Activity-dependent dendritic spine neck changes are correlated with synaptic strength
Open accessAbstract
Significance: Dendritic spines are the main recipients of excitatory information in the brain, and though it is accepted that they must serve an essential function in neural circuits, their precise role remains ill-defined. Here, using minimal synaptic stimulation, we show that spine neck length correlates inversely with synaptic efficacy. In addition, we discovered a previously unidentified form of spine plasticity following a spike timing-dependent plasticity protocol, characterized by rapid shortening of spine neck length and concomitant increases in synaptic strength. These results provide new insights for our understanding of synaptic plasticity, and could provide an explanation for the presence of thousands of long-necked spines in the dendrites of pyramidal neurons, whose somatic synaptic contribution would otherwise be small or negligible.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Reduction of spine neck length after synaptic potentiation mediates enhanced electric coupling of spine and dendrite, thereby increasing the influence of the potentiated spine on the dendritic and somatic membrane potential.
“It was shown that reduction of spine neck length after synaptic potentiation mediates enhanced electric coupling of spine and dendrite, thereby increasing the influence of the potentiated spine on the dendritic and somatic membrane potential (Araya et al., 2014; Tønnesen et al., 2014).”
From Barriers in the brain: resolving dendritic spine morphology and compartmentalization (2014) · cites this paper as Araya et al., 2014
The STDP results report spine-neck shortening alongside increased evoked potentials, and the Discussion says shortened spines become functionally connected to the soma. But the Biophysical Simulations and Discussion do not establish that enhanced electrical coupling mediates the increase: changes in synaptic conductance could also explain it. The copy does not directly demonstrate the claimed increase in dendritic membrane potential. (LLM, conf=0.88)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Malenka, R. C., & Bear, M. F. (2004) · Neuron · doi:10.1016/j.neuron.2004.09.012 · Cited by 3,968 · see citing works
The NEURON Simulation Environment
Hines, M. L., & Carnevale, N. T. (1997) · Neural Computation · doi:10.1162/neco.1997.9.6.1179 · Cited by 2,630 · see citing works
Structural basis of long-term potentiation in single dendritic spines
Matsuzaki, M., Honkura, N., Ellis-Davies, G. C. R., & Kasai, H. (2004) · Nature · doi:10.1038/nature02617 · Cited by 2,500 · see citing works
Matsuzaki, M., Ellis-Davies, G. C. R., Nemoto, T., Miyashita, Y., Iino, M., & Kasai, H. (2001) · Nature Neuroscience · doi:10.1038/nn736 · Cited by 1,563 · cited 4× · see citing works
“S3) (31, 46)—is inversely proportional to the spine neck length, with long-necked spines having small or negligible somatic voltage contributions (31).”
BackgroundResultInfluentialNeurobiology of cerebellar evolution and development
Snider, R. S. (1971) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(71)90269-0 · Cited by 1,515 · see citing works
Electric current flow in excitable cells
(1976) · American Heart Journal · doi:10.1016/s0002-8703(76)80560-1 · Cited by 1,288 · see citing works
Harris, K., & Kater, S. (1994) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.17.030194.002013 · Cited by 1,032 · see citing works
Dendritic spines as basic functional units of neuronal integration
Yuste, R., & Denk, W. (1995) · Nature · doi:10.1038/375682a0 · Cited by 950 · see citing works
Self-citationColonnier, M. (1968) · Brain Research · doi:10.1016/0006-8993(68)90234-5 · Cited by 946 · see citing works
Foundations of Cellular Neurophysiology
Johnston, D., & Wu, S. M.-S. (1994) · Medical Entomology and Zoology · Cited by 918 · see citing works
Activation of CaMKII in single dendritic spines during long-term potentiation
Lee, S.-J. R., Escobedo-Lozoya, Y., Szatmari, E. M., & Yasuda, R. (2009) · Nature · doi:10.1038/nature07842 · Cited by 685 · see citing works
Integrative Properties of Radial Oblique Dendrites in Hippocampal CA1 Pyramidal Neurons
Losonczy, A., & Magee, J. C. (2006) · Neuron · doi:10.1016/j.neuron.2006.03.016 · Cited by 641 · see citing works
Locally dynamic synaptic learning rules in pyramidal neuron dendrites
Harvey, C. D., & Svoboda, K. (2007) · Nature · doi:10.1038/nature06416 · Cited by 625 · see citing works
Protein synthesis and neurotrophin-dependent structural plasticity of single dendritic spines
Tanaka, J.-I., Horiike, Y., Matsuzaki, M., Miyazaki, T., Ellis-Davies, G. C. R., & Kasai, H. (2008) · Science · doi:10.1126/science.1152864 · Cited by 615 · cited 11× · see citing works
“Indeed, a recent study using superresolutionstimulated emission depletion and an uncaging LTP protocol has shown that activated spines undergo changes in spine head, neck length, and neck diameter (56).”
