Functional Biomaterials for Cell Mechanics and Mechanobiology: A Materials Perspective

Shao, Y., & Fu, J. (2013) · Advanced Materials · doi:10.1002/adma.201304431 · Cited by 148 · see citing works

Material approaches to active tissue mechanics

Xi, W., Saw, T. B., Delacour, D., Lim, C. T., & Ladoux, B. (2018) · Nature Reviews Materials · doi:10.1038/s41578-018-0066-z · Cited by 145 · see citing works

Block-Cell-Printing for live single-cell printing

Zhang, K., Chou, C., Xia, X., Hung, M., & Qin, L. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1313661111 · Cited by 142 · see citing works

Switchable adhesive substrates: Revealing geometry dependence in collective cell behavior

Rolli, C. G., Nakayama, H., Yamaguchi, K., Spatz, J. P., Kemkemer, R., & Nakanishi, J. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.12.012 · Cited by 137 · see citing works

Mechanical state transitions in the regulation of tissue form and function

Mao, Y., & Wickström, S. A. (2024) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-024-00719-x · Cited by 138 · see citing works

Mechanical Properties of Materials for Stem Cell Differentiation

Han, S., Kim, J., Lee, G., & Kim, D. (2020) · Advanced Biosystems · doi:10.1002/adbi.202000247 · Cited by 132 · see citing works

Biomaterial–Related Cell Microenvironment in Tissue Engineering and Regenerative Medicine

Gao, J., Yu, X., Wang, X., He, Y., & Ding, J. (2022) · Engineering · doi:10.1016/j.eng.2021.11.025 · Cited by 132 · see citing works

Biofabrication methods for reconstructing extracellular matrix mimetics

Aazmi, A., Zhang, D., Mazzaglia, C., Yu, M., Wang, Z., Yang, H., Huang, Y. Y. S., & Ma, L. (2023) · Bioactive Materials · doi:10.1016/j.bioactmat.2023.08.018 · Cited by 131 · see citing works

Adjustable viscoelasticity allows for efficient collective cell migration

Barriga, E. H., & Mayor, R. (2018) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2018.05.027 · Cited by 130 · see citing works

Biomechano‐Interactive Materials and Interfaces

Cai, P., Hu, B., Leow, W. R., Wang, X., Loh, X. J., Wu, Y., & Chen, X. (2018) · Advanced Materials · doi:10.1002/adma.201800572 · Cited by 128 · see citing works

Compartmentalized Microfluidic Platforms: The Unrivaled Breakthrough of In Vitro Tools for Neurobiological Research

Neto, E., Leitão, L., Sousa, D. M., Alves, C. J., Alencastre, I. S., Aguiar, P., & Lamghari, M. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.1748-16.2016 · Cited by 128 · see citing works

Architecture and migration of an epithelium on a cylindrical wire

Yevick, H. G., Duclos, G., Bonnet, I., & Silberzan, P. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1418857112 · Cited by 126 · see citing works

Convergence of microengineering and cellular self-organization towards functional tissue manufacturing

Laurent, J., Blin, G., Chatelain, F., Vanneaux, V., Fuchs, A., Larghero, J., & Théry, M. (2017) · Nature Biomedical Engineering · doi:10.1038/s41551-017-0166-x · Cited by 117 · see citing works

Hydrogels as Extracellular Matrix Analogs

Díaz, E. C. G., & Varghese, S. (2016) · Gels · doi:10.3390/gels2030020 · Cited by 122 · see citing works

Emergence and Persistence of Collective Cell Migration on Small Circular Micropatterns

Segerer, F. J., Thüroff, F., Alberola, A. P., Frey, E., & Rädler, J. O. (2015) · Physical Review Letters · doi:10.1103/physrevlett.114.228102 · Cited by 122 · see citing works

Tailoring cryo-electron microscopy grids by photo-micropatterning for in-cell structural studies

Toro‐Nahuelpan, M., Zagoriy, I., Senger, F., Blanchoin, L., Théry, M., & Mahamid, J. (2019) · Nature Methods · doi:10.1038/s41592-019-0630-5 · Cited by 113 · see citing works

Epithelial Cell Packing Induces Distinct Modes of Cell Extrusions

Kocgozlu, L., Saw, T. B., Le, A. P., Yow, I., Shagirov, M., Wong, E., Mège, R., Lim, C. T., Toyama, Y., & Ladoux, B. (2016) · Current Biology · doi:10.1016/j.cub.2016.08.057 · Cited by 113 · see citing works

Cyclic Tensile Strain Controls Cell Shape and Directs Actin Stress Fiber Formation and Focal Adhesion Alignment in Spreading Cells

