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Cited by 80Neuroscience and Neuropharmacology ResearchIon channel regulation and functionNeural dynamics and brain function

Sodium channels amplify spine potentials

Open access
Araya, Roberto, Nikolenko, Volodymyr, Eisenthal, Kenneth B., Yuste, Rafael·2007·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.0705282104PMC PMC1924793
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Abstract

Dendritic spines mediate most excitatory synapses in the brain. Past theoretical work and recent experimental evidence have suggested that spines could contain sodium channels. We tested this by measuring the effect of the sodium channel blocker tetrodotoxin (TTX) on depolarizations generated by two-photon uncaging of glutamate on spines from mouse neocortical pyramidal neurons. In practically all spines examined, uncaging potentials were significantly reduced by TTX. This effect was postsynaptic and spatially localized to the spine and occurred with uncaging potentials of different amplitudes and in spines of different neck lengths. Our data confirm that spines from neocortical pyramidal neurons are electrically isolated from the dendrite and indicate that they have sodium channels and are therefore excitable structures. Spine sodium channels could boost synaptic potentials and facilitate action potential backpropagation.

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Crossref · 10.1073/pnas.0705282104

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2 of 2 references verified0 citation errors · 0 not checkable

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  • Active properties of dendritic spines play an important role in interactions between multiple synaptic inputs in dendritic computation.

    “These active properties of dendritic spines are thought to play an important role in the interactions between multiple synaptic inputs in dendritic computation (Araya et al., 2007; Harnett et al., 2012).”

    From Barriers in the brain: resolving dendritic spine morphology and compartmentalization (2014) · cites this paper as Araya et al., 2007

  • Opening of sodium and calcium channels boosts local depolarization, while opening of potassium channels decreases local input resistance and results in smaller synaptic potentials.

    “Opening of sodium and calcium channels boosts local depolarization (Araya et al., 2007; Bloodgood et al., 2009; Holbro et al., 2010; Carter et al., 2012; Hao and Oertner, 2012), while opening of potassium channels decreases local input resistance and results in smaller synaptic potentials (Ngo-Anh et al., 2005; Giessel and Sabatini, 2010).”

    From Barriers in the brain: resolving dendritic spine morphology and compartmentalization (2014) · cites this paper as Araya et al., 2007

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Authors
Araya, R., Nikolenko, V., Eisenthal, K. B., & Yuste, R.
Affiliations
  • Howard Hughes Medical Institute (US)
  • Columbia University (US)
ORCID
Venue
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences
Published
2007-07-24
Volume
104
Issue
30
Pages
12347-12352
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.0705282104
PMC
PMC1924793
OpenAlex
W2127198126
Cited by
80
References
2
Citations by year
2026: 1 · 2025: 1 · 2024: 1 · 2023: 3 · 2022: 6 · 2021: 5 · 2020: 5 · 2019: 3 · 2018: 2 · 2017: 4 · 2016: 3 · 2015: 7 · 2014: 5 · 2013: 5 · 2012: 5
FWCI
2.79
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Columbia Academic Commons (Columbia University)
Funders
  • National Science Foundation
  • Drexel University
  • College of Medicine, Drexel University
  • National Eye Institute
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords
dendritic spines, sodium channels, tetrodotoxin, glutamate uncaging, neocortical pyramidal neurons, action potential backpropagation, postsynaptic potentials, excitatory synapses
MeSH terms
Action Potentials, Animals, Dendrites, Electrophysiology, Mice, Inbred C57BL, Synapses, Tetrodotoxin, Sodium Channels, Mice

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