BackgroundMethodResultInfluentialSynapse formation on neurons born in the adult hippocampus
Toni, N., Teng, E. M., Bushong, E. A., Aimone, J. B., Zhao, C., Consiglio, A., van Praag, H., Martone, M. E., Ellisman, M. H., & Gage, F. H. (2007) · Nature Neuroscience · doi:10.1038/nn1908 · Cited by 579 · see citing works
Gatenby, J. B., & Tahmisian, T. N. (1957) · Journal of the Royal Microscopical Society · doi:10.1111/j.1365-2818.1957.tb02020.x · Cited by 544 · see citing works
Modulation of AMPA receptor unitary conductance by synaptic activity
Benke, T. A., Lüthi, A., Isaac, J. T. R., & Collingridge, G. L. (1998) · Nature · doi:10.1038/31709 · Cited by 533 · see citing works
Ultrastructure of dendritic spines: correlation between synaptic and spine morphologies
Arellano, J. I. (2007) · Frontiers in Neuroscience · doi:10.3389/neuro.01.1.1.010.2007 · Cited by 529 · see citing works
Electric Current Flow in Excitable Cells.
(1975) · Annals of Internal Medicine · doi:10.7326/0003-4819-83-6-916_1 · Cited by 528 · see citing works
Structure, development, and plasticity of dendritic spines
Harris, K. M. (1999) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(99)80050-6 · Cited by 515 · see citing works
Direct measurement of coupling between dendritic spines and shafts
Svoboda, K., Tank, D. W., & Denk, W. (1996) · Science · doi:10.1126/science.272.5262.716 · Cited by 472 · see citing works
The distribution and targeting of neuronal voltage-gated ion channels
Lai, H. C., & Jan, L. Y. (2006) · Nature reviews. Neuroscience · doi:10.1038/nrn1938 · Cited by 469 · see citing works
Inhibition of SRGAP2 function by its human-specific paralogs induces neoteny during spine maturation
Charrier, C., Joshi, K., Coutinho-Budd, J., Kim, J.-E., Lambert, N., de Marchena, J., Jin, W.-L., Vanderhaeghen, P., Ghosh, A., Sassa, T., et al. (2012) · Cell · doi:10.1016/j.cell.2012.03.034 · Cited by 454 · see citing works
Spine neck plasticity regulates compartmentalization of synapses
Tønnesen, J., Katona, G., Rózsa, B., & Nägerl, U. V. (2014) · Nature Neuroscience · doi:10.1038/nn.3682 · Cited by 444 · see citing works
Electron Microscopy of Synaptic Contacts on Dendrite Spines of the Cerebral Cortex
Gray, E. G. (1959) · Nature · doi:10.1038/1831592a0 · Cited by 443 · see citing works
Emptage, N. J., Bliss, T., & Fine, A. (1999) · Neuron · doi:10.1016/s0896-6273(00)80683-2 · Cited by 435 · see citing works
Regulation of hippocampal transmitter release during development and long-term potentiation.
Bolshakov, V. Y., & Siegelbaum, S. (1995) · Science · doi:10.1126/science.7569903 · Cited by 385 · see citing works
Christof Koch, A., & Zador, A. M. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-02-00413.1993 · Cited by 374 · see citing works
Neuronal activity regulates diffusion across the neck of dendritic spines
Bloodgood, B. L., & Sabatini, B. L. (2005) · Science · doi:10.1126/science.1114816 · Cited by 344 · see citing works
Clustered dynamics of inhibitory synapses and dendritic spines in the adult neocortex.
Chen, J. L., Villa, K. L., Cha, J. W., So, P. T. C., Kubota, Y., & Nedivi, E. (2012) · Neuron · doi:10.1016/j.neuron.2012.02.030 · Cited by 341 · see citing works
Koester, H. J., & Sakmann, B. J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.16.9596 · Cited by 338 · see citing works
Facilitation at single synapses probed with optical quantal analysis
Oertner, T. G., Sabatini, B. L., Nimchinsky, E. A., & Svoboda, K. (2002) · Nature Neuroscience · doi:10.1038/nn867 · Cited by 324 · see citing works
Dendritic spines and distributed circuits
Yuste, R. (2011) · Neuron · doi:10.1016/j.neuron.2011.07.024 · Cited by 298 · see citing works
Self-citationSynaptic amplification by dendritic spines enhances input cooperativity
Harnett, M. T., Makara, J. K., Spruston, N., Kath, W. L., & Magee, J. C. (2012) · Nature · doi:10.1038/nature11554 · Cited by 288 · see citing works
Yuste, R., Majewska, A. K., Cash, S. S., & Denk, W. T. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-06-01976.1999 · Cited by 288 · see citing works
Self-citationTwo types of calcium response limited to single spines in cerebellar Purkinje cells.