Greiner, A. M., Chen, H., Spatz, J. P., & Kemkemer, R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0077328 · Cited by 115 · see citing works

Mimicking dynamic in vivo environments with stimuli-responsive materials for cell culture

Kim, J., & Hayward, R. C. (2012) · Trends in biotechnology · doi:10.1016/j.tibtech.2012.04.003 · Cited by 113 · see citing works

Recent advances on gelatin methacrylate hydrogels with controlled microstructures for tissue engineering

Zhang, Y., Chen, H., & Li, J. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.08.171 · Cited by 114 · see citing works

Polarity Reversal by Centrosome Repositioning Primes Cell Scattering during Epithelial-to-Mesenchymal Transition

Burute, M., Orhant‐Prioux, M., Blin, G., Truchet, S., Letort, G., Tseng, Q., Bessy, T., Lowell, S., Young, J., Filhol, O., et al. (2016) · Developmental Cell · doi:10.1016/j.devcel.2016.12.004 · Cited by 107 · see citing works

Periosteum‐Mimetic Structures Made from Freestanding Microgrooved Nanosheets

Shi, X., Fujie, T., Saito, A., Takeoka, S., Hou, Y., Shu, Y., Chen, M. W., Wu, H., & Khademhosseini, A. (2014) · Advanced Materials · doi:10.1002/adma.201305804 · Cited by 106 · see citing works

Cell confinement controls centrosome positioning and lumen initiation during epithelial morphogenesis

Rodriguez-Fraticelli, A., Auzan, M., Alonso, M. A., Bornens, M., & Martín‐Belmonte, F. (2012) · The Journal of Cell Biology · doi:10.1083/jcb.201203075 · Cited by 104 · see citing works

Functional fabrication of recombinant human collagen–phosphorylcholine hydrogels for regenerative medicine applications

Islam, M. M., Cėpla, V., He, C., Edin, E., Rakickas, T., Kobuch, K. A., Ruželė, Ž., Jackson, W. B., Rafat, M., Lohmann, C. P., et al. (2014) · Acta Biomaterialia · doi:10.1016/j.actbio.2014.10.035 · Cited by 104 · see citing works

3D Patterning of cells in Magnetic Scaffolds for Tissue Engineering

Goranov, V. A., Shelyakova, T., Santis, R. D., Haranava, Y., Makhaniok, A., Gloria, A., Tampieri, A., Russo, A., Kon, E., Marcacci, M., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-58738-5 · Cited by 104 · see citing works

Regulation of microtubule-associated motors drives intermediate filament network polarization

Leduc, C., & Etienne‐Manneville, S. (2017) · The Journal of Cell Biology · doi:10.1083/jcb.201607045 · Cited by 101 · see citing works

Influence of Microenvironment on Mesenchymal Stem Cell Therapeutic Potency: From Planar Culture to Microcarriers

Tsai, A., Jeske, R., Chen, X., Yuan, X., & Li, Y. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.00640 · Cited by 97 · see citing works

Controlled 3D culture in Matrigel microbeads to analyze clonal acinar development

Dolega, M. E., Abeille, F., Picollet-D'hahan, N., & Gidrol, X. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.02.042 · Cited by 91 · see citing works

Stem cell bioengineering: building from stem cell biology

Tewary, M., Shakiba, N., & Zandstra, P. W. (2018) · Nature Reviews Genetics · doi:10.1038/s41576-018-0040-z · Cited by 93 · see citing works

Photoresponsive Coumarin Polyesters That Exhibit Cross-Linking and Chain Scission Properties

Maddipatla, M. V. S. N., Wehrung, D., Tang, C., Fan, W., Oyewumi, M. O., Miyoshi, T., & Joy, A. (2013) · Macromolecules · doi:10.1021/ma400584y · Cited by 95 · see citing works

Recent Advances in Bioprinting and Applications for Biosensing

Dias, A. D., Kingsley, D., & Corr, D. (2014) · Biosensors · doi:10.3390/bios4020111 · Cited by 76 · see citing works

Micropatterning Strategies to Engineer Controlled Cell and Tissue Architecture in Vitro

D’Arcangelo, E., & McGuigan, A. P. (2015) · BioTechniques · doi:10.2144/000114245 · Cited by 92 · see citing works

Mitotic cells contract actomyosin cortex and generate pressure to round against or escape epithelial confinement

Sorce, B., Escobedo, C., Toyoda, Y., Stewart, M. P., Cattin, C. J., Newton, R., Banerjee, I., Stettler, A., Roska, B., Eaton, S., et al. (2015) · Nature Communications · doi:10.1038/ncomms9872 · Cited by 91 · see citing works