Denk, W. T., Sugimori, M., & Llinas, R. H. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.18.8279 · Cited by 284 · see citing works
NMDA Receptor-Mediated Subthreshold Ca2+Signals in Spines of Hippocampal Neurons
Kovalchuk, Y., Eilers, J., Lisman, J. E., & Konnerth, A. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-05-01791.2000 · Cited by 270 · see citing works
The spine neck filters membrane potentials
Araya, R., Jiang, J., Eisenthal, K. B., & Yuste, R. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0608755103 · Cited by 258 · see citing works
Self-citationYuste, R. (2010) · doi:10.7551/mitpress/9780262013505.001.0001 · Cited by 241 · see citing works
Self-citationThe dendritic spine: a multifunctional integrative unit
Shepherd, G. M. (1996) · Journal of Neurophysiology · doi:10.1152/jn.1996.75.6.2197 · Cited by 221 · see citing works
Computational study of an excitable dendritic spine
Segev, I., & Rall, W. (1988) · Journal of Neurophysiology · doi:10.1152/jn.1988.60.2.499 · Cited by 217 · see citing works
Synaptic amplification by active membrane in dendritic spines
Miller, J. P., Rall, W., & Rinzel, J. (1985) · Brain Research · doi:10.1016/0006-8993(85)90333-6 · Cited by 208 · see citing works
Cortical area and species differences in dendritic spine morphology
Benavides-Piccione, R., Ballesteros-Yáñez, I., DeFelipe, J., & Yuste, R. (2002) · Journal of Neurocytology · doi:10.1023/a:1024134312173 · Cited by 207 · see citing works
Self-citationRegulation of Spine Calcium Dynamics by Rapid Spine Motility
Majewska, A. K., Tashiro, A., & Yuste, R. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-22-08262.2000 · Cited by 201 · see citing works
Self-citationThe neocortical microcircuit as a tabula rasa
Kalisman, N., Silberberg, G., & Markram, H. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407088102 · Cited by 200 · see citing works
A Critical Role for Myosin IIB in Dendritic Spine Morphology and Synaptic Function
Ryu, J., Liu, L., Wong, T. P., Wu, D., Burette, A., Weinberg, R. J., Wang, Y. T., & Sheng, M. (2006) · Neuron · doi:10.1016/j.neuron.2005.12.017 · Cited by 179 · see citing works
CORTICAL NEURONS WITH PARTICULAR REFERENCE TO THE APICAL DENDRITESPreprint
Chang, H.-T. (1952) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1952.017.01.019 · Cited by 172 · see citing works
Non-synaptic dendritic spines in neocortex
Arellano, J. I., Espinosa, A., Fairén, A. G., Yuste, R., & DeFelipe, J. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.12.015 · Cited by 171 · see citing works
Self-citationEnoki, R., Hu, Y.-L., Hamilton, D. C., & Fine, A. (2009) · Neuron · doi:10.1016/j.neuron.2009.02.026 · Cited by 158 · see citing works
Spine neck plasticity controls postsynaptic calcium signals through electrical compartmentalization
Grunditz, Å., Holbro, N., Tian, L., Zuo, Y., & Oertner, T. G. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.2702-08.2008 · Cited by 157 · see citing works
Davidoff, R. A. (1979) · Neurology · doi:10.1212/wnl.29.12.1639 · Cited by 152 · see citing works
Membrane Potential Changes in Dendritic Spines during Action Potentials and Synaptic Input
Palmer, L. M., & Stuart, G. J. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.5847-08.2009 · Cited by 149 · see citing works
Paspalas, C. D., Wang, M., & Arnsten, A. F. T. (2013) · Cerebral Cortex · doi:10.1093/cercor/bhs152 · Cited by 136 · see citing works
y Cajal, S. R. (1904) · Institutional Repository of the University of Granada (University of Granada) · Cited by 127 · see citing works
Biphasic synaptic Ca influx arising from compartmentalized electrical signals in dendritic spines
Bloodgood, B. L., Giessel, A. J., & Sabatini, B. L. (2009) · PLoS Biology · doi:10.1371/journal.pbio.1000190 · Cited by 119 · see citing works
Two-photon Na + imaging in spines and fine dendrites of central neurons
Rose, C. R., Kovalchuk, Y., Eilers, J., & Konnerth, A. (1999) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s004249900123 · Cited by 116 · see citing works
Cellular mechanisms subserving changes in neuronal activity
Rutledge, L. T. (1975) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(75)90067-x · Cited by 111 · see citing works
On the electrical function of dendritic spines
Tsay, D., & Yuste, R. (2003) · Trends in Neurosciences · doi:10.1016/j.tins.2003.11.008 · Cited by 103 · see citing works
Self-citationMalinow, R., Otmakhov, N., Blum, K. I., & Lisman, J. E. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.17.8170 · Cited by 88 · see citing works
Sodium channels amplify spine potentials
Araya, R., Nikolenko, V., Eisenthal, K. B., & Yuste, R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705282104 · Cited by 80 · see citing works
Self-citationBurkhalter, A., Gonchar, Y., Mellor, R. L., & Nerbonne, J. M. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.2599-06.2006 · Cited by 79 · see citing works
Conti, R., & Lisman, J. (2003) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.0630290100 · Cited by 77 · see citing works
Holthoff, K., Zecevic, D., & Konnerth, A. (2010) · The Journal of Physiology · doi:10.1113/jphysiol.2009.184960 · Cited by 76 · see citing works
Is the function of dendritic spines to concentrate calcium?
Holmes, W. R. (1990) · Brain Research · doi:10.1016/0006-8993(90)90098-v · Cited by 63 · see citing works
Electrical properties of dendritic spines
Christof Koch, A., & Poggio, T. (1983) · Trends in Neurosciences · doi:10.1016/0166-2236(83)90043-7 · Cited by 58 · see citing works
Flagged first, then by citations
1 of the 66 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Malenka RC, Bear MF (2004) LTP and LTD: An embarrassment of riches. Neuron 44(1): 5-21.
Cited by
Sorted by citations
Illuminating dendritic function with computational models
Poirazi, P., & Papoutsi, A. (2020) · Nature reviews. Neuroscience · doi:10.1038/s41583-020-0301-7 · Cited by 303 · see citing works
Structure and function of a neocortical synapse
Holler, S., Köstinger, G., Martin, K. A. C., Schuhknecht, G. F. P., & Stratford, K. J. (2021) · Nature · doi:10.1038/s41586-020-03134-2 · Cited by 249 · see citing works
Local translation in neuronal compartments: how local is local?
Rangaraju, V., Dieck, S. T., & Schuman, E. M. (2017) · EMBO Reports · doi:10.15252/embr.201744045 · Cited by 193 · see citing works
Biochemical Computation for Spine Structural Plasticity
Nishiyama, J., & Yasuda, R. (2015) · Neuron · doi:10.1016/j.neuron.2015.05.043 · Cited by 199 · see citing works
Anatomy and physiology of the thick-tufted layer 5 pyramidal neuron
Ramaswamy, S., & Markram, H. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00233 · Cited by 186 · see citing works
Human Cortical Pyramidal Neurons: From Spines to Spikes via Models
Eyal, G., Verhoog, M. B., Testa-Silva, G., Deitcher, Y., Benavides‐Piccione, R., DeFelipe, J., de Kock, C. P. J., Mansvelder, H. D., & Segev, I. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00181 · Cited by 156 · see citing works
Kumar, D., Koyanagi, I., Carrier‐Ruiz, A., Vergara, P., Srinivasan, S., Sugaya, Y., Kasuya, M., Yu, T., Vogt, K. E., Muratani, M., et al. (2020) · Neuron · doi:10.1016/j.neuron.2020.05.008 · Cited by 144 · see citing works
Dendritic Spines as Tunable Regulators of Synaptic Signals
Tønnesen, J., & Nägerl, U. V. (2016) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2016.00101 · Cited by 136 · see citing works
Fossati, M., Pizzarelli, R., Schmidt, E. R., Kupferman, J. V., Stroebel, D., Polleux, F., & Charrier, C. (2016) · Neuron · doi:10.1016/j.neuron.2016.06.013 · Cited by 133 · see citing works
Voltage compartmentalization in dendritic spines in vivo
Cornejo, V. H., Ofer, N., & Yuste, R. (2021) · Science · doi:10.1126/science.abg0501 · Cited by 120 · see citing works
Self-citationThe Role of Actin Cytoskeleton in Dendritic Spines in the Maintenance of Long-Term Memory
Basu, S., & Lamprecht, R. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00143 · Cited by 108 · see citing works
Approaches and Limitations in the Investigation of Synaptic Transmission and Plasticity
Glasgow, S. D., McPhedrain, R., Madranges, J. F., Kennedy, T. E., & Ruthazer, E. S. (2019) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2019.00020 · Cited by 100 · see citing works
Grienberger, C., Chen, X., & Konnerth, A. (2014) · Trends in Neurosciences · doi:10.1016/j.tins.2014.11.002 · Cited by 97 · see citing works
A spike-timing-dependent plasticity rule for dendritic spines
Tazerart, S., Mitchell, D. E., Miranda‐Rottmann, S., & Araya, R. (2020) · Nature Communications · doi:10.1038/s41467-020-17861-7 · Cited by 93 · see citing works
Self-citationElectrical behaviour of dendritic spines as revealed by voltage imaging
Popovic, M. A., Carnevale, N. T., Rózsa, B. J., & Zečević, D. (2015) · Nature Communications · doi:10.1038/ncomms9436 · Cited by 89 · see citing works
Bell, M. K., Bartol, T., B, T. J. S. A., & Rangamani, P. (2019) · The Journal of General Physiology · doi:10.1085/jgp.201812261 · Cited by 80 · see citing works
Hodges, J., Yu, X., Gilmore, A., Bennett, H. C., Tjia, M., Perna, J., Chen, C.-C., Li, X., Lu, J., & Zuo, Y. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.08.036 · Cited by 80 · see citing works
The new nanophysiology: regulation of ionic flow in neuronal subcompartments
Holcman, D., & Yuste, R. (2015) · Nature reviews. Neuroscience · doi:10.1038/nrn4022 · Cited by 78 · see citing works
Self-citationDendritic Spines Prevent Synaptic Voltage Clamp
Beaulieu-Laroche, L., & Harnett, M. T. (2018) · Neuron · doi:10.1016/j.neuron.2017.11.016 · Cited by 79 · see citing works
Network-level encoding of local neurotransmitters in cortical astrocytes
Cahill, M. K., Collard, M., Tse, V., Reitman, M. E., Etchenique, R., Kirst, C., & Poskanzer, K. E. (2024) · Nature · doi:10.1038/s41586-024-07311-5 · Cited by 76 · see citing works
Control of Synapse Structure and Function by Actin and Its Regulators
Gentile, J. E., Carrizales, M. G., & Koleske, A. J. (2022) · Cells · doi:10.3390/cells11040603 · Cited by 67 · see citing works
Patriarchi, T., Buonarati, O. R., & Hell, J. W. (2018) · The EMBO Journal · doi:10.15252/embj.201899771 · Cited by 65 · see citing works
Attenuation of Synaptic Potentials in Dendritic Spines
Kwon, T., Sakamoto, M., Peterka, D. S., & Yuste, R. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.07.012 · Cited by 64 · see citing works
Self-citationSynaptic modifications in learning and memory – A dendritic spine story
Ma, S., & Zuo, Y. (2021) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2021.05.015 · Cited by 64 · see citing works
Ultrastructural analysis of dendritic spine necks reveals a continuum of spine morphologies
Ofer, N., Berger, D. R., Kasthuri, N., Lichtman, J. W., & Yuste, R. (2021) · Developmental Neurobiology · doi:10.1002/dneu.22829 · Cited by 65 · see citing works
Self-citationBarriers in the brain: resolving dendritic spine morphology and compartmentalization
Adrian, M., Kusters, R., Wierenga, C. J., Storm, C., Hoogenraad, C. C., & Kapitein, L. C. (2014) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2014.00142 · Cited by 62 · see citing works
“…voltage signals from the dendrite propagate without attenuation into the spines (Holthoff et al., 2010; Carter et al., 2012; Popovic et al., 2014), but synaptic potentials generated inside the spine head are filtered when they travel to the dendrite (Araya et al., 2006, 2014; Harnett et al., 2012).”