Polyacrylamide Hydrogel Micropatterning

Vignaud, T., Ennomani, H., & Théry, M. (2014) · Methods in cell biology · doi:10.1016/b978-0-12-417136-7.00006-9 · Cited by 90 · see citing works

Dissecting Collective Cell Behavior in Polarization and Alignment on Micropatterned Substrates

He, S., Liu, C., Li, X., Ma, S., Huo, B., & Ji, B. (2015) · Biophysical Journal · doi:10.1016/j.bpj.2015.06.058 · Cited by 88 · see citing works

(Micro)managing the mechanical microenvironment

Moraes, C., Sun, Y., & Simmons, C. A. (2011) · Integrative Biology · doi:10.1039/c1ib00056j · Cited by 87 · see citing works

Spontaneous osteogenesis of MSCs cultured on 3D microcarriers through alteration of cytoskeletal tension

Tseng, P., Young, T., Wang, T., Peng, H.-W., Hou, S.-M., & Yen, M. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.09.090 · Cited by 87 · see citing works

Theoretical aspects of Systems Biology

Bizzarri, M., Palombo, A., & Cucina, A. (2013) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2013.03.019 · Cited by 87 · see citing works

Controlling cell geometry on substrates of variable stiffness can tune the degree of osteogenesis in human mesenchymal stem cells

Lee, J., Abdeen, A. A., Huang, T. H., & Kilian, K. A. (2014) · Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials · doi:10.1016/j.jmbbm.2014.01.009 · Cited by 87 · see citing works

Materials control of the epigenetics underlying cell plasticity

Nemec, S. R., & Kilian, K. A. (2020) · Nature Reviews Materials · doi:10.1038/s41578-020-00238-z · Cited by 83 · see citing works

Phosphatidylinositol 5-phosphate regulates invasion through binding and activation of Tiam1

Viaud, J., Lagarrigue, F., Ramel, D., Allart, S., Chicanne, G., Ceccato, L., Courilleau, D., Xuereb, J.-M., Pertz, O. C., Payrastre, B., et al. (2014) · Nature Communications · doi:10.1038/ncomms5080 · Cited by 81 · see citing works

Dynamics of Cell Ensembles on Adhesive Micropatterns: Bridging the Gap between Single Cell Spreading and Collective Cell Migration

Albert, P. J., & Schwarz, U. S. (2016) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1004863 · Cited by 81 · see citing works

An opto-thermocapillary cell micromanipulator

Hu, W., Fan, Q., & Ohta, A. T. (2013) · Lab on a Chip · doi:10.1039/c3lc50389e · Cited by 79 · see citing works

More from less – bottom-up reconstitution of cell biology

Ganzinger, K. A., & Schwille, P. (2019) · Journal of Cell Science · doi:10.1242/jcs.227488 · Cited by 77 · see citing works

Viscoelasticity, Like Forces, Plays a Role in Mechanotransduction

Mierke, C. T. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.789841 · Cited by 79 · see citing works

Microfluidic construction of minimalistic neuronal co-cultures

Dinh, N., Chiang, Y.-Y., Hardelauf, H., Baumann, J., Jackson, E., Waide, S., Sisnaiske, J., Frimat, J., van Thriel, C., Janasek, D., et al. (2013) · Lab on a Chip · doi:10.1039/c3lc41224e · Cited by 76 · see citing works

Reprogramming cell shape with laser nano-patterning

Vignaud, T., Galland, R., Tseng, Q., Blanchoin, L., Colombelli, J., & Théry, M. (2012) · Journal of Cell Science · doi:10.1242/jcs.104901 · Cited by 75 · see citing works

Atomic Force Microscopy Mechanical Mapping of Micropatterned Cells Shows Adhesion Geometry-Dependent Mechanical Response on Local and Global Scales

Rigato, A., Rico, F., Eghiaian, F., Piel, M., & Simon Scheuring, A. (2015) · ACS Nano · doi:10.1021/acsnano.5b00430 · Cited by 75 · see citing works

Engineered Tools to Study Intercellular Communication

Yang, B. A., Westerhof, T. M., Sabin, K., Merajver, S. D., & Aguilar, C. A. (2020) · Advanced Science · doi:10.1002/advs.202002825 · Cited by 73 · see citing works

Probing Mammalian Cell Size Homeostasis by Channel-Assisted Cell Reshaping

Varsano, G., Wang, Y., & Wu, M. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.06.057 · Cited by 74 · see citing works