InfluentialInput transformation by dendritic spines of pyramidal neurons
Araya, R. (2014) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2014.00141 · Cited by 58 · see citing works
Self-citationPrincipal cell activity induces spine relocation of adult-born interneurons in the olfactory bulb
Breton-Provencher, V., Bakhshetyan, K., Hardy, D., Bammann, R. R., Cavarretta, F., Snapyan, M., Côté, D., Migliore, M., & Saghatelyan, A. (2016) · Nature Communications · doi:10.1038/ncomms12659 · Cited by 60 · see citing works
The Role of Rac GTPase in Dendritic Spine Morphogenesis and Memory
Costa, J. F., Dines, M., & Lamprecht, R. (2020) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2020.00012 · Cited by 55 · see citing works
Mestdagh, C. F. D. V., Timmerman, J. A., Koopmans, F., Paliukhovich, I., Miedema, S. S. M., Goris, M., van der Loo, R. J., Krenning, G., Li, K. W., Mansvelder, H. D., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-94992-x · Cited by 58 · see citing works
Functional and structural deficits at accumbens synapses in a mouse model of Fragile X
Neuhofer, D., Henstridge, C. M., Dudok, B., Sepers, M. D., Lassalle, O., Katona, I., & Manzoni, O. J. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00100 · Cited by 52 · see citing works
Bywalez, W. G., Patirniche, D., Rupprecht, V., Stemmler, M., Herz, A. V. M., Pálfi, D., Rózsa, B. J., & Egger, V. (2015) · Neuron · doi:10.1016/j.neuron.2014.12.051 · Cited by 55 · see citing works
Janz, P., Savanthrapadian, S., Häussler, U., Kilias, A., Nestel, S., Kretz, O., Kirsch, M., Bartos, M., Egert, U., & Haas, C. A. (2016) · Cerebral Cortex · doi:10.1093/cercor/bhw093 · Cited by 55 · see citing works
Fast calcium transients in dendritic spines driven by extreme statistics
Basnayake, K., Mazaud, D., Bemelmans, A., Rouach, N., Korkotian, E., & Holcman, D. (2019) · PLoS Biology · doi:10.1371/journal.pbio.2006202 · Cited by 51 · see citing works
Musto, A., Rosencrans, R. F., Walker, C. P., Bhattacharjee, S., Raulji, C. M., Belayev, L., Fang, Z., Gordon, W., & Bazan, N. (2016) · Scientific Reports · doi:10.1038/srep30298 · Cited by 48 · see citing works
Cartailler, J., Kwon, T., Yuste, R., & Holcman, D. (2018) · Neuron · doi:10.1016/j.neuron.2018.01.034 · Cited by 50 · see citing works
Self-citationKCC2 Regulates Dendritic Spine Formation in a Brain-Region Specific and BDNF Dependent Manner
Awad, P. N., Amegandjin, C. A., Szczurkowska, J., Carriço, J. N., do Nascimento, A. S. F., Baho, E., Chattopadhyaya, B., Cancedda, L., Carmant, L., & Cristo, G. D. (2018) · Cerebral Cortex · doi:10.1093/cercor/bhy198 · Cited by 50 · see citing works
Pre- and post-synaptic roles for DCC in memory consolidation in the adult mouse hippocampus
Glasgow, S. D., Wong, E. W., Thompson‐Steckel, G., Marçal, N., Séguéla, P., Ruthazer, E. S., & Kennedy, T. E. (2020) · Molecular Brain · doi:10.1186/s13041-020-00597-2 · Cited by 50 · see citing works
Coexistence of Multiple Types of Synaptic Plasticity in Individual Hippocampal CA1 Pyramidal Neurons
Edelmann, E., Cepeda-Prado, E., & Leßmann, V. (2017) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2017.00007 · Cited by 48 · see citing works
RTP801/REDD1 contributes to neuroinflammation severity and memory impairments in Alzheimer’s disease
Pérez‐Sisqués, L., Sancho‐Balsells, A., Solana‐Balaguer, J., Campoy‐Campos, G., Vives-Isern, M., Soler-Palazón, F., Anglada‐Huguet, M., López-Toledano, M. A., Mandelkow, E., Alberch, J., et al. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-03899-y · Cited by 44 · see citing works
Steffens, H., Mott, A. C., Li, S., Wegner, W., Švehla, P., Kan, V. W. Y., Wolf, F., Liebscher, S., & Willig, K. I. (2021) · Science Advances · doi:10.1126/sciadv.abf2806 · Cited by 44 · see citing works
Actin Cytoskeleton Role in the Maintenance of Neuronal Morphology and Long-Term Memory
Lamprecht, R. (2021) · Cells · doi:10.3390/cells10071795 · Cited by 45 · see citing works
Ultrastructural comparison of dendritic spine morphology preserved with cryo and chemical fixation
Tamada, H., Blanc, J., Korogod, N., Petersen, C. C. H., & Knott, G. W. (2020) · eLife · doi:10.7554/elife.56384 · Cited by 42 · see citing works
Quantitative 3-D morphometric analysis of individual dendritic spines
Basu, S., Saha, P. K., Roszkowska, M., Magnowska, M., Bączyńska, E., Das, N., Plewczyński, D., & Włodarczyk, J. (2018) · Scientific Reports · doi:10.1038/s41598-018-21753-8 · Cited by 40 · see citing works
Ca2+/calmodulin binding to PSD‐95 mediates homeostatic synaptic scaling down
Chowdhury, D., Turner, M., Patriarchi, T., Hergarden, A. C., Anderson, D. E., Zhang, Y., Sun, J., Chen, C.-Y., Ames, J. B., & Hell, J. W. (2017) · The EMBO Journal · doi:10.15252/embj.201695829 · Cited by 40 · see citing works
Calcium's role as nuanced modulator of cellular physiology in the brain
Frazier, H. N., Maimaiti, S., Anderson, K. L., Brewer, L. D., Gant, J. C., Porter, N. M., & Thibault, O. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.08.105 · Cited by 39 · see citing works
Chen, F., du Jardin, K. G., Waller, J. A., Sánchez, C., Nyengaard, J. R., & Wegener, G. (2015) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.12.018 · Cited by 37 · see citing works
Ryczko, D., Hanini‐Daoud, M., Condamine, S., Bréant, B. J. B., Fougère, M., Araya, R., & Kolta, A. (2020) · The Journal of Physiology · doi:10.1113/jp280501 · Cited by 32 · see citing works
Self-citationRemodeled cortical inhibition prevents motor seizures in generalized epilepsy
Jiang, X., Lupien‐Meilleur, A., Tazerart, S., Lachance, M., Samarova, E. I., Araya, R., Lacaille, J., & Rossignol, E. (2018) · Annals of Neurology · doi:10.1002/ana.25301 · Cited by 36 · see citing works
Self-citationBarkai, O., Butterman, R., Katz, B., Lev, S., & Binshtok, A. M. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.1546-20.2020 · Cited by 36 · see citing works
Electrodiffusion Phenomena in Neuroscience and the Nernst–Planck–Poisson Equations
Jasielec, J. J. (2021) · Electrochem · doi:10.3390/electrochem2020014 · Cited by 36 · see citing works
δ-Catenin Regulates Spine Architecture via Cadherin and PDZ-dependent Interactions
Yuan, L., Seong, E., Beuscher, J. L., & Arikkath, J. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.632679 · Cited by 34 · see citing works
Sleep loss and structural plasticity
Areal, C. C., Warby, S. C., & Mongrain, V. (2017) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2016.12.010 · Cited by 35 · see citing works
The glutamatergic synapse: a complex machinery for information processing
Maio, V. D. (2021) · Cognitive Neurodynamics · doi:10.1007/s11571-021-09679-w · Cited by 34 · see citing works
3D morphology-based clustering and simulation of human pyramidal cell dendritic spines
Luengo-Sánchez, S., Fernaud-Espinosa, I., Bielza, C., Benavides‐Piccione, R., Larrañaga, P., & DeFelipe, J. (2018) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1006221 · Cited by 32 · see citing works
Basu, S., Plewczyński, D., Saha, S., Roszkowska, M., Magnowska, M., Bączyńska, E., & Włodarczyk, J. (2016) · Bioinformatics · doi:10.1093/bioinformatics/btw172 · Cited by 32 · see citing works
The Role of Synaptopodin in Membrane Protein Diffusion in the Dendritic Spine Neck
Wang, L., Dumoulin, A., Renner, M. L., Triller, A., & Specht, C. G. (2016) · PLoS ONE · doi:10.1371/journal.pone.0148310 · Cited by 29 · see citing works
Li, T., Wu, Y., Yang, L., Fu, Z., & Jia, Y. (2023) · Chaos Solitons & Fractals · doi:10.1016/j.chaos.2023.113554 · Cited by 30 · see citing works
Geometry and the Organizational Principle of Spine Synapses along a Dendrite
Parajuli, L. K., Urakubo, H., Takahashi-Nakazato, A., Ogelman, R., Iwasaki, H., Koike, M., Kwon, H., Ishii, S., Oh, W. C., Fukazawa, Y., et al. (2020) · eNeuro · doi:10.1523/eneuro.0248-20.2020 · Cited by 27 · see citing works
Probing the Interplay between Dendritic Spine Morphology and Membrane-Bound Diffusion
Adrian, M., Kusters, R., Storm, C., Hoogenraad, C. C., & Kapitein, L. C. (2017) · Biophysical Journal · doi:10.1016/j.bpj.2017.06.048 · Cited by 27 · see citing works
Powell, G. L., Leyrer‐Jackson, J. M., Goenaga, J. G., Namba, M. D., Piña, J., Spencer, S. M., Stankeviciute, N. M., Schwartz, D., Allen, N. P., Franco, A. P. D., et al. (2019) · Physiological Reports · doi:10.14814/phy2.13958 · Cited by 28 · see citing works
Impact of maternal immune activation on dendritic spine development
Pękała, M., Doliwa, M., & Kalita, K. B. (2020) · Developmental Neurobiology · doi:10.1002/dneu.22804 · Cited by 26 · see citing works
Rosado, J., Bui, V. D., Haas, C. A., Beck, J., Queisser, G., & Vlachos, A. (2022) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1010069 · Cited by 27 · see citing works
Different forms of structural plasticity in the adult olfactory bulb
Hardy, D., & Saghatelyan, A. (2017) · Neurogenesis · doi:10.1080/23262133.2017.1301850 · Cited by 25 · see citing works