Vascular Mechanobiology: Towards Control of In Situ Regeneration

van Haaften, E. E., Bouten, C. V. C., & Kurniawan, N. A. (2017) · Cells · doi:10.3390/cells6030019 · Cited by 70 · see citing works

Cell engineering: Biophysical regulation of the nucleus

Song, Y., Soto, J., Chen, B., Yang, L., & Li, S. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2019.119743 · Cited by 68 · see citing works

Biomaterial-guided stem cell organoid engineering for modeling development and diseases

Hoang, P., & Ma, Z. (2021) · Acta Biomaterialia · doi:10.1016/j.actbio.2021.01.026 · Cited by 70 · see citing works

Actin cytoskeleton self-organization in single epithelial cells and fibroblasts under isotropic confinement

Jalal, S., Shi, S., Acharya, V., Huang, R. Y., Viasnoff, V., Bershadsky, A. D., & Tee, Y. H. (2019) · Journal of Cell Science · doi:10.1242/jcs.220780 · Cited by 66 · see citing works

Label-Free Characterization of Emerging Human Neuronal Networks

Mir, M., Kim, T., Majumder, A., Xiang, M., Wang, R., Liu, S. C., Gillette, M. U., Stice, S. L., & Popescu, G. (2014) · Scientific Reports · doi:10.1038/srep04434 · Cited by 65 · see citing works

Vinculin tension distributions of individual stress fibers within cell-matrix adhesions

Chang, C.-W., & Kumar, S. (2013) · Journal of Cell Science · doi:10.1242/jcs.119032 · Cited by 65 · see citing works

Agrin-Matrix Metalloproteinase-12 axis confers a mechanically competent microenvironment in skin wound healing

Chakraborty, S., Sampath, D., Lin, M. O. Y., Bilton, M., Huang, C.-K., Nai, M. H., Njah, K., Goy, P.-A. V., Wang, C.-C., Guccione, E., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-26717-7 · Cited by 66 · see citing works

A primer to traction force microscopy

Zancla, A., Mozetic, P., Orsini, M., Forte, G., & Rainer, A. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.101867 · Cited by 65 · see citing works

Specific control of cell–material interactions: Targeting cell receptors using ligand-functionalized polymer substrates

Rodda, A. E., Meagher, L., Nisbet, D. R., & Forsythe, J. S. (2013) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2013.11.006 · Cited by 65 · see citing works

Nanofibers Regulate Single Bone Marrow Stem Cell Osteogenesis via FAK/RhoA/YAP1 Pathway

Chang, B., Ma, C., & Liu, X. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.8b11449 · Cited by 64 · see citing works

Entropic Forces Drive Cellular Contact Guidance

Buskermolen, A. B. C., Suresh, H., Shishvan, S. S., Vigliotti, A., DeSimone, A., Kurniawan, N. A., Bouten, C. V. C., & Deshpande, V. S. (2019) · Biophysical Journal · doi:10.1016/j.bpj.2019.04.003 · Cited by 64 · see citing works

A cell-size threshold limits cell polarity and asymmetric division potential

Hubatsch, L., Péglion, F., Reich, J. D., Rodrigues, N. T. L., Hirani, N., Illukkumbura, R., & Goehring, N. W. (2019) · Nature Physics · doi:10.1038/s41567-019-0601-x · Cited by 64 · see citing works

Subcellular Control over Focal Adhesion Anisotropy, Independent of Cell Morphology, Dictates Stem Cell Fate

Cabezas, M. D., Meckes, B., Mirkin, C. A., & Mrksich, M. (2019) · ACS Nano · doi:10.1021/acsnano.9b03937 · Cited by 63 · see citing works

Micropatterned surfaces: techniques and applications in cell biology

Quist, A. P., & Oscarsson, S. O. (2010) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.2010.489606 · Cited by 36 · see citing works

Single-cell manipulation by two-dimensional micropatterning

Ma, X., Zhang, H., Deng, S., Sun, Q., Hu, Q., Pan, Y., Hu, F., Lee, I., Xing, F., & Pan, L. (2023) · Journal of Innovative Optical Health Sciences · doi:10.1142/s1793545823300112 · Cited by 2 · see citing works

Micropatterning of cell aggregate in three dimension for in vivo mimicking cell culture

Otsuka, H. (2014) · Elsevier eBooks · doi:10.1016/b978-0-444-62614-1.00011-9 · Cited by 6 · see citing works

Micropatterning in cell biology

Piel, M., & Théry, M. (2014) · Cited by 10 · see citing works

Advances in micropatterning technology for mechanotransduction research

Hu, X., & Bao, M. (2024) · Mechanobiology in Medicine · doi:10.1016/j.mbm.2024.100066 · Cited by 18 · see citing works