PDE4D regulates Spine Plasticity and Memory in the Retrosplenial Cortex
Baumgärtel, K., Green, A., Hornberger, D. K., Lapira, J., Rex, C. S., Wheeler, D. G., & Peters, M. (2018) · Scientific Reports · doi:10.1038/s41598-018-22193-0 · Cited by 26 · see citing works
Reelin cells and sex‐dependent synaptopathology in autism following postnatal immune activation
Ardalan, M., Chumak, T., Quist, A., Hermans, E. C., Rafati, A. H., Gravina, G., Shiadeh, S. M. J., Svedin, P., Alabaf, S., Hansen, B., et al. (2022) · British Journal of Pharmacology · doi:10.1111/bph.15859 · Cited by 26 · see citing works
Hansen, C. N., Faw, T. D., White, S., Buford, J. A., Grau, J. W., & Basso, D. M. (2016) · Frontiers in Neural Circuits · doi:10.3389/fncir.2016.00011 · Cited by 25 · see citing works
NOMA-GAP/ARHGAP33 regulates synapse development and autistic-like behavior in the mouse
Schuster, S., Rivalan, M., Strauß, U., Stoenica, L., Trimbuch, T., Rademacher, N., Parthasarathy, S., Lajkó, D., Rosenmund, C., Shoichet, S. A., et al. (2015) · Molecular Psychiatry · doi:10.1038/mp.2015.42 · Cited by 25 · see citing works
PackIO and EphysViewer: software tools for acquisition and analysis of neuroscience dataPreprint
Watson, B. O., Yuste, R., & Packer, A. M. (2016) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/054080 · Cited by 25 · see citing works
Self-citationMiyazaki, K.-I., & Ross, W. N. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.1758-17.2017 · Cited by 24 · see citing works
The role of molecular diffusion within dendritic spines in synaptic function
Obashi, K., Taraska, J. W., & Okabe, S. (2021) · The Journal of General Physiology · doi:10.1085/jgp.202012814 · Cited by 22 · see citing works
Single Synapse LTP: A Matter of Context?
Kruijssen, D. L. H., & Wierenga, C. J. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00496 · Cited by 23 · see citing works
Kasai, H. (2023) · Proceedings of the Japan Academy Series B · doi:10.2183/pjab.99.018 · Cited by 23 · see citing works
Salvatico, C., Specht, C. G., & Triller, A. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.09.020 · Cited by 22 · see citing works
Electrical and Ca2+ signaling in dendritic spines of substantia nigra dopaminergic neurons
Hage, T. A., Sun, Y., & Khaliq, Z. M. (2016) · eLife · doi:10.7554/elife.13905 · Cited by 20 · see citing works
Chan, T. E., Grossman, Y. S., Bloss, E. B., Janssen, W. G. M., Lou, W. Y. W., McEwen, B. S., Dumitriu, D., & Morrison, J. H. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00146 · Cited by 22 · see citing works
Mendes, A., Vignoud, G., Siaume‐Perez, S., Perrin, E., Touboul, J. D., & Venance, L. (2020) · Cerebral Cortex · doi:10.1093/cercor/bhaa024 · Cited by 22 · see citing works
Gemin, O., Serna, P., Zamith, J., Assendorp, N., Fossati, M., Rostaing, P., Triller, A., & Charrier, C. (2021) · PLoS Biology · doi:10.1371/journal.pbio.3001375 · Cited by 22 · see citing works
Tazerart, S., Blanchard, M. G., Miranda‐Rottmann, S., Mitchell, D. E., Pina, B. N., Thomas, C. I., Kamasawa, N., & Araya, R. (2022) · The Journal of Physiology · doi:10.1113/jp282303 · Cited by 20 · see citing works
Self-citationElectrostatics of non-neutral biological microdomains
Cartailler, J., Schuss, Z., & Holcman, D. (2017) · Scientific Reports · doi:10.1038/s41598-017-11590-6 · Cited by 21 · see citing works
Du, Y., Ge, M.-M., Xue, W., Yang, Q., Wang, S., Xu, Y., & Wang, H.-L. (2015) · PLoS ONE · doi:10.1371/journal.pone.0138112 · Cited by 20 · see citing works
The β‐adrenergic hypothesis of synaptic and microglial impairment in Alzheimer's disease
Li, S. (2023) · Journal of Neurochemistry · doi:10.1111/jnc.15782 · Cited by 18 · see citing works
Integration of multiscale dendritic spine structure and function data into systems biology models
Mancuso, J. J., Cheng, J., Yin, Z., Gilliam, J. C., Xia, X., Li, X., & Wong, S. T. C. (2014) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2014.00130 · Cited by 18 · see citing works
In Vivo Superresolution Imaging of Neuronal Structure in the Mouse Brain
Urban, B. E., Xiao, L., Chen, S., Yang, H., Dong, B., Kozorovitskiy, Y., & Zhang, H. F. (2017) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2017.2773540 · Cited by 18 · see citing works
Li, X., Song, Q., Chen, T., & Zhuo, M. (2017) · Molecular Pain · doi:10.1177/1744806917719847 · Cited by 18 · see citing works
Li, X., Song, Q., Chen, Q., Lu, J.-S., Chen, T., & Zhuo, M. (2017) · Molecular Brain · doi:10.1186/s13041-017-0336-5 · Cited by 18 · see citing works
Mitchell, D. E., Miranda‐Rottmann, S., Blanchard, M. G., & Araya, R. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2208963120 · Cited by 16 · see citing works
Self-citationSchröder, J. K., Abdel‐Hafiz, L., Ali, A. A. H., Cousin, T. C., Hallenberger, J., Almeida, F. R., Anstötz, M., Lenz, M., Vlachos, A., von Gall, C., et al. (2023) · Cells · doi:10.3390/cells12131758 · Cited by 17 · see citing works
Ma, S., Li, Z., Gong, S., Lu, C., Xiaoli Li, A., & Li, Y. (2023) · Brain Sciences · doi:10.3390/brainsci13040686 · Cited by 16 · see citing works
Mogensen, J., & Overgaard, M. S. (2017) · Frontiers in Psychology · doi:10.3389/fpsyg.2017.00625 · Cited by 16 · see citing works
Mogensen, J., & Overgaard, M. S. (2018) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2017.0346 · Cited by 16 · see citing works
Linaro, D., Levy, M. J., & Hunt, D. L. (2022) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1010071 · Cited by 15 · see citing works
Actin capping protein regulates postsynaptic spine development through CPI-motif interactions
Myers, K. R., Fan, Y., McConnell, P., Cooper, J. A., & Zheng, J. Q. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.1020949 · Cited by 14 · see citing works
Lukacs, I. P., Francavilla, R., Field, M., Hunter, E., Howarth, M., Horie, S., Plaha, P., Stacey, R. J., Livermore, L. J., Ansorge, O., et al. (2022) · Cerebral Cortex · doi:10.1093/cercor/bhac195 · Cited by 14 · see citing works
Pannexin 1 Regulates Dendritic Protrusion Dynamics in Immature Cortical Neurons
Sanchez‐Arias, J. C., Candlish, R. C., van der Slagt, E., & Swayne, L. A. (2020) · eNeuro · doi:10.1523/eneuro.0079-20.2020 · Cited by 15 · see citing works
Morphological Features of Human Dendritic Spines
Renner, J., & Rasia‐Filho, A. A. (2023) · Advances in neurobiology · doi:10.1007/978-3-031-36159-3_9 · Cited by 16 · see citing works
S-Equol mitigates motivational deficits and dysregulation associated with HIV-1
McLaurin, K. A., Bertrand, S. J., Illenberger, J. M., Harrod, S. B., Mactutus, C. F., & Booze, R. M. (2021) · Scientific Reports · doi:10.1038/s41598-021-91240-0 · Cited by 14 · see citing works
Faghihi, F., & Moustafa, A. A. (2017) · Frontiers in Neurorobotics · doi:10.3389/fnbot.2017.00063 · Cited by 13 · see citing works
Spindle-Shaped Neurons in the Human Posteromedial (Precuneus) Cortex
Fuentealba-Villarroel, F., Renner, J., Hilbig, A., Bruton, O. J., & Rasia‐Filho, A. A. (2022) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2021.769228 · Cited by 13 · see citing works
Regulation of dendritic spines in the amygdala following sleep deprivation
Rexrode, L., Tennin, M., Babu, J., Young, C., Bollavarapu, R., Lawson, L. A., Valeri, J., Pantazopoulos, H., & Gisabella, B. (2023) · Frontiers in Sleep · doi:10.3389/frsle.2023.1145203 · Cited by 12 · see citing works
- Authors
- Araya, R., Vogels, T. P., & Yuste, R.
- Affiliations
- Université de Montréal (CA)
- University of Oxford (GB)
- Columbia University (US)
- Corresponding author
- Araya, Roberto
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2014-06-30
- Volume
- 111
- Issue
- 28
- Pages
- E2895-904
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC4104910
- OpenAlex
- W2164811687
- Cited by
- 197
- References
- 66
- Citations by year
- 2026: 10 · 2025: 7 · 2024: 13 · 2023: 24 · 2022: 20 · 2021: 21 · 2020: 25 · 2019: 10 · 2018: 13 · 2017: 18 · 2016: 18 · 2015: 12 · 2014: 6
- FWCI
- 8.23
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust (100000, 090309/Z/09/Z, 090309)
- European Commission (268436)
- Multidisciplinary University Research Initiative (W911NF1210594)
- National Institute on Drug Abuse (R21DA034195)
- National Eye Institute (R01EY011787)
- National Institute of Neurological Disorders and Stroke (R21NS081393)
- Army Research Office (W911NF-12-1-0594, W911NF)
- Army Research Laboratory (W911NF-12-1-0594, W911NF)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- dendritic spines, synaptic plasticity, excitatory postsynaptic potentials, spike-timing-dependent plasticity, calcium imaging, glutamate uncaging, pyramidal neurons, neocortex, dendritic spine morphology, synaptic efficacy
- MeSH terms
- Animals, Dendrites, Female, Humans, Male, Neck, Synaptic Transmission, Spine, Synapses, Pyramidal Cells, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
